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The map label for this gene is norM [H]

Identifier: 222525315

GI number: 222525315

Start: 2609521

End: 2610933

Strand: Direct

Name: norM [H]

Synonym: Chy400_2057

Alternate gene names: 222525315

Gene position: 2609521-2610933 (Clockwise)

Preceding gene: 222525312

Following gene: 222525316

Centisome position: 49.53

GC content: 62.42

Gene sequence:

>1413_bases
ATGTCGGGTATACTGACGGCGATGCAACCAGAAATGCTTTCAATCGAAAACGAAGAGATCACAACCCATCCTGCCCCGTC
GCACGCCCAACTGGAGAAGCGCGTCTTGCGGCTGGCCTGGCCGGTCATTGGCGAAAATCTGCTCCAGACTATGCTCGGCG
TCGTTGATACGATCCTGGTCGCCTCGCTAGGAGCCGTCGCTTTGGCCGGGGTCGGCGCGGCATTGCAGGTCATCTATGTC
ACGACAGGCGCACTGAGCGCGTTATCGGTTGGCGTGGCGGTGCTGGTCGCGCAGGCATACGGTGGTGGACGGCTGAAAGA
GGCCAGCTTCCTGGCGCGCCAGGGATTGCTCTGGAGTATACTTATCGGGCTGCCGGTGACCGCCATTGGATTGCCGCTTA
CGCCCACGCTGATCGGCCTCTTCGGCCTGGCCCCCGATGTCAGCCAGGTTGGGATTGACTATCTGGCAGTGACCATGAGC
ACCATCACCACACTGACCATGATGTTCCTCATCGGCGGCGTCTTACGCGGAGTCGGTGACACACGTACTCCCATGATCAT
CACGGCTTTTGCCAACGTGATCAATGTTATTGCCAGTGCAGCATTGATCTTCGGCTGGCTGGGCTTACCGGTGTTGGGGG
CGGTTGGTAGTGCCTGGGGATCGGTTATTGCCCGCTTTGCCGGTGCCATCCTCCTGGTCGGTGTGCTATGGCGGGGGCGC
AATGGTGTGCGGGCCGGTGGCCGTGGTGGGTGGTGGCCACGCATGCGCGTGTTGCGCAATATATTGCGCATCGGAATGCC
GGCAGCACTGGAAGAGGTGCTGATCATCGGCGCGATTGCCACATTGACGCCGGTGGTAGCCACGCTGGGCACAGTGCCAC
TCGCCGCTCATCGCGTGGCGATCAACGTGCTCTCGCTCTCCTTCCTGCCCGGCATCGGTTTTGGCCTGGCCGCAACGGCG
CTGGTTGGGCAGGCGATTGGTGCCCAACGTCCGGCAGAAGCCCGCCGCATTGCCACCATCGCAATGCGCTGGGCCTTGAT
CTGGATGGGTGGCCTGGGTGTCTTATTCATGATCTTCGCCGAGGGGCTGGTACGGCTGTTCAACAGCGACCCACAGTTGG
TTGCCGAGGGAGCTGCTGCGGTGCGCGTGGTTGCCCTGACGCAGCCGGCGTGGGCGATTACCTTTGCCCTTGGCGGTGCC
CTGCGCGGTCTGGGCGACACCCTCTCACCGCTGGTGATCAGCGGTTCAGCGATCTGGATTTGTGTCGGGCTGGCGCTGGT
GATTGTGTTATGGTGGCTGCCGGCGCTGTGGGGCATCTGGCTGGCCTTCCTGATCGTCGGGCCATTTGAGGCGCTGGTCT
TCTGGCGGAAATGGCAGCAGCGGATCACATCCTGGCGGCCAGGGTCGGCCTGA

Upstream 100 bases:

>100_bases
AGGGTGTCAACATGCTCCATGAAAATGCCTCCTTTGTCACTCACCTTCTTCCTTTCATTGTACGAGAAATCGGGCAAAGG
TGCGATCCACCAAAGTACCG

Downstream 100 bases:

>100_bases
CTGCTTACAGCACGCACGGTCATTGCGAGAGCGTTGTAACCGGGGACACCTGGCTAGTCTTCCGGGTCGTAAGCCATTCG
CGGCGCTGGTCTTCTGACTG

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSGILTAMQPEMLSIENEEITTHPAPSHAQLEKRVLRLAWPVIGENLLQTMLGVVDTILVASLGAVALAGVGAALQVIYV
TTGALSALSVGVAVLVAQAYGGGRLKEASFLARQGLLWSILIGLPVTAIGLPLTPTLIGLFGLAPDVSQVGIDYLAVTMS
TITTLTMMFLIGGVLRGVGDTRTPMIITAFANVINVIASAALIFGWLGLPVLGAVGSAWGSVIARFAGAILLVGVLWRGR
NGVRAGGRGGWWPRMRVLRNILRIGMPAALEEVLIIGAIATLTPVVATLGTVPLAAHRVAINVLSLSFLPGIGFGLAATA
LVGQAIGAQRPAEARRIATIAMRWALIWMGGLGVLFMIFAEGLVRLFNSDPQLVAEGAAAVRVVALTQPAWAITFALGGA
LRGLGDTLSPLVISGSAIWICVGLALVIVLWWLPALWGIWLAFLIVGPFEALVFWRKWQQRITSWRPGSA

Sequences:

>Translated_470_residues
MSGILTAMQPEMLSIENEEITTHPAPSHAQLEKRVLRLAWPVIGENLLQTMLGVVDTILVASLGAVALAGVGAALQVIYV
TTGALSALSVGVAVLVAQAYGGGRLKEASFLARQGLLWSILIGLPVTAIGLPLTPTLIGLFGLAPDVSQVGIDYLAVTMS
TITTLTMMFLIGGVLRGVGDTRTPMIITAFANVINVIASAALIFGWLGLPVLGAVGSAWGSVIARFAGAILLVGVLWRGR
NGVRAGGRGGWWPRMRVLRNILRIGMPAALEEVLIIGAIATLTPVVATLGTVPLAAHRVAINVLSLSFLPGIGFGLAATA
LVGQAIGAQRPAEARRIATIAMRWALIWMGGLGVLFMIFAEGLVRLFNSDPQLVAEGAAAVRVVALTQPAWAITFALGGA
LRGLGDTLSPLVISGSAIWICVGLALVIVLWWLPALWGIWLAFLIVGPFEALVFWRKWQQRITSWRPGSA
>Mature_469_residues
SGILTAMQPEMLSIENEEITTHPAPSHAQLEKRVLRLAWPVIGENLLQTMLGVVDTILVASLGAVALAGVGAALQVIYVT
TGALSALSVGVAVLVAQAYGGGRLKEASFLARQGLLWSILIGLPVTAIGLPLTPTLIGLFGLAPDVSQVGIDYLAVTMST
ITTLTMMFLIGGVLRGVGDTRTPMIITAFANVINVIASAALIFGWLGLPVLGAVGSAWGSVIARFAGAILLVGVLWRGRN
GVRAGGRGGWWPRMRVLRNILRIGMPAALEEVLIIGAIATLTPVVATLGTVPLAAHRVAINVLSLSFLPGIGFGLAATAL
VGQAIGAQRPAEARRIATIAMRWALIWMGGLGVLFMIFAEGLVRLFNSDPQLVAEGAAAVRVVALTQPAWAITFALGGAL
RGLGDTLSPLVISGSAIWICVGLALVIVLWWLPALWGIWLAFLIVGPFEALVFWRKWQQRITSWRPGSA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=444, Percent_Identity=24.7747747747748, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI153792564, Length=461, Percent_Identity=24.9457700650759, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI226510954, Length=439, Percent_Identity=28.4738041002278, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI48994890, Length=434, Percent_Identity=25.1152073732719, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49286; Mature: 49154

Theoretical pI: Translated: 11.54; Mature: 11.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGILTAMQPEMLSIENEEITTHPAPSHAQLEKRVLRLAWPVIGENLLQTMLGVVDTILV
CCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLGAVALAGVGAALQVIYVTTGALSALSVGVAVLVAQAYGGGRLKEASFLARQGLLWSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LIGLPVTAIGLPLTPTLIGLFGLAPDVSQVGIDYLAVTMSTITTLTMMFLIGGVLRGVGD
HHHCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TRTPMIITAFANVINVIASAALIFGWLGLPVLGAVGSAWGSVIARFAGAILLVGVLWRGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NGVRAGGRGGWWPRMRVLRNILRIGMPAALEEVLIIGAIATLTPVVATLGTVPLAAHRVA
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
INVLSLSFLPGIGFGLAATALVGQAIGAQRPAEARRIATIAMRWALIWMGGLGVLFMIFA
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGLVRLFNSDPQLVAEGAAAVRVVALTQPAWAITFALGGALRGLGDTLSPLVISGSAIWI
HHHHHHHCCCHHHHHCCHHHEEEEEECCCHHHHHHHHHHHHHHCCCHHCHHHCCCCHHHH
CVGLALVIVLWWLPALWGIWLAFLIVGPFEALVFWRKWQQRITSWRPGSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SGILTAMQPEMLSIENEEITTHPAPSHAQLEKRVLRLAWPVIGENLLQTMLGVVDTILV
CCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]