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The map label for this gene is htrA [H]

Identifier: 222525624

GI number: 222525624

Start: 3000937

End: 3002109

Strand: Direct

Name: htrA [H]

Synonym: Chy400_2375

Alternate gene names: 222525624

Gene position: 3000937-3002109 (Clockwise)

Preceding gene: 222525623

Following gene: 222525626

Centisome position: 56.96

GC content: 58.91

Gene sequence:

>1173_bases
ATGAATGTTAATCGTTTAGCATTAATCTTTGTCTTCTTACTCGGCATCTTTATCGGCGTTGCCGGTGGTGCCGCAACCGG
CGGTCTGGTCAGTTATCTGGTGGCCCGCCAGACCGTGGCTCAGGTCGCGGCCACAGTCACGACCATCAATGCCCAGCCGG
TCACTGCAAGCAATGGAACTTCGTCCGCAAACCAAACCGTTACCCAACCGGTCGAGGTTGTCAGTGTCTCTGATGCGATG
GTTGAAGCCGTGAAGCGCGTAGCGCCGGCAGTTGTCACCGTCACCGTTACCGGCAGCACCGGTCAGGGGAGCGGGAGCGG
TGTCATTATCAGTGATCAGGGCTACATCATCACCAACAACCACGTTGTCAGTGGGGGTAATCGTTATTACGTACTCTTCG
CTGATGGTACCCGCCGCGAAGCTGAGCTGGTTGGTACCGACTCGCTCAATGATATTGCAGTGCTGAAAGTCGATGGCGAG
GTGCCGGGTGTCGCCGCTATCGGTGACTCGTCGGCGTTGCAGCCCGGCGAAACGGTGCTGGCTATCGGTAGTCCACTCGG
TAATTTCCGCAACACGGTGACTGCCGGTGTGGTCAGCGCACTGAACCGTTCGGTGCCCGGTAGTGGGATGGAGGGTCTGA
TTCAGACCGATGCCGCGATCAACAGTGGGAACAGCGGTGGCCCGCTGATCAACCTGCGCGGTGAAGTCGTCGGCATCAAC
ACGCTGGTTGTACGCAACGATCTCGGTTTCGGGTCGAGTGCGCCGGTTGAGGGACTTGGCTTCGCGGTGCCGAGCAGCAT
CTTCGCCAACGTTGCCGACCAGATCATCCGTACCGGTCAGGTGCGCTATCCGTTCCTGGGTATTACCTACCTGATGATCG
ATGGTGAAGTTGCCGCAGAGTACAATCTGCCGGTGCAGAATGGCGCTTATATCAATGCCGGTATCAGTGGCCAGCCCGCC
GTCTTGCCGAACACCGCCGCAGCACAGGCCGGTTTGCGTGAAGGCGACATTATCCTCGCCGTGAATGATCAGCGCCTCGA
TGGCACCGTCTCGCTGCGCCAGCTTCTCTTGCAGTATCGCCCTGGTGATACGGTGGAATTGACCATCCTCCGCGATGGAC
AGGAGCAGCGGGTGTCGGTGACCCTGGGTGAACGTCCGGCTGACCTGCGTTGA

Upstream 100 bases:

>100_bases
CCTTCTAACAACCTTCTAACCAAACATTAAAAACTTCCCGTCATGATACTCTTAGCGAAAACGACGGCATCGTTGTCGTC
TGACGCCAGGGAGGTGTACG

Downstream 100 bases:

>100_bases
GAGCCAGGCGTGTTCGCGTCACAGGTTTGGGGTGTGGCAGAAATAGTGCCACACCTTTAGTCATGTTACGGGTGCGTGTG
GAAGCCATGCTGCTGCGCCT

Product: 2-alkenal reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNVNRLALIFVFLLGIFIGVAGGAATGGLVSYLVARQTVAQVAATVTTINAQPVTASNGTSSANQTVTQPVEVVSVSDAM
VEAVKRVAPAVVTVTVTGSTGQGSGSGVIISDQGYIITNNHVVSGGNRYYVLFADGTRREAELVGTDSLNDIAVLKVDGE
VPGVAAIGDSSALQPGETVLAIGSPLGNFRNTVTAGVVSALNRSVPGSGMEGLIQTDAAINSGNSGGPLINLRGEVVGIN
TLVVRNDLGFGSSAPVEGLGFAVPSSIFANVADQIIRTGQVRYPFLGITYLMIDGEVAAEYNLPVQNGAYINAGISGQPA
VLPNTAAAQAGLREGDIILAVNDQRLDGTVSLRQLLLQYRPGDTVELTILRDGQEQRVSVTLGERPADLR

Sequences:

>Translated_390_residues
MNVNRLALIFVFLLGIFIGVAGGAATGGLVSYLVARQTVAQVAATVTTINAQPVTASNGTSSANQTVTQPVEVVSVSDAM
VEAVKRVAPAVVTVTVTGSTGQGSGSGVIISDQGYIITNNHVVSGGNRYYVLFADGTRREAELVGTDSLNDIAVLKVDGE
VPGVAAIGDSSALQPGETVLAIGSPLGNFRNTVTAGVVSALNRSVPGSGMEGLIQTDAAINSGNSGGPLINLRGEVVGIN
TLVVRNDLGFGSSAPVEGLGFAVPSSIFANVADQIIRTGQVRYPFLGITYLMIDGEVAAEYNLPVQNGAYINAGISGQPA
VLPNTAAAQAGLREGDIILAVNDQRLDGTVSLRQLLLQYRPGDTVELTILRDGQEQRVSVTLGERPADLR
>Mature_390_residues
MNVNRLALIFVFLLGIFIGVAGGAATGGLVSYLVARQTVAQVAATVTTINAQPVTASNGTSSANQTVTQPVEVVSVSDAM
VEAVKRVAPAVVTVTVTGSTGQGSGSGVIISDQGYIITNNHVVSGGNRYYVLFADGTRREAELVGTDSLNDIAVLKVDGE
VPGVAAIGDSSALQPGETVLAIGSPLGNFRNTVTAGVVSALNRSVPGSGMEGLIQTDAAINSGNSGGPLINLRGEVVGIN
TLVVRNDLGFGSSAPVEGLGFAVPSSIFANVADQIIRTGQVRYPFLGITYLMIDGEVAAEYNLPVQNGAYINAGISGQPA
VLPNTAAAQAGLREGDIILAVNDQRLDGTVSLRQLLLQYRPGDTVELTILRDGQEQRVSVTLGERPADLR

Specific function: May be involved in processing, maturation, or secretion of extracellular enzymes [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=289, Percent_Identity=37.3702422145329, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI22129776, Length=306, Percent_Identity=35.9477124183007, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI24308541, Length=312, Percent_Identity=34.2948717948718, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI7019477, Length=292, Percent_Identity=34.9315068493151, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI1789629, Length=332, Percent_Identity=37.0481927710843, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1786356, Length=283, Percent_Identity=39.5759717314488, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI1789630, Length=316, Percent_Identity=36.3924050632911, Blast_Score=158, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24646839, Length=300, Percent_Identity=32.3333333333333, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 40040; Mature: 40040

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVNRLALIFVFLLGIFIGVAGGAATGGLVSYLVARQTVAQVAATVTTINAQPVTASNGT
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCEECCCCC
SSANQTVTQPVEVVSVSDAMVEAVKRVAPAVVTVTVTGSTGQGSGSGVIISDQGYIITNN
CCCCCCCCCCEEEEEHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEECCCCEEEECC
HVVSGGNRYYVLFADGTRREAELVGTDSLNDIAVLKVDGEVPGVAAIGDSSALQPGETVL
EEEECCCEEEEEEECCCCCCEEEECCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCEEE
AIGSPLGNFRNTVTAGVVSALNRSVPGSGMEGLIQTDAAINSGNSGGPLINLRGEVVGIN
EECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEECCCCCCCCEEEECCCEEEEE
TLVVRNDLGFGSSAPVEGLGFAVPSSIFANVADQIIRTGQVRYPFLGITYLMIDGEVAAE
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCEEEEEEEEECCCEEEE
YNLPVQNGAYINAGISGQPAVLPNTAAAQAGLREGDIILAVNDQRLDGTVSLRQLLLQYR
ECCCCCCCCEEECCCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCC
PGDTVELTILRDGQEQRVSVTLGERPADLR
CCCEEEEEEEECCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MNVNRLALIFVFLLGIFIGVAGGAATGGLVSYLVARQTVAQVAATVTTINAQPVTASNGT
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCEECCCCC
SSANQTVTQPVEVVSVSDAMVEAVKRVAPAVVTVTVTGSTGQGSGSGVIISDQGYIITNN
CCCCCCCCCCEEEEEHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEECCCCEEEECC
HVVSGGNRYYVLFADGTRREAELVGTDSLNDIAVLKVDGEVPGVAAIGDSSALQPGETVL
EEEECCCEEEEEEECCCCCCEEEECCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCEEE
AIGSPLGNFRNTVTAGVVSALNRSVPGSGMEGLIQTDAAINSGNSGGPLINLRGEVVGIN
EECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEECCCCCCCCEEEECCCEEEEE
TLVVRNDLGFGSSAPVEGLGFAVPSSIFANVADQIIRTGQVRYPFLGITYLMIDGEVAAE
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCEEEEEEEEECCCEEEE
YNLPVQNGAYINAGISGQPAVLPNTAAAQAGLREGDIILAVNDQRLDGTVSLRQLLLQYR
ECCCCCCCCEEECCCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCC
PGDTVELTILRDGQEQRVSVTLGERPADLR
CCCEEEEEEEECCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10692364; 11133960; 11555295 [H]