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The map label for this gene is cocE [H]

Identifier: 222524404

GI number: 222524404

Start: 1426782

End: 1428539

Strand: Reverse

Name: cocE [H]

Synonym: Chy400_1128

Alternate gene names: 222524404

Gene position: 1428539-1426782 (Counterclockwise)

Preceding gene: 222524407

Following gene: 222524403

Centisome position: 27.11

GC content: 59.56

Gene sequence:

>1758_bases
ATGCGCTGGATCGGTTGGTCGCTGGCTGGAGCCGGAGTAACGGCAGCAACGCTCTTCGCTCTACGTCGCCCTTTACTGGC
GAGGCTCCTTGGTTTGCGCCCCGCTGAATATGCCGTCCGGGTGGTGCGTGACATTCCTATTCGTATGCCCGATGGTGTCA
CCCTCTACGCTGACCACTATGCCCCACGCACAGGTGGCCCACACCCGACGATTCTCATCCGTACACCTTACGGTCGTCCC
GGCGAACTTGGCCCGCTGGGTGTCTTTGAGCATACCGGTTGTATGCTCTTTGCTGAACGTGGCTACAACGTGATCGTGCA
GGGAGTACGCGGGCGTTACCGCTCTGAAGGCGAATTTGAGCCGTTTGTGAATGAAGCTGCCGATGGGCGGGCGACGATGG
ACTGGATTGCTGCCCAACCCTGGTTCGATGGCAATCTTGGCTTGTGGGGGCCGAGCTATGTCGGCTATGCGCAGTGGGGG
TTGGCGATTGATGGGCCGCCATATCTGAAGGCGATTGTCCCAATCATGACCAGTGCCCGCTTCTCGCCACTCTTCTATCC
CGGCGGTGCATTCGCCTTCGAGTCAACGCTGCGTTGGGTCTTTTTGATCGATGCCTCTGACCGCCACCGTCATAACCTCG
ACCTGTCTGCGCTGTGGCGAGTGTTTGTGGTCGGCGAGCGGATTCTGGATCGCGCTCTTCATCACCAGCCTTACGCCACA
GCCGATACTATCGCGACCGGTGCGCCGGTATCCTTTTTCCAGCGCTGGCTCACCGATACCGATCCCCAGGGCGCCTACTG
GTCGCGGGTTGATATGCATCGTCAGTTGCACCGGATTGACGCTGCTGTCCATCTGGTTGCCGGCTGGTACGATATTTTTC
TCTCCGGCCAGTTGGCCGATTACGCGGCGCTGGTCGCAGCCGGTAAGCGTCCATACCTGACGATTCTGCCACTGGCGCAT
ACCGGTCTTTCACAACCACTGGAAGGGATGCGCGAGGGGTTGTGGTGGTTTGACGCTCATCTGAAGGGCAAACGCGAGTT
GTTGGCCCGCCGACCGGTGCGGCTTAAACTTATGGGCAGTAACGAGTGGCACGAGATGGATTTCTGGCCGCCACCGGCAA
CCCTGCACCGCTACTTTCTCCAGCCAGGACGGGGGCTTGACCGGCAACCACCACCGGCCGCTGCGCAACCGAGCAGGTTT
TGCTACAATCCTGCCGATCCGCCGCCATCGATTGGCGGTGCCGTCCTGAGTCCGCTGGCCGGGCCACGTGATCAACGTGC
GCTTGAGGCGCGGAGTGATGTGTTGACATTTACCAGTCCCCCGCTTACTGCCGATCTAGATGTGATCGGGCCGGTGCGCC
TGGTCCTCTATGTCAAGAGTGATCGCCCCTTTTTCGATGTTGTCGGTCGGCTGTGCGATGTCTACCCCGATGGGCGGAGT
ATTAACATTTGCGATGGTATCATTCGTGTGCGGCCAGACATTGGCGAATGCCAGCCCGATGGCTCACGCCGTATCGAGAT
CGATCTCTCAGCAACTGCCCAGCGCTTTCGGCGCGGGCATCGCCTGCGTTTACAGGTGACCGGTGGCGGCAGTCCGCGAT
GGGGGCCGCATCCCGGTGATCATAGCCCTTATGGACAGAGAAACGGTGGTTCACCGCTGGAACAGTCTATTTATCACGAT
GCTGCCCATCCGTCGGTATTGATTTTGCCGGTGGTGAATGGCACAGTATCGCGTGATCAAACTGCATCCGCAACGTGA

Upstream 100 bases:

>100_bases
CACCGGGCATCCACTTTCTCGTACCGTTGACAGCAACCGCCCTGCTGTGCTATCATCAATGACGCATTGTGTTATAAAGT
AAGGCATAGCGGAGTGGCAC

Downstream 100 bases:

>100_bases
AACAGACTGACCAGTTGGTAGCATCTTCTCTGATCCGTCTTGGGATAGATGGCAGTCAGGTTCGGTTGATGGCAGGTATT
GTATGAACGAAGGGAGCTAC

Product: X-Pro dipeptidyl-peptidase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MRWIGWSLAGAGVTAATLFALRRPLLARLLGLRPAEYAVRVVRDIPIRMPDGVTLYADHYAPRTGGPHPTILIRTPYGRP
GELGPLGVFEHTGCMLFAERGYNVIVQGVRGRYRSEGEFEPFVNEAADGRATMDWIAAQPWFDGNLGLWGPSYVGYAQWG
LAIDGPPYLKAIVPIMTSARFSPLFYPGGAFAFESTLRWVFLIDASDRHRHNLDLSALWRVFVVGERILDRALHHQPYAT
ADTIATGAPVSFFQRWLTDTDPQGAYWSRVDMHRQLHRIDAAVHLVAGWYDIFLSGQLADYAALVAAGKRPYLTILPLAH
TGLSQPLEGMREGLWWFDAHLKGKRELLARRPVRLKLMGSNEWHEMDFWPPPATLHRYFLQPGRGLDRQPPPAAAQPSRF
CYNPADPPPSIGGAVLSPLAGPRDQRALEARSDVLTFTSPPLTADLDVIGPVRLVLYVKSDRPFFDVVGRLCDVYPDGRS
INICDGIIRVRPDIGECQPDGSRRIEIDLSATAQRFRRGHRLRLQVTGGGSPRWGPHPGDHSPYGQRNGGSPLEQSIYHD
AAHPSVLILPVVNGTVSRDQTASAT

Sequences:

>Translated_585_residues
MRWIGWSLAGAGVTAATLFALRRPLLARLLGLRPAEYAVRVVRDIPIRMPDGVTLYADHYAPRTGGPHPTILIRTPYGRP
GELGPLGVFEHTGCMLFAERGYNVIVQGVRGRYRSEGEFEPFVNEAADGRATMDWIAAQPWFDGNLGLWGPSYVGYAQWG
LAIDGPPYLKAIVPIMTSARFSPLFYPGGAFAFESTLRWVFLIDASDRHRHNLDLSALWRVFVVGERILDRALHHQPYAT
ADTIATGAPVSFFQRWLTDTDPQGAYWSRVDMHRQLHRIDAAVHLVAGWYDIFLSGQLADYAALVAAGKRPYLTILPLAH
TGLSQPLEGMREGLWWFDAHLKGKRELLARRPVRLKLMGSNEWHEMDFWPPPATLHRYFLQPGRGLDRQPPPAAAQPSRF
CYNPADPPPSIGGAVLSPLAGPRDQRALEARSDVLTFTSPPLTADLDVIGPVRLVLYVKSDRPFFDVVGRLCDVYPDGRS
INICDGIIRVRPDIGECQPDGSRRIEIDLSATAQRFRRGHRLRLQVTGGGSPRWGPHPGDHSPYGQRNGGSPLEQSIYHD
AAHPSVLILPVVNGTVSRDQTASAT
>Mature_585_residues
MRWIGWSLAGAGVTAATLFALRRPLLARLLGLRPAEYAVRVVRDIPIRMPDGVTLYADHYAPRTGGPHPTILIRTPYGRP
GELGPLGVFEHTGCMLFAERGYNVIVQGVRGRYRSEGEFEPFVNEAADGRATMDWIAAQPWFDGNLGLWGPSYVGYAQWG
LAIDGPPYLKAIVPIMTSARFSPLFYPGGAFAFESTLRWVFLIDASDRHRHNLDLSALWRVFVVGERILDRALHHQPYAT
ADTIATGAPVSFFQRWLTDTDPQGAYWSRVDMHRQLHRIDAAVHLVAGWYDIFLSGQLADYAALVAAGKRPYLTILPLAH
TGLSQPLEGMREGLWWFDAHLKGKRELLARRPVRLKLMGSNEWHEMDFWPPPATLHRYFLQPGRGLDRQPPPAAAQPSRF
CYNPADPPPSIGGAVLSPLAGPRDQRALEARSDVLTFTSPPLTADLDVIGPVRLVLYVKSDRPFFDVVGRLCDVYPDGRS
INICDGIIRVRPDIGECQPDGSRRIEIDLSATAQRFRRGHRLRLQVTGGGSPRWGPHPGDHSPYGQRNGGSPLEQSIYHD
AAHPSVLILPVVNGTVSRDQTASAT

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 64918; Mature: 64918

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWIGWSLAGAGVTAATLFALRRPLLARLLGLRPAEYAVRVVRDIPIRMPDGVTLYADHY
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEECCC
APRTGGPHPTILIRTPYGRPGELGPLGVFEHTGCMLFAERGYNVIVQGVRGRYRSEGEFE
CCCCCCCCCEEEEECCCCCCCCCCCCCEECCCCEEEEECCCCEEEEECCCCCCCCCCCCC
PFVNEAADGRATMDWIAAQPWFDGNLGLWGPSYVGYAQWGLAIDGPPYLKAIVPIMTSAR
HHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHCCEEECCCHHHHHHHHHHHCCC
FSPLFYPGGAFAFESTLRWVFLIDASDRHRHNLDLSALWRVFVVGERILDRALHHQPYAT
CCCEEECCCCHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
ADTIATGAPVSFFQRWLTDTDPQGAYWSRVDMHRQLHRIDAAVHLVAGWYDIFLSGQLAD
HHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHCCCCHHH
YAALVAAGKRPYLTILPLAHTGLSQPLEGMREGLWWFDAHLKGKRELLARRPVRLKLMGS
HHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCEEEECCCCCHHHHHHCCCEEEEEECC
NEWHEMDFWPPPATLHRYFLQPGRGLDRQPPPAAAQPSRFCYNPADPPPSIGGAVLSPLA
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCC
GPRDQRALEARSDVLTFTSPPLTADLDVIGPVRLVLYVKSDRPFFDVVGRLCDVYPDGRS
CCCHHHHHHHHCCEEEECCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCE
INICDGIIRVRPDIGECQPDGSRRIEIDLSATAQRFRRGHRLRLQVTGGGSPRWGPHPGD
EEEECCEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCC
HSPYGQRNGGSPLEQSIYHDAAHPSVLILPVVNGTVSRDQTASAT
CCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MRWIGWSLAGAGVTAATLFALRRPLLARLLGLRPAEYAVRVVRDIPIRMPDGVTLYADHY
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEECCC
APRTGGPHPTILIRTPYGRPGELGPLGVFEHTGCMLFAERGYNVIVQGVRGRYRSEGEFE
CCCCCCCCCEEEEECCCCCCCCCCCCCEECCCCEEEEECCCCEEEEECCCCCCCCCCCCC
PFVNEAADGRATMDWIAAQPWFDGNLGLWGPSYVGYAQWGLAIDGPPYLKAIVPIMTSAR
HHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHCCEEECCCHHHHHHHHHHHCCC
FSPLFYPGGAFAFESTLRWVFLIDASDRHRHNLDLSALWRVFVVGERILDRALHHQPYAT
CCCEEECCCCHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
ADTIATGAPVSFFQRWLTDTDPQGAYWSRVDMHRQLHRIDAAVHLVAGWYDIFLSGQLAD
HHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHCCCCHHH
YAALVAAGKRPYLTILPLAHTGLSQPLEGMREGLWWFDAHLKGKRELLARRPVRLKLMGS
HHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCEEEECCCCCHHHHHHCCCEEEEEECC
NEWHEMDFWPPPATLHRYFLQPGRGLDRQPPPAAAQPSRFCYNPADPPPSIGGAVLSPLA
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCC
GPRDQRALEARSDVLTFTSPPLTADLDVIGPVRLVLYVKSDRPFFDVVGRLCDVYPDGRS
CCCHHHHHHHHCCEEEECCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCE
INICDGIIRVRPDIGECQPDGSRRIEIDLSATAQRFRRGHRLRLQVTGGGSPRWGPHPGD
EEEECCEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCC
HSPYGQRNGGSPLEQSIYHDAAHPSVLILPVVNGTVSRDQTASAT
CCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]