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The map label for this gene is tuaD [H]

Identifier: 222526321

GI number: 222526321

Start: 3806690

End: 3808030

Strand: Direct

Name: tuaD [H]

Synonym: Chy400_3087

Alternate gene names: 222526321

Gene position: 3806690-3808030 (Clockwise)

Preceding gene: 222526320

Following gene: 222526322

Centisome position: 72.25

GC content: 54.29

Gene sequence:

>1341_bases
GTGAAAAACATCTGTGTGGTAGGTACAGGCTATGTTGGACTGACGACCGGTGTCTGTTTTGCCGATCTCGGTCATTCTGT
TACCTGTATCGAAATTGACTTGCACAAACTGGAATTGCTCCGCAGCGGTAAATCCCCCATCTTCGAGCCTGGTCTGGAAG
AGTTGCAAGAGCGCAATATGCGCGCCGGTCGCTTGCGCTTCACCGATGATTATGCCGTCGGTATTCCCGATGCTGAGTTT
ATCTTCATCACAGTCGGTACCCCCATGGGCGAAGACGGCTCGGCTGATCTAACGTATGTCAAAGCCGCCGCACGTAGCAT
TGGTCAATACTTGCGTTCGGGTTCAATCATTATCGACAAGAGCACCGTGCCGGTAGGCACCGGTGATATGGTCGAAAACA
TCATTGCCGAGTATGCCGGACCTGATGTGAAGTTTGATGTCGTGTCGAACCCGGAGTTCTTGCGCGAAGGGAGTGCGCTG
AGTGATTTCTTCAAGCCCGACCGCATTGTCCTCGGTGCGAAGAATCGCGAGGCGGCACAACGGGTAGCTGCGCTGCATGA
AACATTGGGCGCGCCGATTATCATCACCGATCTGCGCACAGCCGAGATGATTAAATATGCATCCAATGCCTTTCTGGCGA
CCCGCATTTCGTTCATCAATGAAATTGCGCAAATCTGCGAGCGTCTGGGCGCTGATGTGCGTGAGGTTGCTCGCGGTATG
GGTGCCGACAAACGCATTGGCCCCCACTTTCTGGAAGCCGGCGTTGGCTACGGTGGCTCCTGTTTCCCGAAAGATGTGCT
GGCGCTGTACCACATGGCTGCCTCTGCCGGTTGCCACCCGCAGTTGCTTCAGGCAGTGATGGACATCAACAGCGATGCGC
GCAAGCGGTTTGTGAAGAAGGTCGAAACAGTCCTGGGTGATCTCGAAGGCCGCGTTATTGGGGTGCTGGGTCTGTCATTC
AAGCCCAATACTGATGATATGCGTGAGGCACCGAGCGTTGATATTATCAATTCCCTCCTGAAGAAGGGGGCCAGGGTCAA
GGCGTATGACCCGGTAGCCATGGCGCGTGCCGAAGAGCTGTTGCCAACAGTAACCTTTACCGCGACAGCGTATGATGTGG
CAAAAGATGCCGATGCGTTGCTGCTGGTTACTGAATGGAATGAGTTCAAGCAGTTGGACTGGCAACGCATCAAACGCTAT
ATGCGCCAGCCGGTCGTAATTGATGGCCGTAATCTCTACGATCCGCGTGAGATGCGCAATTTGGGCTTCATCTATTGGGG
GGTTGGTCGCGGTGAGGCACCGGTGCCGATTATGGAAGAAGCGCAGAATATCGGTGATTAG

Upstream 100 bases:

>100_bases
GGGAGCATTATTCATCAAAATGTCACGCCGATTCCGTACAACCATCATGACAATTGCGATGGATAATGCTTCATTGAAGG
CAACATAAGGAGACACAAAC

Downstream 100 bases:

>100_bases
GCGCTAGCAAACGTTGCTGAAGCGACACCCTCCTTGCTAAAAGTGAGCTTTTTTCACTGATGGGAAAGAGTGGCATAATA
CTGCCACTCTTTTTGCTGTT

Product: nucleotide sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKNICVVGTGYVGLTTGVCFADLGHSVTCIEIDLHKLELLRSGKSPIFEPGLEELQERNMRAGRLRFTDDYAVGIPDAEF
IFITVGTPMGEDGSADLTYVKAAARSIGQYLRSGSIIIDKSTVPVGTGDMVENIIAEYAGPDVKFDVVSNPEFLREGSAL
SDFFKPDRIVLGAKNREAAQRVAALHETLGAPIIITDLRTAEMIKYASNAFLATRISFINEIAQICERLGADVREVARGM
GADKRIGPHFLEAGVGYGGSCFPKDVLALYHMAASAGCHPQLLQAVMDINSDARKRFVKKVETVLGDLEGRVIGVLGLSF
KPNTDDMREAPSVDIINSLLKKGARVKAYDPVAMARAEELLPTVTFTATAYDVAKDADALLLVTEWNEFKQLDWQRIKRY
MRQPVVIDGRNLYDPREMRNLGFIYWGVGRGEAPVPIMEEAQNIGD

Sequences:

>Translated_446_residues
MKNICVVGTGYVGLTTGVCFADLGHSVTCIEIDLHKLELLRSGKSPIFEPGLEELQERNMRAGRLRFTDDYAVGIPDAEF
IFITVGTPMGEDGSADLTYVKAAARSIGQYLRSGSIIIDKSTVPVGTGDMVENIIAEYAGPDVKFDVVSNPEFLREGSAL
SDFFKPDRIVLGAKNREAAQRVAALHETLGAPIIITDLRTAEMIKYASNAFLATRISFINEIAQICERLGADVREVARGM
GADKRIGPHFLEAGVGYGGSCFPKDVLALYHMAASAGCHPQLLQAVMDINSDARKRFVKKVETVLGDLEGRVIGVLGLSF
KPNTDDMREAPSVDIINSLLKKGARVKAYDPVAMARAEELLPTVTFTATAYDVAKDADALLLVTEWNEFKQLDWQRIKRY
MRQPVVIDGRNLYDPREMRNLGFIYWGVGRGEAPVPIMEEAQNIGD
>Mature_446_residues
MKNICVVGTGYVGLTTGVCFADLGHSVTCIEIDLHKLELLRSGKSPIFEPGLEELQERNMRAGRLRFTDDYAVGIPDAEF
IFITVGTPMGEDGSADLTYVKAAARSIGQYLRSGSIIIDKSTVPVGTGDMVENIIAEYAGPDVKFDVVSNPEFLREGSAL
SDFFKPDRIVLGAKNREAAQRVAALHETLGAPIIITDLRTAEMIKYASNAFLATRISFINEIAQICERLGADVREVARGM
GADKRIGPHFLEAGVGYGGSCFPKDVLALYHMAASAGCHPQLLQAVMDINSDARKRFVKKVETVLGDLEGRVIGVLGLSF
KPNTDDMREAPSVDIINSLLKKGARVKAYDPVAMARAEELLPTVTFTATAYDVAKDADALLLVTEWNEFKQLDWQRIKRY
MRQPVVIDGRNLYDPREMRNLGFIYWGVGRGEAPVPIMEEAQNIGD

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=463, Percent_Identity=36.0691144708423, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI296040438, Length=368, Percent_Identity=36.9565217391304, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI296040443, Length=314, Percent_Identity=37.2611464968153, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI48994968, Length=431, Percent_Identity=27.1461716937355, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1788340, Length=359, Percent_Identity=31.1977715877437, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17560350, Length=463, Percent_Identity=36.7170626349892, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17136908, Length=461, Percent_Identity=34.9240780911063, Blast_Score=285, Evalue=6e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48883; Mature: 48883

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNICVVGTGYVGLTTGVCFADLGHSVTCIEIDLHKLELLRSGKSPIFEPGLEELQERNM
CCCEEEEECCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCCCCCCCCCHHHHHHCCC
RAGRLRFTDDYAVGIPDAEFIFITVGTPMGEDGSADLTYVKAAARSIGQYLRSGSIIIDK
CCCCEEECCCCEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEC
STVPVGTGDMVENIIAEYAGPDVKFDVVSNPEFLREGSALSDFFKPDRIVLGAKNREAAQ
CCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCHHHHHCCCCEEEEECCCHHHHH
RVAALHETLGAPIIITDLRTAEMIKYASNAFLATRISFINEIAQICERLGADVREVARGM
HHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
GADKRIGPHFLEAGVGYGGSCFPKDVLALYHMAASAGCHPQLLQAVMDINSDARKRFVKK
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHH
VETVLGDLEGRVIGVLGLSFKPNTDDMREAPSVDIINSLLKKGARVKAYDPVAMARAEEL
HHHHHHCCCCCEEEEEECCCCCCCCHHHHCCCHHHHHHHHHCCCCEEECCCHHHHHHHHH
LPTVTFTATAYDVAKDADALLLVTEWNEFKQLDWQRIKRYMRQPVVIDGRNLYDPREMRN
CCEEEEEEHHHHHHCCCCEEEEEECCCHHHHCCHHHHHHHHHCCEEEECCCCCCHHHHHC
LGFIYWGVGRGEAPVPIMEEAQNIGD
CCEEEEECCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MKNICVVGTGYVGLTTGVCFADLGHSVTCIEIDLHKLELLRSGKSPIFEPGLEELQERNM
CCCEEEEECCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCCCCCCCCCHHHHHHCCC
RAGRLRFTDDYAVGIPDAEFIFITVGTPMGEDGSADLTYVKAAARSIGQYLRSGSIIIDK
CCCCEEECCCCEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEC
STVPVGTGDMVENIIAEYAGPDVKFDVVSNPEFLREGSALSDFFKPDRIVLGAKNREAAQ
CCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCHHHHHCCCCEEEEECCCHHHHH
RVAALHETLGAPIIITDLRTAEMIKYASNAFLATRISFINEIAQICERLGADVREVARGM
HHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
GADKRIGPHFLEAGVGYGGSCFPKDVLALYHMAASAGCHPQLLQAVMDINSDARKRFVKK
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHH
VETVLGDLEGRVIGVLGLSFKPNTDDMREAPSVDIINSLLKKGARVKAYDPVAMARAEEL
HHHHHHCCCCCEEEEEECCCCCCCCHHHHCCCHHHHHHHHHCCCCEEECCCHHHHHHHHH
LPTVTFTATAYDVAKDADALLLVTEWNEFKQLDWQRIKRYMRQPVVIDGRNLYDPREMRN
CCEEEEEEHHHHHHCCCCEEEEEECCCHHHHCCHHHHHHHHHCCEEEECCCCCCHHHHHC
LGFIYWGVGRGEAPVPIMEEAQNIGD
CCEEEEECCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]