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The map label for this gene is ddc [H]

Identifier: 222526312

GI number: 222526312

Start: 3797006

End: 3798427

Strand: Reverse

Name: ddc [H]

Synonym: Chy400_3078

Alternate gene names: 222526312

Gene position: 3798427-3797006 (Counterclockwise)

Preceding gene: 222526314

Following gene: 222526306

Centisome position: 72.09

GC content: 60.97

Gene sequence:

>1422_bases
ATGCAGCCTGATGAGTTTCGTCGCCTCGGCTATCAGATTATCGATATGATCGCCGATTACCGTGCGACTATTGCTCAGCG
CCCGGTCTGGTCACAGTTACGCCCCGGTGAGCTGCGTAGTCAGCTTCCGGCCAATCCACCTGAACATCCCGAACCGGCCA
CCGACATTCTGACCGATATTGAACGCCTGATTATCCCTGGCCTTTCCAACTGGCAACATCCACGGTTCTTTGGCTATTTC
CCGGCCAATGCCAGTCTGGCGTCATTGCTTGGCGATATGCTCAGCGGCGGTCTCGGTCAGTTAGGACTCAACTGGCAGGC
CAGCCCGCCATTGACCGAACTGGAAGAGCTGACCACCGATTGGATGCGGCAGTTGCTCGGCTTAAGCGAGACGTGGCGTG
GCGTTATTCAGGACACCGCCAGCACCAGTACGCTGGTTGCACTACTCTGTGCCCGTGAGCGTGCGACCGACCACTGCCAG
GTGCGCGGCGGGCTACAGGCGCTGCCGGCACCGCTGGTAGTGTATACCTCAACCCAAAGCCACAGCTCGGTCGAAAAGGC
GGTGCTTCTGGCCGGTTTCGGGCGCGACAATCTTCGGCTGATTCCGGTTGACGATCAGTTTGCCATGCGCGTGGATGCCC
TCGAAGCGGCCATCGCCGCCGACCGCGCCGCCGGACGGGTGCCATGTGCCGTTGTCGCCAGCATTGGCGCAACTGCGACA
ACCGCATGCGATCCGCTCGAACCGATTGGTGCTCTGTGTCAGCGCGAGGGTATCTGGTTGCACGTTGATGCCGCAATGGC
CGGATCGGCGATGATCTTGCCCGAATGTCGGCAGCTCTGGCAGGGGATCGAACAGGCCGATAGTCTGGTACTCAATCCGC
ACAAATGGCTGGGGGCGGCATTCGATTGTTCGCTGTACTATGTGCGCGACCCGCAGCATCTGATCAGAGTTATGTCTACT
AATCCCAGCTATCTGCAAACCAGTGCCGACGGTACGGTCACCAACTACCGTGATTGGGGGATTCCGCTCGGTCGGCGCTT
CCGGGCGCTGAAACTCTACTTTCTCCTGCGCTGTGAAGGTGCCGAGGGCTTACGTGCCCGCCTGCGGCGCGATCTGGCTA
ACGCACGCTGGCTGGCCGCACAGGTCGATGCAACACCTCACTGGCGACGCCTGGCACCGGTGCCGCTGCAAACAGTTTGT
GTCCGCCACGAACCACCCGGACTGACGGGAGAGGCGCTCGATCAGCACACGTTACGCTGGGTCGGTATGATTAACGCCAG
CGGGGCAGCTTACCTCACGCCGGCAGTACTCGATGGACGCTGGATGGTGCGGGTGAGTATCGGCGCCGAGCCAACCGAAC
ACGCCGATGTTGTGGCCTTGTGGGAGCTGATGCAAGCCATGGCCACACGTGTCGCACCGTAG

Upstream 100 bases:

>100_bases
CGACTCCCAATCTCTGCAACTGACAGGAAGCACCGGTATAACCCATCGGCAACATGCAGTACAATGCACATGGCCGCAGA
TCAGTTTCAAGGAGCATCGT

Downstream 100 bases:

>100_bases
CCGTTACAGTATAAGAGACGGTATGTCCAGGGGACATGTGAGGTCAGGTCAGCGACGTAGCACAGGCTGCGAGCTGTGCT
ACGTCTGCCTGAGAGATGAT

Product: Aromatic-L-amino-acid decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MQPDEFRRLGYQIIDMIADYRATIAQRPVWSQLRPGELRSQLPANPPEHPEPATDILTDIERLIIPGLSNWQHPRFFGYF
PANASLASLLGDMLSGGLGQLGLNWQASPPLTELEELTTDWMRQLLGLSETWRGVIQDTASTSTLVALLCARERATDHCQ
VRGGLQALPAPLVVYTSTQSHSSVEKAVLLAGFGRDNLRLIPVDDQFAMRVDALEAAIAADRAAGRVPCAVVASIGATAT
TACDPLEPIGALCQREGIWLHVDAAMAGSAMILPECRQLWQGIEQADSLVLNPHKWLGAAFDCSLYYVRDPQHLIRVMST
NPSYLQTSADGTVTNYRDWGIPLGRRFRALKLYFLLRCEGAEGLRARLRRDLANARWLAAQVDATPHWRRLAPVPLQTVC
VRHEPPGLTGEALDQHTLRWVGMINASGAAYLTPAVLDGRWMVRVSIGAEPTEHADVVALWELMQAMATRVAP

Sequences:

>Translated_473_residues
MQPDEFRRLGYQIIDMIADYRATIAQRPVWSQLRPGELRSQLPANPPEHPEPATDILTDIERLIIPGLSNWQHPRFFGYF
PANASLASLLGDMLSGGLGQLGLNWQASPPLTELEELTTDWMRQLLGLSETWRGVIQDTASTSTLVALLCARERATDHCQ
VRGGLQALPAPLVVYTSTQSHSSVEKAVLLAGFGRDNLRLIPVDDQFAMRVDALEAAIAADRAAGRVPCAVVASIGATAT
TACDPLEPIGALCQREGIWLHVDAAMAGSAMILPECRQLWQGIEQADSLVLNPHKWLGAAFDCSLYYVRDPQHLIRVMST
NPSYLQTSADGTVTNYRDWGIPLGRRFRALKLYFLLRCEGAEGLRARLRRDLANARWLAAQVDATPHWRRLAPVPLQTVC
VRHEPPGLTGEALDQHTLRWVGMINASGAAYLTPAVLDGRWMVRVSIGAEPTEHADVVALWELMQAMATRVAP
>Mature_473_residues
MQPDEFRRLGYQIIDMIADYRATIAQRPVWSQLRPGELRSQLPANPPEHPEPATDILTDIERLIIPGLSNWQHPRFFGYF
PANASLASLLGDMLSGGLGQLGLNWQASPPLTELEELTTDWMRQLLGLSETWRGVIQDTASTSTLVALLCARERATDHCQ
VRGGLQALPAPLVVYTSTQSHSSVEKAVLLAGFGRDNLRLIPVDDQFAMRVDALEAAIAADRAAGRVPCAVVASIGATAT
TACDPLEPIGALCQREGIWLHVDAAMAGSAMILPECRQLWQGIEQADSLVLNPHKWLGAAFDCSLYYVRDPQHLIRVMST
NPSYLQTSADGTVTNYRDWGIPLGRRFRALKLYFLLRCEGAEGLRARLRRDLANARWLAAQVDATPHWRRLAPVPLQTVC
VRHEPPGLTGEALDQHTLRWVGMINASGAAYLTPAVLDGRWMVRVSIGAEPTEHADVVALWELMQAMATRVAP

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=484, Percent_Identity=39.8760330578512, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI132814448, Length=484, Percent_Identity=39.8760330578512, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI92110055, Length=484, Percent_Identity=38.4297520661157, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI194294551, Length=401, Percent_Identity=31.4214463840399, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI197383062, Length=391, Percent_Identity=29.4117647058824, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI58331246, Length=368, Percent_Identity=28.5326086956522, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI197276620, Length=379, Percent_Identity=26.6490765171504, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4503875, Length=379, Percent_Identity=26.6490765171504, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17534819, Length=484, Percent_Identity=38.4297520661157, Blast_Score=331, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI17534817, Length=484, Percent_Identity=38.4297520661157, Blast_Score=331, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI71981211, Length=519, Percent_Identity=28.3236994219653, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI71981217, Length=528, Percent_Identity=28.4090909090909, Blast_Score=254, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17551992, Length=508, Percent_Identity=29.3307086614173, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI133931025, Length=479, Percent_Identity=29.8538622129436, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17555682, Length=382, Percent_Identity=26.7015706806283, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71993058, Length=349, Percent_Identity=28.9398280802292, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71993062, Length=343, Percent_Identity=27.6967930029155, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI193205882, Length=278, Percent_Identity=23.7410071942446, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28573972, Length=484, Percent_Identity=38.8429752066116, Blast_Score=328, Evalue=7e-90,
Organism=Drosophila melanogaster, GI24585139, Length=482, Percent_Identity=37.551867219917, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI221476190, Length=482, Percent_Identity=37.551867219917, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24585143, Length=482, Percent_Identity=37.551867219917, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24652373, Length=483, Percent_Identity=38.7163561076605, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI24586044, Length=486, Percent_Identity=37.2427983539095, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI17136190, Length=489, Percent_Identity=36.8098159509202, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI24585135, Length=489, Percent_Identity=35.5828220858896, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI17136594, Length=408, Percent_Identity=30.1470588235294, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24657193, Length=374, Percent_Identity=27.0053475935829, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24657185, Length=374, Percent_Identity=27.0053475935829, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24657188, Length=374, Percent_Identity=27.0053475935829, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI21356415, Length=331, Percent_Identity=26.8882175226586, Blast_Score=125, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 52091; Mature: 52091

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPDEFRRLGYQIIDMIADYRATIAQRPVWSQLRPGELRSQLPANPPEHPEPATDILTDI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHCCCCCCCCCCCCHHHHHHHH
ERLIIPGLSNWQHPRFFGYFPANASLASLLGDMLSGGLGQLGLNWQASPPLTELEELTTD
HHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
WMRQLLGLSETWRGVIQDTASTSTLVALLCARERATDHCQVRGGLQALPAPLVVYTSTQS
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHCCCCHHCCCCEEEEECCCC
HSSVEKAVLLAGFGRDNLRLIPVDDQFAMRVDALEAAIAADRAAGRVPCAVVASIGATAT
HHHHHHHHEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCC
TACDPLEPIGALCQREGIWLHVDAAMAGSAMILPECRQLWQGIEQADSLVLNPHKWLGAA
CCCCCHHHHHHHHHCCCEEEEEEHHHCCCEEECHHHHHHHHHHHHHCCEEECCHHHHCCE
FDCSLYYVRDPQHLIRVMSTNPSYLQTSADGTVTNYRDWGIPLGRRFRALKLYFLLRCEG
EEEEEEEEECHHHHHHHHCCCCCEEEECCCCCEECCCCCCCCHHHHHHHEEEEEEEEECC
AEGLRARLRRDLANARWLAAQVDATPHWRRLAPVPLQTVCVRHEPPGLTGEALDQHTLRW
CHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHEEEECCCCCCCHHHHHHHHHHE
VGMINASGAAYLTPAVLDGRWMVRVSIGAEPTEHADVVALWELMQAMATRVAP
EEEEECCCCCEECHHEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQPDEFRRLGYQIIDMIADYRATIAQRPVWSQLRPGELRSQLPANPPEHPEPATDILTDI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHCCCCCCCCCCCCHHHHHHHH
ERLIIPGLSNWQHPRFFGYFPANASLASLLGDMLSGGLGQLGLNWQASPPLTELEELTTD
HHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
WMRQLLGLSETWRGVIQDTASTSTLVALLCARERATDHCQVRGGLQALPAPLVVYTSTQS
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHCCCCHHCCCCEEEEECCCC
HSSVEKAVLLAGFGRDNLRLIPVDDQFAMRVDALEAAIAADRAAGRVPCAVVASIGATAT
HHHHHHHHEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCC
TACDPLEPIGALCQREGIWLHVDAAMAGSAMILPECRQLWQGIEQADSLVLNPHKWLGAA
CCCCCHHHHHHHHHCCCEEEEEEHHHCCCEEECHHHHHHHHHHHHHCCEEECCHHHHCCE
FDCSLYYVRDPQHLIRVMSTNPSYLQTSADGTVTNYRDWGIPLGRRFRALKLYFLLRCEG
EEEEEEEEECHHHHHHHHCCCCCEEEECCCCCEECCCCCCCCHHHHHHHEEEEEEEEECC
AEGLRARLRRDLANARWLAAQVDATPHWRRLAPVPLQTVCVRHEPPGLTGEALDQHTLRW
CHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHEEEECCCCCCCHHHHHHHHHHE
VGMINASGAAYLTPAVLDGRWMVRVSIGAEPTEHADVVALWELMQAMATRVAP
EEEEECCCCCEECHHEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]