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The map label for this gene is ilvD [H]

Identifier: 222526322

GI number: 222526322

Start: 3808206

End: 3809891

Strand: Direct

Name: ilvD [H]

Synonym: Chy400_3088

Alternate gene names: 222526322

Gene position: 3808206-3809891 (Clockwise)

Preceding gene: 222526321

Following gene: 222526324

Centisome position: 72.28

GC content: 57.71

Gene sequence:

>1686_bases
ATGAGCGATAATCGCCGCAGTCGCATGATCACCGAAGGGCCGCAGCGCTCGCCGAATCGGGCGATGTTACGCGCTGTGGG
GTTTGGCGACAACGATTTCACCAAGCCGATTGTGGGAGTGGCCAATGGCCATAGTACGCTGACACCCTGTAACGCCGGGT
TGGGTGCGCTGGCTGCCCGTGCAGAAGAGGCCATTCGGGCTGCCGGTGGGATGCCGCAAATCTTCGGTACCATTACCGTT
AGTGATGGTATTTCAATGGGTACCGAAGGTATGAAGTATTCGCTGGTCAGCCGTGAAGTGATTGCCGATTCAATTGAAAC
GGTTGTCAATGCTCAGCGCATGGACGGCATTCTGGCGGTGGGTGGTTGTGACAAGAATATGCCGGGTGCGCTGATTGCCA
TGGCGCGGCTGGATATTCCGGCCATCTTTGTGTACGGTGGGACGATTAAGCCCGGACATTATAAGGGGCGTGACCTGACG
ATTGTCAGTGCCTTTGAAGCAGTCGGTGAATACAGTGCCGGTCGCATTGATGAGCACGAGCTGCTTGAGATTGAGCGTCA
TGCCTGTCCTGGCGCCGGCTCATGTGGCGGGATGTACACCGCCAATACGATGTCGTCGGCAATTGAAGCCCTCGGTTTGA
GTCTGCCCGGCTCTTCCACGATGGCTGCCGAAGATGAAGAGAAGGCATTGAGCGCGGCGCGGTCTGGTGAAGTGCTGGTT
GAGGCGATTCGCGCCAATCGTACTGCCCGCCAGATGCTGACCCGCAAGTCGCTTGAGAATGCGATTGCGGTAGTGATGGC
GCTCGGTGGTTCAACCAACGCGGTCTTGCATTTGCTAGCGATTGCACATGCCGCCGATGTCCCGCTTACGATTGATGATT
TCGAGACAATTCGCCAGCGGGTGCCGGTGCTCTGCGACCTGAAACCCTCTGGCCGCTACGTGGCGACCGATCTGCACCGG
GTCGGTGGGGTGCCGCAGGTGATGAAGATACTGTTGAATGCCGGCTTACTACACGGCGATTGTATGACTATCACTGGGCA
GACGATTGCCGAGACGCTGGCCGATGTGCCTGATGAACCTCCGGCCAATCAGGACGTCATTCGTCCGTTCAGTCAACCAA
TCTATCCTCAAGGGCATCTGGCTATTCTACGCGGCAATCTGGCCGAAGAGGGTTGTGTTGCCAAGATTACCGGTATCAAG
CAACGCCGTATTACCGGCCCCGCTCGGGTCTTTGATGCTGAAGAGGAGTGCCTGGAGGCTATTCTAAGCGGGAAGATTAA
GGCCGGTGATGTAGTGGTCATCCGCTACGAAGGGCCAAAGGGTGGCCCCGGTATGCGTGAAATGCTGGCACCAACGTCGG
CTATTATTGGGGCTGGTTTGGGTGACAGCGTGGGGTTGATTACCGATGGTCGCTTTTCCGGTGGTACCTACGGCCTGGTC
GTCGGCCACGTTGCCCCAGAGGCCGCCGTCGGTGGTACGATTGCGTTGGTCGAAGAGGGTGACAGTATCACGATTGATGC
CGATGCTCGTCTGCTGCAATTGAATGTCTCTGATGAAGAACTGGCACGGCGACGGGCTGCCTGGCAGCCGCGACCACCAC
GCTACACTCGTGGTGTTTTGGCCAAATATGCCCGTCTGGTGTCGTCGGCCAGTCTGGGCGCGGTAACCGACCGGTTTAGC
GAGTAG

Upstream 100 bases:

>100_bases
TAATACTGCCACTCTTTTTGCTGTTACCGGCAGCACCGACTAAAAATAGCGTTACAATAGGCCATGTACCTTGTGGTTCA
GATGTGTGAGGAGGCTCATA

Downstream 100 bases:

>100_bases
TTGCATACCATTGCGGCAGAGGCACTGCTCTCTGCCGCAATGGCTTCATAGCCGTCATTCCTTGACCGGTGTCCAACCGA
TCACACCGTTTGGTGCGTAG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MSDNRRSRMITEGPQRSPNRAMLRAVGFGDNDFTKPIVGVANGHSTLTPCNAGLGALAARAEEAIRAAGGMPQIFGTITV
SDGISMGTEGMKYSLVSREVIADSIETVVNAQRMDGILAVGGCDKNMPGALIAMARLDIPAIFVYGGTIKPGHYKGRDLT
IVSAFEAVGEYSAGRIDEHELLEIERHACPGAGSCGGMYTANTMSSAIEALGLSLPGSSTMAAEDEEKALSAARSGEVLV
EAIRANRTARQMLTRKSLENAIAVVMALGGSTNAVLHLLAIAHAADVPLTIDDFETIRQRVPVLCDLKPSGRYVATDLHR
VGGVPQVMKILLNAGLLHGDCMTITGQTIAETLADVPDEPPANQDVIRPFSQPIYPQGHLAILRGNLAEEGCVAKITGIK
QRRITGPARVFDAEEECLEAILSGKIKAGDVVVIRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGLV
VGHVAPEAAVGGTIALVEEGDSITIDADARLLQLNVSDEELARRRAAWQPRPPRYTRGVLAKYARLVSSASLGAVTDRFS
E

Sequences:

>Translated_561_residues
MSDNRRSRMITEGPQRSPNRAMLRAVGFGDNDFTKPIVGVANGHSTLTPCNAGLGALAARAEEAIRAAGGMPQIFGTITV
SDGISMGTEGMKYSLVSREVIADSIETVVNAQRMDGILAVGGCDKNMPGALIAMARLDIPAIFVYGGTIKPGHYKGRDLT
IVSAFEAVGEYSAGRIDEHELLEIERHACPGAGSCGGMYTANTMSSAIEALGLSLPGSSTMAAEDEEKALSAARSGEVLV
EAIRANRTARQMLTRKSLENAIAVVMALGGSTNAVLHLLAIAHAADVPLTIDDFETIRQRVPVLCDLKPSGRYVATDLHR
VGGVPQVMKILLNAGLLHGDCMTITGQTIAETLADVPDEPPANQDVIRPFSQPIYPQGHLAILRGNLAEEGCVAKITGIK
QRRITGPARVFDAEEECLEAILSGKIKAGDVVVIRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGLV
VGHVAPEAAVGGTIALVEEGDSITIDADARLLQLNVSDEELARRRAAWQPRPPRYTRGVLAKYARLVSSASLGAVTDRFS
E
>Mature_560_residues
SDNRRSRMITEGPQRSPNRAMLRAVGFGDNDFTKPIVGVANGHSTLTPCNAGLGALAARAEEAIRAAGGMPQIFGTITVS
DGISMGTEGMKYSLVSREVIADSIETVVNAQRMDGILAVGGCDKNMPGALIAMARLDIPAIFVYGGTIKPGHYKGRDLTI
VSAFEAVGEYSAGRIDEHELLEIERHACPGAGSCGGMYTANTMSSAIEALGLSLPGSSTMAAEDEEKALSAARSGEVLVE
AIRANRTARQMLTRKSLENAIAVVMALGGSTNAVLHLLAIAHAADVPLTIDDFETIRQRVPVLCDLKPSGRYVATDLHRV
GGVPQVMKILLNAGLLHGDCMTITGQTIAETLADVPDEPPANQDVIRPFSQPIYPQGHLAILRGNLAEEGCVAKITGIKQ
RRITGPARVFDAEEECLEAILSGKIKAGDVVVIRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGLVV
GHVAPEAAVGGTIALVEEGDSITIDADARLLQLNVSDEELARRRAAWQPRPPRYTRGVLAKYARLVSSASLGAVTDRFSE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=608, Percent_Identity=41.6118421052632, Blast_Score=430, Evalue=1e-121,
Organism=Escherichia coli, GI1788157, Length=481, Percent_Identity=32.2245322245322, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI2367371, Length=513, Percent_Identity=34.8927875243665, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1786464, Length=538, Percent_Identity=33.457249070632, Blast_Score=193, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322476, Length=562, Percent_Identity=51.067615658363, Blast_Score=553, Evalue=1e-158,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 58983; Mature: 58852

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNRRSRMITEGPQRSPNRAMLRAVGFGDNDFTKPIVGVANGHSTLTPCNAGLGALAAR
CCCCCCCCCCCCCCCCCCCHHEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHH
AEEAIRAAGGMPQIFGTITVSDGISMGTEGMKYSLVSREVIADSIETVVNAQRMDGILAV
HHHHHHHCCCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCEEEE
GGCDKNMPGALIAMARLDIPAIFVYGGTIKPGHYKGRDLTIVSAFEAVGEYSAGRIDEHE
CCCCCCCCHHHHHHHHCCCCEEEEECCEECCCCCCCCCEEEEHHHHHHCCCCCCCCCHHH
LLEIERHACPGAGSCGGMYTANTMSSAIEALGLSLPGSSTMAAEDEEKALSAARSGEVLV
HHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHH
EAIRANRTARQMLTRKSLENAIAVVMALGGSTNAVLHLLAIAHAADVPLTIDDFETIRQR
HHHHHCHHHHHHHHHHHHHHHHEEEHEECCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
VPVLCDLKPSGRYVATDLHRVGGVPQVMKILLNAGLLHGDCMTITGQTIAETLADVPDEP
CCEEEECCCCCCEEEHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHCCCCCC
PANQDVIRPFSQPIYPQGHLAILRGNLAEEGCVAKITGIKQRRITGPARVFDAEEECLEA
CCCHHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEECCCHHHCCCCCHHHCCCHHHHHHH
ILSGKIKAGDVVVIRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGLV
HHCCCCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCCCEEECCCCCCCEEEEE
VGHVAPEAAVGGTIALVEEGDSITIDADARLLQLNVSDEELARRRAAWQPRPPRYTRGVL
EECCCCCHHCCCEEEEEECCCEEEEECCCEEEEEECCHHHHHHHHHCCCCCCCHHHHHHH
AKYARLVSSASLGAVTDRFSE
HHHHHHHHCCCCHHHHHHCCC
>Mature Secondary Structure 
SDNRRSRMITEGPQRSPNRAMLRAVGFGDNDFTKPIVGVANGHSTLTPCNAGLGALAAR
CCCCCCCCCCCCCCCCCCHHEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHH
AEEAIRAAGGMPQIFGTITVSDGISMGTEGMKYSLVSREVIADSIETVVNAQRMDGILAV
HHHHHHHCCCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCEEEE
GGCDKNMPGALIAMARLDIPAIFVYGGTIKPGHYKGRDLTIVSAFEAVGEYSAGRIDEHE
CCCCCCCCHHHHHHHHCCCCEEEEECCEECCCCCCCCCEEEEHHHHHHCCCCCCCCCHHH
LLEIERHACPGAGSCGGMYTANTMSSAIEALGLSLPGSSTMAAEDEEKALSAARSGEVLV
HHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHH
EAIRANRTARQMLTRKSLENAIAVVMALGGSTNAVLHLLAIAHAADVPLTIDDFETIRQR
HHHHHCHHHHHHHHHHHHHHHHEEEHEECCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
VPVLCDLKPSGRYVATDLHRVGGVPQVMKILLNAGLLHGDCMTITGQTIAETLADVPDEP
CCEEEECCCCCCEEEHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHCCCCCC
PANQDVIRPFSQPIYPQGHLAILRGNLAEEGCVAKITGIKQRRITGPARVFDAEEECLEA
CCCHHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEECCCHHHCCCCCHHHCCCHHHHHHH
ILSGKIKAGDVVVIRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGLV
HHCCCCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCCCEEECCCCCCCEEEEE
VGHVAPEAAVGGTIALVEEGDSITIDADARLLQLNVSDEELARRRAAWQPRPPRYTRGVL
EECCCCCHHCCCEEEEEECCCEEEEECCCEEEEEECCHHHHHHHHHCCCCCCCHHHHHHH
AKYARLVSSASLGAVTDRFSE
HHHHHHHHCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA