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The map label for this gene is adk [H]

Identifier: 222526435

GI number: 222526435

Start: 3990920

End: 3991570

Strand: Reverse

Name: adk [H]

Synonym: Chy400_3202

Alternate gene names: 222526435

Gene position: 3991570-3990920 (Counterclockwise)

Preceding gene: 222526436

Following gene: 222526434

Centisome position: 75.76

GC content: 56.68

Gene sequence:

>651_bases
GTGACAGGACGAACGATACTTTTGATAGGACCGCCTGGTGCCGGCAAGACCACTATTGCCGGCCAACTGGCGCAAGTGAC
CGGGATGGCGGTTATTGCCACCGGTCAACAACTGCGGGCCGAGATTCGTGCTCAGAGTGCGCTCGGTCGGTACATTGAGC
CATTACTCGAACAGGGTCAACTGGCACCGGATAGCGTCATGGCGGAACTGATGCGGAACTGGTTGCAGCGCATTCCTATT
GATCAAGACTGCCTTCTCGACGGGTACCCGCGTAGTGTCGCGCAGGCACACATGCTGGAGACAATTCTGGCCGATCTGGG
ACGACGAGTAGACGCAGTGATCGTGCTGACCCTGGACGAGGCGACCATAGTACACCGACTGAGCGGTCGCCGGATTTGTC
GGCGAGATGACGGCCAGGACATCACCGTCCATATCGATGATACAGCAAAGATTGCCCAATGCCTGGCACGAGGTGGCACC
CTGGTACAACGAGAAGATGATCATCCCGACGTGATTCGCACACGTCTACGCCTTTACGAACAAGAGACTGCACCCGTGCT
GAATTACTACACCGGTCGCGTGCCTGTTCATTATGTCAATGCCGATCAATCGCCAGCAGCCGTTGTTGCCCTGATTCGCG
ACATCATCTAG

Upstream 100 bases:

>100_bases
AGCACTGGCAACCTTCCAGACTCTGAAACAGATTGCACCCGACTACCCTGGTCTCGACGACGCTATCAACCGTGTTTCAG
GCTAAACAACGAACAACATC

Downstream 100 bases:

>100_bases
CTATATTCGCTATGTCATAACCAAAGGAGGTTACAACGATGGGTGATAAGGTTGCACTCATCACCGGCGCCGCCAGTGGC
ATCGGCCTGGCCTGCGCCGA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTGRTILLIGPPGAGKTTIAGQLAQVTGMAVIATGQQLRAEIRAQSALGRYIEPLLEQGQLAPDSVMAELMRNWLQRIPI
DQDCLLDGYPRSVAQAHMLETILADLGRRVDAVIVLTLDEATIVHRLSGRRICRRDDGQDITVHIDDTAKIAQCLARGGT
LVQREDDHPDVIRTRLRLYEQETAPVLNYYTGRVPVHYVNADQSPAAVVALIRDII

Sequences:

>Translated_216_residues
MTGRTILLIGPPGAGKTTIAGQLAQVTGMAVIATGQQLRAEIRAQSALGRYIEPLLEQGQLAPDSVMAELMRNWLQRIPI
DQDCLLDGYPRSVAQAHMLETILADLGRRVDAVIVLTLDEATIVHRLSGRRICRRDDGQDITVHIDDTAKIAQCLARGGT
LVQREDDHPDVIRTRLRLYEQETAPVLNYYTGRVPVHYVNADQSPAAVVALIRDII
>Mature_215_residues
TGRTILLIGPPGAGKTTIAGQLAQVTGMAVIATGQQLRAEIRAQSALGRYIEPLLEQGQLAPDSVMAELMRNWLQRIPID
QDCLLDGYPRSVAQAHMLETILADLGRRVDAVIVLTLDEATIVHRLSGRRICRRDDGQDITVHIDDTAKIAQCLARGGTL
VQREDDHPDVIRTRLRLYEQETAPVLNYYTGRVPVHYVNADQSPAAVVALIRDII

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=206, Percent_Identity=31.5533980582524, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI7524346, Length=206, Percent_Identity=31.5533980582524, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI310110345, Length=205, Percent_Identity=33.6585365853659, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI53832003, Length=205, Percent_Identity=33.6585365853659, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI8051579, Length=205, Percent_Identity=33.6585365853659, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI53832001, Length=205, Percent_Identity=33.6585365853659, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI19923437, Length=194, Percent_Identity=31.4432989690722, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4502011, Length=213, Percent_Identity=28.6384976525822, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI28144899, Length=210, Percent_Identity=27.6190476190476, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI28144897, Length=210, Percent_Identity=27.6190476190476, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI22749187, Length=212, Percent_Identity=27.3584905660377, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786680, Length=186, Percent_Identity=31.7204301075269, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17552384, Length=184, Percent_Identity=30.9782608695652, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17537943, Length=189, Percent_Identity=26.4550264550265, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=208, Percent_Identity=33.1730769230769, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321018, Length=188, Percent_Identity=30.3191489361702, Blast_Score=85, Evalue=7e-18,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=31.3084112149533, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17737899, Length=189, Percent_Identity=31.7460317460317, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24645822, Length=189, Percent_Identity=31.7460317460317, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23776; Mature: 23645

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRTILLIGPPGAGKTTIAGQLAQVTGMAVIATGQQLRAEIRAQSALGRYIEPLLEQGQ
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
LAPDSVMAELMRNWLQRIPIDQDCLLDGYPRSVAQAHMLETILADLGRRVDAVIVLTLDE
CCHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
ATIVHRLSGRRICRRDDGQDITVHIDDTAKIAQCLARGGTLVQREDDHPDVIRTRLRLYE
HHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
QETAPVLNYYTGRVPVHYVNADQSPAAVVALIRDII
HHCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
TGRTILLIGPPGAGKTTIAGQLAQVTGMAVIATGQQLRAEIRAQSALGRYIEPLLEQGQ
CCCEEEEEECCCCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
LAPDSVMAELMRNWLQRIPIDQDCLLDGYPRSVAQAHMLETILADLGRRVDAVIVLTLDE
CCHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
ATIVHRLSGRRICRRDDGQDITVHIDDTAKIAQCLARGGTLVQREDDHPDVIRTRLRLYE
HHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
QETAPVLNYYTGRVPVHYVNADQSPAAVVALIRDII
HHCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA