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The map label for this gene is fabF [H]

Identifier: 222524497

GI number: 222524497

Start: 1556241

End: 1557482

Strand: Reverse

Name: fabF [H]

Synonym: Chy400_1221

Alternate gene names: 222524497

Gene position: 1557482-1556241 (Counterclockwise)

Preceding gene: 222524498

Following gene: 222524496

Centisome position: 29.56

GC content: 59.58

Gene sequence:

>1242_bases
ATGGATCGACGGGTGGTGGTGACCGGAATGGGGGCAATCAGCCCACTTGGTCTCAGCGTAGCCGAACTCTGGCAGGGGAT
CGTCGCAGCGCGGAGCGGCGTCGGTCCGATCACATTGTTCGATTCGACCGGTTTTGATACCCGGTTTGCCGCTGAGGTGA
AGGGCTTCGATCCCACGAATTATATGGATCGCAAAGAGGCGCGACGCACCGACCGCTTCGTGCAGTTTGCGGTGGCTGCG
ACCAGAGAAGCGTTACGCGATGCCGAGCTTGAGATCACGCCCGCCAATCGTGATGAGATCGGGGTCTTTATTGCCAGTGG
GATCGGTGGCATTGGCACCCTCTCGGAGCAGTTAGACGTTCTGCGCAGTCGCGGGCCGGGGCGGATCAGTCCCTTCCTCA
TTCCGGCGATGATCACCAATCTGGCCGCCGGTCAGGTTTCCATTGTCACCGGTGCCCGTGGGCCGAGCTACTGTGTGACA
TCGGCCTGTGCGAGTTCAGCCCACGCCATCGGCGAGGCGGCAGAGACCATTCGCCGTGGATGGGCAAAGGCGATCATTGT
TGGTGGCAGTGAAGCCAGCATTACCCCTATTGGCGTCGCCGGCTTCAATGCGATGCGTGCCCTCTCGACGCGCAACGAAG
ACTATGCCCACGCCTCACGACCATTTGACGCCGAGCGTGATGGGTTTGTGATGGGTGAGGGTGCAGCGGTACTCATCCTC
GAAGACCTTGAATTCGCTCTTGCCCGTGGTGCGCGTATTTTAGCCGAGGTGGTGGGGTATGGTGCAACATCTGATGCCTA
CCATATCTCGAATCTGGCCGAGGATGGCGAAGGTGTCGCACGGGCGATTCGGTTGGCCCTGCAGCGGGGTGCTCTGGCAC
CAGAGGATGTGGATTATATCAATGCGCACGCCACCTCAACTCCGGCTGGTGACCCGGTTGAGACAACCGCTATCAAGCAG
GTCTTCGGCGGACGCGAGAAATCACCGCCGGTGAGTGCCAGCAAGTCGCAGTTCGGTCATCTGCTCGGTGCAGCCGGTGC
TATCGAAGCAGTTGTGACTATCCTGGCGATGCAGAACAATCTCCTGCCGGCAACCATCAATCTTCAGCAACCAGACCCGG
CCTGTGATCTCGATTTTGTGCCCGGTCAGCCGCGTCCGGCTCGGATTGAGGTGGCCCTAAGCAACTCGTTTGGCTTTGGC
GGACACAATGTGTGCCTTGCCTTTCGTAAATACCACGGATAG

Upstream 100 bases:

>100_bases
CCGGCATAGTTCAGCCATCAGGCAATTGTCGTCAGATAGTGAGCAACATGATATAATGCGCGCCGATGTTAGTAGTTACA
TACAACACTAAGGAGTAATC

Downstream 100 bases:

>100_bases
GCGCTATGAGTGATCGACTGGCCGAACTTGAGCGGGCAATCGGGATCACCTTTCGTGATCGAACGCTGTTGCAGACGGCA
TTTATGCACCGTTCGCTGTT

Product: 3-oxoacyl-(acyl-carrier-protein) synthase 2

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MDRRVVVTGMGAISPLGLSVAELWQGIVAARSGVGPITLFDSTGFDTRFAAEVKGFDPTNYMDRKEARRTDRFVQFAVAA
TREALRDAELEITPANRDEIGVFIASGIGGIGTLSEQLDVLRSRGPGRISPFLIPAMITNLAAGQVSIVTGARGPSYCVT
SACASSAHAIGEAAETIRRGWAKAIIVGGSEASITPIGVAGFNAMRALSTRNEDYAHASRPFDAERDGFVMGEGAAVLIL
EDLEFALARGARILAEVVGYGATSDAYHISNLAEDGEGVARAIRLALQRGALAPEDVDYINAHATSTPAGDPVETTAIKQ
VFGGREKSPPVSASKSQFGHLLGAAGAIEAVVTILAMQNNLLPATINLQQPDPACDLDFVPGQPRPARIEVALSNSFGFG
GHNVCLAFRKYHG

Sequences:

>Translated_413_residues
MDRRVVVTGMGAISPLGLSVAELWQGIVAARSGVGPITLFDSTGFDTRFAAEVKGFDPTNYMDRKEARRTDRFVQFAVAA
TREALRDAELEITPANRDEIGVFIASGIGGIGTLSEQLDVLRSRGPGRISPFLIPAMITNLAAGQVSIVTGARGPSYCVT
SACASSAHAIGEAAETIRRGWAKAIIVGGSEASITPIGVAGFNAMRALSTRNEDYAHASRPFDAERDGFVMGEGAAVLIL
EDLEFALARGARILAEVVGYGATSDAYHISNLAEDGEGVARAIRLALQRGALAPEDVDYINAHATSTPAGDPVETTAIKQ
VFGGREKSPPVSASKSQFGHLLGAAGAIEAVVTILAMQNNLLPATINLQQPDPACDLDFVPGQPRPARIEVALSNSFGFG
GHNVCLAFRKYHG
>Mature_413_residues
MDRRVVVTGMGAISPLGLSVAELWQGIVAARSGVGPITLFDSTGFDTRFAAEVKGFDPTNYMDRKEARRTDRFVQFAVAA
TREALRDAELEITPANRDEIGVFIASGIGGIGTLSEQLDVLRSRGPGRISPFLIPAMITNLAAGQVSIVTGARGPSYCVT
SACASSAHAIGEAAETIRRGWAKAIIVGGSEASITPIGVAGFNAMRALSTRNEDYAHASRPFDAERDGFVMGEGAAVLIL
EDLEFALARGARILAEVVGYGATSDAYHISNLAEDGEGVARAIRLALQRGALAPEDVDYINAHATSTPAGDPVETTAIKQ
VFGGREKSPPVSASKSQFGHLLGAAGAIEAVVTILAMQNNLLPATINLQQPDPACDLDFVPGQPRPARIEVALSNSFGFG
GHNVCLAFRKYHG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=39.8568019093079, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=43.1137724550898, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI41872631, Length=426, Percent_Identity=26.9953051643192, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=48.1662591687042, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1788663, Length=412, Percent_Identity=36.4077669902913, Blast_Score=228, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=38.2211538461538, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=42.8030303030303, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI212642053, Length=358, Percent_Identity=25.6983240223464, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17550940, Length=275, Percent_Identity=28, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=38.7024608501119, Blast_Score=303, Evalue=4e-83,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=42.1428571428571, Blast_Score=312, Evalue=2e-85,
Organism=Drosophila melanogaster, GI19920632, Length=390, Percent_Identity=24.8717948717949, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI221330659, Length=396, Percent_Identity=24.4949494949495, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24581345, Length=371, Percent_Identity=23.7196765498652, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43333; Mature: 43333

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRRVVVTGMGAISPLGLSVAELWQGIVAARSGVGPITLFDSTGFDTRFAAEVKGFDPTN
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCC
YMDRKEARRTDRFVQFAVAATREALRDAELEITPANRDEIGVFIASGIGGIGTLSEQLDV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCHHHHHHHHH
LRSRGPGRISPFLIPAMITNLAAGQVSIVTGARGPSYCVTSACASSAHAIGEAAETIRRG
HHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
WAKAIIVGGSEASITPIGVAGFNAMRALSTRNEDYAHASRPFDAERDGFVMGEGAAVLIL
CEEEEEEECCCCCCCEEEHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEEECCEEEEEE
EDLEFALARGARILAEVVGYGATSDAYHISNLAEDGEGVARAIRLALQRGALAPEDVDYI
EHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCE
NAHATSTPAGDPVETTAIKQVFGGREKSPPVSASKSQFGHLLGAAGAIEAVVTILAMQNN
ECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
LLPATINLQQPDPACDLDFVPGQPRPARIEVALSNSFGFGGHNVCLAFRKYHG
CCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MDRRVVVTGMGAISPLGLSVAELWQGIVAARSGVGPITLFDSTGFDTRFAAEVKGFDPTN
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCC
YMDRKEARRTDRFVQFAVAATREALRDAELEITPANRDEIGVFIASGIGGIGTLSEQLDV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCHHHHHHHHH
LRSRGPGRISPFLIPAMITNLAAGQVSIVTGARGPSYCVTSACASSAHAIGEAAETIRRG
HHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
WAKAIIVGGSEASITPIGVAGFNAMRALSTRNEDYAHASRPFDAERDGFVMGEGAAVLIL
CEEEEEEECCCCCCCEEEHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEEECCEEEEEE
EDLEFALARGARILAEVVGYGATSDAYHISNLAEDGEGVARAIRLALQRGALAPEDVDYI
EHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCE
NAHATSTPAGDPVETTAIKQVFGGREKSPPVSASKSQFGHLLGAAGAIEAVVTILAMQNN
ECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
LLPATINLQQPDPACDLDFVPGQPRPARIEVALSNSFGFGGHNVCLAFRKYHG
CCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]