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The map label for this gene is hutH

Identifier: 222524341

GI number: 222524341

Start: 1352379

End: 1353950

Strand: Reverse

Name: hutH

Synonym: Chy400_1064

Alternate gene names: 222524341

Gene position: 1353950-1352379 (Counterclockwise)

Preceding gene: 222524342

Following gene: 222524339

Centisome position: 25.7

GC content: 61.51

Gene sequence:

>1572_bases
ATGCAGATTCGTGAAGTCATTCTTGATGGCGAAAGCCTGACCATCGAACAGGTACTGGCCGTCGCTTACGGCCAGCCCGG
TACCCCTGTCGTGCGCCTGGCCCCAATTGCCCGGCAGCGAGTCGAACGGGCCGCGCAGGCGGTGCAAGACTTGCTGGCAC
GCGGTGTGGTTGCTTACGGCATTACCACCGGTTTTGGTGCATTTAAAGATCGGGTCATTGCCCCCGACCAGGTTGAACGC
CTGCAATACAACATCCTGGTCAGCCACGCTGTAGGGGTTGGGCCGGTCTTTGATATTCCTACCACCCGCGCCATCATGCT
CATTCGCGCCAACACGCTGGCCCGTGGGCATTCGGGCGTGCGTTTGCAGACGGTTGAACGTCTGCTTGATATGCTCAACC
AGGGCATACATCCCCGGATTCCCTGCAAGGGATCACTGGGCGCGAGTGGCGATCTGGCGCCACTGGCCCATATGGCGTTG
CCGCTCATCGGGTTGGGCGAGGTCGAATGGCAGGGTGAGGTATTGCCGGCGGCAACGGCTTTGGAACGACTGGGCTGGCA
ACCGCTTCATCTGGCCGCTAAAGAGGGGCTGGCCTTAACCAACGGTACCGCGGTCATGTGTGCGCTGGGCGTGATCGAAA
CCGCCCGCGCCGAGACCCTGAGCGCCACTGCCGATATTGCCGGCTGCCTCAGCTTAGAAGCGCTCTACGGCACACCGGCA
GCGTTCGATGCCCGTTTGCACGCACTGCGCCCCTTCCCCCGCCAGATCGAATGCGCTGCCCATCTGCGCCGCTTACTGGC
CGGCAGCACCTTCGTCCGCAACAACGACCCGCGCCACGTCCAGGATGCCTACACCCTGCGCTGCATCCCACAGGTACACG
GTGCCGTGCGCGATGCAATTGCCTATGCCCGTTGGGTCTTTGCCATTGAACTGAATGCCGTCACCGACAACCCGCTCCTG
TTCGTTGACGACGATGGCAACGTCGAAGTCATCTCCGGCGGCAATTTTCACGGCGAGCCGCTGGCAATCGCTCTCGATTA
CCTGGGCCTGGCTGTAGCCGAACTCGGCAACATCGCCGAACGACGCCTAATGCGGCTCACCGATGAAGCATCCAACACCC
ATGTCTTGCCGGCCTTCCTGACCAGGGCCGGTGGGCTGAATTCGGGCTTCATGATCGTCCAGTACACGGCAGCGGCTCTG
GCTACCGAAAACAAAGTGCTCGCCCACCCGGCCAGTGTCGATAGCATTCCCACATCGGCAAACGTTGAAGATCACGTCAG
CATGGGTGTCACTGCCGGCCTGAAACTGCGCAGCATCATCGACAACGTCAGCCAGATTCTGGCGCTTGAGCTATTCGCTG
CGGCGCAGGGCATCGACTTCCGCCGCCAGGAACTGGGCAGTCAGGCCCGACTGGGGCGCGGCACCGGGCCGGTGTACGAA
CTGATTCGTCAATACGTACCATTCATCGCCGAAGACACCCTCCTCCACCCCTACATCACTATCATCAGTGAACTCGTCGC
TCAGGGCAAGATCGCCGCTGCCGCTGCCGTTCACGACGACGCGGATGCGTAA

Upstream 100 bases:

>100_bases
AGTTAGGCGGTACGCCGATCGCGCAGGTCATCAAACGCGGTCAGATTGTCTGGAAGTCGTGATTCAGTTGCCAACATGCC
AACACACTCAACGAGGAGCT

Downstream 100 bases:

>100_bases
GCATCGCTCACCGCAATCCAGACATCGCCAGCCGGGAAGACGAAACAGCGCGTGCGGAAGCCTGACGCTTCCGCACGCTG
CCCAGGCTCTGACGATAACT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MQIREVILDGESLTIEQVLAVAYGQPGTPVVRLAPIARQRVERAAQAVQDLLARGVVAYGITTGFGAFKDRVIAPDQVER
LQYNILVSHAVGVGPVFDIPTTRAIMLIRANTLARGHSGVRLQTVERLLDMLNQGIHPRIPCKGSLGASGDLAPLAHMAL
PLIGLGEVEWQGEVLPAATALERLGWQPLHLAAKEGLALTNGTAVMCALGVIETARAETLSATADIAGCLSLEALYGTPA
AFDARLHALRPFPRQIECAAHLRRLLAGSTFVRNNDPRHVQDAYTLRCIPQVHGAVRDAIAYARWVFAIELNAVTDNPLL
FVDDDGNVEVISGGNFHGEPLAIALDYLGLAVAELGNIAERRLMRLTDEASNTHVLPAFLTRAGGLNSGFMIVQYTAAAL
ATENKVLAHPASVDSIPTSANVEDHVSMGVTAGLKLRSIIDNVSQILALELFAAAQGIDFRRQELGSQARLGRGTGPVYE
LIRQYVPFIAEDTLLHPYITIISELVAQGKIAAAAAVHDDADA

Sequences:

>Translated_523_residues
MQIREVILDGESLTIEQVLAVAYGQPGTPVVRLAPIARQRVERAAQAVQDLLARGVVAYGITTGFGAFKDRVIAPDQVER
LQYNILVSHAVGVGPVFDIPTTRAIMLIRANTLARGHSGVRLQTVERLLDMLNQGIHPRIPCKGSLGASGDLAPLAHMAL
PLIGLGEVEWQGEVLPAATALERLGWQPLHLAAKEGLALTNGTAVMCALGVIETARAETLSATADIAGCLSLEALYGTPA
AFDARLHALRPFPRQIECAAHLRRLLAGSTFVRNNDPRHVQDAYTLRCIPQVHGAVRDAIAYARWVFAIELNAVTDNPLL
FVDDDGNVEVISGGNFHGEPLAIALDYLGLAVAELGNIAERRLMRLTDEASNTHVLPAFLTRAGGLNSGFMIVQYTAAAL
ATENKVLAHPASVDSIPTSANVEDHVSMGVTAGLKLRSIIDNVSQILALELFAAAQGIDFRRQELGSQARLGRGTGPVYE
LIRQYVPFIAEDTLLHPYITIISELVAQGKIAAAAAVHDDADA
>Mature_523_residues
MQIREVILDGESLTIEQVLAVAYGQPGTPVVRLAPIARQRVERAAQAVQDLLARGVVAYGITTGFGAFKDRVIAPDQVER
LQYNILVSHAVGVGPVFDIPTTRAIMLIRANTLARGHSGVRLQTVERLLDMLNQGIHPRIPCKGSLGASGDLAPLAHMAL
PLIGLGEVEWQGEVLPAATALERLGWQPLHLAAKEGLALTNGTAVMCALGVIETARAETLSATADIAGCLSLEALYGTPA
AFDARLHALRPFPRQIECAAHLRRLLAGSTFVRNNDPRHVQDAYTLRCIPQVHGAVRDAIAYARWVFAIELNAVTDNPLL
FVDDDGNVEVISGGNFHGEPLAIALDYLGLAVAELGNIAERRLMRLTDEASNTHVLPAFLTRAGGLNSGFMIVQYTAAAL
ATENKVLAHPASVDSIPTSANVEDHVSMGVTAGLKLRSIIDNVSQILALELFAAAQGIDFRRQELGSQARLGRGTGPVYE
LIRQYVPFIAEDTLLHPYITIISELVAQGKIAAAAAVHDDADA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=520, Percent_Identity=43.4615384615385, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17567831, Length=523, Percent_Identity=42.0650095602294, Blast_Score=365, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_CHLAA (A9WHT8)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001634595.1
- ProteinModelPortal:   A9WHT8
- SMR:   A9WHT8
- GeneID:   5828302
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_0974
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 55891; Mature: 55891

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIREVILDGESLTIEQVLAVAYGQPGTPVVRLAPIARQRVERAAQAVQDLLARGVVAYG
CCHHHEEECCCCCCHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCHHHHH
ITTGFGAFKDRVIAPDQVERLQYNILVSHAVGVGPVFDIPTTRAIMLIRANTLARGHSGV
HHHCCHHHHCCCCCCHHHHHHHHHEEEEHHCCCCCCCCCCCCEEEEEEEECHHHCCCCCC
RLQTVERLLDMLNQGIHPRIPCKGSLGASGDLAPLAHMALPLIGLGEVEWQGEVLPAATA
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LERLGWQPLHLAAKEGLALTNGTAVMCALGVIETARAETLSATADIAGCLSLEALYGTPA
HHHCCCCCEEHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AFDARLHALRPFPRQIECAAHLRRLLAGSTFVRNNDPRHVQDAYTLRCIPQVHGAVRDAI
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHCCHHHEEECHHHHHHHHHHH
AYARWVFAIELNAVTDNPLLFVDDDGNVEVISGGNFHGEPLAIALDYLGLAVAELGNIAE
HHHHEEEEEEEEEECCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
RRLMRLTDEASNTHVLPAFLTRAGGLNSGFMIVQYTAAALATENKVLAHPASVDSIPTSA
HHHHHHHCCCCCCEEHHHHHHHCCCCCCCEEEEEEHHHHHHCCCCEEECCCCCCCCCCCC
NVEDHVSMGVTAGLKLRSIIDNVSQILALELFAAAQGIDFRRQELGSQARLGRGTGPVYE
CCHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCCCHHHH
LIRQYVPFIAEDTLLHPYITIISELVAQGKIAAAAAVHDDADA
HHHHHHCHHHCCHHHHHHHHHHHHHHHCCCHHHHEECCCCCCC
>Mature Secondary Structure
MQIREVILDGESLTIEQVLAVAYGQPGTPVVRLAPIARQRVERAAQAVQDLLARGVVAYG
CCHHHEEECCCCCCHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCHHHHH
ITTGFGAFKDRVIAPDQVERLQYNILVSHAVGVGPVFDIPTTRAIMLIRANTLARGHSGV
HHHCCHHHHCCCCCCHHHHHHHHHEEEEHHCCCCCCCCCCCCEEEEEEEECHHHCCCCCC
RLQTVERLLDMLNQGIHPRIPCKGSLGASGDLAPLAHMALPLIGLGEVEWQGEVLPAATA
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LERLGWQPLHLAAKEGLALTNGTAVMCALGVIETARAETLSATADIAGCLSLEALYGTPA
HHHCCCCCEEHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AFDARLHALRPFPRQIECAAHLRRLLAGSTFVRNNDPRHVQDAYTLRCIPQVHGAVRDAI
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHCCHHHEEECHHHHHHHHHHH
AYARWVFAIELNAVTDNPLLFVDDDGNVEVISGGNFHGEPLAIALDYLGLAVAELGNIAE
HHHHEEEEEEEEEECCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
RRLMRLTDEASNTHVLPAFLTRAGGLNSGFMIVQYTAAALATENKVLAHPASVDSIPTSA
HHHHHHHCCCCCCEEHHHHHHHCCCCCCCEEEEEEHHHHHHCCCCEEECCCCCCCCCCCC
NVEDHVSMGVTAGLKLRSIIDNVSQILALELFAAAQGIDFRRQELGSQARLGRGTGPVYE
CCHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCCCHHHH
LIRQYVPFIAEDTLLHPYITIISELVAQGKIAAAAAVHDDADA
HHHHHHCHHHCCHHHHHHHHHHHHHHHCCCHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA