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The map label for this gene is purC

Identifier: 222524654

GI number: 222524654

Start: 1760843

End: 1761592

Strand: Reverse

Name: purC

Synonym: Chy400_1381

Alternate gene names: 222524654

Gene position: 1761592-1760843 (Counterclockwise)

Preceding gene: 222524655

Following gene: 222524653

Centisome position: 33.43

GC content: 58.27

Gene sequence:

>750_bases
ATGGAACTCGGCTATGTTTTGACCGAAGGGAAGACCAAAATTGTGTACGCTCACCCGACCGATCCCGACCTGGCGATTCT
CTATCACAAAGATGGGATTACTGCCGGTGATGGTGCCCGGCGGAGTGTGATTGAGGGAAAGGGGGAACTGGCCGGGCAGA
CGACAGCCAATGTCTTTCGGTTGCTCAACCGGGCCGGGATTGCCACCCACTTTGTTGATGCGCCTGAGCCGAGGTTAACA
GTGGTGCGGCGCTGTAGGATGATCCCGCTCGAAGTCGTAATGCGGCGATTACCGGCTGGATCATACTTGCGACGCCATCC
AGAAGCCGCCGGGCAACGCTTCGATCCGCCGCTGGTGGAATTTTTTCTCAAAGATGATGCCCGCCACGACCCCCAAATCG
CTCCGCAAGAGATCATTGCCCAGGGGATCGCAACCCCTGCAGAAGTCGAGCAGATGACGGACACGGGGAGAAAGGTATTT
GTGACCCTGGAAGCAGCGTGGCAACAACTTGACGTAACCCTGGTCGATCTGAAGATTGAATTTGGCCGTACTGCACAGGG
CGATCTCCTGGTTGCCGATGTCATCGACAACGACTCGTGGCGAATCTGGCCATCCGGCGATCCGGCACAGATGCTTGACA
AGCAGGTCTACCGCAATGCCCAGGTGGTTGATGAGGCACTGCTGGCCGATGTGCGGGCGCGGTATGCGTTGGTTGCCGAG
CTGACGGGTCGGTGGGGAGCGGGTTCGTAG

Upstream 100 bases:

>100_bases
CTGCGGCAACCGCGCTCGCTACCATTGCCGATGCCTGTCTGGTTGGACGAGTGACCGCAACGCCTGAAGTACGGCTGGTT
GATGCCTGAAGGAGGCAGCA

Downstream 100 bases:

>100_bases
AACAAGGGTCAGTTGCCGCACAAGGGATTCCTCGTAACCGGTGGTGAGAACCTCTGATGGCGATGGGGATGTATCGCATC
TTACAAATTGCCTGGAGCTG

Product: phosphoribosylaminoimidazolesuccinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MELGYVLTEGKTKIVYAHPTDPDLAILYHKDGITAGDGARRSVIEGKGELAGQTTANVFRLLNRAGIATHFVDAPEPRLT
VVRRCRMIPLEVVMRRLPAGSYLRRHPEAAGQRFDPPLVEFFLKDDARHDPQIAPQEIIAQGIATPAEVEQMTDTGRKVF
VTLEAAWQQLDVTLVDLKIEFGRTAQGDLLVADVIDNDSWRIWPSGDPAQMLDKQVYRNAQVVDEALLADVRARYALVAE
LTGRWGAGS

Sequences:

>Translated_249_residues
MELGYVLTEGKTKIVYAHPTDPDLAILYHKDGITAGDGARRSVIEGKGELAGQTTANVFRLLNRAGIATHFVDAPEPRLT
VVRRCRMIPLEVVMRRLPAGSYLRRHPEAAGQRFDPPLVEFFLKDDARHDPQIAPQEIIAQGIATPAEVEQMTDTGRKVF
VTLEAAWQQLDVTLVDLKIEFGRTAQGDLLVADVIDNDSWRIWPSGDPAQMLDKQVYRNAQVVDEALLADVRARYALVAE
LTGRWGAGS
>Mature_249_residues
MELGYVLTEGKTKIVYAHPTDPDLAILYHKDGITAGDGARRSVIEGKGELAGQTTANVFRLLNRAGIATHFVDAPEPRLT
VVRRCRMIPLEVVMRRLPAGSYLRRHPEAAGQRFDPPLVEFFLKDDARHDPQIAPQEIIAQGIATPAEVEQMTDTGRKVF
VTLEAAWQQLDVTLVDLKIEFGRTAQGDLLVADVIDNDSWRIWPSGDPAQMLDKQVYRNAQVVDEALLADVRARYALVAE
LTGRWGAGS

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=248, Percent_Identity=41.5322580645161, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI5453539, Length=248, Percent_Identity=41.5322580645161, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI119220559, Length=255, Percent_Identity=40, Blast_Score=182, Evalue=3e-46,
Organism=Escherichia coli, GI1788820, Length=214, Percent_Identity=29.9065420560748, Blast_Score=103, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17531275, Length=248, Percent_Identity=40.3225806451613, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI18860083, Length=248, Percent_Identity=45.5645161290323, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24583917, Length=246, Percent_Identity=42.2764227642276, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI160714955, Length=110, Percent_Identity=45.4545454545455, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_CHLAA (A9WK38)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001634878.1
- ProteinModelPortal:   A9WK38
- SMR:   A9WK38
- GeneID:   5828365
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_1261
- HOGENOM:   HBG306070
- OMA:   SWRIWPG
- ProtClustDB:   CLSK974244
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27580; Mature: 27580

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELGYVLTEGKTKIVYAHPTDPDLAILYHKDGITAGDGARRSVIEGKGELAGQTTANVFR
CCCCEEEECCCEEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCHHHHHHH
LLNRAGIATHFVDAPEPRLTVVRRCRMIPLEVVMRRLPAGSYLRRHPEAAGQRFDPPLVE
HHHHCCCCEEECCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHCCHHCCCCCCCHHHH
FFLKDDARHDPQIAPQEIIAQGIATPAEVEQMTDTGRKVFVTLEAAWQQLDVTLVDLKIE
HHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEHHHHHHCEEEEEEEEE
FGRTAQGDLLVADVIDNDSWRIWPSGDPAQMLDKQVYRNAQVVDEALLADVRARYALVAE
CCCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTGRWGAGS
HHCCCCCCC
>Mature Secondary Structure
MELGYVLTEGKTKIVYAHPTDPDLAILYHKDGITAGDGARRSVIEGKGELAGQTTANVFR
CCCCEEEECCCEEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCHHHHHHH
LLNRAGIATHFVDAPEPRLTVVRRCRMIPLEVVMRRLPAGSYLRRHPEAAGQRFDPPLVE
HHHHCCCCEEECCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHCCHHCCCCCCCHHHH
FFLKDDARHDPQIAPQEIIAQGIATPAEVEQMTDTGRKVFVTLEAAWQQLDVTLVDLKIE
HHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEHHHHHHCEEEEEEEEE
FGRTAQGDLLVADVIDNDSWRIWPSGDPAQMLDKQVYRNAQVVDEALLADVRARYALVAE
CCCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTGRWGAGS
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA