| Definition | Wolbachia sp. wRi, complete genome. |
|---|---|
| Accession | NC_012416 |
| Length | 1,445,873 |
Click here to switch to the map view.
The map label for this gene is virB4 [H]
Identifier: 225630562
GI number: 225630562
Start: 892020
End: 894425
Strand: Reverse
Name: virB4 [H]
Synonym: WRi_008230
Alternate gene names: 225630562
Gene position: 894425-892020 (Counterclockwise)
Preceding gene: 225630563
Following gene: 225630561
Centisome position: 61.86
GC content: 35.33
Gene sequence:
>2406_bases ATGCTGAGGTTTAGGGCTATTCAATCAAAGAATAAATCTACTCTGAACAGGGAAGTTCACGCTGCTGAATTTATTCCTTA TTCTTGCTATTGGAATAGCACAACCTTGATGACAAAAGAAAATTGGTTGGTTAAGGTTATAAAATTAAGTGGTTTTGCAT TTGAAACTGCCGATGACGAGGATTTAGTCATACAGAACAACATCAGGAATCAGATGCTAAGAAGCATTTCATCTCCGGCA TTTAGTTTGTATTTTCATACTATCAGACGTAAGAAAAATATTTTTTCTGATGAATTTGCAAGTCAAGGTTTGCCGAATTT TTTCGCTAATCACGTAAATCTAAAATGGAGAGAAAAACACGCAACAAGGCAATCATTTATTAATGACCTATACATTACGA TTATCCGTAGAGCGGACACAAAAGGAGTAGAATTTTTGTCACATCTACTAAAAAAATTCGGACATGTAACTTCAAAACAT GCTTGGGAAAGTGATATACGTGCCACGTATGAAGATTTAGAGGAAACGACAAATCGTGTAGTGACAAGCCTTAGAAATTA TTCGCCTAAAATTCTTGGAGTAAAAGAAACTCCAGATGGTTTGTTCTGCGAAATAATGGAGTTTCTATCTAGAATCGTAA ATTGTGGCTTCGTTACAAATACGCTTTTTCCGCTAAGAACTGAAATATCAAGGTACTTACCAGTACATAGGTTATTCTTT GGCCGTAAGATGATACAGGTTGTGACTCATAATGAGAGTAAATATGCTGGAATAATTAGTATCAAAGAATATGGAAATCA TACTTCTGCAGGAATGCTTGATTCGTTTTTACAACTTCCTTACGAGTTTATAATTACGCAATCTTTTCAATTTATAAACA GGCAAATGGCGATTGGAAAAATGCAGATACAGCAAAATCGAATGATACAGTCTGCAGATAAAGCTATTTCTCAAATAGCA GAAATTTCTCAAGCGCTTGATGACGCAATGAGTGGTAAGATTGCGTTTGGTCAACATCACCTGACTATTTTATGTATAGA AAAAAGTCCTAAATCATTGGATAACGCTCTGTCGTTGGTAGAATCAGAGCTTTCTAATTGCGGTGTTTACCCTATACGTG AGAGAGTTAACCTTGAACCAGCATTTTGGGCGCAAATTCCTGGTAATTTCGATTATATAGTGAGAAAAGCTACAATAAGT AGTCTTAATTTGGCTGGATTTGCATCTCAACATAATTATCCTACTGGTAATAAATTCAATAACCACTGGGGAGATGCCGT TACAGTTTTTGACACGACATCTGGTACTCCATTTTTTTTCAACTTTCATATAAGGGATGTTGGACACACTATGATAATTG GCCCAACTGGTGCTGGTAAAACTGTTTTAATGAATTTCCTGTGTGCCCAAGCGATGAAGTTTTCTCCAAGGATATTCTTT TTTGATAAAGATCGCGGTGCAGAGATTTTCTTAAGAGCACTTAGTGGTATCTATACTGTAATAGAACCAAGAACTAAAAC AAATTTTAATCCTTTACAACTTGATGATACCTCTGATAATAGAACATTTTTAATGGAGTGGATAAAGTCTTTAATTTCGG TATATAATGATAAATTTACTTCAGAAGATATTGCACGAATTAATGATGCAATTGAAGGAAATTTTAAATTAAGAAAAGAA GACAGATTCTTGAGAAACCTCGTACCGTTTTTAGGGCTTGCAGGTCCTGATACTCTAGCTGGGGCAATATCTATGTGGCA TGATAATGGTTCTCATGCTGCAATATTTGACAATAAAGAAGATTTGCTAGATTTTTCACGAGCAAGAGTATTTGGTTTTG AGATGGCTAGCTTGCTCAAAGATCCTGTTGCTCTTGGACCGGTCTTGATTTATTTATTTCATAGGATTAGTATATCTCTT GATGGCACTCCATCTATTATCGTTCTTGATGAGGCATGGGCGTTAATAGATAATCCAGTTTTTGCACCCAAGATAAAAGA CTGGTTGAAGGTACTGAGAAAACTAAATGCTTTTGTGATTTTTGCTACTCAGAGTGTTGAGGATGCAAGTAAAAGTACTA TTAGCGATACGCTTGTACAACAAACAGCGACACAGATTTTTTTACCAAATCTGAAAGCTACTAGTGTCTATCGGGATGTT TTTATGTTAACTGAACGTGAATATATATTAATTAAGCACACAGATCCGAGTACTAGATTCTTTTTGGTGAAACAAGGAGT CAATGCTGTAGTAGCTAGAATAGACTTAAAAGGCCTGGATGATATAATCAACGTATTATCCGGACGTGCAGAAAGTGTTC TATTGTTACACGATATATTAAATGAAGTTGGGGACAACCCAAAAGTATGGTTGCCTATATTTTATCAGAAGGTAAAAAAT GTTTAA
Upstream 100 bases:
>100_bases GTTTATTGAATTATTTATGGTAAAATTGGGAAAGTGCTCGAAATGTTTAAATCGTTTTTACCATGGAGCCAATTCTTATG ATATTGCTTAACGTTGTGTG
Downstream 100 bases:
>100_bases GACTAAGCTGTCATTGCTATTAATTGCGATATTTTTACTAAATATAGACTTTTTACTCTCATATCCAGTGCTTGCAGATG GAGTAAGTGGTACTGACAAG
Product: type IV secretion system ATPase VirB4
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 801; Mature: 801
Protein sequence:
>801_residues MLRFRAIQSKNKSTLNREVHAAEFIPYSCYWNSTTLMTKENWLVKVIKLSGFAFETADDEDLVIQNNIRNQMLRSISSPA FSLYFHTIRRKKNIFSDEFASQGLPNFFANHVNLKWREKHATRQSFINDLYITIIRRADTKGVEFLSHLLKKFGHVTSKH AWESDIRATYEDLEETTNRVVTSLRNYSPKILGVKETPDGLFCEIMEFLSRIVNCGFVTNTLFPLRTEISRYLPVHRLFF GRKMIQVVTHNESKYAGIISIKEYGNHTSAGMLDSFLQLPYEFIITQSFQFINRQMAIGKMQIQQNRMIQSADKAISQIA EISQALDDAMSGKIAFGQHHLTILCIEKSPKSLDNALSLVESELSNCGVYPIRERVNLEPAFWAQIPGNFDYIVRKATIS SLNLAGFASQHNYPTGNKFNNHWGDAVTVFDTTSGTPFFFNFHIRDVGHTMIIGPTGAGKTVLMNFLCAQAMKFSPRIFF FDKDRGAEIFLRALSGIYTVIEPRTKTNFNPLQLDDTSDNRTFLMEWIKSLISVYNDKFTSEDIARINDAIEGNFKLRKE DRFLRNLVPFLGLAGPDTLAGAISMWHDNGSHAAIFDNKEDLLDFSRARVFGFEMASLLKDPVALGPVLIYLFHRISISL DGTPSIIVLDEAWALIDNPVFAPKIKDWLKVLRKLNAFVIFATQSVEDASKSTISDTLVQQTATQIFLPNLKATSVYRDV FMLTEREYILIKHTDPSTRFFLVKQGVNAVVARIDLKGLDDIINVLSGRAESVLLLHDILNEVGDNPKVWLPIFYQKVKN V
Sequences:
>Translated_801_residues MLRFRAIQSKNKSTLNREVHAAEFIPYSCYWNSTTLMTKENWLVKVIKLSGFAFETADDEDLVIQNNIRNQMLRSISSPA FSLYFHTIRRKKNIFSDEFASQGLPNFFANHVNLKWREKHATRQSFINDLYITIIRRADTKGVEFLSHLLKKFGHVTSKH AWESDIRATYEDLEETTNRVVTSLRNYSPKILGVKETPDGLFCEIMEFLSRIVNCGFVTNTLFPLRTEISRYLPVHRLFF GRKMIQVVTHNESKYAGIISIKEYGNHTSAGMLDSFLQLPYEFIITQSFQFINRQMAIGKMQIQQNRMIQSADKAISQIA EISQALDDAMSGKIAFGQHHLTILCIEKSPKSLDNALSLVESELSNCGVYPIRERVNLEPAFWAQIPGNFDYIVRKATIS SLNLAGFASQHNYPTGNKFNNHWGDAVTVFDTTSGTPFFFNFHIRDVGHTMIIGPTGAGKTVLMNFLCAQAMKFSPRIFF FDKDRGAEIFLRALSGIYTVIEPRTKTNFNPLQLDDTSDNRTFLMEWIKSLISVYNDKFTSEDIARINDAIEGNFKLRKE DRFLRNLVPFLGLAGPDTLAGAISMWHDNGSHAAIFDNKEDLLDFSRARVFGFEMASLLKDPVALGPVLIYLFHRISISL DGTPSIIVLDEAWALIDNPVFAPKIKDWLKVLRKLNAFVIFATQSVEDASKSTISDTLVQQTATQIFLPNLKATSVYRDV FMLTEREYILIKHTDPSTRFFLVKQGVNAVVARIDLKGLDDIINVLSGRAESVLLLHDILNEVGDNPKVWLPIFYQKVKN V >Mature_801_residues MLRFRAIQSKNKSTLNREVHAAEFIPYSCYWNSTTLMTKENWLVKVIKLSGFAFETADDEDLVIQNNIRNQMLRSISSPA FSLYFHTIRRKKNIFSDEFASQGLPNFFANHVNLKWREKHATRQSFINDLYITIIRRADTKGVEFLSHLLKKFGHVTSKH AWESDIRATYEDLEETTNRVVTSLRNYSPKILGVKETPDGLFCEIMEFLSRIVNCGFVTNTLFPLRTEISRYLPVHRLFF GRKMIQVVTHNESKYAGIISIKEYGNHTSAGMLDSFLQLPYEFIITQSFQFINRQMAIGKMQIQQNRMIQSADKAISQIA EISQALDDAMSGKIAFGQHHLTILCIEKSPKSLDNALSLVESELSNCGVYPIRERVNLEPAFWAQIPGNFDYIVRKATIS SLNLAGFASQHNYPTGNKFNNHWGDAVTVFDTTSGTPFFFNFHIRDVGHTMIIGPTGAGKTVLMNFLCAQAMKFSPRIFF FDKDRGAEIFLRALSGIYTVIEPRTKTNFNPLQLDDTSDNRTFLMEWIKSLISVYNDKFTSEDIARINDAIEGNFKLRKE DRFLRNLVPFLGLAGPDTLAGAISMWHDNGSHAAIFDNKEDLLDFSRARVFGFEMASLLKDPVALGPVLIYLFHRISISL DGTPSIIVLDEAWALIDNPVFAPKIKDWLKVLRKLNAFVIFATQSVEDASKSTISDTLVQQTATQIFLPNLKATSVYRDV FMLTEREYILIKHTDPSTRFFLVKQGVNAVVARIDLKGLDDIINVLSGRAESVLLLHDILNEVGDNPKVWLPIFYQKVKN V
Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-
COG id: COG3451
COG function: function code U; Type IV secretory pathway, VirB4 components
Gene ontology:
Cell location: Cell inner membrane (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trbE/virB4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR004346 - InterPro: IPR018145 [H]
Pfam domain/function: PF03135 CagE_TrbE_VirB [H]
EC number: NA
Molecular weight: Translated: 91233; Mature: 91233
Theoretical pI: Translated: 8.67; Mature: 8.67
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLRFRAIQSKNKSTLNREVHAAEFIPYSCYWNSTTLMTKENWLVKVIKLSGFAFETADDE CCCEECCCCCCCHHHHHHHHHHHCCEEEEEECCEEEEECCCCEEEEEEECCEEEECCCCC DLVIQNNIRNQMLRSISSPAFSLYFHTIRRKKNIFSDEFASQGLPNFFANHVNLKWREKH CEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHCCCEEEHHHH ATRQSFINDLYITIIRRADTKGVEFLSHLLKKFGHVTSKHAWESDIRATYEDLEETTNRV HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH VTSLRNYSPKILGVKETPDGLFCEIMEFLSRIVNCGFVTNTLFPLRTEISRYLPVHRLFF HHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCHHHHHHH GRKMIQVVTHNESKYAGIISIKEYGNHTSAGMLDSFLQLPYEFIITQSFQFINRQMAIGK HHHHEEEEECCCCCEEEEEEEHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH MQIQQNRMIQSADKAISQIAEISQALDDAMSGKIAFGQHHLTILCIEKSPKSLDNALSLV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCCHHHHHHHHHH ESELSNCGVYPIRERVNLEPAFWAQIPGNFDYIVRKATISSLNLAGFASQHNYPTGNKFN HHHHHHCCCCEEHHHCCCCCCEEEECCCCHHHEEEEHHHHHCCEEEECCCCCCCCCCCCC NHWGDAVTVFDTTSGTPFFFNFHIRDVGHTMIIGPTGAGKTVLMNFLCAQAMKFSPRIFF CCCCCEEEEEECCCCCEEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEE FDKDRGAEIFLRALSGIYTVIEPRTKTNFNPLQLDDTSDNRTFLMEWIKSLISVYNDKFT EECCCCHHHHHHHHHHHHEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCC SEDIARINDAIEGNFKLRKEDRFLRNLVPFLGLAGPDTLAGAISMWHDNGSHAAIFDNKE HHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHEEECCCCEEEEECCHH DLLDFSRARVFGFEMASLLKDPVALGPVLIYLFHRISISLDGTPSIIVLDEAWALIDNPV HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCEEEEECCHHHHCCCC FAPKIKDWLKVLRKLNAFVIFATQSVEDASKSTISDTLVQQTATQIFLPNLKATSVYRDV CCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH FMLTEREYILIKHTDPSTRFFLVKQGVNAVVARIDLKGLDDIINVLSGRAESVLLLHDIL HHEECCCEEEEEECCCCCEEEEEECCCHHEEHHHHHCCHHHHHHHHCCCCCHHHHHHHHH NEVGDNPKVWLPIFYQKVKNV HHHCCCCCEEHHHHHHHHCCC >Mature Secondary Structure MLRFRAIQSKNKSTLNREVHAAEFIPYSCYWNSTTLMTKENWLVKVIKLSGFAFETADDE CCCEECCCCCCCHHHHHHHHHHHCCEEEEEECCEEEEECCCCEEEEEEECCEEEECCCCC DLVIQNNIRNQMLRSISSPAFSLYFHTIRRKKNIFSDEFASQGLPNFFANHVNLKWREKH CEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHCCCEEEHHHH ATRQSFINDLYITIIRRADTKGVEFLSHLLKKFGHVTSKHAWESDIRATYEDLEETTNRV HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH VTSLRNYSPKILGVKETPDGLFCEIMEFLSRIVNCGFVTNTLFPLRTEISRYLPVHRLFF HHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCHHHHHHH GRKMIQVVTHNESKYAGIISIKEYGNHTSAGMLDSFLQLPYEFIITQSFQFINRQMAIGK HHHHEEEEECCCCCEEEEEEEHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH MQIQQNRMIQSADKAISQIAEISQALDDAMSGKIAFGQHHLTILCIEKSPKSLDNALSLV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCCHHHHHHHHHH ESELSNCGVYPIRERVNLEPAFWAQIPGNFDYIVRKATISSLNLAGFASQHNYPTGNKFN HHHHHHCCCCEEHHHCCCCCCEEEECCCCHHHEEEEHHHHHCCEEEECCCCCCCCCCCCC NHWGDAVTVFDTTSGTPFFFNFHIRDVGHTMIIGPTGAGKTVLMNFLCAQAMKFSPRIFF CCCCCEEEEEECCCCCEEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEE FDKDRGAEIFLRALSGIYTVIEPRTKTNFNPLQLDDTSDNRTFLMEWIKSLISVYNDKFT EECCCCHHHHHHHHHHHHEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCC SEDIARINDAIEGNFKLRKEDRFLRNLVPFLGLAGPDTLAGAISMWHDNGSHAAIFDNKE HHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHEEECCCCEEEEECCHH DLLDFSRARVFGFEMASLLKDPVALGPVLIYLFHRISISLDGTPSIIVLDEAWALIDNPV HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCEEEEECCHHHHCCCC FAPKIKDWLKVLRKLNAFVIFATQSVEDASKSTISDTLVQQTATQIFLPNLKATSVYRDV CCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH FMLTEREYILIKHTDPSTRFFLVKQGVNAVVARIDLKGLDDIINVLSGRAESVLLLHDIL HHEECCCEEEEEECCCCCEEEEEECCCHHEEHHHHHCCHHHHHHHHCCCCCHHHHHHHHH NEVGDNPKVWLPIFYQKVKNV HHHCCCCCEEHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10749166; 10882236; 7494028 [H]