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The map label for this gene is rsbRA [H]

Identifier: 222527013

GI number: 222527013

Start: 4724136

End: 4725248

Strand: Reverse

Name: rsbRA [H]

Synonym: Chy400_3792

Alternate gene names: 222527013

Gene position: 4725248-4724136 (Counterclockwise)

Preceding gene: 222527016

Following gene: 222527011

Centisome position: 89.68

GC content: 51.12

Gene sequence:

>1113_bases
ATGTTCAACTCGATACGCACCCTGCTCAATGTCCGTCACCCTGATGAAGAGGTACGCCAGCGTGGGCGAAATATCATTGT
TATTGCGCTGGGTTTGCTCGGTATCAACCTGGTGGTGGTAATTTCGCTGCTGTTTAATCTTTCTCAAGTCACAAGATTGT
TTGCTACTTCTGCGGTCAGTGTTATTCTATACATTTTTGTGATCTTTATAACGTTTAGGGGTTTTGTTGAGCTTGCCGGA
TGGCTGACGGTCATGATCTCGCTGGTCGGCACTTTAGCCGCACTGTTTGTTACGCCCAATGGGTTAACAATCATTTTTCT
GGCAGTTCCTCTGGTGCTGGCGGCAACCGTTTTAAGTCTGCGTAGTCTGATCCTCGTCTTCTTGCTTACAGCATGCAGTT
TAGCAGGTATTGCTTTTTTTCTCGAACCGACGCCACTCAGCCTTACCACACGCGACTTTTTAATTCCTGTGAGTTTGCTC
TGTGCCTTTCTCGGCATTGTCAGTTTTGTGCAGAGTGCCGGGAATGAGGCACTTCATCGGCGGTTGCAGGCGGCGCTCCA
ACAGGCAAAGCAAACTGCCGATCAGTTGCGGTTGTTGAACGACGAGCTTGATCGACGGGTTGATGCACAGACAGAAGCCT
TGCAGGAGGCGCTAAGCGAGTTAGAGGAGCGTACTTTACAACAAGATCGCCTGCTCGCCGAGGTAATTGCACAACGTGAC
GTGATTCGGAACCTGAGTGTTCCGGTGTTGCCGGCTGGAACCGATCTGCTGGCTATTCCATTAGTAGGAACGATTGATCA
GGAACGGCTGGCAACCATTCAGCAACAGGCCCTGACTGCCGTCGAACAGCGACGGGCACGCTGGTTAATTCTCGATGTCA
CCGGTGTACCATTCATCGATACCGGGGTGGCTGGTGGATTGATTCAGTTGGTACAAAGTGTTCGCCTGTTGGGTGCCGAT
GTGGTGCTGGTCGGTGTACGCCCGGAAGTTGCGCAGACGATGGTGAGTCTAGGTATTGAGCTGCCAATTACCCATGTATA
CAGCGATCTGGCCGGTGCGATTGAAGATTTGCATCATCACACAGACCACTCTCGCCAGAATAATCGACGGTGA

Upstream 100 bases:

>100_bases
TTGTGGTTGATCTGACATACTGCGATTGATGAAAGTTGTCAAAAAACCGTTAACCTATTATAATCATTGTCTGGTCAAAG
ATACAAGCAACGGTGTTTCT

Downstream 100 bases:

>100_bases
TTGCTGTACGCTATGTTATTACCGGCGTCAGTCCGGTCAGGGGGTATTGCCAGAGCTTGCTGGTGAACGTATCACTCGTA
GTACCGGGTGGGTATGGGTG

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MFNSIRTLLNVRHPDEEVRQRGRNIIVIALGLLGINLVVVISLLFNLSQVTRLFATSAVSVILYIFVIFITFRGFVELAG
WLTVMISLVGTLAALFVTPNGLTIIFLAVPLVLAATVLSLRSLILVFLLTACSLAGIAFFLEPTPLSLTTRDFLIPVSLL
CAFLGIVSFVQSAGNEALHRRLQAALQQAKQTADQLRLLNDELDRRVDAQTEALQEALSELEERTLQQDRLLAEVIAQRD
VIRNLSVPVLPAGTDLLAIPLVGTIDQERLATIQQQALTAVEQRRARWLILDVTGVPFIDTGVAGGLIQLVQSVRLLGAD
VVLVGVRPEVAQTMVSLGIELPITHVYSDLAGAIEDLHHHTDHSRQNNRR

Sequences:

>Translated_370_residues
MFNSIRTLLNVRHPDEEVRQRGRNIIVIALGLLGINLVVVISLLFNLSQVTRLFATSAVSVILYIFVIFITFRGFVELAG
WLTVMISLVGTLAALFVTPNGLTIIFLAVPLVLAATVLSLRSLILVFLLTACSLAGIAFFLEPTPLSLTTRDFLIPVSLL
CAFLGIVSFVQSAGNEALHRRLQAALQQAKQTADQLRLLNDELDRRVDAQTEALQEALSELEERTLQQDRLLAEVIAQRD
VIRNLSVPVLPAGTDLLAIPLVGTIDQERLATIQQQALTAVEQRRARWLILDVTGVPFIDTGVAGGLIQLVQSVRLLGAD
VVLVGVRPEVAQTMVSLGIELPITHVYSDLAGAIEDLHHHTDHSRQNNRR
>Mature_370_residues
MFNSIRTLLNVRHPDEEVRQRGRNIIVIALGLLGINLVVVISLLFNLSQVTRLFATSAVSVILYIFVIFITFRGFVELAG
WLTVMISLVGTLAALFVTPNGLTIIFLAVPLVLAATVLSLRSLILVFLLTACSLAGIAFFLEPTPLSLTTRDFLIPVSLL
CAFLGIVSFVQSAGNEALHRRLQAALQQAKQTADQLRLLNDELDRRVDAQTEALQEALSELEERTLQQDRLLAEVIAQRD
VIRNLSVPVLPAGTDLLAIPLVGTIDQERLATIQQQALTAVEQRRARWLILDVTGVPFIDTGVAGGLIQLVQSVRLLGAD
VVLVGVRPEVAQTMVSLGIELPITHVYSDLAGAIEDLHHHTDHSRQNNRR

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 40553; Mature: 40553

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNSIRTLLNVRHPDEEVRQRGRNIIVIALGLLGINLVVVISLLFNLSQVTRLFATSAVS
CCHHHHHHHHCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VILYIFVIFITFRGFVELAGWLTVMISLVGTLAALFVTPNGLTIIFLAVPLVLAATVLSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RSLILVFLLTACSLAGIAFFLEPTPLSLTTRDFLIPVSLLCAFLGIVSFVQSAGNEALHR
HHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RLQAALQQAKQTADQLRLLNDELDRRVDAQTEALQEALSELEERTLQQDRLLAEVIAQRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIRNLSVPVLPAGTDLLAIPLVGTIDQERLATIQQQALTAVEQRRARWLILDVTGVPFID
HHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEC
TGVAGGLIQLVQSVRLLGADVVLVGVRPEVAQTMVSLGIELPITHVYSDLAGAIEDLHHH
CCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
TDHSRQNNRR
CCCCCCCCCC
>Mature Secondary Structure
MFNSIRTLLNVRHPDEEVRQRGRNIIVIALGLLGINLVVVISLLFNLSQVTRLFATSAVS
CCHHHHHHHHCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VILYIFVIFITFRGFVELAGWLTVMISLVGTLAALFVTPNGLTIIFLAVPLVLAATVLSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RSLILVFLLTACSLAGIAFFLEPTPLSLTTRDFLIPVSLLCAFLGIVSFVQSAGNEALHR
HHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RLQAALQQAKQTADQLRLLNDELDRRVDAQTEALQEALSELEERTLQQDRLLAEVIAQRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIRNLSVPVLPAGTDLLAIPLVGTIDQERLATIQQQALTAVEQRRARWLILDVTGVPFID
HHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEC
TGVAGGLIQLVQSVRLLGADVVLVGVRPEVAQTMVSLGIELPITHVYSDLAGAIEDLHHH
CCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
TDHSRQNNRR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]