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The map label for this gene is mtnA

Identifier: 222526504

GI number: 222526504

Start: 4078209

End: 4079252

Strand: Reverse

Name: mtnA

Synonym: Chy400_3271

Alternate gene names: 222526504

Gene position: 4079252-4078209 (Counterclockwise)

Preceding gene: 222526505

Following gene: 222526503

Centisome position: 77.42

GC content: 58.43

Gene sequence:

>1044_bases
ATGGAACTCCGCACAGTCTGGTGGGAAAATGACGCAGTCTGCCTGATCGATCAGCGCAAGTTACCACACACGATGGAGGT
TGTGCGCTGCACCGATCTGGCAGCAGTTGCATACGCGATTCGGAGTATGCAAGTACGTGGTGCACCAGCCATTGGCTGCA
CTGCCGCATACGGTATGGCCCTCGTCGCGCAGCAAAGTGTTGCGCTTACCCCTTCAGCACTCCTGACCGAACTCGTCCAG
GCCAAAGCAACGCTCGATTCGCAACGCCCAACCGCCGTCAATCTGGCGTGGGCCACCAGCCGCATGCTCCGCCGGGCGGA
GGCGGTGGCAAGCGAAGGAGTGGAAGCGATCAAACACGCGCTGCACGCTGAGGCAGAAGCGATCTTTGCTGAAGACCTGG
CAATGTGTCACGCCATTGGTGAGCATGGGGCGTCATTGATCCCGCCACGAGGTCACGTCCTCACCCACTGTAACGCTGGT
GGGCTGGCAACAGCCGGTTATGGTACTGCCCTGGCCCCGATCCGCACCGCCTTTGCCCAGGGGCGGCCTGTCCATGTCTT
TGTTGATGAGACGCGGCCATTCCTGCAAGGTGCCCGATTGACGGCGTGGGAACTCTTGCAAGCCGGCATTCCGCAGACGT
TGATCACCGATAATATGGCTGCCTTTATGATGCAGCGTGGGCAGATAGATTGCGTGATTGTCGGTGCGGATCGCATTGCA
GCTAATGGGGATGTCGCAAACAAAATTGGTACATATGGCCTGGCAGTACTCGCACGCTACCACAATATTCCCTTCTACGT
CGCTGCACCCTCTTCAACCATCGATCTCGCGACAGCAAGCGGCGCCGATATTCCGATTGAAGAGCGTGATCCTGCCGAAG
TCACCCACATTGCCGGCGTAGCAATTGCGCCCCAGGGTGTGCGAGCTGCGCATCCGGCTTTTGATGTGACACCAAACGAA
TTGGTGACAGCGATTATTACGGAACGGGGCATCGTGCGACCGCCATATCTGGCCGCATTGCGTCAGCTTGAGAGTGGGCG
ATGA

Upstream 100 bases:

>100_bases
CAAATCCAGCGGCAATGGATATCATTGGCCGAAAGATGAGAGGAACGAAGTCTATCGGAGCCTCTCGCCGTGCGAGTGGC
TCCATCTTATTGCGACGCCT

Downstream 100 bases:

>100_bases
GCAGGTTCGGAGCACTGTTACCGGCCTGTCAGCCACTCTTGCGCGGTGGTCTCCCTCACCAGAGCCTGGCGCAGGCTGCA
CAATTGATCTGTCGCTATCA

Product: translation initiation factor, aIF-2BI family

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MELRTVWWENDAVCLIDQRKLPHTMEVVRCTDLAAVAYAIRSMQVRGAPAIGCTAAYGMALVAQQSVALTPSALLTELVQ
AKATLDSQRPTAVNLAWATSRMLRRAEAVASEGVEAIKHALHAEAEAIFAEDLAMCHAIGEHGASLIPPRGHVLTHCNAG
GLATAGYGTALAPIRTAFAQGRPVHVFVDETRPFLQGARLTAWELLQAGIPQTLITDNMAAFMMQRGQIDCVIVGADRIA
ANGDVANKIGTYGLAVLARYHNIPFYVAAPSSTIDLATASGADIPIEERDPAEVTHIAGVAIAPQGVRAAHPAFDVTPNE
LVTAIITERGIVRPPYLAALRQLESGR

Sequences:

>Translated_347_residues
MELRTVWWENDAVCLIDQRKLPHTMEVVRCTDLAAVAYAIRSMQVRGAPAIGCTAAYGMALVAQQSVALTPSALLTELVQ
AKATLDSQRPTAVNLAWATSRMLRRAEAVASEGVEAIKHALHAEAEAIFAEDLAMCHAIGEHGASLIPPRGHVLTHCNAG
GLATAGYGTALAPIRTAFAQGRPVHVFVDETRPFLQGARLTAWELLQAGIPQTLITDNMAAFMMQRGQIDCVIVGADRIA
ANGDVANKIGTYGLAVLARYHNIPFYVAAPSSTIDLATASGADIPIEERDPAEVTHIAGVAIAPQGVRAAHPAFDVTPNE
LVTAIITERGIVRPPYLAALRQLESGR
>Mature_347_residues
MELRTVWWENDAVCLIDQRKLPHTMEVVRCTDLAAVAYAIRSMQVRGAPAIGCTAAYGMALVAQQSVALTPSALLTELVQ
AKATLDSQRPTAVNLAWATSRMLRRAEAVASEGVEAIKHALHAEAEAIFAEDLAMCHAIGEHGASLIPPRGHVLTHCNAG
GLATAGYGTALAPIRTAFAQGRPVHVFVDETRPFLQGARLTAWELLQAGIPQTLITDNMAAFMMQRGQIDCVIVGADRIA
ANGDVANKIGTYGLAVLARYHNIPFYVAAPSSTIDLATASGADIPIEERDPAEVTHIAGVAIAPQGVRAAHPAFDVTPNE
LVTAIITERGIVRPPYLAALRQLESGR

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=352, Percent_Identity=44.0340909090909, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI23943880, Length=340, Percent_Identity=38.5294117647059, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI4503503, Length=201, Percent_Identity=30.3482587064677, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI78000158, Length=165, Percent_Identity=32.1212121212121, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI78000156, Length=165, Percent_Identity=32.1212121212121, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI187607323, Length=165, Percent_Identity=32.1212121212121, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI7657058, Length=179, Percent_Identity=31.8435754189944, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17557462, Length=329, Percent_Identity=39.209726443769, Blast_Score=213, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI17557123, Length=184, Percent_Identity=31.5217391304348, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325375, Length=386, Percent_Identity=37.0466321243523, Blast_Score=205, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6322878, Length=204, Percent_Identity=31.3725490196078, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357667, Length=364, Percent_Identity=41.2087912087912, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24651647, Length=364, Percent_Identity=41.2087912087912, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI21358605, Length=199, Percent_Identity=27.6381909547739, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_CHLAA (A9WGQ8)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001636613.1
- ProteinModelPortal:   A9WGQ8
- SMR:   A9WGQ8
- GeneID:   5827499
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_3025
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   CLSK972978
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 36871; Mature: 36871

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: ACT_SITE 237-237 BINDING 89-89 BINDING 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRTVWWENDAVCLIDQRKLPHTMEVVRCTDLAAVAYAIRSMQVRGAPAIGCTAAYGMA
CCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LVAQQSVALTPSALLTELVQAKATLDSQRPTAVNLAWATSRMLRRAEAVASEGVEAIKHA
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
LHAEAEAIFAEDLAMCHAIGEHGASLIPPRGHVLTHCNAGGLATAGYGTALAPIRTAFAQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEECCCCHHHHHHHHHHHC
GRPVHVFVDETRPFLQGARLTAWELLQAGIPQTLITDNMAAFMMQRGQIDCVIVGADRIA
CCCEEEEECCCCHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEECCEEE
ANGDVANKIGTYGLAVLARYHNIPFYVAAPSSTIDLATASGADIPIEERDPAEVTHIAGV
CCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHCCE
AIAPQGVRAAHPAFDVTPNELVTAIITERGIVRPPYLAALRQLESGR
EECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MELRTVWWENDAVCLIDQRKLPHTMEVVRCTDLAAVAYAIRSMQVRGAPAIGCTAAYGMA
CCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LVAQQSVALTPSALLTELVQAKATLDSQRPTAVNLAWATSRMLRRAEAVASEGVEAIKHA
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
LHAEAEAIFAEDLAMCHAIGEHGASLIPPRGHVLTHCNAGGLATAGYGTALAPIRTAFAQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEECCCCHHHHHHHHHHHC
GRPVHVFVDETRPFLQGARLTAWELLQAGIPQTLITDNMAAFMMQRGQIDCVIVGADRIA
CCCEEEEECCCCHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEECCEEE
ANGDVANKIGTYGLAVLARYHNIPFYVAAPSSTIDLATASGADIPIEERDPAEVTHIAGV
CCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHCCE
AIAPQGVRAAHPAFDVTPNELVTAIITERGIVRPPYLAALRQLESGR
EECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA