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The map label for this gene is clpP [H]

Identifier: 222526286

GI number: 222526286

Start: 3765477

End: 3766070

Strand: Direct

Name: clpP [H]

Synonym: Chy400_3052

Alternate gene names: 222526286

Gene position: 3765477-3766070 (Clockwise)

Preceding gene: 222526285

Following gene: 222526288

Centisome position: 71.47

GC content: 56.23

Gene sequence:

>594_bases
ATGCCTTCTGTACCGGTACCAACGATTGTAGAACGCACGAGCCGTGGAGAGCGAAGCTGGGATATTTTTTCGCGCCTGCT
GAAAGAGCGAGTGGTGTTGATCGGTGAACCTATCGACGATGAACTGGCTTCATCGGTGATCGCTCAGTTGCTGGTGTTGC
AACAGCAAGACCCTGAACGCGATATCTGGATGTACATTAACAGTCCTGGTGGCGTTATCCGGGCCGGCCTGGCGATCTAC
GACACGATGCAACTGGTTACCCCCGATATTTGCACAGTGTGCGTAGGTCGTGCCGCGAGTATGGCGACTGTCTTGCTCTG
TGCTGGCACGAAGGGGAAACGGTTTGCCCTGCCACACGCCACCATCCACTCGCATCCGGCGGGCGGTGGCGCCGAAGGGT
ATGCTCCCGATGTCCAGATTGCGGTCGATGAAATGCTGCGTCTGCAGCGGTTGCTGCGCGAGATCATGGCTAAACATTCC
GGGCAACCCGTCGAGCGCCTTGAAGCCGATTTTAGTCGTGATTTCTATATGACCGCACCACAGGCGCTGGAGTACGGATT
GATCGATGCTATTCTGACACCAAACCGGTCGTGA

Upstream 100 bases:

>100_bases
AGCCATACGAGATTGCAATGCGCGCAGCTATTGTGAAGCGACAGTCGAAATCGGTCACTGGGAGTTGTGTGATTGTCGAT
AATGAAGAAAGAGGATAGCA

Downstream 100 bases:

>100_bases
AGGCAGGTTGGTTTAGGTGTCGCGCGAGCCAGTCAACCGTGAGCGTAATGCATTCCAGGTCTATCGGGAGCGAGATATGA
CTGGCGAACGGCAAGAGATG

Product: endopeptidase Clp

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MPSVPVPTIVERTSRGERSWDIFSRLLKERVVLIGEPIDDELASSVIAQLLVLQQQDPERDIWMYINSPGGVIRAGLAIY
DTMQLVTPDICTVCVGRAASMATVLLCAGTKGKRFALPHATIHSHPAGGGAEGYAPDVQIAVDEMLRLQRLLREIMAKHS
GQPVERLEADFSRDFYMTAPQALEYGLIDAILTPNRS

Sequences:

>Translated_197_residues
MPSVPVPTIVERTSRGERSWDIFSRLLKERVVLIGEPIDDELASSVIAQLLVLQQQDPERDIWMYINSPGGVIRAGLAIY
DTMQLVTPDICTVCVGRAASMATVLLCAGTKGKRFALPHATIHSHPAGGGAEGYAPDVQIAVDEMLRLQRLLREIMAKHS
GQPVERLEADFSRDFYMTAPQALEYGLIDAILTPNRS
>Mature_196_residues
PSVPVPTIVERTSRGERSWDIFSRLLKERVVLIGEPIDDELASSVIAQLLVLQQQDPERDIWMYINSPGGVIRAGLAIYD
TMQLVTPDICTVCVGRAASMATVLLCAGTKGKRFALPHATIHSHPAGGGAEGYAPDVQIAVDEMLRLQRLLREIMAKHSG
QPVERLEADFSRDFYMTAPQALEYGLIDAILTPNRS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=187, Percent_Identity=51.8716577540107, Blast_Score=202, Evalue=2e-52,
Organism=Escherichia coli, GI1786641, Length=188, Percent_Identity=52.1276595744681, Blast_Score=227, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17538017, Length=194, Percent_Identity=46.3917525773196, Blast_Score=193, Evalue=5e-50,
Organism=Drosophila melanogaster, GI20129427, Length=187, Percent_Identity=48.6631016042781, Blast_Score=191, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21654; Mature: 21523

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00381 CLP_PROTEASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSVPVPTIVERTSRGERSWDIFSRLLKERVVLIGEPIDDELASSVIAQLLVLQQQDPER
CCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCC
DIWMYINSPGGVIRAGLAIYDTMQLVTPDICTVCVGRAASMATVLLCAGTKGKRFALPHA
EEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHEECCCCCCEEECCCC
TIHSHPAGGGAEGYAPDVQIAVDEMLRLQRLLREIMAKHSGQPVERLEADFSRDFYMTAP
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCH
QALEYGLIDAILTPNRS
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PSVPVPTIVERTSRGERSWDIFSRLLKERVVLIGEPIDDELASSVIAQLLVLQQQDPER
CCCCCCHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCC
DIWMYINSPGGVIRAGLAIYDTMQLVTPDICTVCVGRAASMATVLLCAGTKGKRFALPHA
EEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHEECCCCCCEEECCCC
TIHSHPAGGGAEGYAPDVQIAVDEMLRLQRLLREIMAKHSGQPVERLEADFSRDFYMTAP
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCH
QALEYGLIDAILTPNRS
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA