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The map label for this gene is yhxA [H]

Identifier: 222525626

GI number: 222525626

Start: 3003578

End: 3004933

Strand: Direct

Name: yhxA [H]

Synonym: Chy400_2377

Alternate gene names: 222525626

Gene position: 3003578-3004933 (Clockwise)

Preceding gene: 222525624

Following gene: 222525630

Centisome position: 57.01

GC content: 59.96

Gene sequence:

>1356_bases
GTGAACACCCTGCAAGAACAGCTTCAGGCCGACCATGAGTATCTCATCCACCCCCTCACCCACCCGACGGCGCACCAGAA
TCCGAAAATCTGGGTTGCCGGTCGTGGTTCAATTGTGATTGACGCCGAGGGGCGCGAGTATATTGACGGTCTGAGCGGAC
TGTGGAATGTCAATGTCGGCCATGGTCGGGCCGAGCTGGCCGAAGCGGCCTGCAACCAGATGAAGCAACTGGCCTACTAC
TCGGCTTACGTTGGCTCGACGAACCTGCCGGCAATTGAACTGGCGCGGAAACTCAGCGAACTCTTCTATCCGAGTATCAA
CCACTTCTTCTTCACCTCGGGCGGTGCCGAGAGCACCGAAAGCTCGTTCAAGACCGCACGTTTCTACTGGAAGGCGGTCG
GCAAGCCGGAGAAGGTCAAGTTTATTTCGCGCATGAAGGGCTATCACGGCGTCACTATGGCGGCGATGAGTGCTACCGGC
CTGCCCGCGTACTGGCCGATGTTTGAGCCGCGTGTACCGGGATTCATCCATATCGAGTCGCCGTACCCCTACCGCTTCGT
CAATCCTACCCCGCACCTGAGCGATGGGGTGGCCGCAGCCAACCTGCTCGAAGAGGCGATTGTACGTGAAGGGCCGGACA
CGGTTGCAGCCTTCATCGCTGAACCGGTGCAGGGGGCCGGTGGCGTCATTCCCCCGCAAGACGACTACTTCAAGCGCATT
CGCGAAATCTGCGACTACTACGATGTGCTCTTGATCAGCGATGAAGTCATCACCGGGTTTGGGCGTACCGGGCGCTGGTT
TGGGCTGGAACACTACGGAATCGAGCCGGATATTGCCCAGTTCGCGAAGGGGATTACATCGGGCTACATTCCCCTCGGTG
GCATCGGCGTGAGCGACCGCATCTACGAGGCTATCCAGTCGGTGCCACCCGAACAGCGCTGGATGCACGCCTTCACCTAT
TCAGGCCACCCGACCGCCTGTGCCGTTGCCCTGGCCAACATCGCCATCATCGAACGCGAGGGCCTGGTGCAGCGGGCCGC
CGAAGTTGGCGATTACATGCTGCGGCGACTGCAAGAGCTGTACGCCCTACCGCATGTCGGGAACGTCCGAGGTAAAGGTA
TGATGGCCGGAATTGAACTGGTCGCAGACACTGCAACCAAAGCGCCCTTCCCTGCCAGTGCCAACGTCGGCGTGCGCGTC
CAAAAAGAGATGACTGCTCGCGGCCTCTTCACCCGTGTCGTGGGGGACACGATCTGTCTGGCGCCGCCGCTGGTCACCAC
CTACGAACAGATCGATCAGATCGTGCAAATCATCGCCGACTCGATTGAAGCCACGGTAGCTGCGGTTAAGGCGTGA

Upstream 100 bases:

>100_bases
CCACTGCGTACCACCTGCCGCGCAGGTACAGCTTGCCGTCTCTCCACTTCTCCGCTACAATCCAACCATCAACACCGATA
TTCCCAACAAGGAGGAGCGC

Downstream 100 bases:

>100_bases
TGTCGGCAAGTTGCCCCTCACTTCTCCCGCTCTGGGCAAAGTTCAGGGGTGGGTAGACGCGGTACAAGGTGTCCATTGGC
GAAGCGGTGAGTGTCGTAGG

Product: class III aminotransferase

Products: L-Glutamate; L-Glutamate 5-semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MNTLQEQLQADHEYLIHPLTHPTAHQNPKIWVAGRGSIVIDAEGREYIDGLSGLWNVNVGHGRAELAEAACNQMKQLAYY
SAYVGSTNLPAIELARKLSELFYPSINHFFFTSGGAESTESSFKTARFYWKAVGKPEKVKFISRMKGYHGVTMAAMSATG
LPAYWPMFEPRVPGFIHIESPYPYRFVNPTPHLSDGVAAANLLEEAIVREGPDTVAAFIAEPVQGAGGVIPPQDDYFKRI
REICDYYDVLLISDEVITGFGRTGRWFGLEHYGIEPDIAQFAKGITSGYIPLGGIGVSDRIYEAIQSVPPEQRWMHAFTY
SGHPTACAVALANIAIIEREGLVQRAAEVGDYMLRRLQELYALPHVGNVRGKGMMAGIELVADTATKAPFPASANVGVRV
QKEMTARGLFTRVVGDTICLAPPLVTTYEQIDQIVQIIADSIEATVAAVKA

Sequences:

>Translated_451_residues
MNTLQEQLQADHEYLIHPLTHPTAHQNPKIWVAGRGSIVIDAEGREYIDGLSGLWNVNVGHGRAELAEAACNQMKQLAYY
SAYVGSTNLPAIELARKLSELFYPSINHFFFTSGGAESTESSFKTARFYWKAVGKPEKVKFISRMKGYHGVTMAAMSATG
LPAYWPMFEPRVPGFIHIESPYPYRFVNPTPHLSDGVAAANLLEEAIVREGPDTVAAFIAEPVQGAGGVIPPQDDYFKRI
REICDYYDVLLISDEVITGFGRTGRWFGLEHYGIEPDIAQFAKGITSGYIPLGGIGVSDRIYEAIQSVPPEQRWMHAFTY
SGHPTACAVALANIAIIEREGLVQRAAEVGDYMLRRLQELYALPHVGNVRGKGMMAGIELVADTATKAPFPASANVGVRV
QKEMTARGLFTRVVGDTICLAPPLVTTYEQIDQIVQIIADSIEATVAAVKA
>Mature_451_residues
MNTLQEQLQADHEYLIHPLTHPTAHQNPKIWVAGRGSIVIDAEGREYIDGLSGLWNVNVGHGRAELAEAACNQMKQLAYY
SAYVGSTNLPAIELARKLSELFYPSINHFFFTSGGAESTESSFKTARFYWKAVGKPEKVKFISRMKGYHGVTMAAMSATG
LPAYWPMFEPRVPGFIHIESPYPYRFVNPTPHLSDGVAAANLLEEAIVREGPDTVAAFIAEPVQGAGGVIPPQDDYFKRI
REICDYYDVLLISDEVITGFGRTGRWFGLEHYGIEPDIAQFAKGITSGYIPLGGIGVSDRIYEAIQSVPPEQRWMHAFTY
SGHPTACAVALANIAIIEREGLVQRAAEVGDYMLRRLQELYALPHVGNVRGKGMMAGIELVADTATKAPFPASANVGVRV
QKEMTARGLFTRVVGDTICLAPPLVTTYEQIDQIVQIIADSIEATVAAVKA

Specific function: Essential for glycerol catabolism [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=441, Percent_Identity=30.8390022675737, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI13994255, Length=441, Percent_Identity=27.437641723356, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI284507298, Length=333, Percent_Identity=31.8318318318318, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI37574042, Length=444, Percent_Identity=27.7027027027027, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI226442705, Length=442, Percent_Identity=28.0542986425339, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI24119277, Length=419, Percent_Identity=27.9236276849642, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI226442709, Length=412, Percent_Identity=28.1553398058252, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI188536080, Length=407, Percent_Identity=25.0614250614251, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38679950, Length=407, Percent_Identity=25.0614250614251, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38679946, Length=407, Percent_Identity=25.0614250614251, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI145693181, Length=426, Percent_Identity=31.924882629108, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1788044, Length=424, Percent_Identity=29.4811320754717, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1786991, Length=443, Percent_Identity=30.4740406320542, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1789759, Length=425, Percent_Identity=30.3529411764706, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1789016, Length=456, Percent_Identity=29.1666666666667, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1787560, Length=408, Percent_Identity=31.6176470588235, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1786349, Length=324, Percent_Identity=25.9259259259259, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25144271, Length=420, Percent_Identity=30.952380952381, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI32564660, Length=457, Percent_Identity=29.7592997811816, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI25144274, Length=299, Percent_Identity=32.4414715719064, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=385, Percent_Identity=27.5324675324675, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17541228, Length=449, Percent_Identity=22.4944320712695, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=429, Percent_Identity=30.5361305361305, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324386, Length=472, Percent_Identity=26.9067796610169, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324432, Length=442, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321456, Length=372, Percent_Identity=25.2688172043011, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357415, Length=442, Percent_Identity=32.3529411764706, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28574759, Length=450, Percent_Identity=30.2222222222222, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI161085790, Length=447, Percent_Identity=29.7539149888143, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21356575, Length=419, Percent_Identity=28.4009546539379, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI281366494, Length=256, Percent_Identity=25.78125, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24667139, Length=256, Percent_Identity=25.78125, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24667143, Length=256, Percent_Identity=25.78125, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.13 [C]

Molecular weight: Translated: 49437; Mature: 49437

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLQEQLQADHEYLIHPLTHPTAHQNPKIWVAGRGSIVIDAEGREYIDGLSGLWNVNVG
CCHHHHHHHCCHHHEEECCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHCCCCEEECCC
HGRAELAEAACNQMKQLAYYSAYVGSTNLPAIELARKLSELFYPSINHFFFTSGGAESTE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHH
SSFKTARFYWKAVGKPEKVKFISRMKGYHGVTMAAMSATGLPAYWPMFEPRVPGFIHIES
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEECC
PYPYRFVNPTPHLSDGVAAANLLEEAIVREGPDTVAAFIAEPVQGAGGVIPPQDDYFKRI
CCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
REICDYYDVLLISDEVITGFGRTGRWFGLEHYGIEPDIAQFAKGITSGYIPLGGIGVSDR
HHHHHHHHEEEECCHHHHCCCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHH
IYEAIQSVPPEQRWMHAFTYSGHPTACAVALANIAIIEREGLVQRAAEVGDYMLRRLQEL
HHHHHHCCCCHHHHEEHEEECCCCHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHH
YALPHVGNVRGKGMMAGIELVADTATKAPFPASANVGVRVQKEMTARGLFTRVVGDTICL
HCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHC
APPLVTTYEQIDQIVQIIADSIEATVAAVKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTLQEQLQADHEYLIHPLTHPTAHQNPKIWVAGRGSIVIDAEGREYIDGLSGLWNVNVG
CCHHHHHHHCCHHHEEECCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHCCCCEEECCC
HGRAELAEAACNQMKQLAYYSAYVGSTNLPAIELARKLSELFYPSINHFFFTSGGAESTE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHH
SSFKTARFYWKAVGKPEKVKFISRMKGYHGVTMAAMSATGLPAYWPMFEPRVPGFIHIES
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEECC
PYPYRFVNPTPHLSDGVAAANLLEEAIVREGPDTVAAFIAEPVQGAGGVIPPQDDYFKRI
CCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
REICDYYDVLLISDEVITGFGRTGRWFGLEHYGIEPDIAQFAKGITSGYIPLGGIGVSDR
HHHHHHHHEEEECCHHHHCCCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHH
IYEAIQSVPPEQRWMHAFTYSGHPTACAVALANIAIIEREGLVQRAAEVGDYMLRRLQEL
HHHHHHCCCCHHHHEEHEEECCCCHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHH
YALPHVGNVRGKGMMAGIELVADTATKAPFPASANVGVRVQKEMTARGLFTRVVGDTICL
HCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHC
APPLVTTYEQIDQIVQIIADSIEATVAAVKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; Ornithine [C]

Specific reaction: 2-Oxoglutarate + Ornithine --> L-Glutamate + L-Glutamate 5-semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8969498; 8436953 [H]