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The map label for this gene is serA [H]

Identifier: 222526360

GI number: 222526360

Start: 3869514

End: 3870470

Strand: Direct

Name: serA [H]

Synonym: Chy400_3126

Alternate gene names: 222526360

Gene position: 3869514-3870470 (Clockwise)

Preceding gene: 222526358

Following gene: 222526361

Centisome position: 73.44

GC content: 58.62

Gene sequence:

>957_bases
ATGAAGCTTGTCTTGCCGGGCCTGCTACGTGATGAACTTCTCCCGCGCATTGCTGCGGTTGCCCCCGATGCCACAATCGT
CTGGTACGACCGTGATGGTCAACCAGAAGCCCCTATCGACGATGCCGAGGTCCTTCTACGCTGGTTTTTTACCAGTGAAC
AACTGGCACGTCTGGTGCGACAGATGCCGGCGTTGCGCTGGCTGCACATTCCCCGTGCCGGCGTAGACGGCTCGCTCATT
CCCGAAGTGCTGGAACGTGATATTATCGTGACCAATTCAGCCGGCGTGCATGCCATCCCGATCAGCGAGTTTGTCATGCT
CTTTGCCCTGAGTCATGTCAAACAGGCCCTTCATCTGCACCAGTTGCAGGCTGCCCATCGCTGGCGCGACCAGGACCTGC
AATTGCGAGAGCTGGCCGGCAGCACGATGCTGATCATCGGCCTGGGCCAGATCGGACAGGCCATTGCCGAACGTGCCAGT
GCCTTCGGGATGCGGGTATGGGGATCGCGCCGCACCCCACGCCCAACCCCAGGCGTCGAGCGCGTTGTTGGTGAGGGTGA
ATGGCGATCATTACTTCCGGCAGCCGATTTTGTTGTCATTGCCACCCCGCTCACACCGGCAACACGCCACATGTTTGGCA
GAGCAGAGCTGGCGCTGATGAAGCCTGATGCCTATCTGATCAACATTGCCCGCGGTGAAATCATCGACGAAGCAGCATTG
ATTGAGGCGCTGCGCGAACGGCGGATTGCCGGTGCCGGCCTCGATGTGTTTGCGCAGGAACCACTACCCCCGGATAGCCC
GTTCTGGACGCTACCGAACGTCTTTGTTACTCCTCACGTATCCTGGAGTTCGCCGCACATCCGGTCGCGTACCCTTGATC
TCTTCGCTACCAATCTACGAGCGTTTCTCCAACAACAGCCAATGATCAATGTTGTGGACAAACAGGCCGGGTATTAG

Upstream 100 bases:

>100_bases
CATACCCATCTTTTGACTGATCAGGTAATAACCGGTCTCAGGTACAATAGCAACTAAATCGATCCCGTTTAAGGCTTCAT
CCATACAGGAGCACATTCTT

Downstream 100 bases:

>100_bases
TCCAGTACACACTATCCATGTTATTCTGAAAACAACGAGCAGATACCTGTTGTACCAATCGCTATAGTTAAAGAGGAGAA
CGCCTGCATGACCTCAACGA

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKLVLPGLLRDELLPRIAAVAPDATIVWYDRDGQPEAPIDDAEVLLRWFFTSEQLARLVRQMPALRWLHIPRAGVDGSLI
PEVLERDIIVTNSAGVHAIPISEFVMLFALSHVKQALHLHQLQAAHRWRDQDLQLRELAGSTMLIIGLGQIGQAIAERAS
AFGMRVWGSRRTPRPTPGVERVVGEGEWRSLLPAADFVVIATPLTPATRHMFGRAELALMKPDAYLINIARGEIIDEAAL
IEALRERRIAGAGLDVFAQEPLPPDSPFWTLPNVFVTPHVSWSSPHIRSRTLDLFATNLRAFLQQQPMINVVDKQAGY

Sequences:

>Translated_318_residues
MKLVLPGLLRDELLPRIAAVAPDATIVWYDRDGQPEAPIDDAEVLLRWFFTSEQLARLVRQMPALRWLHIPRAGVDGSLI
PEVLERDIIVTNSAGVHAIPISEFVMLFALSHVKQALHLHQLQAAHRWRDQDLQLRELAGSTMLIIGLGQIGQAIAERAS
AFGMRVWGSRRTPRPTPGVERVVGEGEWRSLLPAADFVVIATPLTPATRHMFGRAELALMKPDAYLINIARGEIIDEAAL
IEALRERRIAGAGLDVFAQEPLPPDSPFWTLPNVFVTPHVSWSSPHIRSRTLDLFATNLRAFLQQQPMINVVDKQAGY
>Mature_318_residues
MKLVLPGLLRDELLPRIAAVAPDATIVWYDRDGQPEAPIDDAEVLLRWFFTSEQLARLVRQMPALRWLHIPRAGVDGSLI
PEVLERDIIVTNSAGVHAIPISEFVMLFALSHVKQALHLHQLQAAHRWRDQDLQLRELAGSTMLIIGLGQIGQAIAERAS
AFGMRVWGSRRTPRPTPGVERVVGEGEWRSLLPAADFVVIATPLTPATRHMFGRAELALMKPDAYLINIARGEIIDEAAL
IEALRERRIAGAGLDVFAQEPLPPDSPFWTLPNVFVTPHVSWSSPHIRSRTLDLFATNLRAFLQQQPMINVVDKQAGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=33.4677419354839, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=27.1293375394322, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI4557497, Length=238, Percent_Identity=33.6134453781513, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI61743967, Length=238, Percent_Identity=33.6134453781513, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI145580578, Length=273, Percent_Identity=31.1355311355311, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4557499, Length=273, Percent_Identity=31.1355311355311, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI145580575, Length=258, Percent_Identity=30.6201550387597, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI87082289, Length=265, Percent_Identity=32.0754716981132, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789279, Length=167, Percent_Identity=35.3293413173653, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081824, Length=142, Percent_Identity=37.3239436619718, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787645, Length=146, Percent_Identity=33.5616438356164, Blast_Score=81, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=249, Percent_Identity=30.9236947791165, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25147481, Length=222, Percent_Identity=25.2252252252252, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322116, Length=278, Percent_Identity=27.6978417266187, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=244, Percent_Identity=29.9180327868852, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=304, Percent_Identity=25, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=177, Percent_Identity=30.5084745762712, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6324980, Length=190, Percent_Identity=26.3157894736842, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=126, Percent_Identity=32.5396825396825, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45552429, Length=253, Percent_Identity=31.6205533596838, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24585514, Length=253, Percent_Identity=31.6205533596838, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28574282, Length=253, Percent_Identity=31.6205533596838, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28574284, Length=253, Percent_Identity=31.6205533596838, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI45551003, Length=253, Percent_Identity=31.6205533596838, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI19921140, Length=256, Percent_Identity=30.46875, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574286, Length=253, Percent_Identity=28.0632411067194, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28571528, Length=177, Percent_Identity=35.5932203389831, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24585516, Length=255, Percent_Identity=28.6274509803922, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24646446, Length=312, Percent_Identity=27.2435897435897, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646448, Length=312, Percent_Identity=27.2435897435897, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646452, Length=312, Percent_Identity=27.2435897435897, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646450, Length=312, Percent_Identity=27.2435897435897, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI62472511, Length=312, Percent_Identity=27.2435897435897, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35468; Mature: 35468

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVLPGLLRDELLPRIAAVAPDATIVWYDRDGQPEAPIDDAEVLLRWFFTSEQLARLVR
CCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCHHHHHHHHH
QMPALRWLHIPRAGVDGSLIPEVLERDIIVTNSAGVHAIPISEFVMLFALSHVKQALHLH
HCCHHEEEECCCCCCCCCHHHHHHCCCEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHH
QLQAAHRWRDQDLQLRELAGSTMLIIGLGQIGQAIAERASAFGMRVWGSRRTPRPTPGVE
HHHHHHHCCCCCCHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
RVVGEGEWRSLLPAADFVVIATPLTPATRHMFGRAELALMKPDAYLINIARGEIIDEAAL
HHHCCCCHHHHCCCCCEEEEECCCCHHHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHH
IEALRERRIAGAGLDVFAQEPLPPDSPFWTLPNVFVTPHVSWSSPHIRSRTLDLFATNLR
HHHHHHHHHCCCCCCCEECCCCCCCCCCEECCCEEEECCCCCCCCCHHHHHHHHHHHHHH
AFLQQQPMINVVDKQAGY
HHHHCCCCHHHHHHCCCC
>Mature Secondary Structure
MKLVLPGLLRDELLPRIAAVAPDATIVWYDRDGQPEAPIDDAEVLLRWFFTSEQLARLVR
CCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCHHHHHHHHH
QMPALRWLHIPRAGVDGSLIPEVLERDIIVTNSAGVHAIPISEFVMLFALSHVKQALHLH
HCCHHEEEECCCCCCCCCHHHHHHCCCEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHH
QLQAAHRWRDQDLQLRELAGSTMLIIGLGQIGQAIAERASAFGMRVWGSRRTPRPTPGVE
HHHHHHHCCCCCCHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
RVVGEGEWRSLLPAADFVVIATPLTPATRHMFGRAELALMKPDAYLINIARGEIIDEAAL
HHHCCCCHHHHCCCCCEEEEECCCCHHHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHH
IEALRERRIAGAGLDVFAQEPLPPDSPFWTLPNVFVTPHVSWSSPHIRSRTLDLFATNLR
HHHHHHHHHCCCCCCCEECCCCCCCCCCEECCCEEEECCCCCCCCCHHHHHHHHHHHHHH
AFLQQQPMINVVDKQAGY
HHHHCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]