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The map label for this gene is kinB [H]

Identifier: 222525240

GI number: 222525240

Start: 2512752

End: 2514908

Strand: Reverse

Name: kinB [H]

Synonym: Chy400_1980

Alternate gene names: 222525240

Gene position: 2514908-2512752 (Counterclockwise)

Preceding gene: 222525241

Following gene: 222525239

Centisome position: 47.73

GC content: 53.27

Gene sequence:

>2157_bases
ATGAAGCATAACACCTGGCAACTGCAAACGATTATCCGTCGCCTCTTGCCGTTGCCGGCATTGGGGTTAAGCTGGCTGCT
AACCCAATTCAGTCTACCGTCTGCCGCCTGGGGTGGATTGATTGGTTACGGTTTGGTCAATGTTGCCTTACTACTACTCC
TTCGCCATCACCCAACTTCGACTAACCGCCTCCTGACACTCGCCGGCCTGAGCGATTTGCTCATGATCATCTGGTCGATC
TTCCTGATCAGCACCAGCCCGCTGCTGGCCGTTGTTCAAGGGGTGGGTGCCTTGCGCGCATGGCGCTACCGGTTCCATTC
ATTCTGGCCGGCACTGCTGCCGGCGTTGATTGGCCTGCTCTACCCGTTTACCACTCCTTCGCCCTGGACAGACAATCCAC
TAACGTTGACCACGCTGGTGCCGGTTGGAAGCTTCCTGTTAAGCATCATTACTGTTCTGGCTTTGGTCTGGTTTGGGCAG
CGACGCAATCTGGTAGCGCTCGATTGGAGGGCACGGTACGATCAGCTTCGCCGCGAACAAAAACAGCAGGTTGCCGGCCT
GGAAGCCTCGAACAACGACCTACGTGAGCGGCTACGGCGGATGGAGGCTCTCGGCGAAAGCCTGCGTGCTATCAGCAGTT
CGCTGAGCCTGGATGATGTGCTGCGCCAGATTCTCGACTCGCTGACCCATATGTTGGGCGTGCAGCGCATCGATAATGTG
GCGCTGACATTGGCCCGCGATAACGGCCTTGAACACCAGATTCTGCACAACGATGCACAACAATCGGACTGGGCAACCGC
CTTGGCGCAAGTCGTTATTACCGAAAAACGAACCGTCTTGCTGGACGCCCACGAGATAGCGCAAGAACCGGTATGGCATT
CCCTGGCCGATCAGCAATGGCAGGCCGCGCTCAGTGTTCCTCTCTTCGATCCCGATCAGCCTGACCGGATTCGCGGTGCC
CTCAGTGTGGTGAGTCGGCAGAGTGAAGCCTTCTCTCCGGCTGAAGAGCGTCATTTGACCTCGTTTAGCATCCAGGCCAT
GATTGCGATTCGGAACGCCGAACTCCACGTTCAGTTGAGTCGGCAACAGGCGATGCTCAGCGCCATTCTGCACGATATGG
CCGATGGTCTGATCGTGTACGATGAAGCGGGCAACGTCTACCTCGACAACGCCGTAGCACGACAGGCGATAGCGCATAGT
GCTGCTTACAATGGCAGACTGGCCGATCATCTGATCGATACGGCACGTCAGCTTTACCAGAGCAAGGTTTCGTTTAGCAA
AGAAATTATCGACGGAGAAGCCGAGCAGGCTCGCTGGTACCAGATTCACGCCACTCTGGTGAATCCGTCACCCGATACTT
GCCTGGCTGTGCTGGTGTTACACGATATTACCGACCAGAAAGTACAGGAGCGGCAGCGCCGGGAATTTATTGGCAAACTT
GCTCATGAGCTGCGTAATCCGCTGAACGTTCTTAACGGTAATCTTGATATTGTCCTTAAGGAAAGTGATAAAGTCGGTAC
GCTTACCGAAGCGCAACGCTATTTTCTCGGTGAAGTGAAAGACAGTTATAAGCGCTTGTGGAAACGCATCGAGGAGTTGA
TAGAGATCAATCGTAATGGCACCAGTCAATTGAAGCTGCGCCCGGTGCGCACAAATATTATTGACATTATTATTAACACG
TGCGTTCAACAACAACAGCCAGCTAAATCTCACGGCGTCGATCTGTGTTGGGAGGTGCCAGATCAGTTACCCGATATGTT
TCTTGATGAGGAACGGATTGGTCAGGTATTGACAAATCTGATTGAGAATGCGATCAAGGCAATGCCCGATGGTGGTCAGA
TCACCGTGAGTGCCGAACAACAGCAAGATTATGTTCTGGTGCACGTGACCGATACCGGGATCGGTATTCCAGCCGATCAG
ATTGAAAAGGTGTTTCTGCCCTATCATCAGGTACCAAGCCATGTTAATGGTCGCGAGACGAAAAACACACACCTCGGCCT
TGGGCTGGCAATCTGTAAACAATTTGTAGAAGCCCACAATGGCAGAATCTGGATATCGCACAGTGAAGTCGGGAAAGGAA
CACGCTTTACCTTTTCCCTCCCCATAATGCCCGAGACCGAACAAACGATTAAAACCGGCAGTCAAACCACTGCGTAA

Upstream 100 bases:

>100_bases
CAAAGGTAGAGGAAGACCCGGATCATCCACGTCACGTCATTACAGTACGTAATCTCGGCTATAAGTTTGAGCCATAGTTT
GAGATGCGTCGACCATTGCC

Downstream 100 bases:

>100_bases
ATGAAATCTTTTCTGAATATTTCGTTATCTTAATTGCTGTTGAAATGTGCTATATTTGCCATAAGAATATTTTGTTGCAA
TATGTAGCTTTGAGGACGCT

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 718; Mature: 718

Protein sequence:

>718_residues
MKHNTWQLQTIIRRLLPLPALGLSWLLTQFSLPSAAWGGLIGYGLVNVALLLLLRHHPTSTNRLLTLAGLSDLLMIIWSI
FLISTSPLLAVVQGVGALRAWRYRFHSFWPALLPALIGLLYPFTTPSPWTDNPLTLTTLVPVGSFLLSIITVLALVWFGQ
RRNLVALDWRARYDQLRREQKQQVAGLEASNNDLRERLRRMEALGESLRAISSSLSLDDVLRQILDSLTHMLGVQRIDNV
ALTLARDNGLEHQILHNDAQQSDWATALAQVVITEKRTVLLDAHEIAQEPVWHSLADQQWQAALSVPLFDPDQPDRIRGA
LSVVSRQSEAFSPAEERHLTSFSIQAMIAIRNAELHVQLSRQQAMLSAILHDMADGLIVYDEAGNVYLDNAVARQAIAHS
AAYNGRLADHLIDTARQLYQSKVSFSKEIIDGEAEQARWYQIHATLVNPSPDTCLAVLVLHDITDQKVQERQRREFIGKL
AHELRNPLNVLNGNLDIVLKESDKVGTLTEAQRYFLGEVKDSYKRLWKRIEELIEINRNGTSQLKLRPVRTNIIDIIINT
CVQQQQPAKSHGVDLCWEVPDQLPDMFLDEERIGQVLTNLIENAIKAMPDGGQITVSAEQQQDYVLVHVTDTGIGIPADQ
IEKVFLPYHQVPSHVNGRETKNTHLGLGLAICKQFVEAHNGRIWISHSEVGKGTRFTFSLPIMPETEQTIKTGSQTTA

Sequences:

>Translated_718_residues
MKHNTWQLQTIIRRLLPLPALGLSWLLTQFSLPSAAWGGLIGYGLVNVALLLLLRHHPTSTNRLLTLAGLSDLLMIIWSI
FLISTSPLLAVVQGVGALRAWRYRFHSFWPALLPALIGLLYPFTTPSPWTDNPLTLTTLVPVGSFLLSIITVLALVWFGQ
RRNLVALDWRARYDQLRREQKQQVAGLEASNNDLRERLRRMEALGESLRAISSSLSLDDVLRQILDSLTHMLGVQRIDNV
ALTLARDNGLEHQILHNDAQQSDWATALAQVVITEKRTVLLDAHEIAQEPVWHSLADQQWQAALSVPLFDPDQPDRIRGA
LSVVSRQSEAFSPAEERHLTSFSIQAMIAIRNAELHVQLSRQQAMLSAILHDMADGLIVYDEAGNVYLDNAVARQAIAHS
AAYNGRLADHLIDTARQLYQSKVSFSKEIIDGEAEQARWYQIHATLVNPSPDTCLAVLVLHDITDQKVQERQRREFIGKL
AHELRNPLNVLNGNLDIVLKESDKVGTLTEAQRYFLGEVKDSYKRLWKRIEELIEINRNGTSQLKLRPVRTNIIDIIINT
CVQQQQPAKSHGVDLCWEVPDQLPDMFLDEERIGQVLTNLIENAIKAMPDGGQITVSAEQQQDYVLVHVTDTGIGIPADQ
IEKVFLPYHQVPSHVNGRETKNTHLGLGLAICKQFVEAHNGRIWISHSEVGKGTRFTFSLPIMPETEQTIKTGSQTTA
>Mature_718_residues
MKHNTWQLQTIIRRLLPLPALGLSWLLTQFSLPSAAWGGLIGYGLVNVALLLLLRHHPTSTNRLLTLAGLSDLLMIIWSI
FLISTSPLLAVVQGVGALRAWRYRFHSFWPALLPALIGLLYPFTTPSPWTDNPLTLTTLVPVGSFLLSIITVLALVWFGQ
RRNLVALDWRARYDQLRREQKQQVAGLEASNNDLRERLRRMEALGESLRAISSSLSLDDVLRQILDSLTHMLGVQRIDNV
ALTLARDNGLEHQILHNDAQQSDWATALAQVVITEKRTVLLDAHEIAQEPVWHSLADQQWQAALSVPLFDPDQPDRIRGA
LSVVSRQSEAFSPAEERHLTSFSIQAMIAIRNAELHVQLSRQQAMLSAILHDMADGLIVYDEAGNVYLDNAVARQAIAHS
AAYNGRLADHLIDTARQLYQSKVSFSKEIIDGEAEQARWYQIHATLVNPSPDTCLAVLVLHDITDQKVQERQRREFIGKL
AHELRNPLNVLNGNLDIVLKESDKVGTLTEAQRYFLGEVKDSYKRLWKRIEELIEINRNGTSQLKLRPVRTNIIDIIINT
CVQQQQPAKSHGVDLCWEVPDQLPDMFLDEERIGQVLTNLIENAIKAMPDGGQITVSAEQQQDYVLVHVTDTGIGIPADQ
IEKVFLPYHQVPSHVNGRETKNTHLGLGLAICKQFVEAHNGRIWISHSEVGKGTRFTFSLPIMPETEQTIKTGSQTTA

Specific function: Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. KinB functions as a membrane-associated protein kinase that phosphorylates AlgB, probably in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=241, Percent_Identity=29.045643153527, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=34.375, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI145693157, Length=265, Percent_Identity=30.188679245283, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788549, Length=371, Percent_Identity=26.1455525606469, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI48994928, Length=372, Percent_Identity=25.8064516129032, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=248, Percent_Identity=29.4354838709677, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789149, Length=251, Percent_Identity=28.2868525896414, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1788713, Length=294, Percent_Identity=25.8503401360544, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1786912, Length=241, Percent_Identity=25.3112033195021, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790300, Length=253, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI87082128, Length=244, Percent_Identity=27.0491803278689, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790861, Length=223, Percent_Identity=25.5605381165919, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1786783, Length=231, Percent_Identity=26.8398268398268, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=254, Percent_Identity=25.5905511811024, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013656
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF08448 PAS_4 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 80644; Mature: 80644

