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The map label for this gene is gmk [H]

Identifier: 225630124

GI number: 225630124

Start: 325763

End: 326368

Strand: Direct

Name: gmk [H]

Synonym: WRi_003060

Alternate gene names: 225630124

Gene position: 325763-326368 (Clockwise)

Preceding gene: 225630123

Following gene: 225630125

Centisome position: 22.53

GC content: 35.97

Gene sequence:

>606_bases
ATGACCGTAAAAAGTGAGGGCGTATTATTGGTTCTATCCTCCCCTTCTGGAGCTGGAAAAACTACTATATCAGCAAAATT
ACTTGAGCGATCAACTAATTTAGTTAGGTCTGTTTCTATGACTACGCGCAAGCCTCGCCCCGGCGAAATAAATGGAAAAG
ACTATTTTTTCGTTACCGAAGAAAAATTTCACGAGTTATGCAAAGCTGGCCAAATGCTTGAATACGCCAAAGTTTTTGAG
AATTTTTATGGTATACCAAGAAATTTTATAGAGCAAAACTTAAGCAATGGAATAAGCGTTTTACTCAGCATAGACTGGCA
AGGAGCATTTCACTTATTCAAGCTCATGAGAAAAAAAGTTGTAAGTGTTTTTATACTTCCCCCTTCAATGGAAGAGCTTA
GGTTGCGTTTGCAAAAGCGTAATAGTGATGATGCAAGCGAAATAGAGCGCAGATTAGCCGAAGCTCAAAAAGAGATAAGC
AAACGTGATAAATATGATTATGTAATAATCAATGATGATATTGATAAAAGTGTAGAAGAGATAAGCTCCATACTAAATAA
AGAAAGACTTAAAAAACTAAAAGAAAAACCAAGTCTGGAAGACTGA

Upstream 100 bases:

>100_bases
TCTTCTCTCATTGGCACCAACTTATCAAATTCTAATTTAGAAGGTTCTAGCTTTTTAAACTCTGATCCAAAAAGCACCAT
GTTAAAAAATGCAAAGAAAA

Downstream 100 bases:

>100_bases
TAAAAACATCAATTTGGATATTTGCAGCTATAGTTTCTTATCCTATTTTAGCCAGTAGCACGTTTCGCAGTTTAGCTATA
TTTATTATTTTTTAAGATTA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MTVKSEGVLLVLSSPSGAGKTTISAKLLERSTNLVRSVSMTTRKPRPGEINGKDYFFVTEEKFHELCKAGQMLEYAKVFE
NFYGIPRNFIEQNLSNGISVLLSIDWQGAFHLFKLMRKKVVSVFILPPSMEELRLRLQKRNSDDASEIERRLAEAQKEIS
KRDKYDYVIINDDIDKSVEEISSILNKERLKKLKEKPSLED

Sequences:

>Translated_201_residues
MTVKSEGVLLVLSSPSGAGKTTISAKLLERSTNLVRSVSMTTRKPRPGEINGKDYFFVTEEKFHELCKAGQMLEYAKVFE
NFYGIPRNFIEQNLSNGISVLLSIDWQGAFHLFKLMRKKVVSVFILPPSMEELRLRLQKRNSDDASEIERRLAEAQKEIS
KRDKYDYVIINDDIDKSVEEISSILNKERLKKLKEKPSLED
>Mature_200_residues
TVKSEGVLLVLSSPSGAGKTTISAKLLERSTNLVRSVSMTTRKPRPGEINGKDYFFVTEEKFHELCKAGQMLEYAKVFEN
FYGIPRNFIEQNLSNGISVLLSIDWQGAFHLFKLMRKKVVSVFILPPSMEELRLRLQKRNSDDASEIERRLAEAQKEISK
RDKYDYVIINDDIDKSVEEISSILNKERLKKLKEKPSLED

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=183, Percent_Identity=36.6120218579235, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4504221, Length=183, Percent_Identity=36.6120218579235, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI226874831, Length=183, Percent_Identity=36.6120218579235, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI38570142, Length=184, Percent_Identity=29.3478260869565, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI21361598, Length=192, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=194, Percent_Identity=43.298969072165, Blast_Score=170, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=33.1491712707182, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=33.1491712707182, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71988041, Length=180, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557440, Length=182, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=182, Percent_Identity=26.3736263736264, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=37.1584699453552, Blast_Score=124, Evalue=8e-30,
Organism=Drosophila melanogaster, GI21356141, Length=194, Percent_Identity=31.4432989690722, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI161077626, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554481, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640542, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554489, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85724806, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007136, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23075; Mature: 22944

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKSEGVLLVLSSPSGAGKTTISAKLLERSTNLVRSVSMTTRKPRPGEINGKDYFFVTE
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECH
EKFHELCKAGQMLEYAKVFENFYGIPRNFIEQNLSNGISVLLSIDWQGAFHLFKLMRKKV
HHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHH
VSVFILPPSMEELRLRLQKRNSDDASEIERRLAEAQKEISKRDKYDYVIINDDIDKSVEE
HEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHH
ISSILNKERLKKLKEKPSLED
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TVKSEGVLLVLSSPSGAGKTTISAKLLERSTNLVRSVSMTTRKPRPGEINGKDYFFVTE
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECH
EKFHELCKAGQMLEYAKVFENFYGIPRNFIEQNLSNGISVLLSIDWQGAFHLFKLMRKKV
HHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHH
VSVFILPPSMEELRLRLQKRNSDDASEIERRLAEAQKEISKRDKYDYVIINDDIDKSVEE
HEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHH
ISSILNKERLKKLKEKPSLED
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA