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The map label for this gene is dtpA [H]

Identifier: 225630140

GI number: 225630140

Start: 349919

End: 351385

Strand: Direct

Name: dtpA [H]

Synonym: WRi_003220

Alternate gene names: 225630140

Gene position: 349919-351385 (Clockwise)

Preceding gene: 225630137

Following gene: 225630143

Centisome position: 24.2

GC content: 33.74

Gene sequence:

>1467_bases
ATGGATCAGAAGACAGATAAGTTTCCACAATTTTTAAAAATGTTGTGCTTTGTTGAAATGTGGGAACGTTTCTCTTACTA
TGGAATGAGGGCACTTTTGGTCCTATTTTTGACTTCTCACTTAGGTTTCACTGATGAGAGGGCCTTTACTATTTACTCAT
TATTTGCTGCAACAGGTTATGCTATACCAATACTTGGAGGTTTTTTAGCTGATAAGTTGATGGGATTCCGCAACATGGTG
TTGCTTGGAGGGATAGTGATGATAGCAGGTCATGCTTGCATGTCATTGGTTAAGTTTGAACCAGGTTTATTATATTTAGG
TTTATCTCTAATAGCCATAGGTACTGGTATGTTTAAAGGGAACGTAACTAACTTACTTAGTTCATGCTATGGCAAAGACG
ATCCTGAACGTAGCAGAGGCTTTACTTTATTTTACGTAGGTGTGAATATTGGAGCAATATTGGCTTCTATTTCATGTGGT
TATGTAGCCCACTTGTTTGGCTGGCACTACGGCTTTGGTTTAGCTGGTATTGGGATGTCTATAGGGCTAATCTTTTTTCT
CAAATTTCAGAATCTTTTAGGAGATAGCGGCCTTTCTCCTTATCCAGAGCTTATGAATAAGCGCATATTAGGGATTAAAA
TTTTTGGTATAGTATTGATAGGAAGCTTTCTGTCATCATCAATAATTGCTAAAATGCTTATACATAGTGAATTTTTTACT
AATATGCTCATATTTATTGGAATAACAGCTCTGGGCATATTTATTTATATAATATCTAAATTATCAGCAGAACAAAGACG
AAAATTAGTGGCATTATCTATTCTTGTGGTATTTTTCTTGTGTTTTTTTGCTTTAGAAATGCAGCTTGGCTCTTTGGTTA
ACTTATTCACCGAAAGAAACGTTATTAACAATGTATTAGGTATAACAATCCCAGCTTCAGTTTCTCAAGCCATAAATCCT
TTGTCAATTATAATATTTGGCTTTCTTTTTGGAACATACATGAAGTTTAAGCAAAAATATGCAACTTCCATGTTTACCCT
TGGCCTTCTGACAATGGCTATGTGTTTTTTCACACTGTACATAGGATGTTTAAACTCTAACATTGAAGGTAAAGTAGAAT
ACTTATATTTAATAATTGCTATCTCCTTTATGGGACTGGGAGAATTATGTATTGCTCCATTAGTCCAAGAACAAGCAACT
ACACTAGCCCCCAAAAACCTTAGAGGAGTAGTGATGGGTATAGTAATGCTGTCATTAGCGTTTTCTAACCTAGCCGGAGT
TGCAATATCAAAATTTATGTCAGTTCCTTCAGTAAATGGTAAAATAAATTATTTAGAATCTTTAGAAATATATAAAGAGG
GTTTTTTAAAGGTGGGAATATTTAATTTAATGCTCGTTATTGTATTTTTATTCTTCTTCAATTTTATACATAAAGTTGTT
ACTAACTCATCTTGTACAAAAAATTGA

Upstream 100 bases:

>100_bases
CCAACAAACTATTCTGCCGAGCTTCCAATACCTTTTTTTAAGTTTTACTTGCAGTTTTTATTGTTTTACTTAACATTAAC
CCAAGCTTTAGGGGTATTTT

Downstream 100 bases:

>100_bases
TATAGGTAAGCTCAAATTTGTAGGTTTAAGGTACCCGTTCAGCAGAGGTAGCAATTAAACTTTGTAACTTTTGAAAAAGA
TTATGATTGCATTTTTTCAA

Product: putative amino acid/peptide transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MDQKTDKFPQFLKMLCFVEMWERFSYYGMRALLVLFLTSHLGFTDERAFTIYSLFAATGYAIPILGGFLADKLMGFRNMV
LLGGIVMIAGHACMSLVKFEPGLLYLGLSLIAIGTGMFKGNVTNLLSSCYGKDDPERSRGFTLFYVGVNIGAILASISCG
YVAHLFGWHYGFGLAGIGMSIGLIFFLKFQNLLGDSGLSPYPELMNKRILGIKIFGIVLIGSFLSSSIIAKMLIHSEFFT
NMLIFIGITALGIFIYIISKLSAEQRRKLVALSILVVFFLCFFALEMQLGSLVNLFTERNVINNVLGITIPASVSQAINP
LSIIIFGFLFGTYMKFKQKYATSMFTLGLLTMAMCFFTLYIGCLNSNIEGKVEYLYLIIAISFMGLGELCIAPLVQEQAT
TLAPKNLRGVVMGIVMLSLAFSNLAGVAISKFMSVPSVNGKINYLESLEIYKEGFLKVGIFNLMLVIVFLFFFNFIHKVV
TNSSCTKN

Sequences:

>Translated_488_residues
MDQKTDKFPQFLKMLCFVEMWERFSYYGMRALLVLFLTSHLGFTDERAFTIYSLFAATGYAIPILGGFLADKLMGFRNMV
LLGGIVMIAGHACMSLVKFEPGLLYLGLSLIAIGTGMFKGNVTNLLSSCYGKDDPERSRGFTLFYVGVNIGAILASISCG
YVAHLFGWHYGFGLAGIGMSIGLIFFLKFQNLLGDSGLSPYPELMNKRILGIKIFGIVLIGSFLSSSIIAKMLIHSEFFT
NMLIFIGITALGIFIYIISKLSAEQRRKLVALSILVVFFLCFFALEMQLGSLVNLFTERNVINNVLGITIPASVSQAINP
LSIIIFGFLFGTYMKFKQKYATSMFTLGLLTMAMCFFTLYIGCLNSNIEGKVEYLYLIIAISFMGLGELCIAPLVQEQAT
TLAPKNLRGVVMGIVMLSLAFSNLAGVAISKFMSVPSVNGKINYLESLEIYKEGFLKVGIFNLMLVIVFLFFFNFIHKVV
TNSSCTKN
>Mature_488_residues
MDQKTDKFPQFLKMLCFVEMWERFSYYGMRALLVLFLTSHLGFTDERAFTIYSLFAATGYAIPILGGFLADKLMGFRNMV
LLGGIVMIAGHACMSLVKFEPGLLYLGLSLIAIGTGMFKGNVTNLLSSCYGKDDPERSRGFTLFYVGVNIGAILASISCG
YVAHLFGWHYGFGLAGIGMSIGLIFFLKFQNLLGDSGLSPYPELMNKRILGIKIFGIVLIGSFLSSSIIAKMLIHSEFFT
NMLIFIGITALGIFIYIISKLSAEQRRKLVALSILVVFFLCFFALEMQLGSLVNLFTERNVINNVLGITIPASVSQAINP
LSIIIFGFLFGTYMKFKQKYATSMFTLGLLTMAMCFFTLYIGCLNSNIEGKVEYLYLIIAISFMGLGELCIAPLVQEQAT
TLAPKNLRGVVMGIVMLSLAFSNLAGVAISKFMSVPSVNGKINYLESLEIYKEGFLKVGIFNLMLVIVFLFFFNFIHKVV
TNSSCTKN

Specific function: Proton-dependent permease that transports di- and tripeptides [H]

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4827008, Length=201, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI226371746, Length=194, Percent_Identity=30.9278350515464, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI226371748, Length=186, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787922, Length=479, Percent_Identity=30.8977035490605, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1786927, Length=469, Percent_Identity=33.2622601279318, Blast_Score=235, Evalue=6e-63,
Organism=Escherichia coli, GI1790572, Length=494, Percent_Identity=31.3765182186235, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1789911, Length=482, Percent_Identity=29.6680497925311, Blast_Score=213, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71987453, Length=384, Percent_Identity=24.21875, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24639585, Length=350, Percent_Identity=28.2857142857143, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24639583, Length=350, Percent_Identity=28.2857142857143, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24639581, Length=349, Percent_Identity=28.3667621776504, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28571102, Length=207, Percent_Identity=28.5024154589372, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571100, Length=207, Percent_Identity=28.5024154589372, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571098, Length=207, Percent_Identity=28.5024154589372, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456 [H]

Pfam domain/function: PF00854 PTR2 [H]

EC number: NA

Molecular weight: Translated: 53982; Mature: 53982

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS50850 MFS ; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCC
>Mature Secondary Structure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CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]