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The map label for this gene is yngG [H]

Identifier: 222525687

GI number: 222525687

Start: 3078498

End: 3079451

Strand: Reverse

Name: yngG [H]

Synonym: Chy400_2438

Alternate gene names: 222525687

Gene position: 3079451-3078498 (Counterclockwise)

Preceding gene: 222525688

Following gene: 222525686

Centisome position: 58.45

GC content: 59.43

Gene sequence:

>954_bases
ATGGAAGCAGTAACGATTGTTGACGTCGCACCCCGTGATGGGTTGCAGAACGAGCCTGACGTGTTAGAGCCGGCCACCCG
GGTTGAGTTGATCGAGCGCCTGCTCGCAGCCGGTGTGCCACGGATCGAGATCGGTTCGTTTGTTAACCCGCGTCAGGTGC
CGCAGATGGCCGGAATTGATCAGATTGCACGGATGTTGATTGAACGTGGTCATAATCTGGCTGCCCGTACCACGAATGAT
CTCTTCCGTTTTACCGCCCTTGTCCCCAACCAGCGCGGCTATGAACTGGCCGCTGCCGCCGGACTACGCCACGTGCGGCT
GGTGCTGGCCGCCAGTGATGGTCTGAATCGGGCAAACTTTAAGCGCACAACCGCCGAGTCGCTGATTGAATTCAGCCGCT
TCGCGCTCAATATTCGACGTGATGGTCTCACGTTCGGGGTGGCAATTGGTGCCGCCTTTGGGTGTCCGTTCGATGGCTAT
GTTTCACCCGAACGGGTTCGTGCGATTGCCGAACACGCTGTCGATATTGGTGCCGGCGAGATCATTCTGGCCGATACGAC
CGGGATGGCAGTACCGACACAGGTTGCGGCATTGTGTCGGACGATTCTAGATCGCATCCCCGATGTCACAGTGACGCTCC
ATCTGCACAATACGCGCAATACCGGTTATGCTAACGCCTTCGCCGCCTGGCAGGTCGGTATTCGTTCGTTCGATGCTGCG
CTCGGTGGGATCGGCGGCTGCCCATTCGCACCGCGCGCAGTAGGCAATATCGCCAGCGAGGACCTGGTGCATCTCTTCAA
CGGTCTTGGGGTACCAACCGGGATCGATCTGTCGGCGCTCATTGCTGCATCCGACTGGCTCAGTGCCACACTTGGCCGCC
CCTTGCCGGCACTGGTCGGGAAGGCCGGGCCGGTCTATCCGCAGGTGGTGTCAATGGCACCCTACCTGTCATAA

Upstream 100 bases:

>100_bases
CCGGTCCTGCGCTCGGTCAGCACAATCGCGAAATCTTTACCGATCTGCTTGGTCTGACGGAGGATGATCTGGCAATGCTG
CAAGCGAAGCGGGTGATTTG

Downstream 100 bases:

>100_bases
GCTACTGTCCGGGGAGTACGTGGTTTTATCGGGAGGAATGGAGACATGAGTTATCGCATTGGAGTCGATGTTGGTGGAAC
GTTCACCGACCTGATGCTCT

Product: pyruvate carboxyltransferase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MEAVTIVDVAPRDGLQNEPDVLEPATRVELIERLLAAGVPRIEIGSFVNPRQVPQMAGIDQIARMLIERGHNLAARTTND
LFRFTALVPNQRGYELAAAAGLRHVRLVLAASDGLNRANFKRTTAESLIEFSRFALNIRRDGLTFGVAIGAAFGCPFDGY
VSPERVRAIAEHAVDIGAGEIILADTTGMAVPTQVAALCRTILDRIPDVTVTLHLHNTRNTGYANAFAAWQVGIRSFDAA
LGGIGGCPFAPRAVGNIASEDLVHLFNGLGVPTGIDLSALIAASDWLSATLGRPLPALVGKAGPVYPQVVSMAPYLS

Sequences:

>Translated_317_residues
MEAVTIVDVAPRDGLQNEPDVLEPATRVELIERLLAAGVPRIEIGSFVNPRQVPQMAGIDQIARMLIERGHNLAARTTND
LFRFTALVPNQRGYELAAAAGLRHVRLVLAASDGLNRANFKRTTAESLIEFSRFALNIRRDGLTFGVAIGAAFGCPFDGY
VSPERVRAIAEHAVDIGAGEIILADTTGMAVPTQVAALCRTILDRIPDVTVTLHLHNTRNTGYANAFAAWQVGIRSFDAA
LGGIGGCPFAPRAVGNIASEDLVHLFNGLGVPTGIDLSALIAASDWLSATLGRPLPALVGKAGPVYPQVVSMAPYLS
>Mature_317_residues
MEAVTIVDVAPRDGLQNEPDVLEPATRVELIERLLAAGVPRIEIGSFVNPRQVPQMAGIDQIARMLIERGHNLAARTTND
LFRFTALVPNQRGYELAAAAGLRHVRLVLAASDGLNRANFKRTTAESLIEFSRFALNIRRDGLTFGVAIGAAFGCPFDGY
VSPERVRAIAEHAVDIGAGEIILADTTGMAVPTQVAALCRTILDRIPDVTVTLHLHNTRNTGYANAFAAWQVGIRSFDAA
LGGIGGCPFAPRAVGNIASEDLVHLFNGLGVPTGIDLSALIAASDWLSATLGRPLPALVGKAGPVYPQVVSMAPYLS

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI109150422, Length=301, Percent_Identity=32.890365448505, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI109150427, Length=301, Percent_Identity=32.890365448505, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI62198232, Length=299, Percent_Identity=32.4414715719064, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI260654708, Length=135, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17510563, Length=303, Percent_Identity=33.003300330033, Blast_Score=170, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24582381, Length=299, Percent_Identity=33.7792642140468, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 33648; Mature: 33648

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50991 PYR_CT ; PS01094 UPF0076

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAVTIVDVAPRDGLQNEPDVLEPATRVELIERLLAAGVPRIEIGSFVNPRQVPQMAGID
CCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCHHHCHHHCCHH
QIARMLIERGHNLAARTTNDLFRFTALVPNQRGYELAAAAGLRHVRLVLAASDGLNRANF
HHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHCHHHEEEEEEECCCCCCHHH
KRTTAESLIEFSRFALNIRRDGLTFGVAIGAAFGCPFDGYVSPERVRAIAEHAVDIGAGE
HHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
IILADTTGMAVPTQVAALCRTILDRIPDVTVTLHLHNTRNTGYANAFAAWQVGIRSFDAA
EEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
LGGIGGCPFAPRAVGNIASEDLVHLFNGLGVPTGIDLSALIAASDWLSATLGRPLPALVG
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHC
KAGPVYPQVVSMAPYLS
CCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MEAVTIVDVAPRDGLQNEPDVLEPATRVELIERLLAAGVPRIEIGSFVNPRQVPQMAGID
CCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCHHHCHHHCCHH
QIARMLIERGHNLAARTTNDLFRFTALVPNQRGYELAAAAGLRHVRLVLAASDGLNRANF
HHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHCHHHEEEEEEECCCCCCHHH
KRTTAESLIEFSRFALNIRRDGLTFGVAIGAAFGCPFDGYVSPERVRAIAEHAVDIGAGE
HHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
IILADTTGMAVPTQVAALCRTILDRIPDVTVTLHLHNTRNTGYANAFAAWQVGIRSFDAA
EEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
LGGIGGCPFAPRAVGNIASEDLVHLFNGLGVPTGIDLSALIAASDWLSATLGRPLPALVG
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHC
KAGPVYPQVVSMAPYLS
CCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]