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The map label for this gene is tmk [H]

Identifier: 222525656

GI number: 222525656

Start: 3034307

End: 3034987

Strand: Direct

Name: tmk [H]

Synonym: Chy400_2407

Alternate gene names: 222525656

Gene position: 3034307-3034987 (Clockwise)

Preceding gene: 222525655

Following gene: 222525657

Centisome position: 57.59

GC content: 54.19

Gene sequence:

>681_bases
ATGAAACAAGGGTTCTTTATCACATTTGAAGGGCCGGAAGGAGCCGGGAAAAGCACACAGGCTCGACGATTGTATGAGCG
ATTACAGTCTATCGGCTACCCTACAATTTTGACTCGTGAGCCAGGTGGTACTCGCATCAGTGAATTGATTCGGCGCATTC
TGGTGGATCTCCGCCATACCGAGATGGCACCAACAACCGAGATACTGCTGTTCTCGGCAGCCCGGGCCCAATTGGTGAGC
GAGTTGATCCGGCCATACCTGGCAACCGGTGGTATCGTGGTGTGTGATCGCTACGCCGACTCGACGTTTGCCTATCAGGG
GTACGGTCTGGGTCGCGATCTTGAAGAGTTACGGACGATTACCGATATTGCTACCGGTGGTTTGAAACCCGACCTGACCC
TGTATTTGCGAATTGATGTTGAAGTCGGTTTGCAGCGTAAACGCGCCAGTCGTGAACGAATTGAACCTGGCAGTGTGCAA
CCACCGGAATGGAATCGACTCGATGCTCGTGATCTGGCGTACCATCAACGGGTAGCTCAGGGCTTCAACGAGTTGATGGC
GCAAGAGCCTGAGCGCTGGTATGCGTTGGATGCCGATCAACCGGTAGATGAGTTAGCCGAACAGATCTGGCAGGTTGTGA
TGGCCCGGTTAGCGCAGGTGATGCCGCTTGCTGCGCAATGA

Upstream 100 bases:

>100_bases
CCTAACCGACGGGTGAAGATCTTCCGGTAGCAGATCGACAGATTGCTGAAGATCGGCTATCCTTAACGAAGGTTAAACCG
TCATTGCTGGTAGCGATTTC

Downstream 100 bases:

>100_bases
TGCGTGTATTGCATAGCATATAAGGGTGAAGATCATGCGCCTCATTCTTGCTGTTGTTCAGTCTCAAGACGCAACAAATC
TGGTAGAAGCGCTAACCGAG

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKQGFFITFEGPEGAGKSTQARRLYERLQSIGYPTILTREPGGTRISELIRRILVDLRHTEMAPTTEILLFSAARAQLVS
ELIRPYLATGGIVVCDRYADSTFAYQGYGLGRDLEELRTITDIATGGLKPDLTLYLRIDVEVGLQRKRASRERIEPGSVQ
PPEWNRLDARDLAYHQRVAQGFNELMAQEPERWYALDADQPVDELAEQIWQVVMARLAQVMPLAAQ

Sequences:

>Translated_226_residues
MKQGFFITFEGPEGAGKSTQARRLYERLQSIGYPTILTREPGGTRISELIRRILVDLRHTEMAPTTEILLFSAARAQLVS
ELIRPYLATGGIVVCDRYADSTFAYQGYGLGRDLEELRTITDIATGGLKPDLTLYLRIDVEVGLQRKRASRERIEPGSVQ
PPEWNRLDARDLAYHQRVAQGFNELMAQEPERWYALDADQPVDELAEQIWQVVMARLAQVMPLAAQ
>Mature_226_residues
MKQGFFITFEGPEGAGKSTQARRLYERLQSIGYPTILTREPGGTRISELIRRILVDLRHTEMAPTTEILLFSAARAQLVS
ELIRPYLATGGIVVCDRYADSTFAYQGYGLGRDLEELRTITDIATGGLKPDLTLYLRIDVEVGLQRKRASRERIEPGSVQ
PPEWNRLDARDLAYHQRVAQGFNELMAQEPERWYALDADQPVDELAEQIWQVVMARLAQVMPLAAQ

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI42544174, Length=209, Percent_Identity=31.1004784688995, Blast_Score=78, Evalue=6e-15,
Organism=Escherichia coli, GI1787340, Length=212, Percent_Identity=37.2641509433962, Blast_Score=126, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28573735, Length=220, Percent_Identity=29.0909090909091, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 25579; Mature: 25579

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQGFFITFEGPEGAGKSTQARRLYERLQSIGYPTILTREPGGTRISELIRRILVDLRHT
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHC
EMAPTTEILLFSAARAQLVSELIRPYLATGGIVVCDRYADSTFAYQGYGLGRDLEELRTI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCHHHHHHH
TDIATGGLKPDLTLYLRIDVEVGLQRKRASRERIEPGSVQPPEWNRLDARDLAYHQRVAQ
HHHHCCCCCCCEEEEEEEEHHHCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GFNELMAQEPERWYALDADQPVDELAEQIWQVVMARLAQVMPLAAQ
HHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKQGFFITFEGPEGAGKSTQARRLYERLQSIGYPTILTREPGGTRISELIRRILVDLRHT
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHC
EMAPTTEILLFSAARAQLVSELIRPYLATGGIVVCDRYADSTFAYQGYGLGRDLEELRTI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCHHHHHHH
TDIATGGLKPDLTLYLRIDVEVGLQRKRASRERIEPGSVQPPEWNRLDARDLAYHQRVAQ
HHHHCCCCCCCEEEEEEEEHHHCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GFNELMAQEPERWYALDADQPVDELAEQIWQVVMARLAQVMPLAAQ
HHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA