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The map label for this gene is groL2

Identifier: 222526358

GI number: 222526358

Start: 3866568

End: 3868205

Strand: Direct

Name: groL2

Synonym: Chy400_3124

Alternate gene names: 222526358

Gene position: 3866568-3868205 (Clockwise)

Preceding gene: 222526357

Following gene: 222526360

Centisome position: 73.38

GC content: 58.18

Gene sequence:

>1638_bases
ATGGCGAAGCAACTGATCTTTGATCAGCAAGCTCGTACAGCGCTGAAACACGGTATTGATACGCTGGCTCTGGCTGTCAA
GACGACCCTTGGCCCACGTGGCCGCAATGTTGCGCTCGACAAGAAGTGGGGTGCCCCGACGGTAACCCACGATGGTGTGA
GCGTTGCCAAAGAGATTGAACTGAAAGATCCGTTTGCCAACCTCGGCGTGCAGTTGCTCAAGCAGGCCGCAGTCAAGACG
AATGATGTTGCTGGTGACGGTACGACGACGGCAACCGTTCTGGCCCAGGCCATCATCAACGAAGGCTTGAAGCTGGTTGC
AGCCGGTGCCAATCCGATGCTGCTCAAACGCGGCCTCGATAAGGGTGGTCAGGCGCTGGTGGCTCGTATCAAAGAGCAGG
CGATTACGCTCAAAACCCGTGATGAGATTCGGAATGTCGCTACCATCTCGGCCCAGGATGCCGAAGTCGGTGAACTGCTG
GCTACGGTGATGGACAAGATTGGCCGCGATGGTGTCGTAACGGTTGAAGAAGGGAAGAGCACGCATCTCGAGCACGAGCT
GGTCGAAGGTATGCAATTCGACCGCGGCTATATCTCGCCCTACTTCATCACCGACTCTGCCCGCATGGAGGCAGTGCTCG
ATGAGCCATACATTCTGATCACCGACAAGAAGATCAGCGCGATCAAAGATCTGTTGCCGATCCTCGAGGCAGTGCTGAGC
AGCGGGAAGAAGGATCTGCTGGTCATCGCCGAGGATGTTGATGGTGAAGCGCTGGCGACCCTGGTCGTTAACAAGCTGCG
TGGCACGCTCAATGCCCTGGCCGTGAAAGCGCCCGGCTTCGGTGATCGGCGCAAAGCCATGCTCCAGGACATTGCTATCC
TCACCGGTGGTACCGTCATCTCGGAGGAGATCGGTCGCAAGCTCGAAAGCGCGACCCTGCAAGACCTTGGTCGTGCCCGC
CGGGTCAAGGCCGACAAAGATAACACCGTTATCGTTGAAGGTCACGGCGACAAGCAGGCCATTCAGGCCCGGATTGCCCA
GCTCAAGCAGCAGATTGAAACCACAACCTCCGATTACGACCGCGAGAAGCTGCAAGAGCGGGTGGCGAAGTTGTCGGGTG
GTGTCGCCGTCATTAAGGTTGGCGCACCGACCGAACCGGCCATGAAAGAGCGCAAAGCTCGCGTTGAAGATGCGCTCAAC
GCAACCAGGGCTGCGGTCGAAGAGGGCATCGTGCCCGGTGGTGGTGTTGCCCTGCTGAATGCGATCCCGGCGCTTGATAA
TGTCACGACCCAGTTTGAAGAAGAGCGGATGGCGCTCAATGTCTTGCGGCGGGCGCTCGAAGAGCCACTGCGCCAGCTCG
CCACCAATGCCGGTGAAGATGGTTCAGTGGTGGTCGAGAATGTTCGCAACGAGCAGCGGAAGCATAACAACAACCACTAC
GGCTACGATGTGATGACCGGTACCTACGTCGATCTGATGCAGGCCGGCATTATCGACCCGGCGAAGGTAGTGCGCTCCGC
TCTCGAAAATGCGATCAGCGTTGCCGGGATGGTGCTGACCACCGAGGCCCTGATCGTCGATGCACCCGAACCGAAGAAGA
AGAACGGTACGCCACCGATGCCGGACGATGACTTCTAA

Upstream 100 bases:

>100_bases
ACGCCAAATATGCCGGTACGGAATTTAAGATTGACGATGAGGAATACCTGATTCTCCAGGAGAAGGATATTCTCGGTATC
ATTGAAGGGGAGTAAGCAGT

Downstream 100 bases:

>100_bases
TCCAATCCGGTAGGCACAATGACACGTGCGCATGTCGCAAATCCCCGACATGCGCACGTTTTGCGTTCGTACTGACCTTT
ATGATCTGCTGAGTCACGCT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAKQLIFDQQARTALKHGIDTLALAVKTTLGPRGRNVALDKKWGAPTVTHDGVSVAKEIELKDPFANLGVQLLKQAAVKT
NDVAGDGTTTATVLAQAIINEGLKLVAAGANPMLLKRGLDKGGQALVARIKEQAITLKTRDEIRNVATISAQDAEVGELL
ATVMDKIGRDGVVTVEEGKSTHLEHELVEGMQFDRGYISPYFITDSARMEAVLDEPYILITDKKISAIKDLLPILEAVLS
SGKKDLLVIAEDVDGEALATLVVNKLRGTLNALAVKAPGFGDRRKAMLQDIAILTGGTVISEEIGRKLESATLQDLGRAR
RVKADKDNTVIVEGHGDKQAIQARIAQLKQQIETTTSDYDREKLQERVAKLSGGVAVIKVGAPTEPAMKERKARVEDALN
ATRAAVEEGIVPGGGVALLNAIPALDNVTTQFEEERMALNVLRRALEEPLRQLATNAGEDGSVVVENVRNEQRKHNNNHY
GYDVMTGTYVDLMQAGIIDPAKVVRSALENAISVAGMVLTTEALIVDAPEPKKKNGTPPMPDDDF

Sequences:

>Translated_545_residues
MAKQLIFDQQARTALKHGIDTLALAVKTTLGPRGRNVALDKKWGAPTVTHDGVSVAKEIELKDPFANLGVQLLKQAAVKT
NDVAGDGTTTATVLAQAIINEGLKLVAAGANPMLLKRGLDKGGQALVARIKEQAITLKTRDEIRNVATISAQDAEVGELL
ATVMDKIGRDGVVTVEEGKSTHLEHELVEGMQFDRGYISPYFITDSARMEAVLDEPYILITDKKISAIKDLLPILEAVLS
SGKKDLLVIAEDVDGEALATLVVNKLRGTLNALAVKAPGFGDRRKAMLQDIAILTGGTVISEEIGRKLESATLQDLGRAR
RVKADKDNTVIVEGHGDKQAIQARIAQLKQQIETTTSDYDREKLQERVAKLSGGVAVIKVGAPTEPAMKERKARVEDALN
ATRAAVEEGIVPGGGVALLNAIPALDNVTTQFEEERMALNVLRRALEEPLRQLATNAGEDGSVVVENVRNEQRKHNNNHY
GYDVMTGTYVDLMQAGIIDPAKVVRSALENAISVAGMVLTTEALIVDAPEPKKKNGTPPMPDDDF
>Mature_544_residues
AKQLIFDQQARTALKHGIDTLALAVKTTLGPRGRNVALDKKWGAPTVTHDGVSVAKEIELKDPFANLGVQLLKQAAVKTN
DVAGDGTTTATVLAQAIINEGLKLVAAGANPMLLKRGLDKGGQALVARIKEQAITLKTRDEIRNVATISAQDAEVGELLA
TVMDKIGRDGVVTVEEGKSTHLEHELVEGMQFDRGYISPYFITDSARMEAVLDEPYILITDKKISAIKDLLPILEAVLSS
GKKDLLVIAEDVDGEALATLVVNKLRGTLNALAVKAPGFGDRRKAMLQDIAILTGGTVISEEIGRKLESATLQDLGRARR
VKADKDNTVIVEGHGDKQAIQARIAQLKQQIETTTSDYDREKLQERVAKLSGGVAVIKVGAPTEPAMKERKARVEDALNA
TRAAVEEGIVPGGGVALLNAIPALDNVTTQFEEERMALNVLRRALEEPLRQLATNAGEDGSVVVENVRNEQRKHNNNHYG
YDVMTGTYVDLMQAGIIDPAKVVRSALENAISVAGMVLTTEALIVDAPEPKKKNGTPPMPDDDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=534, Percent_Identity=47.565543071161, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI31542947, Length=534, Percent_Identity=47.565543071161, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI5453607, Length=542, Percent_Identity=22.8782287822878, Blast_Score=83, Evalue=8e-16,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=59.2452830188679, Blast_Score=601, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=46.3276836158192, Blast_Score=475, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=46.2264150943396, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17564182, Length=539, Percent_Identity=21.7068645640074, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=527, Percent_Identity=50.0948766603416, Blast_Score=509, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6322524, Length=140, Percent_Identity=30.7142857142857, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322350, Length=535, Percent_Identity=22.6168224299065, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641193, Length=531, Percent_Identity=47.6459510357815, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24641191, Length=531, Percent_Identity=47.6459510357815, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45550936, Length=530, Percent_Identity=45.0943396226415, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45550132, Length=530, Percent_Identity=45.0943396226415, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45550935, Length=530, Percent_Identity=45.0943396226415, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI17864606, Length=530, Percent_Identity=40.377358490566, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24584129, Length=537, Percent_Identity=34.8230912476723, Blast_Score=295, Evalue=6e-80,
Organism=Drosophila melanogaster, GI19921262, Length=537, Percent_Identity=34.8230912476723, Blast_Score=295, Evalue=6e-80,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_CHLAA (A9WFA3)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001636476.1
- ProteinModelPortal:   A9WFA3
- SMR:   A9WFA3
- GeneID:   5827360
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_2888
- HOGENOM:   HBG625289
- OMA:   TISAQDP
- ProtClustDB:   CLSK2516911
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58572; Mature: 58441

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQLIFDQQARTALKHGIDTLALAVKTTLGPRGRNVALDKKWGAPTVTHDGVSVAKEIE
CCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHC
LKDPFANLGVQLLKQAAVKTNDVAGDGTTTATVLAQAIINEGLKLVAAGANPMLLKRGLD
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHCCC
KGGQALVARIKEQAITLKTRDEIRNVATISAQDAEVGELLATVMDKIGRDGVVTVEEGKS
CCHHHHHHHHHHHHHEEECHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCC
THLEHELVEGMQFDRGYISPYFITDSARMEAVLDEPYILITDKKISAIKDLLPILEAVLS
HHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
SGKKDLLVIAEDVDGEALATLVVNKLRGTLNALAVKAPGFGDRRKAMLQDIAILTGGTVI
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCHHH
SEEIGRKLESATLQDLGRARRVKADKDNTVIVEGHGDKQAIQARIAQLKQQIETTTSDYD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHH
REKLQERVAKLSGGVAVIKVGAPTEPAMKERKARVEDALNATRAAVEEGIVPGGGVALLN
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AIPALDNVTTQFEEERMALNVLRRALEEPLRQLATNAGEDGSVVVENVRNEQRKHNNNHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
GYDVMTGTYVDLMQAGIIDPAKVVRSALENAISVAGMVLTTEALIVDAPEPKKKNGTPPM
CEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCC
PDDDF
CCCCC
>Mature Secondary Structure 
AKQLIFDQQARTALKHGIDTLALAVKTTLGPRGRNVALDKKWGAPTVTHDGVSVAKEIE
CCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHC
LKDPFANLGVQLLKQAAVKTNDVAGDGTTTATVLAQAIINEGLKLVAAGANPMLLKRGLD
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHCCC
KGGQALVARIKEQAITLKTRDEIRNVATISAQDAEVGELLATVMDKIGRDGVVTVEEGKS
CCHHHHHHHHHHHHHEEECHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCC
THLEHELVEGMQFDRGYISPYFITDSARMEAVLDEPYILITDKKISAIKDLLPILEAVLS
HHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
SGKKDLLVIAEDVDGEALATLVVNKLRGTLNALAVKAPGFGDRRKAMLQDIAILTGGTVI
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCHHH
SEEIGRKLESATLQDLGRARRVKADKDNTVIVEGHGDKQAIQARIAQLKQQIETTTSDYD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHH
REKLQERVAKLSGGVAVIKVGAPTEPAMKERKARVEDALNATRAAVEEGIVPGGGVALLN
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AIPALDNVTTQFEEERMALNVLRRALEEPLRQLATNAGEDGSVVVENVRNEQRKHNNNHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
GYDVMTGTYVDLMQAGIIDPAKVVRSALENAISVAGMVLTTEALIVDAPEPKKKNGTPPM
CEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCC
PDDDF
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA