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The map label for this gene is purM [H]

Identifier: 222524655

GI number: 222524655

Start: 1761604

End: 1762632

Strand: Reverse

Name: purM [H]

Synonym: Chy400_1382

Alternate gene names: 222524655

Gene position: 1762632-1761604 (Counterclockwise)

Preceding gene: 222524656

Following gene: 222524654

Centisome position: 33.45

GC content: 62.0

Gene sequence:

>1029_bases
ATGTCGCAATATAGTGCAGCCGGCGTGGATATTGCTGCGGCAACGCGGGCGAAAGAGTTGATGGCAGACGCGGTGCGGAG
TACACACGGGCCGGCAGTGCTGGCCGGGATGGGAGCTTTTGGTGGATGTTTCGATGCGGCACTGGCGCTGGCCGGGATGC
AGGCGCCCGTTCTGGTCAGCAGTACCGATGGGGTGGGTACCAAGACGCTGGTGGCCGCGGCGTTGGGGCGGTACGATACG
GTTGGGCAAGACCTGGTCAATCACGCGGTGAACGATATTCTGGTGCAGGGGGCGCGGCCACTGTTCTTTCTCGACTATAT
CGCTGTCGCTAAACTCGATCCGGCACAGGTAGCTGCGATTGTGACCGGTGTGGCCGAGGGGTGTCGGGCGGCTGGTTGTG
CCCTGATCGGTGGGGAAACGGCGGAAATGCCGGATGTGTACGCGCCGGGGGCGTTCGATCTGGCCGGGACGATTGTGGGG
GTTGTAGAACGAACGGCGATGTTGCCGCGCCCTGATATTGTGCCCGGCGATGCGATCCTGGCCTTGCCCAGTACCGGCTT
GCACACCAATGGCTATTCGCTTGCCCGTCGGCTGGTGGCGCGCCACTTTGCGACCGACGGCTATGCGGCCCGTCCGTCAA
TTCTCAACGGCCAGACCATTGGCGAAGCGTTGCTGGCGATCCATCGCTGTTACCTGGCAGAGGTGAATGCACTACGAGCC
GCAGTGCTGGTGAAAGCGCTCTGTCACATTACCGGCGGCGGCATTTACGACAACCTTCCCCGCGTGCTGCCTGCCGGTCT
GGGGGCCGAGATTGTACGGGGAAGCTGGCCAATTCCCCCGATCTGTCAGTTGCTGGTCGATATTGGTGGACTTGACGAGC
GGGAAGCGTTTCATGCCCTGAATATGGGTCTGGGGATGCTGGTCATTGTTCCTGCCGATGCTGCGGCAACCGCGCTCGCT
ACCATTGCCGATGCCTGTCTGGTTGGACGAGTGACCGCAACGCCTGAAGTACGGCTGGTTGATGCCTGA

Upstream 100 bases:

>100_bases
TCGGCGCGAGCAGTGTCACAACCGTGCAGGTACAACACGTCTTCCGGGCTGAAAGTGAGGCGTTTGCGCGCCTCTGCGCA
CGTCTTGACGAGGAGTAGTT

Downstream 100 bases:

>100_bases
AGGAGGCAGCAATGGAACTCGGCTATGTTTTGACCGAAGGGAAGACCAAAATTGTGTACGCTCACCCGACCGATCCCGAC
CTGGCGATTCTCTATCACAA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSQYSAAGVDIAAATRAKELMADAVRSTHGPAVLAGMGAFGGCFDAALALAGMQAPVLVSSTDGVGTKTLVAAALGRYDT
VGQDLVNHAVNDILVQGARPLFFLDYIAVAKLDPAQVAAIVTGVAEGCRAAGCALIGGETAEMPDVYAPGAFDLAGTIVG
VVERTAMLPRPDIVPGDAILALPSTGLHTNGYSLARRLVARHFATDGYAARPSILNGQTIGEALLAIHRCYLAEVNALRA
AVLVKALCHITGGGIYDNLPRVLPAGLGAEIVRGSWPIPPICQLLVDIGGLDEREAFHALNMGLGMLVIVPADAAATALA
TIADACLVGRVTATPEVRLVDA

Sequences:

>Translated_342_residues
MSQYSAAGVDIAAATRAKELMADAVRSTHGPAVLAGMGAFGGCFDAALALAGMQAPVLVSSTDGVGTKTLVAAALGRYDT
VGQDLVNHAVNDILVQGARPLFFLDYIAVAKLDPAQVAAIVTGVAEGCRAAGCALIGGETAEMPDVYAPGAFDLAGTIVG
VVERTAMLPRPDIVPGDAILALPSTGLHTNGYSLARRLVARHFATDGYAARPSILNGQTIGEALLAIHRCYLAEVNALRA
AVLVKALCHITGGGIYDNLPRVLPAGLGAEIVRGSWPIPPICQLLVDIGGLDEREAFHALNMGLGMLVIVPADAAATALA
TIADACLVGRVTATPEVRLVDA
>Mature_341_residues
SQYSAAGVDIAAATRAKELMADAVRSTHGPAVLAGMGAFGGCFDAALALAGMQAPVLVSSTDGVGTKTLVAAALGRYDTV
GQDLVNHAVNDILVQGARPLFFLDYIAVAKLDPAQVAAIVTGVAEGCRAAGCALIGGETAEMPDVYAPGAFDLAGTIVGV
VERTAMLPRPDIVPGDAILALPSTGLHTNGYSLARRLVARHFATDGYAARPSILNGQTIGEALLAIHRCYLAEVNALRAA
VLVKALCHITGGGIYDNLPRVLPAGLGAEIVRGSWPIPPICQLLVDIGGLDEREAFHALNMGLGMLVIVPADAAATALAT
IADACLVGRVTATPEVRLVDA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=339, Percent_Identity=42.1828908554572, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI209869995, Length=339, Percent_Identity=42.1828908554572, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI209869993, Length=339, Percent_Identity=42.1828908554572, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=41.6909620991254, Blast_Score=248, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17567511, Length=315, Percent_Identity=37.7777777777778, Blast_Score=178, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6321203, Length=309, Percent_Identity=40.1294498381877, Blast_Score=227, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24582400, Length=289, Percent_Identity=35.6401384083045, Blast_Score=167, Evalue=9e-42,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 34890; Mature: 34759

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQYSAAGVDIAAATRAKELMADAVRSTHGPAVLAGMGAFGGCFDAALALAGMQAPVLVS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEE
STDGVGTKTLVAAALGRYDTVGQDLVNHAVNDILVQGARPLFFLDYIAVAKLDPAQVAAI
CCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHH
VTGVAEGCRAAGCALIGGETAEMPDVYAPGAFDLAGTIVGVVERTAMLPRPDIVPGDAIL
HHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
ALPSTGLHTNGYSLARRLVARHFATDGYAARPSILNGQTIGEALLAIHRCYLAEVNALRA
EECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVLVKALCHITGGGIYDNLPRVLPAGLGAEIVRGSWPIPPICQLLVDIGGLDEREAFHAL
HHHHHHHHHHCCCCHHHCCHHHHCCCCCHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHH
NMGLGMLVIVPADAAATALATIADACLVGRVTATPEVRLVDA
HCCCCEEEEECCCHHHHHHHHHHHHHHHCCEECCCCEEEECC
>Mature Secondary Structure 
SQYSAAGVDIAAATRAKELMADAVRSTHGPAVLAGMGAFGGCFDAALALAGMQAPVLVS
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEE
STDGVGTKTLVAAALGRYDTVGQDLVNHAVNDILVQGARPLFFLDYIAVAKLDPAQVAAI
CCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHH
VTGVAEGCRAAGCALIGGETAEMPDVYAPGAFDLAGTIVGVVERTAMLPRPDIVPGDAIL
HHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
ALPSTGLHTNGYSLARRLVARHFATDGYAARPSILNGQTIGEALLAIHRCYLAEVNALRA
EECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVLVKALCHITGGGIYDNLPRVLPAGLGAEIVRGSWPIPPICQLLVDIGGLDEREAFHAL
HHHHHHHHHHCCCCHHHCCHHHHCCCCCHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHH
NMGLGMLVIVPADAAATALATIADACLVGRVTATPEVRLVDA
HCCCCEEEEECCCHHHHHHHHHHHHHHHCCEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]