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHNTWQLQTIIRRLLPLPALGLSWLLTQFSLPSAAWGGLIGYGLVNVALLLLLRHHPTS
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
TNRLLTLAGLSDLLMIIWSIFLISTSPLLAVVQGVGALRAWRYRFHSFWPALLPALIGLL
CCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YPFTTPSPWTDNPLTLTTLVPVGSFLLSIITVLALVWFGQRRNLVALDWRARYDQLRREQ
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHH
KQQVAGLEASNNDLRERLRRMEALGESLRAISSSLSLDDVLRQILDSLTHMLGVQRIDNV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHE
ALTLARDNGLEHQILHNDAQQSDWATALAQVVITEKRTVLLDAHEIAQEPVWHSLADQQW
EEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHH
QAALSVPLFDPDQPDRIRGALSVVSRQSEAFSPAEERHLTSFSIQAMIAIRNAELHVQLS
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEECCEEEEEEH
RQQAMLSAILHDMADGLIVYDEAGNVYLDNAVARQAIAHSAAYNGRLADHLIDTARQLYQ
HHHHHHHHHHHHHHCCEEEEECCCCEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SKVSFSKEIIDGEAEQARWYQIHATLVNPSPDTCLAVLVLHDITDQKVQERQRREFIGKL
HHHHHHHHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AHELRNPLNVLNGNLDIVLKESDKVGTLTEAQRYFLGEVKDSYKRLWKRIEELIEINRNG
HHHHHCHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TSQLKLRPVRTNIIDIIINTCVQQQQPAKSHGVDLCWEVPDQLPDMFLDEERIGQVLTNL
CCCEEEEEHHHHHHHHHHHHHHHCCCCCHHCCCCEEECCCHHHHHHHCCHHHHHHHHHHH
IENAIKAMPDGGQITVSAEQQQDYVLVHVTDTGIGIPADQIEKVFLPYHQVPSHVNGRET
HHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHCCHHHCCCCCCCCCC
KNTHLGLGLAICKQFVEAHNGRIWISHSEVGKGTRFTFSLPIMPETEQTIKTGSQTTA
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MKHNTWQLQTIIRRLLPLPALGLSWLLTQFSLPSAAWGGLIGYGLVNVALLLLLRHHPTS
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
TNRLLTLAGLSDLLMIIWSIFLISTSPLLAVVQGVGALRAWRYRFHSFWPALLPALIGLL
CCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YPFTTPSPWTDNPLTLTTLVPVGSFLLSIITVLALVWFGQRRNLVALDWRARYDQLRREQ
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHH
KQQVAGLEASNNDLRERLRRMEALGESLRAISSSLSLDDVLRQILDSLTHMLGVQRIDNV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHE
ALTLARDNGLEHQILHNDAQQSDWATALAQVVITEKRTVLLDAHEIAQEPVWHSLADQQW
EEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHH
QAALSVPLFDPDQPDRIRGALSVVSRQSEAFSPAEERHLTSFSIQAMIAIRNAELHVQLS
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEECCEEEEEEH
RQQAMLSAILHDMADGLIVYDEAGNVYLDNAVARQAIAHSAAYNGRLADHLIDTARQLYQ
HHHHHHHHHHHHHHCCEEEEECCCCEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SKVSFSKEIIDGEAEQARWYQIHATLVNPSPDTCLAVLVLHDITDQKVQERQRREFIGKL
HHHHHHHHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AHELRNPLNVLNGNLDIVLKESDKVGTLTEAQRYFLGEVKDSYKRLWKRIEELIEINRNG
HHHHHCHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TSQLKLRPVRTNIIDIIINTCVQQQQPAKSHGVDLCWEVPDQLPDMFLDEERIGQVLTNL
CCCEEEEEHHHHHHHHHHHHHHHCCCCCHHCCCCEEECCCHHHHHHHCCHHHHHHHHHHH
IENAIKAMPDGGQITVSAEQQQDYVLVHVTDTGIGIPADQIEKVFLPYHQVPSHVNGRET
HHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHCCHHHCCCCCCCCCC
KNTHLGLGLAICKQFVEAHNGRIWISHSEVGKGTRFTFSLPIMPETEQTIKTGSQTTA
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9218420 [H]