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The map label for this gene is guaA [H]

Identifier: 222524339

GI number: 222524339

Start: 1349733

End: 1351274

Strand: Reverse

Name: guaA [H]

Synonym: Chy400_1062

Alternate gene names: 222524339

Gene position: 1351274-1349733 (Counterclockwise)

Preceding gene: 222524341

Following gene: 222524338

Centisome position: 25.65

GC content: 59.47

Gene sequence:

>1542_bases
ATGACCACACACAGCATACCGGTACTGGATTTTGGTTCGCAAACCGCTCAGCTCATCGTGCGGCGGTTGCGTGAGCTAGG
CTACTACAGCGAGTTATTACCACACGACGCCCCCGAAGATCAGGTGCGAGCGCTGGCGCCGGTTGGTATTGTACTCAGCG
GTGGCCCGGCAAGTGTCTACGAACCTGGCGCCCCTACGCTCCCGTCGTGGTTGCTGGAGAGTGATCTACCGGTCTTCGGT
ATCTGCTACGGTATGCAACTAATCAGCCACACCCTGGGCGGGATTGTCACCCGGCCGGCTGGCCGCGAATACGGCCCGGC
GATGATCACCATCACTCATCCGCACCCCCTCTTCGCCGACACCCCAACCGAGCAACCGGTCTGGATGAGCCACGGTGATC
GGATCGAACAGTTGCCCACCGGCTTCACAGCGATTGCTGCCAATCCGGCAACCCCCTTCGCCGCCATTGCTGATGATCGG
CGCAAGTGGTATGGTGTTCAGTTTCACCCCGAAGTGGTGCATACCGTCTATGGCCGAACCATCCTGACCAACTTTGCCCG
TCTGTGTGGGGCACGCCCTGAATGGCAACCGAACAGCTTCGTCGCCGAAGCCATCGAGCGGGTCAAAGCCCAGGTCGGCG
ATCACGGGCGCGTTATCTGTGCGTTGTCTGGCGGTGTCGACTCAGCCGTGGCCGCGCTCATTATTCATCGCGCTATCGGC
GACCGCCTGACCTGCGTCTTTGTTGATAATGGTCTGTTACGGGCAGGCGAAGCGGAACAGGTGATCGCTACCTTCAGCGA
GCATTTTCACGTGCCGCTGATTGCGGTTGATGCCCGCGAAGAGTTTATGACCGCTCTGAAAGGGGTGACTGACCCCGAAC
AGAAGCGCAAAATTATCGGCGAGAAATTCATTCGGATCTTCGAGCGTGAAGCCCGCGCCCTCGCCGGGGTTGAATTCCTC
GCCCAGGGCACTCTCTACCCCGACGTCATCGAGTCGACAGCCCCCGACCGCCCAAAGGCGGCGAAAATTAAAACCCACCA
TAATGTTGGCGGTCTACCAGCCGACATGCAGCTCAAACTGGTCGAGCCGCTGCGCTATCTGTTCAAAGACGAAGTACGCG
CCGCTGGCTTACAACTCGGGCTGCCCGAAACGTGGGTCTGGCGCCATCCCTTCCCTGGGCCGGGGCTGGCAGTGCGTATT
ATCGGTGAAGTAACCTGGGAGCGCCTGGAGATACTGCGGCAGGCGGATAAGATCTTTTTGGAAGAGTTGCATGCCAGTGG
CTATTATCGCGCCACCCAGCAGGCGTTTGCCGTCCTGCTACCGGTACAGAGTGTGGGGGTGATGGGTGATGGTCGTACCT
ACGGCGTCACGATTGCCTTGCGCGCGATTACGACCGAAGACTACATGACCGCCGACTGGGCACGTCTGCCTTACGAGCTG
CTGGCCCACGTGAGCAGCCGCATCGTCAACGAAGTCGAAGGGGTCAATCGGGTTGTGTACGATATTTCGTCGAAGCCACC
GGCAACTATCGAATGGGAGTAG

Upstream 100 bases:

>100_bases
GCGCGTTTTCGTTTGACATGTATTCCTGCCCGAAACAGCGTAAATCGCCACCTGACGCGGAGCAGTCGGCGGGAACATCT
ATACCTGATGAGGACACCAC

Downstream 100 bases:

>100_bases
TCAGCATCGGCAGCGCCGTGCTACAATAGAGCCATGCGCATACCACGAACAATCGCAATTGACGGCCAATCGGCCGCAGG
GAAAAGTACATTAGGTGCAC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTTHSIPVLDFGSQTAQLIVRRLRELGYYSELLPHDAPEDQVRALAPVGIVLSGGPASVYEPGAPTLPSWLLESDLPVFG
ICYGMQLISHTLGGIVTRPAGREYGPAMITITHPHPLFADTPTEQPVWMSHGDRIEQLPTGFTAIAANPATPFAAIADDR
RKWYGVQFHPEVVHTVYGRTILTNFARLCGARPEWQPNSFVAEAIERVKAQVGDHGRVICALSGGVDSAVAALIIHRAIG
DRLTCVFVDNGLLRAGEAEQVIATFSEHFHVPLIAVDAREEFMTALKGVTDPEQKRKIIGEKFIRIFEREARALAGVEFL
AQGTLYPDVIESTAPDRPKAAKIKTHHNVGGLPADMQLKLVEPLRYLFKDEVRAAGLQLGLPETWVWRHPFPGPGLAVRI
IGEVTWERLEILRQADKIFLEELHASGYYRATQQAFAVLLPVQSVGVMGDGRTYGVTIALRAITTEDYMTADWARLPYEL
LAHVSSRIVNEVEGVNRVVYDISSKPPATIEWE

Sequences:

>Translated_513_residues
MTTHSIPVLDFGSQTAQLIVRRLRELGYYSELLPHDAPEDQVRALAPVGIVLSGGPASVYEPGAPTLPSWLLESDLPVFG
ICYGMQLISHTLGGIVTRPAGREYGPAMITITHPHPLFADTPTEQPVWMSHGDRIEQLPTGFTAIAANPATPFAAIADDR
RKWYGVQFHPEVVHTVYGRTILTNFARLCGARPEWQPNSFVAEAIERVKAQVGDHGRVICALSGGVDSAVAALIIHRAIG
DRLTCVFVDNGLLRAGEAEQVIATFSEHFHVPLIAVDAREEFMTALKGVTDPEQKRKIIGEKFIRIFEREARALAGVEFL
AQGTLYPDVIESTAPDRPKAAKIKTHHNVGGLPADMQLKLVEPLRYLFKDEVRAAGLQLGLPETWVWRHPFPGPGLAVRI
IGEVTWERLEILRQADKIFLEELHASGYYRATQQAFAVLLPVQSVGVMGDGRTYGVTIALRAITTEDYMTADWARLPYEL
LAHVSSRIVNEVEGVNRVVYDISSKPPATIEWE
>Mature_512_residues
TTHSIPVLDFGSQTAQLIVRRLRELGYYSELLPHDAPEDQVRALAPVGIVLSGGPASVYEPGAPTLPSWLLESDLPVFGI
CYGMQLISHTLGGIVTRPAGREYGPAMITITHPHPLFADTPTEQPVWMSHGDRIEQLPTGFTAIAANPATPFAAIADDRR
KWYGVQFHPEVVHTVYGRTILTNFARLCGARPEWQPNSFVAEAIERVKAQVGDHGRVICALSGGVDSAVAALIIHRAIGD
RLTCVFVDNGLLRAGEAEQVIATFSEHFHVPLIAVDAREEFMTALKGVTDPEQKRKIIGEKFIRIFEREARALAGVEFLA
QGTLYPDVIESTAPDRPKAAKIKTHHNVGGLPADMQLKLVEPLRYLFKDEVRAAGLQLGLPETWVWRHPFPGPGLAVRII
GEVTWERLEILRQADKIFLEELHASGYYRATQQAFAVLLPVQSVGVMGDGRTYGVTIALRAITTEDYMTADWARLPYELL
AHVSSRIVNEVEGVNRVVYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=548, Percent_Identity=34.4890510948905, Blast_Score=266, Evalue=3e-71,
Organism=Escherichia coli, GI1788854, Length=519, Percent_Identity=52.9865125240848, Blast_Score=565, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI133901714, Length=567, Percent_Identity=35.8024691358025, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71992717, Length=567, Percent_Identity=35.626102292769, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71992710, Length=567, Percent_Identity=35.626102292769, Blast_Score=285, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6323873, Length=515, Percent_Identity=52.0388349514563, Blast_Score=535, Evalue=1e-153,
Organism=Drosophila melanogaster, GI281365319, Length=551, Percent_Identity=34.3012704174229, Blast_Score=272, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56573; Mature: 56441

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHSIPVLDFGSQTAQLIVRRLRELGYYSELLPHDAPEDQVRALAPVGIVLSGGPASVY
CCCCCCCEEECCCHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCEEEEEECCCCCCC
EPGAPTLPSWLLESDLPVFGICYGMQLISHTLGGIVTRPAGREYGPAMITITHPHPLFAD
CCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCC
TPTEQPVWMSHGDRIEQLPTGFTAIAANPATPFAAIADDRRKWYGVQFHPEVVHTVYGRT
CCCCCCEECCCCCHHHHCCCCCEEEECCCCCCHHHHHCCHHHEECCEECHHHHHHHHHHH
ILTNFARLCGARPEWQPNSFVAEAIERVKAQVGDHGRVICALSGGVDSAVAALIIHRAIG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHC
DRLTCVFVDNGLLRAGEAEQVIATFSEHFHVPLIAVDAREEFMTALKGVTDPEQKRKIIG
CCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHH
EKFIRIFEREARALAGVEFLAQGTLYPDVIESTAPDRPKAAKIKTHHNVGGLPADMQLKL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHH
VEPLRYLFKDEVRAAGLQLGLPETWVWRHPFPGPGLAVRIIGEVTWERLEILRQADKIFL
HHHHHHHHHHHHHHCCEECCCCCCEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
EELHASGYYRATQQAFAVLLPVQSVGVMGDGRTYGVTIALRAITTEDYMTADWARLPYEL
HHHHCCCCHHHHHHHHHHHEEHHHHCEECCCCEEEEEEEEEEEECCCHHCCHHHHCCHHH
LAHVSSRIVNEVEGVNRVVYDISSKPPATIEWE
HHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC
>Mature Secondary Structure 
TTHSIPVLDFGSQTAQLIVRRLRELGYYSELLPHDAPEDQVRALAPVGIVLSGGPASVY
CCCCCCEEECCCHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCEEEEEECCCCCCC
EPGAPTLPSWLLESDLPVFGICYGMQLISHTLGGIVTRPAGREYGPAMITITHPHPLFAD
CCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCC
TPTEQPVWMSHGDRIEQLPTGFTAIAANPATPFAAIADDRRKWYGVQFHPEVVHTVYGRT
CCCCCCEECCCCCHHHHCCCCCEEEECCCCCCHHHHHCCHHHEECCEECHHHHHHHHHHH
ILTNFARLCGARPEWQPNSFVAEAIERVKAQVGDHGRVICALSGGVDSAVAALIIHRAIG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHC
DRLTCVFVDNGLLRAGEAEQVIATFSEHFHVPLIAVDAREEFMTALKGVTDPEQKRKIIG
CCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHH
EKFIRIFEREARALAGVEFLAQGTLYPDVIESTAPDRPKAAKIKTHHNVGGLPADMQLKL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHH
VEPLRYLFKDEVRAAGLQLGLPETWVWRHPFPGPGLAVRIIGEVTWERLEILRQADKIFL
HHHHHHHHHHHHHHCCEECCCCCCEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
EELHASGYYRATQQAFAVLLPVQSVGVMGDGRTYGVTIALRAITTEDYMTADWARLPYEL
HHHHCCCCHHHHHHHHHHHEEHHHHCEECCCCEEEEEEEEEEEECCCHHCCHHHHCCHHH
LAHVSSRIVNEVEGVNRVVYDISSKPPATIEWE
HHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA