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The map label for this gene is recQ [H]

Identifier: 222525462

GI number: 222525462

Start: 2801664

End: 2803355

Strand: Direct

Name: recQ [H]

Synonym: Chy400_2210

Alternate gene names: 222525462

Gene position: 2801664-2803355 (Clockwise)

Preceding gene: 222525461

Following gene: 222525465

Centisome position: 53.17

GC content: 55.67

Gene sequence:

>1692_bases
ATGGTCACTCAGCAACATCCCTCTACCTCAAACCTGCCATCTGAAGCCACCGTCATTTTGCGCGATGTTTTTGGTTTCAG
TACGTTCCGCCCTCATCAAGAGCAGATTATCGGCCGTGTATTGCGTGGCGAATCGACCCTGGCCGTCTTACCGACCGGTG
CCGGCAAGTCGTTGACCTATCAGTTACCGGCCCAGCTTTTACCACAGGCCACAGTGGTGATTAGCCCTTTGATCGCGTTA
ATGAAGGATCAGGTAGACCGGTTACCACCTGCCGTCCAGGAACGGGCAACCATCATCAACTCCACCCTTACCGCAGGAGA
GGTGCGCGACCGCTTACGGGCAATTGCTGCCGGTAAGTACAAACTGGTTTATGTCGCTCCCGAACGCCTGCGACAACGCT
CATTCCTTTTTGCGCTTCGTCACTGTGGCGTGTCCCGTCTTGTGATCGACGAGGCGCACTGTATCAGCTTATGGGGACAA
AATTTTCGCCCTGATTATTTGTTCATCAACCGGGCGATGAACGAACTCGGCCAACCGCCAGTTCTGGCTGTGACAGCTAC
GGCTGCCTCTGATACGATCCATACGCTGCAAACGATGATCGGCCCGCTGACGGTCGTTCAGGCACCTGTCTTTCGCCCTA
ACCTGTTTTTTCAGGTGATCCAGGTGCGACCAGGGATGTCAAAGGCACGTAGTCTGATTGAACTCTGCCGGAAGATCAAT
GGCTCAATCATCGTGTATGCCCGTGCGCGCCAGACTTGTGAAGACCTGGCGCTGGAGCTGCGTTCTGCCGGTGTTGCTGC
CGATCACTATCACGCTCTGCATCCTGATCGAGCAGGTGTGCAAGAGCGGTTCATGAACGGAAAGACGCGGGTTCTGGTTG
CGACAGTCGCGTTTGGGATGGGGGTTGACAAAGCCGATATTCGTGCTGTCATCCACTACAATCTTCCCGCCTCACTCGAA
GCCTACTACCAGGAGGCGGGCCGGGCCGGGCGTGATGGCTTGCCGGCGCGCTGTATTCTCTTTTTCAGCGAGAATGATGC
TCGTGTATTGCGGACCTGGTTGCAATCAACGACAATTACCCGCGAGAATCTGCGTGAGTTGTACCGTCAAGTCAGGCGTA
CAATCACCTATCCCGCAGGTGTGATTGATCTTGATGCGTTACAATCCCAGTTTGGTCCCGCTGGTGAAGTGCTGACGCGA
GTCGGGATCAGTGTCTTGGAACAGGTAGGTCTGCTCAAACGTCATTTCGACCTGCCGCTGGCAGCGGTGGTCGAACGAAC
CGGGACGGTAGCTGCCACAGACTGGTTACACCATCTTCCACGGGAAGCGATTGAAATCGATCTCATGCTCCTTGCCCATC
AGCACAACATTCCGGTAGCTCACATTGAAGCAGTGTTGTTAGAAGCGCAAGCCGCTGGCCTGCTACGTTACCGACCGGGA
CTACGCCTGCCGCTCATTGAACTCTTGTCACCGCCAGCCGACGCAGGCGAGCGTGTCGAGGGCTGGCTGGAAAGGTTCCG
GCAATATCAGGAGCAGCGGATTGAGTCCATGGTCGATTACGCTCGCAGTCAGCGTTGCCGACACCAGATACTGGCAGCGT
ATTTTGGTCAACAACTTGCCGCCTGTCGTATCGGTTGCGACGTCTGCTCCTCATCACGGGCACTTAAAGTTGGCAGGCGC
GAGTGGCATTAA

Upstream 100 bases:

>100_bases
CGATTCTGGCGTACCCTTTGCGCGGTGTAGACGGTTATATATATGTACGGTCTACACTGACTCAAATGCTGCCGGCAGTG
TTATATCAGTGGTATTGGCT

Downstream 100 bases:

>100_bases
GTGATGTCAGTCCCAGAGCGTGGAACCGCCGAATCGGCGTTGCCGATCCCACAGAGTTGGAACACGGTTCGGCGAGGATA
CCGTTGCCCGTGGTGCGTGG

Product: RecQ family ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 563; Mature: 563

Protein sequence:

>563_residues
MVTQQHPSTSNLPSEATVILRDVFGFSTFRPHQEQIIGRVLRGESTLAVLPTGAGKSLTYQLPAQLLPQATVVISPLIAL
MKDQVDRLPPAVQERATIINSTLTAGEVRDRLRAIAAGKYKLVYVAPERLRQRSFLFALRHCGVSRLVIDEAHCISLWGQ
NFRPDYLFINRAMNELGQPPVLAVTATAASDTIHTLQTMIGPLTVVQAPVFRPNLFFQVIQVRPGMSKARSLIELCRKIN
GSIIVYARARQTCEDLALELRSAGVAADHYHALHPDRAGVQERFMNGKTRVLVATVAFGMGVDKADIRAVIHYNLPASLE
AYYQEAGRAGRDGLPARCILFFSENDARVLRTWLQSTTITRENLRELYRQVRRTITYPAGVIDLDALQSQFGPAGEVLTR
VGISVLEQVGLLKRHFDLPLAAVVERTGTVAATDWLHHLPREAIEIDLMLLAHQHNIPVAHIEAVLLEAQAAGLLRYRPG
LRLPLIELLSPPADAGERVEGWLERFRQYQEQRIESMVDYARSQRCRHQILAAYFGQQLAACRIGCDVCSSSRALKVGRR
EWH

Sequences:

>Translated_563_residues
MVTQQHPSTSNLPSEATVILRDVFGFSTFRPHQEQIIGRVLRGESTLAVLPTGAGKSLTYQLPAQLLPQATVVISPLIAL
MKDQVDRLPPAVQERATIINSTLTAGEVRDRLRAIAAGKYKLVYVAPERLRQRSFLFALRHCGVSRLVIDEAHCISLWGQ
NFRPDYLFINRAMNELGQPPVLAVTATAASDTIHTLQTMIGPLTVVQAPVFRPNLFFQVIQVRPGMSKARSLIELCRKIN
GSIIVYARARQTCEDLALELRSAGVAADHYHALHPDRAGVQERFMNGKTRVLVATVAFGMGVDKADIRAVIHYNLPASLE
AYYQEAGRAGRDGLPARCILFFSENDARVLRTWLQSTTITRENLRELYRQVRRTITYPAGVIDLDALQSQFGPAGEVLTR
VGISVLEQVGLLKRHFDLPLAAVVERTGTVAATDWLHHLPREAIEIDLMLLAHQHNIPVAHIEAVLLEAQAAGLLRYRPG
LRLPLIELLSPPADAGERVEGWLERFRQYQEQRIESMVDYARSQRCRHQILAAYFGQQLAACRIGCDVCSSSRALKVGRR
EWH
>Mature_563_residues
MVTQQHPSTSNLPSEATVILRDVFGFSTFRPHQEQIIGRVLRGESTLAVLPTGAGKSLTYQLPAQLLPQATVVISPLIAL
MKDQVDRLPPAVQERATIINSTLTAGEVRDRLRAIAAGKYKLVYVAPERLRQRSFLFALRHCGVSRLVIDEAHCISLWGQ
NFRPDYLFINRAMNELGQPPVLAVTATAASDTIHTLQTMIGPLTVVQAPVFRPNLFFQVIQVRPGMSKARSLIELCRKIN
GSIIVYARARQTCEDLALELRSAGVAADHYHALHPDRAGVQERFMNGKTRVLVATVAFGMGVDKADIRAVIHYNLPASLE
AYYQEAGRAGRDGLPARCILFFSENDARVLRTWLQSTTITRENLRELYRQVRRTITYPAGVIDLDALQSQFGPAGEVLTR
VGISVLEQVGLLKRHFDLPLAAVVERTGTVAATDWLHHLPREAIEIDLMLLAHQHNIPVAHIEAVLLEAQAAGLLRYRPG
LRLPLIELLSPPADAGERVEGWLERFRQYQEQRIESMVDYARSQRCRHQILAAYFGQQLAACRIGCDVCSSSRALKVGRR
EWH

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI51242947, Length=392, Percent_Identity=40.3061224489796, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI51242943, Length=392, Percent_Identity=40.3061224489796, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI148612816, Length=393, Percent_Identity=40.2035623409669, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI14591902, Length=376, Percent_Identity=35.6382978723404, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI14591904, Length=376, Percent_Identity=35.6382978723404, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI4557365, Length=401, Percent_Identity=35.4114713216958, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI284005309, Length=382, Percent_Identity=40.8376963350785, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI169218196, Length=375, Percent_Identity=35.4666666666667, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI110735439, Length=375, Percent_Identity=35.4666666666667, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI7661920, Length=358, Percent_Identity=22.9050279329609, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI48994977, Length=356, Percent_Identity=43.2584269662921, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI87082221, Length=352, Percent_Identity=26.4204545454545, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71987997, Length=378, Percent_Identity=38.8888888888889, Blast_Score=251, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI71987993, Length=378, Percent_Identity=38.8888888888889, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI25145561, Length=375, Percent_Identity=39.4666666666667, Blast_Score=237, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI32564293, Length=387, Percent_Identity=35.4005167958656, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17552866, Length=365, Percent_Identity=38.3561643835616, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71987143, Length=351, Percent_Identity=25.0712250712251, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71995724, Length=358, Percent_Identity=24.3016759776536, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17507121, Length=358, Percent_Identity=24.0223463687151, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323844, Length=393, Percent_Identity=35.8778625954198, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6324217, Length=332, Percent_Identity=25.6024096385542, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321856, Length=347, Percent_Identity=23.6311239193084, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321360, Length=327, Percent_Identity=24.7706422018349, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320224, Length=347, Percent_Identity=22.7665706051873, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24646066, Length=380, Percent_Identity=36.8421052631579, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI21358123, Length=389, Percent_Identity=37.5321336760925, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24664226, Length=367, Percent_Identity=35.4223433242507, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI62472181, Length=367, Percent_Identity=35.4223433242507, Blast_Score=204, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24664230, Length=367, Percent_Identity=35.4223433242507, Blast_Score=204, Evalue=2e-52,
Organism=Drosophila melanogaster, GI281361218, Length=364, Percent_Identity=26.6483516483516, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24644481, Length=364, Percent_Identity=26.6483516483516, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24644483, Length=364, Percent_Identity=26.6483516483516, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644487, Length=364, Percent_Identity=26.6483516483516, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45551833, Length=364, Percent_Identity=26.6483516483516, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644485, Length=364, Percent_Identity=26.6483516483516, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644479, Length=364, Percent_Identity=26.6483516483516, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24645031, Length=362, Percent_Identity=23.2044198895028, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666101, Length=348, Percent_Identity=25, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21355075, Length=349, Percent_Identity=24.6418338108883, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 62816; Mature: 62816

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTQQHPSTSNLPSEATVILRDVFGFSTFRPHQEQIIGRVLRGESTLAVLPTGAGKSLTY
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEE
QLPAQLLPQATVVISPLIALMKDQVDRLPPAVQERATIINSTLTAGEVRDRLRAIAAGKY
ECCHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCE
KLVYVAPERLRQRSFLFALRHCGVSRLVIDEAHCISLWGQNFRPDYLFINRAMNELGQPP
EEEEECHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
VLAVTATAASDTIHTLQTMIGPLTVVQAPVFRPNLFFQVIQVRPGMSKARSLIELCRKIN
EEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCC
GSIIVYARARQTCEDLALELRSAGVAADHYHALHPDRAGVQERFMNGKTRVLVATVAFGM
CCEEEEECHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHCCCCEEEEEEHHHHC
GVDKADIRAVIHYNLPASLEAYYQEAGRAGRDGLPARCILFFSENDARVLRTWLQSTTIT
CCCHHHEEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCC
RENLRELYRQVRRTITYPAGVIDLDALQSQFGPAGEVLTRVGISVLEQVGLLKRHFDLPL
HHHHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
AAVVERTGTVAATDWLHHLPREAIEIDLMLLAHQHNIPVAHIEAVLLEAQAAGLLRYRPG
HHHHHHCCCCHHHHHHHHCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCC
LRLPLIELLSPPADAGERVEGWLERFRQYQEQRIESMVDYARSQRCRHQILAAYFGQQLA
CCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACRIGCDVCSSSRALKVGRREWH
HHHHHHHHHCCCCHHHCCCCCCC
>Mature Secondary Structure
MVTQQHPSTSNLPSEATVILRDVFGFSTFRPHQEQIIGRVLRGESTLAVLPTGAGKSLTY
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEE
QLPAQLLPQATVVISPLIALMKDQVDRLPPAVQERATIINSTLTAGEVRDRLRAIAAGKY
ECCHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCE
KLVYVAPERLRQRSFLFALRHCGVSRLVIDEAHCISLWGQNFRPDYLFINRAMNELGQPP
EEEEECHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
VLAVTATAASDTIHTLQTMIGPLTVVQAPVFRPNLFFQVIQVRPGMSKARSLIELCRKIN
EEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCC
GSIIVYARARQTCEDLALELRSAGVAADHYHALHPDRAGVQERFMNGKTRVLVATVAFGM
CCEEEEECHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHCCCCEEEEEEHHHHC
GVDKADIRAVIHYNLPASLEAYYQEAGRAGRDGLPARCILFFSENDARVLRTWLQSTTIT
CCCHHHEEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCC
RENLRELYRQVRRTITYPAGVIDLDALQSQFGPAGEVLTRVGISVLEQVGLLKRHFDLPL
HHHHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
AAVVERTGTVAATDWLHHLPREAIEIDLMLLAHQHNIPVAHIEAVLLEAQAAGLLRYRPG
HHHHHHCCCCHHHHHHHHCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCC
LRLPLIELLSPPADAGERVEGWLERFRQYQEQRIESMVDYARSQRCRHQILAAYFGQQLA
CCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACRIGCDVCSSSRALKVGRREWH
HHHHHHHHHCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]