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The map label for this gene is yycF [H]

Identifier: 222525241

GI number: 222525241

Start: 2514932

End: 2515612

Strand: Reverse

Name: yycF [H]

Synonym: Chy400_1981

Alternate gene names: 222525241

Gene position: 2515612-2514932 (Counterclockwise)

Preceding gene: 222525243

Following gene: 222525240

Centisome position: 47.74

GC content: 49.34

Gene sequence:

>681_bases
ATGAATATTTTGGTTGTTGATGATGACATCCCCAGTGCAAGAATGACTTCTTACTTGCTTGAAGAAGCTGGTTATCGTGT
ATTTCGGGCACACGATGCATCCAACATTCTCCAGTTGATCGAGCAACACAATCCCGATCTCATCTTGCTGGATGTCATGA
TGCCTAAAATTGATGGGTTCGAGGTTTGTCGCCAGATTCGACGCAACTCCGACATTCCGATCATCTTCCTCTCGGCTCGC
CATCAACTCCAGGATCGGGTGATGGGGCTTCAAATCGGTGGTGACGACTATCTGGTCAAACCGTTTGAACCTTCGGAATT
GCTGGCGCGTGTTGAAGCTGTCTTACGACGACGCAACGCCGATGTGCTCAACACCTCGACCCGTCTCAGTCAGGGCAATA
TCACGCTCGATCCCGTCGAACACAAAGTTCTCTTCACCGACGGTCGCGTTGTGGAATTGACCCCACTCGAATTTCGATTG
CTCTACTACCTGATGAAGAATTCGGGACGCATCTTGAACGTAACCCAAATTTTGAGTAAAGTATGGGGGTACGACTACGA
AGGTGAAAGCAATCTGGTCGCCGTCTACATCCGCCGTCTGCGTACAAAGGTAGAGGAAGACCCGGATCATCCACGTCACG
TCATTACAGTACGTAATCTCGGCTATAAGTTTGAGCCATAG

Upstream 100 bases:

>100_bases
CAACTCTAGCCAAAAGCAAGCTATAAGTGGTACAATTAATGCGCCGTAGTTGTAGAGGTCGTATTGTTGCACCACCAGCA
AAGCAAACAGGGAGCGCCGC

Downstream 100 bases:

>100_bases
TTTGAGATGCGTCGACCATTGCCATGAAGCATAACACCTGGCAACTGCAAACGATTATCCGTCGCCTCTTGCCGTTGCCG
GCATTGGGGTTAAGCTGGCT

Product: winged helix family two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNILVVDDDIPSARMTSYLLEEAGYRVFRAHDASNILQLIEQHNPDLILLDVMMPKIDGFEVCRQIRRNSDIPIIFLSAR
HQLQDRVMGLQIGGDDYLVKPFEPSELLARVEAVLRRRNADVLNTSTRLSQGNITLDPVEHKVLFTDGRVVELTPLEFRL
LYYLMKNSGRILNVTQILSKVWGYDYEGESNLVAVYIRRLRTKVEEDPDHPRHVITVRNLGYKFEP

Sequences:

>Translated_226_residues
MNILVVDDDIPSARMTSYLLEEAGYRVFRAHDASNILQLIEQHNPDLILLDVMMPKIDGFEVCRQIRRNSDIPIIFLSAR
HQLQDRVMGLQIGGDDYLVKPFEPSELLARVEAVLRRRNADVLNTSTRLSQGNITLDPVEHKVLFTDGRVVELTPLEFRL
LYYLMKNSGRILNVTQILSKVWGYDYEGESNLVAVYIRRLRTKVEEDPDHPRHVITVRNLGYKFEP
>Mature_226_residues
MNILVVDDDIPSARMTSYLLEEAGYRVFRAHDASNILQLIEQHNPDLILLDVMMPKIDGFEVCRQIRRNSDIPIIFLSAR
HQLQDRVMGLQIGGDDYLVKPFEPSELLARVEAVLRRRNADVLNTSTRLSQGNITLDPVEHKVLFTDGRVVELTPLEFRL
LYYLMKNSGRILNVTQILSKVWGYDYEGESNLVAVYIRRLRTKVEEDPDHPRHVITVRNLGYKFEP

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF. Binds to the ftsAZ P1 promoter seque

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=40, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=39.0134529147982, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=39.7321428571429, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=35.8407079646018, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=36.0869565217391, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=29.8245614035088, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=33.4821428571429, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=34.2222222222222, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=32.8888888888889, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.4449339207048, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=31.1688311688312, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=33.6322869955157, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=30.5084745762712, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1787229, Length=212, Percent_Identity=32.0754716981132, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790437, Length=175, Percent_Identity=29.1428571428571, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=32.0754716981132, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=103, Percent_Identity=35.9223300970874, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26145; Mature: 26145

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILVVDDDIPSARMTSYLLEEAGYRVFRAHDASNILQLIEQHNPDLILLDVMMPKIDGF
CEEEEECCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCHH
EVCRQIRRNSDIPIIFLSARHQLQDRVMGLQIGGDDYLVKPFEPSELLARVEAVLRRRNA
HHHHHHHCCCCCCEEEECCHHHHHHHHEEEEECCCCEEECCCCHHHHHHHHHHHHHHCCC
DVLNTSTRLSQGNITLDPVEHKVLFTDGRVVELTPLEFRLLYYLMKNSGRILNVTQILSK
CCCCCCCEECCCCEEECCCCEEEEEECCEEEEECCHHHHHHHHHHHCCCCEEEHHHHHHH
VWGYDYEGESNLVAVYIRRLRTKVEEDPDHPRHVITVRNLGYKFEP
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEECCC
>Mature Secondary Structure
MNILVVDDDIPSARMTSYLLEEAGYRVFRAHDASNILQLIEQHNPDLILLDVMMPKIDGF
CEEEEECCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCHH
EVCRQIRRNSDIPIIFLSARHQLQDRVMGLQIGGDDYLVKPFEPSELLARVEAVLRRRNA
HHHHHHHCCCCCCEEEECCHHHHHHHHEEEEECCCCEEECCCCHHHHHHHHHHHHHHCCC
DVLNTSTRLSQGNITLDPVEHKVLFTDGRVVELTPLEFRLLYYLMKNSGRILNVTQILSK
CCCCCCCEECCCCEEECCCCEEEEEECCEEEEECCHHHHHHHHHHHCCCCEEEHHHHHHH
VWGYDYEGESNLVAVYIRRLRTKVEEDPDHPRHVITVRNLGYKFEP
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 9829949; 10878122 [H]