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The map label for this gene is ffh [H]

Identifier: 222525465

GI number: 222525465

Start: 2806976

End: 2808328

Strand: Direct

Name: ffh [H]

Synonym: Chy400_2213

Alternate gene names: 222525465

Gene position: 2806976-2808328 (Clockwise)

Preceding gene: 222525462

Following gene: 222525466

Centisome position: 53.27

GC content: 53.88

Gene sequence:

>1353_bases
ATGTTTGAAAGTCTTTCTGATCGCTTACAGGCCGTTTTTCAAAAACTAGGCAGTAAGGGTCGTCTCACCGAAGATGATGT
CCGTGAGGCGATGAAGCAGGTGCGCCTGGCCCTGCTCGAAGCCGACGTTAACTTTCGGGTCGTCAAAGAGTTTGTGGCTA
AAGTGACCGAGCAGGCTATTGGCGAAGAGGTCACCAAAAGCCTGACCCCACATCAACAGGTGATCAAGATCGTTCATCAA
GAATTGATCAACCTGTTGGGTACAGAAAACGTTCCCCTGCAAGAGGCACGCCCTGGCCCGACAGTGATCATGCTGGTAGG
TTTGCAGGGTACCGGTAAAACGACATTAGCTGCCAAACTGGCGCTCCATTTGCGCAAGAAGGGTAAGCGGGTCTTGCTAG
TTGCGGCTGACGTCTATCGTCCGGCGGCAATTACGCAATTACAGGCATTGGGTCGGCAGCTCAATATTCCGGTGTACAGC
GAAGGCACACAGGCCAGCCCGCCGGATATTGCCGAGCATGCACTTGAACATGCCCGTAAGGAACTGTTTAATGTGGTCAT
TATTGACACTGCCGGTCGGCTTCAGATCGACGAGCCGCTCATGCAAGAGCTGGAGCAGATTGAGAATCGGGTGCATCCTA
TCGAGCGGTTGCTGGTCGTTGATGCCATGACCGGTCAGGAAGCGGTGCGTGTGGCCGAGACGTTCAATCAGCGTGTCAAG
CTAACCGGCGTGGTGATGACCAAGATGGACGGCGATGCACGGGGTGGTGCAGCGCTGTCGGTTCGTGCTGTGACCGGTGT
GCCGATCAAATTTCTCTCGACCGGCGAGAAGGTTGATGGTAATACACTCGAAGTCTTCCACCCTGATCGACTGGCGTCGC
GCATTCTTGGCATGGGTGATGTGTTATCACTGATTGAACGCGCCGAACAGCTCTACGACGCCGAGCAGGCGAAGAAGATG
CAGAAGCGTCTTAGCAAGGGTGAATTCGACTTCGAGGACTTTCTCAATTCACTCCACCAGATGCGGAAATTGGGGCCGTT
GCAGCAAATTATTGCAATGATTCCCGGTCTCAATCAGTTAGCCCGGAATGAAGAGTTGCTTGATGAGCGCCATGTCAAGC
GAGTTGAAGCCATTATCTACTCGATGACTCCTGAAGAGCGACGACGACCGGAAATCATCAAGGGGAGTCGGCGCGAGCGT
ATTGCCCGTGGCAGTGGCACCTCGGTGCAAGAGGTCAGTCAATTGGTCAAGCAGTTTCAACAGATGCAGCGCATGATGAA
ACAACTGGCCAGTAAAGGCGGTAAGGGTCGTGGTGGTATCGATCCAAACGAACTGCTGCGTCGCCTGCGCTGA

Upstream 100 bases:

>100_bases
GTTCGGTTCCAGATAACATTGACGCCAGCGCTGCTCACCCGTACAATGCTAACAGCAAGAATACTGATCGTAGCAAGTCA
CAACGAAACGAGTACCGGCT

Downstream 100 bases:

>100_bases
CACAGGGTATTGATAGGTGATCCGTAAATGACGGTTTGCGTTAATGGCCGTGTTGCTGAGACACTTGCAACGCGAAGATA
ATTTTGTGCTATACTATAGA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MFESLSDRLQAVFQKLGSKGRLTEDDVREAMKQVRLALLEADVNFRVVKEFVAKVTEQAIGEEVTKSLTPHQQVIKIVHQ
ELINLLGTENVPLQEARPGPTVIMLVGLQGTGKTTLAAKLALHLRKKGKRVLLVAADVYRPAAITQLQALGRQLNIPVYS
EGTQASPPDIAEHALEHARKELFNVVIIDTAGRLQIDEPLMQELEQIENRVHPIERLLVVDAMTGQEAVRVAETFNQRVK
LTGVVMTKMDGDARGGAALSVRAVTGVPIKFLSTGEKVDGNTLEVFHPDRLASRILGMGDVLSLIERAEQLYDAEQAKKM
QKRLSKGEFDFEDFLNSLHQMRKLGPLQQIIAMIPGLNQLARNEELLDERHVKRVEAIIYSMTPEERRRPEIIKGSRRER
IARGSGTSVQEVSQLVKQFQQMQRMMKQLASKGGKGRGGIDPNELLRRLR

Sequences:

>Translated_450_residues
MFESLSDRLQAVFQKLGSKGRLTEDDVREAMKQVRLALLEADVNFRVVKEFVAKVTEQAIGEEVTKSLTPHQQVIKIVHQ
ELINLLGTENVPLQEARPGPTVIMLVGLQGTGKTTLAAKLALHLRKKGKRVLLVAADVYRPAAITQLQALGRQLNIPVYS
EGTQASPPDIAEHALEHARKELFNVVIIDTAGRLQIDEPLMQELEQIENRVHPIERLLVVDAMTGQEAVRVAETFNQRVK
LTGVVMTKMDGDARGGAALSVRAVTGVPIKFLSTGEKVDGNTLEVFHPDRLASRILGMGDVLSLIERAEQLYDAEQAKKM
QKRLSKGEFDFEDFLNSLHQMRKLGPLQQIIAMIPGLNQLARNEELLDERHVKRVEAIIYSMTPEERRRPEIIKGSRRER
IARGSGTSVQEVSQLVKQFQQMQRMMKQLASKGGKGRGGIDPNELLRRLR
>Mature_450_residues
MFESLSDRLQAVFQKLGSKGRLTEDDVREAMKQVRLALLEADVNFRVVKEFVAKVTEQAIGEEVTKSLTPHQQVIKIVHQ
ELINLLGTENVPLQEARPGPTVIMLVGLQGTGKTTLAAKLALHLRKKGKRVLLVAADVYRPAAITQLQALGRQLNIPVYS
EGTQASPPDIAEHALEHARKELFNVVIIDTAGRLQIDEPLMQELEQIENRVHPIERLLVVDAMTGQEAVRVAETFNQRVK
LTGVVMTKMDGDARGGAALSVRAVTGVPIKFLSTGEKVDGNTLEVFHPDRLASRILGMGDVLSLIERAEQLYDAEQAKKM
QKRLSKGEFDFEDFLNSLHQMRKLGPLQQIIAMIPGLNQLARNEELLDERHVKRVEAIIYSMTPEERRRPEIIKGSRRER
IARGSGTSVQEVSQLVKQFQQMQRMMKQLASKGGKGRGGIDPNELLRRLR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=443, Percent_Identity=32.5056433408578, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI226371618, Length=386, Percent_Identity=33.160621761658, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI89061728, Length=149, Percent_Identity=37.5838926174497, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI23308697, Length=292, Percent_Identity=27.7397260273973, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI295424842, Length=292, Percent_Identity=27.7397260273973, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=51.288056206089, Blast_Score=435, Evalue=1e-123,
Organism=Escherichia coli, GI1789874, Length=267, Percent_Identity=35.9550561797753, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=451, Percent_Identity=31.9290465631929, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI193206261, Length=281, Percent_Identity=30.2491103202847, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=420, Percent_Identity=35, Blast_Score=252, Evalue=1e-67,
Organism=Drosophila melanogaster, GI17647949, Length=437, Percent_Identity=31.350114416476, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24641198, Length=282, Percent_Identity=29.0780141843972, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50331; Mature: 50331

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLSDRLQAVFQKLGSKGRLTEDDVREAMKQVRLALLEADVNFRVVKEFVAKVTEQAI
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVTKSLTPHQQVIKIVHQELINLLGTENVPLQEARPGPTVIMLVGLQGTGKTTLAAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHH
ALHLRKKGKRVLLVAADVYRPAAITQLQALGRQLNIPVYSEGTQASPPDIAEHALEHARK
HHHHHHCCCEEEEEECCHHCCHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHH
ELFNVVIIDTAGRLQIDEPLMQELEQIENRVHPIERLLVVDAMTGQEAVRVAETFNQRVK
HHHEEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEE
LTGVVMTKMDGDARGGAALSVRAVTGVPIKFLSTGEKVDGNTLEVFHPDRLASRILGMGD
EEEEEEEECCCCCCCCCEEEEEEECCCCCCEECCCCCCCCCEEEEECHHHHHHHHHCHHH
VLSLIERAEQLYDAEQAKKMQKRLSKGEFDFEDFLNSLHQMRKLGPLQQIIAMIPGLNQL
HHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHH
ARNEELLDERHVKRVEAIIYSMTPEERRRPEIIKGSRRERIARGSGTSVQEVSQLVKQFQ
HCCHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHCCCHHHHHHCCCCCCHHHHHHHHHHHH
QMQRMMKQLASKGGKGRGGIDPNELLRRLR
HHHHHHHHHHHCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MFESLSDRLQAVFQKLGSKGRLTEDDVREAMKQVRLALLEADVNFRVVKEFVAKVTEQAI
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVTKSLTPHQQVIKIVHQELINLLGTENVPLQEARPGPTVIMLVGLQGTGKTTLAAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHH
ALHLRKKGKRVLLVAADVYRPAAITQLQALGRQLNIPVYSEGTQASPPDIAEHALEHARK
HHHHHHCCCEEEEEECCHHCCHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHH
ELFNVVIIDTAGRLQIDEPLMQELEQIENRVHPIERLLVVDAMTGQEAVRVAETFNQRVK
HHHEEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEE
LTGVVMTKMDGDARGGAALSVRAVTGVPIKFLSTGEKVDGNTLEVFHPDRLASRILGMGD
EEEEEEEECCCCCCCCCEEEEEEECCCCCCEECCCCCCCCCEEEEECHHHHHHHHHCHHH
VLSLIERAEQLYDAEQAKKMQKRLSKGEFDFEDFLNSLHQMRKLGPLQQIIAMIPGLNQL
HHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHH
ARNEELLDERHVKRVEAIIYSMTPEERRRPEIIKGSRRERIARGSGTSVQEVSQLVKQFQ
HCCHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHCCCHHHHHHCCCCCCHHHHHHHHHHHH
QMQRMMKQLASKGGKGRGGIDPNELLRRLR
HHHHHHHHHHHCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]