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The map label for this gene is metC [H]

Identifier: 225630607

GI number: 225630607

Start: 952883

End: 954124

Strand: Reverse

Name: metC [H]

Synonym: WRi_008780

Alternate gene names: 225630607

Gene position: 954124-952883 (Counterclockwise)

Preceding gene: 225630608

Following gene: 225630606

Centisome position: 65.99

GC content: 36.8

Gene sequence:

>1242_bases
GTGAAGGAAGAGTCTTTATTAGTTAAAGCAGGAAGAAAATTTAAGGACTATAAAGGTTCTATGAACCCGCCAGTTTATCA
TTCTTCTACCATATTATTCCCTACTTACAAGGACTACTTAAATGCAGCAAATGGAGAAAGTATATACGATGTAATCAACG
ATGATGTTGCAAGAGATTACAGCTATAGTAATGTTGGTACTCCCACTGTTCATTATTTTTCAAATGCACTGGCTGAAATT
GAAGGGAGTGGACAAGCGCTTATTTTTCCTTCCGGACTATTTGCACTTACTTTTGCTATTTTGACTTTCACTAAAGCAGG
TTCTCATGTTTTAATTCAGGATAACAGTTATTACCGACTCAAGAGATTTGCCGAAAATGAGTTACCAAACAGGGGAATAG
AAGTAACTTTTTATGATCCAACACAGGATATAACTGATTTAATTCAGAGTAATACTTCATTGATAATGATCGAGACTCCT
GGTTCTGTAACGTTTGAGATTTCGAATATAGAGCATATAGTAAAAGTTGCTAAAGAACGTGGAATCGTAACCGTTTGCGA
CAATTCATGGGCCACTCCTTTGTTATTTAAGCCGCTTGATTATGGAATTGATGTTGCACTATATGCGGTAACAAAGTATC
TAGCCGGTCACTCAGATTTATTGATGGGGACTATGATTGCTGAAGGTGAAATTTTTAAATTGCTTTATGAGAGCTATAAA
AATTATGGAGTAACCATTCAATCGCACGACTGTTATCTTGCACATAGGGGACTAAGAACACTGCACACACGTATGAAAAA
GTACCAAAATACAGCAATGGAAGTGGCAAAGTGGCTAGAAGCACAGCAAAAAGTTAGAAAGGTTTTATATCCAGCACTTC
CCTCCCATCCTCAACACGAATTATGGAAAAGTTACTTTAAAGGAGCAAGCGGCGTATTCAGTATAGTATTGGGTAGAGAA
TATTCATGTGAAGAACTAAGCTGCATGGTTGATCACATGAAAATTTTTGGTATCGGTGCTTCTTGGGGAGGGTGCGACAG
TTTGATATTACCAATAGATCGTAGATCTATGTCAAGATCTGTAATGAATTCAGATTATGGTGGAAGTTTTATACGGATAT
TTTGTGGACTGGAAGATCCTGAAGATTTAATCTTTGACCTTAATGACGCACTAAAAAGGTTACCATGTTTAGACTTTCAA
AACGATGAAGTAGGACATGAAACTGAGAGAATTACTGCATAA

Upstream 100 bases:

>100_bases
ATCTATGAATTATTAAAGAGTGAGATAGAGCTAATACATGCAATTTCTCTTCACTTGTATACGCAAAACGAGTACAATTT
AAAAAATAAATAATAAAAAT

Downstream 100 bases:

>100_bases
CATTATTGATGTTAACTTTGATATTGAAATCAAAGGCGTCACATGTAATCCCAAGAAAATCAAGGAAGGTTATCTTTTTG
TTTGTGTGTCAGAAAGGGAT

Product: Cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MKEESLLVKAGRKFKDYKGSMNPPVYHSSTILFPTYKDYLNAANGESIYDVINDDVARDYSYSNVGTPTVHYFSNALAEI
EGSGQALIFPSGLFALTFAILTFTKAGSHVLIQDNSYYRLKRFAENELPNRGIEVTFYDPTQDITDLIQSNTSLIMIETP
GSVTFEISNIEHIVKVAKERGIVTVCDNSWATPLLFKPLDYGIDVALYAVTKYLAGHSDLLMGTMIAEGEIFKLLYESYK
NYGVTIQSHDCYLAHRGLRTLHTRMKKYQNTAMEVAKWLEAQQKVRKVLYPALPSHPQHELWKSYFKGASGVFSIVLGRE
YSCEELSCMVDHMKIFGIGASWGGCDSLILPIDRRSMSRSVMNSDYGGSFIRIFCGLEDPEDLIFDLNDALKRLPCLDFQ
NDEVGHETERITA

Sequences:

>Translated_413_residues
MKEESLLVKAGRKFKDYKGSMNPPVYHSSTILFPTYKDYLNAANGESIYDVINDDVARDYSYSNVGTPTVHYFSNALAEI
EGSGQALIFPSGLFALTFAILTFTKAGSHVLIQDNSYYRLKRFAENELPNRGIEVTFYDPTQDITDLIQSNTSLIMIETP
GSVTFEISNIEHIVKVAKERGIVTVCDNSWATPLLFKPLDYGIDVALYAVTKYLAGHSDLLMGTMIAEGEIFKLLYESYK
NYGVTIQSHDCYLAHRGLRTLHTRMKKYQNTAMEVAKWLEAQQKVRKVLYPALPSHPQHELWKSYFKGASGVFSIVLGRE
YSCEELSCMVDHMKIFGIGASWGGCDSLILPIDRRSMSRSVMNSDYGGSFIRIFCGLEDPEDLIFDLNDALKRLPCLDFQ
NDEVGHETERITA
>Mature_413_residues
MKEESLLVKAGRKFKDYKGSMNPPVYHSSTILFPTYKDYLNAANGESIYDVINDDVARDYSYSNVGTPTVHYFSNALAEI
EGSGQALIFPSGLFALTFAILTFTKAGSHVLIQDNSYYRLKRFAENELPNRGIEVTFYDPTQDITDLIQSNTSLIMIETP
GSVTFEISNIEHIVKVAKERGIVTVCDNSWATPLLFKPLDYGIDVALYAVTKYLAGHSDLLMGTMIAEGEIFKLLYESYK
NYGVTIQSHDCYLAHRGLRTLHTRMKKYQNTAMEVAKWLEAQQKVRKVLYPALPSHPQHELWKSYFKGASGVFSIVLGRE
YSCEELSCMVDHMKIFGIGASWGGCDSLILPIDRRSMSRSVMNSDYGGSFIRIFCGLEDPEDLIFDLNDALKRLPCLDFQ
NDEVGHETERITA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=293, Percent_Identity=34.4709897610922, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI299473759, Length=239, Percent_Identity=34.3096234309623, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI25453487, Length=290, Percent_Identity=30.6896551724138, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1789383, Length=403, Percent_Identity=34.4913151364764, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1790375, Length=405, Percent_Identity=30.6172839506173, Blast_Score=171, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17538055, Length=340, Percent_Identity=35, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17560056, Length=356, Percent_Identity=35.6741573033708, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI71980708, Length=382, Percent_Identity=30.1047120418848, Blast_Score=184, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6321170, Length=336, Percent_Identity=38.3928571428571, Blast_Score=253, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6319307, Length=354, Percent_Identity=29.6610169491525, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321904, Length=339, Percent_Identity=28.9085545722714, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6321254, Length=421, Percent_Identity=27.0783847980998, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323333, Length=421, Percent_Identity=23.9904988123515, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922554, Length=346, Percent_Identity=35.5491329479769, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 46568; Mature: 46568

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEESLLVKAGRKFKDYKGSMNPPVYHSSTILFPTYKDYLNAANGESIYDVINDDVARDY
CCCCHHHHHCCCCHHHCCCCCCCCCEECCEEEECCHHHHHCCCCCCHHHHHHHHHHHCCC
SYSNVGTPTVHYFSNALAEIEGSGQALIFPSGLFALTFAILTFTKAGSHVLIQDNSYYRL
CCCCCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEECCCHHHH
KRFAENELPNRGIEVTFYDPTQDITDLIQSNTSLIMIETPGSVTFEISNIEHIVKVAKER
HHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHHHHC
GIVTVCDNSWATPLLFKPLDYGIDVALYAVTKYLAGHSDLLMGTMIAEGEIFKLLYESYK
CEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHH
NYGVTIQSHDCYLAHRGLRTLHTRMKKYQNTAMEVAKWLEAQQKVRKVLYPALPSHPQHE
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LWKSYFKGASGVFSIVLGREYSCEELSCMVDHMKIFGIGASWGGCDSLILPIDRRSMSRS
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHEEEEECCCCCCCCCEEEECCHHHHHHH
VMNSDYGGSFIRIFCGLEDPEDLIFDLNDALKRLPCLDFQNDEVGHETERITA
HHCCCCCCCEEEEEECCCCHHHHHCCHHHHHHHCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MKEESLLVKAGRKFKDYKGSMNPPVYHSSTILFPTYKDYLNAANGESIYDVINDDVARDY
CCCCHHHHHCCCCHHHCCCCCCCCCEECCEEEECCHHHHHCCCCCCHHHHHHHHHHHCCC
SYSNVGTPTVHYFSNALAEIEGSGQALIFPSGLFALTFAILTFTKAGSHVLIQDNSYYRL
CCCCCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEECCCHHHH
KRFAENELPNRGIEVTFYDPTQDITDLIQSNTSLIMIETPGSVTFEISNIEHIVKVAKER
HHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHHHHC
GIVTVCDNSWATPLLFKPLDYGIDVALYAVTKYLAGHSDLLMGTMIAEGEIFKLLYESYK
CEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHH
NYGVTIQSHDCYLAHRGLRTLHTRMKKYQNTAMEVAKWLEAQQKVRKVLYPALPSHPQHE
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LWKSYFKGASGVFSIVLGREYSCEELSCMVDHMKIFGIGASWGGCDSLILPIDRRSMSRS
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHEEEEECCCCCCCCCEEEECCHHHHHHH
VMNSDYGGSFIRIFCGLEDPEDLIFDLNDALKRLPCLDFQNDEVGHETERITA
HHCCCCCCCEEEEEECCCCHHHHHCCHHHHHHHCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]