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The map label for this gene is appC [H]

Identifier: 222524136

GI number: 222524136

Start: 1075357

End: 1076385

Strand: Direct

Name: appC [H]

Synonym: Chy400_0852

Alternate gene names: 222524136

Gene position: 1075357-1076385 (Clockwise)

Preceding gene: 222524135

Following gene: 222524137

Centisome position: 20.41

GC content: 56.17

Gene sequence:

>1029_bases
ATGTCTGAAATAGAAATGAACGGCGCCATAGGGATTTCGGCCAGTGCCCGTGCCCAGCAGATGACCACGCGGATGGCGGC
GAAACCACGTTCGCTGCTTAGCGATGCCTGGCGGCGCTTTCGCAAGCATCGCATGGCAATGCTGGGGGTCGTTATACTGT
TCACACTGGCCCTGTTCTCATTTGTTGGGCCATATTTCTATGTACCGCGTCTGGCCGCAGAACTAGAGGCAATTGGCTCA
CCATTTTTGCAGGATCGGGTTGACCTGCAAACGGCAATTGACCATCTCGATTTTCTTAATATTCTCTCGGCGCCGAGTGC
CATTCATCCCTTCGGAACCGATGATCTCGGTCGTGATTTGCTGGCACGCACTTTGTACGGTGGCCGGGTTTCTCTGCTGG
TCGGTCTGACCGCGATGGCAATTGCGATTTCGCTCGGTACCATCATTGGTGCCACCGCCGGTTTCCTGGGAGGGGTTGTT
GATCAGATTTTGATGCGGATTACCGATCTGTTTCTCTCGCTACCGGCCATTCCCCTTACGTTGCTGGTGGTCTATCTGTT
CCGCGATCCGGTCATTCAACTCATGGGGTCGCCGGAAGCCGGTATCTTCACGATTGTGGTCACGGTGATCGGGAGTCTGG
CCTGGATGAGTACGGCCCGGATTGTGCGCGCCACCTTCCTGTCGCTTAAGGAGAAGGAGTTTGTTGAGGCCGCCATTGCG
CTGGGTATCAGCCGTCCGGCAATTATGTTTCGCCACATTCTACCCAACGCCATCGGTCCGATTATCGTCGCTGCAACGCT
GGAAGTGGGGAGTGCGATTATCACCGAGTCAACCCTGTCGTTCCTGGGTGTCGGTTTCCCACCTGATACACCGACCTGGG
GCCGGCTGGTGACCGACGGCAGCCAGTATTTGCAGGCAGCCCCCTGGCTGGCCCTCTTCCCCGGTATGTTGATCTTTCTG
ACGGTGCTTAGCATTAATTTCGTCGGTGATGGTCTGCGCGATGCACTCGATCCACGTTCACGGCTGTAA

Upstream 100 bases:

>100_bases
TTGACGGTGGTGTTTAATTTGATTGCCGATATTCTCTACGGTGTGCTCGATCCACGAGTACGCTATTCGTAAACGAGAGG
CAACCGGAAGGGGTTAGCGT

Downstream 100 bases:

>100_bases
GATTGGGTTGAGCCGATGAGCCGCAATCTCACACCGCTGCAACAACTGGTCGTTGAAGCGCTGCAAGAAGACGAGCGTCT
GACCGCCGGCTTATCCGATG

Product: binding-protein-dependent transport systems inner membrane component

Products: ADP; phosphate; oligopeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSEIEMNGAIGISASARAQQMTTRMAAKPRSLLSDAWRRFRKHRMAMLGVVILFTLALFSFVGPYFYVPRLAAELEAIGS
PFLQDRVDLQTAIDHLDFLNILSAPSAIHPFGTDDLGRDLLARTLYGGRVSLLVGLTAMAIAISLGTIIGATAGFLGGVV
DQILMRITDLFLSLPAIPLTLLVVYLFRDPVIQLMGSPEAGIFTIVVTVIGSLAWMSTARIVRATFLSLKEKEFVEAAIA
LGISRPAIMFRHILPNAIGPIIVAATLEVGSAIITESTLSFLGVGFPPDTPTWGRLVTDGSQYLQAAPWLALFPGMLIFL
TVLSINFVGDGLRDALDPRSRL

Sequences:

>Translated_342_residues
MSEIEMNGAIGISASARAQQMTTRMAAKPRSLLSDAWRRFRKHRMAMLGVVILFTLALFSFVGPYFYVPRLAAELEAIGS
PFLQDRVDLQTAIDHLDFLNILSAPSAIHPFGTDDLGRDLLARTLYGGRVSLLVGLTAMAIAISLGTIIGATAGFLGGVV
DQILMRITDLFLSLPAIPLTLLVVYLFRDPVIQLMGSPEAGIFTIVVTVIGSLAWMSTARIVRATFLSLKEKEFVEAAIA
LGISRPAIMFRHILPNAIGPIIVAATLEVGSAIITESTLSFLGVGFPPDTPTWGRLVTDGSQYLQAAPWLALFPGMLIFL
TVLSINFVGDGLRDALDPRSRL
>Mature_341_residues
SEIEMNGAIGISASARAQQMTTRMAAKPRSLLSDAWRRFRKHRMAMLGVVILFTLALFSFVGPYFYVPRLAAELEAIGSP
FLQDRVDLQTAIDHLDFLNILSAPSAIHPFGTDDLGRDLLARTLYGGRVSLLVGLTAMAIAISLGTIIGATAGFLGGVVD
QILMRITDLFLSLPAIPLTLLVVYLFRDPVIQLMGSPEAGIFTIVVTVIGSLAWMSTARIVRATFLSLKEKEFVEAAIAL
GISRPAIMFRHILPNAIGPIIVAATLEVGSAIITESTLSFLGVGFPPDTPTWGRLVTDGSQYLQAAPWLALFPGMLIFLT
VLSINFVGDGLRDALDPRSRL

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787498, Length=329, Percent_Identity=37.9939209726444, Blast_Score=195, Evalue=3e-51,
Organism=Escherichia coli, GI1787054, Length=316, Percent_Identity=36.3924050632911, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1787760, Length=247, Percent_Identity=37.246963562753, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789964, Length=236, Percent_Identity=40.6779661016949, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1789889, Length=244, Percent_Identity=34.0163934426229, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1788505, Length=344, Percent_Identity=30.8139534883721, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1787549, Length=323, Percent_Identity=28.4829721362229, Blast_Score=103, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 36912; Mature: 36781

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIEMNGAIGISASARAQQMTTRMAAKPRSLLSDAWRRFRKHRMAMLGVVILFTLALFS
CCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVGPYFYVPRLAAELEAIGSPFLQDRVDLQTAIDHLDFLNILSAPSAIHPFGTDDLGRDL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
LARTLYGGRVSLLVGLTAMAIAISLGTIIGATAGFLGGVVDQILMRITDLFLSLPAIPLT
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LLVVYLFRDPVIQLMGSPEAGIFTIVVTVIGSLAWMSTARIVRATFLSLKEKEFVEAAIA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGISRPAIMFRHILPNAIGPIIVAATLEVGSAIITESTLSFLGVGFPPDTPTWGRLVTDG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCH
SQYLQAAPWLALFPGMLIFLTVLSINFVGDGLRDALDPRSRL
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
>Mature Secondary Structure 
SEIEMNGAIGISASARAQQMTTRMAAKPRSLLSDAWRRFRKHRMAMLGVVILFTLALFS
CCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVGPYFYVPRLAAELEAIGSPFLQDRVDLQTAIDHLDFLNILSAPSAIHPFGTDDLGRDL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
LARTLYGGRVSLLVGLTAMAIAISLGTIIGATAGFLGGVVDQILMRITDLFLSLPAIPLT
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LLVVYLFRDPVIQLMGSPEAGIFTIVVTVIGSLAWMSTARIVRATFLSLKEKEFVEAAIA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGISRPAIMFRHILPNAIGPIIVAATLEVGSAIITESTLSFLGVGFPPDTPTWGRLVTDG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCH
SQYLQAAPWLALFPGMLIFLTVLSINFVGDGLRDALDPRSRL
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; oligopeptides [Periplasm]; H2O [C]

Specific reaction: ATP + oligopeptides [Periplasm] + H2O = ADP + phosphate + oligopeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]