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The map label for this gene is kynU [H]

Identifier: 222524651

GI number: 222524651

Start: 1757228

End: 1758496

Strand: Reverse

Name: kynU [H]

Synonym: Chy400_1378

Alternate gene names: 222524651

Gene position: 1758496-1757228 (Counterclockwise)

Preceding gene: 222524652

Following gene: 222524644

Centisome position: 33.37

GC content: 57.29

Gene sequence:

>1269_bases
ATGACCGTGCCCCTGGATCGCTCCTACGCAGACCAGCTTGATGCGGCTGATGATTTGGCCGGTATGCAGCAGGCGTTTGT
TAATCTTGAACCGGATATGATCTACCTGGACGGCAACTCGCTGGGACGGTTGCCGCGTGCTGCGGTTGATCTGGCCGATG
ATCTGGTGCGCAGACAGTGGGGAGAGCGCCTGATTCGCGGGTGGAATGAGGGCTGGTTTGATCTGCCAGAGCGGATCGGG
GCAAAAATCGCTCGTCTGATTGGTGCTGCGCCAGATGAGGTGATTGTCGCCGATAGTACATCGGTCAATTTGTTTAAGCT
GGTTGTAGCTGCTCTGCGGGCGCAACGGGGTCGGATGCGGATCATCAGCGATGACCTCAACTTTCCCTCAGACCTCTACA
TCTTGCAGGGTGTCGTCGATCTGCTTGGATCGGGGCATGAAATTGCCCTGGCGTATTCAGCCGACGGCATTCACGGCCCG
GTTGAGACGATACTGAGCCTGCTTGACCACAACACAGCCCTGCTGACCCTCTCCCACGTTACCTTCAAAAGTGGCTTTCT
CTATGATATGAAAGCCCTGACTGCGGCAGCCCACGCGGTTGGTGCGTTGACGATATGGGATTTGAGTCACTCGGTTGGGG
CGGTGCCGATTGATCTCAACGGGAGTGGCGTTGATCTCGCGGTTGGTTGTTGCTACAAATATTTGAACGGTGGCCCTGGC
GCCCCAGCATTTTTGTATATTCGGCGCGATCTGCAGGAACGTCTGATCAACCCGATTAGCGGCTGGATGGGGCAGCGTGA
TCTGTTCAATTTTGACCTGGATTACGCGCCGACAGCCGGTCTGCGCCGCTTTCTTACCGGCACGCCACCCATCATGTCGC
TGGCGCTGATTGAGCCGGGCGTCGATCTCATTCTGGCTGCCGGGATTGAACGCTTGCGGGCCAAATCGATTGCCCAAACC
GAGTACCTGATTGAGTTGTGGCAGCAACGGTTGGCCCCGCTCGGTTACACGCTCAACTCACCCCGCGACCCGGCGCGTCG
CGGTTCACACGTCTCACTCGGCCATCCTGCCGGTCTTGGCATTGATCTGGCCCTGATCAATGAGCTGAATGTGCTGCCCG
ATTTTCGGGCCCCCGATAACATCCGGCTCGGCATTACGCCGCTCTACACCAGTTTTCGCGACATCTACATCGCGGTTGAG
CGTTTGGCTCAGGCGGTGATCGAACAGCGCTATCTGAAGTATCAGTCAAACCGACCGACAGTGACGTAA

Upstream 100 bases:

>100_bases
CGATCCGATACGGATTCCGGTGCCGACGCTCATGCCAACGCCTGTGCCATAAAACGTAGATGGAAGCAACACTTTATTGT
ACCGTTGGAAGGAATTGATG

Downstream 100 bases:

>100_bases
CGATATGAGCGGCCTGTTGATGAGGAAAGCCTGTTTGCTTCACTACAGGCGCTCTTCCCGTAGCGATCAGCTTGTTCGGG
AAGCCTGCAAATTCGTTCAG

Product: class V aminotransferase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTVPLDRSYADQLDAADDLAGMQQAFVNLEPDMIYLDGNSLGRLPRAAVDLADDLVRRQWGERLIRGWNEGWFDLPERIG
AKIARLIGAAPDEVIVADSTSVNLFKLVVAALRAQRGRMRIISDDLNFPSDLYILQGVVDLLGSGHEIALAYSADGIHGP
VETILSLLDHNTALLTLSHVTFKSGFLYDMKALTAAAHAVGALTIWDLSHSVGAVPIDLNGSGVDLAVGCCYKYLNGGPG
APAFLYIRRDLQERLINPISGWMGQRDLFNFDLDYAPTAGLRRFLTGTPPIMSLALIEPGVDLILAAGIERLRAKSIAQT
EYLIELWQQRLAPLGYTLNSPRDPARRGSHVSLGHPAGLGIDLALINELNVLPDFRAPDNIRLGITPLYTSFRDIYIAVE
RLAQAVIEQRYLKYQSNRPTVT

Sequences:

>Translated_422_residues
MTVPLDRSYADQLDAADDLAGMQQAFVNLEPDMIYLDGNSLGRLPRAAVDLADDLVRRQWGERLIRGWNEGWFDLPERIG
AKIARLIGAAPDEVIVADSTSVNLFKLVVAALRAQRGRMRIISDDLNFPSDLYILQGVVDLLGSGHEIALAYSADGIHGP
VETILSLLDHNTALLTLSHVTFKSGFLYDMKALTAAAHAVGALTIWDLSHSVGAVPIDLNGSGVDLAVGCCYKYLNGGPG
APAFLYIRRDLQERLINPISGWMGQRDLFNFDLDYAPTAGLRRFLTGTPPIMSLALIEPGVDLILAAGIERLRAKSIAQT
EYLIELWQQRLAPLGYTLNSPRDPARRGSHVSLGHPAGLGIDLALINELNVLPDFRAPDNIRLGITPLYTSFRDIYIAVE
RLAQAVIEQRYLKYQSNRPTVT
>Mature_421_residues
TVPLDRSYADQLDAADDLAGMQQAFVNLEPDMIYLDGNSLGRLPRAAVDLADDLVRRQWGERLIRGWNEGWFDLPERIGA
KIARLIGAAPDEVIVADSTSVNLFKLVVAALRAQRGRMRIISDDLNFPSDLYILQGVVDLLGSGHEIALAYSADGIHGPV
ETILSLLDHNTALLTLSHVTFKSGFLYDMKALTAAAHAVGALTIWDLSHSVGAVPIDLNGSGVDLAVGCCYKYLNGGPGA
PAFLYIRRDLQERLINPISGWMGQRDLFNFDLDYAPTAGLRRFLTGTPPIMSLALIEPGVDLILAAGIERLRAKSIAQTE
YLIELWQQRLAPLGYTLNSPRDPARRGSHVSLGHPAGLGIDLALINELNVLPDFRAPDNIRLGITPLYTSFRDIYIAVER
LAQAVIEQRYLKYQSNRPTVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=426, Percent_Identity=26.7605633802817, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI74101437, Length=257, Percent_Identity=28.0155642023346, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17550466, Length=411, Percent_Identity=28.4671532846715, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323261, Length=421, Percent_Identity=26.8408551068884, Blast_Score=140, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 46291; Mature: 46160

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPLDRSYADQLDAADDLAGMQQAFVNLEPDMIYLDGNSLGRLPRAAVDLADDLVRRQW
CCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
GERLIRGWNEGWFDLPERIGAKIARLIGAAPDEVIVADSTSVNLFKLVVAALRAQRGRMR
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEE
IISDDLNFPSDLYILQGVVDLLGSGHEIALAYSADGIHGPVETILSLLDHNTALLTLSHV
EEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEHH
TFKSGFLYDMKALTAAAHAVGALTIWDLSHSVGAVPIDLNGSGVDLAVGCCYKYLNGGPG
HHHCCCHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
APAFLYIRRDLQERLINPISGWMGQRDLFNFDLDYAPTAGLRRFLTGTPPIMSLALIEPG
CCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHEEEECCCC
VDLILAAGIERLRAKSIAQTEYLIELWQQRLAPLGYTLNSPRDPARRGSHVSLGHPAGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCEEECCCCCCCC
IDLALINELNVLPDFRAPDNIRLGITPLYTSFRDIYIAVERLAQAVIEQRYLKYQSNRPT
EEEEEHHHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VT
CC
>Mature Secondary Structure 
TVPLDRSYADQLDAADDLAGMQQAFVNLEPDMIYLDGNSLGRLPRAAVDLADDLVRRQW
CCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
GERLIRGWNEGWFDLPERIGAKIARLIGAAPDEVIVADSTSVNLFKLVVAALRAQRGRMR
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEE
IISDDLNFPSDLYILQGVVDLLGSGHEIALAYSADGIHGPVETILSLLDHNTALLTLSHV
EEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEHH
TFKSGFLYDMKALTAAAHAVGALTIWDLSHSVGAVPIDLNGSGVDLAVGCCYKYLNGGPG
HHHCCCHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
APAFLYIRRDLQERLINPISGWMGQRDLFNFDLDYAPTAGLRRFLTGTPPIMSLALIEPG
CCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHEEEECCCC
VDLILAAGIERLRAKSIAQTEYLIELWQQRLAPLGYTLNSPRDPARRGSHVSLGHPAGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCEEECCCCCCCC
IDLALINELNVLPDFRAPDNIRLGITPLYTSFRDIYIAVERLAQAVIEQRYLKYQSNRPT
EEEEEHHHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA