Click here to switch to the map view.

The map label for this gene is vraS [H]

Identifier: 222524597

GI number: 222524597

Start: 1690031

End: 1691341

Strand: Reverse

Name: vraS [H]

Synonym: Chy400_1321

Alternate gene names: 222524597

Gene position: 1691341-1690031 (Counterclockwise)

Preceding gene: 222524598

Following gene: 222524593

Centisome position: 32.1

GC content: 56.14

Gene sequence:

>1311_bases
ATGGCAGAATGGGCAGGTGGACAGGGAACGCAGGAACAAGCGGTTGACAAAGGCCCGGTAACAACTGACCGCCCCCGTCC
TGATCGCATATCGCCGATGAATACAGCGCGTCGGCTTCTGCGTTATCTCGGTCATCAGCGCTTACCCCATGTTGTCGTAC
AGATTGGTTGCGAGATACTGGGTGCGCAGCGGGGTGCCTTGTACCTGCTCGACCAGAACCAGGAGGTTACGCTGATTGCT
CAGTACCCTGACGACAAAGATGTGCAGGTTCCTGATGATCTCGATGAAGCACGGTTATCATGGCACACGTTGCATGATTT
TCTGCCGCAACTGGTGGATTGTGCTCACGACCACGAAGCACGGTTTCATTACTGCTCTGGCGGCGATTGCTGGCTCACGC
TGAGTATTCCTTTGCAGTGGGAAGGGCAAAATATCGCGGTTGTGCAACTGTCTTACAAACCAGACGTGACGATTGATCAA
ACCAGTATGCTGGGGCTGGTTTACGAATACGCTGAGCTGGCAGCGCTGACCCTGGTACAGCATTGGCGTTGTATCCATCC
TGCGCACAGCAGTGGTACCCAGGCCGTTCCCCCTTCGTCGTTGACTAATGATTACTCATTCTCGTCGGGTGTATCGCTGG
CGCTGGCGGTCAGCGAAGCCGAGCGGGCCAGGATCGCTCGTGATTTACACGACGGTGCCCGTTCGGCGATCCTGGGGGTG
CAGTTGCACCTGGAAGCGCTGCGCCTGGCCTGCATGCAAGGTGACTCCCTGGCAATCCAGGATCATCTTGCCCGTGGGCG
GGCGGCGCTTGATGCTATCGAACAGGAACTATCACATATTGTGCGTGACCTGTATCCACCACAAGTTGGTGAAGCGGATT
TTCCAACTGTCCTGGTTAATCTCAGTGAACGCTGGTCGGCGGCAACGCGGATTCCGGTGGAGTATGCGTTTGCTCCCAAC
ATACCTGTGCTCGAAACGGCCCAGGTGATTGCGCTGTACCGGATTGTGCAGGAAGCGCTGGCTAATTGTAACCGTCATGC
TCAGGCATCACGGGTTACCATTAGTCTGGCCTGCGCCGACGATACGTTGCTGTTAACGGTAGCCGATAACGGTCGTGGTG
GTGCCAATCTGCGTGGTGGCGGGATTGGCCTCTTGAGTATGGCTCAGCGTGCTCACGCAATTGGGGCCAGTTTTCATATC
GACTCACCGCCTGATCAGGGCACCCGGATTGAGGTGAAATTGCCACTCAGGCGTCGCGAACCGGATGTGCATGTATGCAG
TGGTGATTGTCATGAGGGGGCTGATGAATGA

Upstream 100 bases:

>100_bases
ATTTGCCCTGTTGAACAGTTGAATGATGTTCAACAAAAGAGACAGTAATCTTCACATACAAACATACTGGTCATTCAGTT
ATCAGAATGGAGAGAAAGCC

Downstream 100 bases:

>100_bases
TTCCCCCATACCTCTACCCTGACTCCGTGCCGCTCCCCCTGCCATAACGGCACGCGACAGGTGTCGCGGAGGAGGCGCTT
CCAGAGTTGCGCGTGTTGGA

Product: putative signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MAEWAGGQGTQEQAVDKGPVTTDRPRPDRISPMNTARRLLRYLGHQRLPHVVVQIGCEILGAQRGALYLLDQNQEVTLIA
QYPDDKDVQVPDDLDEARLSWHTLHDFLPQLVDCAHDHEARFHYCSGGDCWLTLSIPLQWEGQNIAVVQLSYKPDVTIDQ
TSMLGLVYEYAELAALTLVQHWRCIHPAHSSGTQAVPPSSLTNDYSFSSGVSLALAVSEAERARIARDLHDGARSAILGV
QLHLEALRLACMQGDSLAIQDHLARGRAALDAIEQELSHIVRDLYPPQVGEADFPTVLVNLSERWSAATRIPVEYAFAPN
IPVLETAQVIALYRIVQEALANCNRHAQASRVTISLACADDTLLLTVADNGRGGANLRGGGIGLLSMAQRAHAIGASFHI
DSPPDQGTRIEVKLPLRRREPDVHVCSGDCHEGADE

Sequences:

>Translated_436_residues
MAEWAGGQGTQEQAVDKGPVTTDRPRPDRISPMNTARRLLRYLGHQRLPHVVVQIGCEILGAQRGALYLLDQNQEVTLIA
QYPDDKDVQVPDDLDEARLSWHTLHDFLPQLVDCAHDHEARFHYCSGGDCWLTLSIPLQWEGQNIAVVQLSYKPDVTIDQ
TSMLGLVYEYAELAALTLVQHWRCIHPAHSSGTQAVPPSSLTNDYSFSSGVSLALAVSEAERARIARDLHDGARSAILGV
QLHLEALRLACMQGDSLAIQDHLARGRAALDAIEQELSHIVRDLYPPQVGEADFPTVLVNLSERWSAATRIPVEYAFAPN
IPVLETAQVIALYRIVQEALANCNRHAQASRVTISLACADDTLLLTVADNGRGGANLRGGGIGLLSMAQRAHAIGASFHI
DSPPDQGTRIEVKLPLRRREPDVHVCSGDCHEGADE
>Mature_435_residues
AEWAGGQGTQEQAVDKGPVTTDRPRPDRISPMNTARRLLRYLGHQRLPHVVVQIGCEILGAQRGALYLLDQNQEVTLIAQ
YPDDKDVQVPDDLDEARLSWHTLHDFLPQLVDCAHDHEARFHYCSGGDCWLTLSIPLQWEGQNIAVVQLSYKPDVTIDQT
SMLGLVYEYAELAALTLVQHWRCIHPAHSSGTQAVPPSSLTNDYSFSSGVSLALAVSEAERARIARDLHDGARSAILGVQ
LHLEALRLACMQGDSLAIQDHLARGRAALDAIEQELSHIVRDLYPPQVGEADFPTVLVNLSERWSAATRIPVEYAFAPNI
PVLETAQVIALYRIVQEALANCNRHAQASRVTISLACADDTLLLTVADNGRGGANLRGGGIGLLSMAQRAHAIGASFHID
SPPDQGTRIEVKLPLRRREPDVHVCSGDCHEGADE

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. Probably activates vraR by phosphorylation [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=216, Percent_Identity=29.6296296296296, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR017202 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47732; Mature: 47601

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEWAGGQGTQEQAVDKGPVTTDRPRPDRISPMNTARRLLRYLGHQRLPHVVVQIGCEIL
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
GAQRGALYLLDQNQEVTLIAQYPDDKDVQVPDDLDEARLSWHTLHDFLPQLVDCAHDHEA
CCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
RFHYCSGGDCWLTLSIPLQWEGQNIAVVQLSYKPDVTIDQTSMLGLVYEYAELAALTLVQ
CEEEECCCCEEEEEEEEEEECCCEEEEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHH
HWRCIHPAHSSGTQAVPPSSLTNDYSFSSGVSLALAVSEAERARIARDLHDGARSAILGV
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHEEHH
QLHLEALRLACMQGDSLAIQDHLARGRAALDAIEQELSHIVRDLYPPQVGEADFPTVLVN
HHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
LSERWSAATRIPVEYAFAPNIPVLETAQVIALYRIVQEALANCNRHAQASRVTISLACAD
CHHHCCHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECC
DTLLLTVADNGRGGANLRGGGIGLLSMAQRAHAIGASFHIDSPPDQGTRIEVKLPLRRRE
CEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCC
PDVHVCSGDCHEGADE
CCEEEECCCCCCCCCC
>Mature Secondary Structure 
AEWAGGQGTQEQAVDKGPVTTDRPRPDRISPMNTARRLLRYLGHQRLPHVVVQIGCEIL
CCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
GAQRGALYLLDQNQEVTLIAQYPDDKDVQVPDDLDEARLSWHTLHDFLPQLVDCAHDHEA
CCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
RFHYCSGGDCWLTLSIPLQWEGQNIAVVQLSYKPDVTIDQTSMLGLVYEYAELAALTLVQ
CEEEECCCCEEEEEEEEEEECCCEEEEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHH
HWRCIHPAHSSGTQAVPPSSLTNDYSFSSGVSLALAVSEAERARIARDLHDGARSAILGV
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHEEHH
QLHLEALRLACMQGDSLAIQDHLARGRAALDAIEQELSHIVRDLYPPQVGEADFPTVLVN
HHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
LSERWSAATRIPVEYAFAPNIPVLETAQVIALYRIVQEALANCNRHAQASRVTISLACAD
CHHHCCHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECC
DTLLLTVADNGRGGANLRGGGIGLLSMAQRAHAIGASFHIDSPPDQGTRIEVKLPLRRRE
CEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCC
PDVHVCSGDCHEGADE
CCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA