Click here to switch to the map view.

The map label for this gene is glcD [H]

Identifier: 222524018

GI number: 222524018

Start: 916698

End: 919007

Strand: Direct

Name: glcD [H]

Synonym: Chy400_0733

Alternate gene names: 222524018

Gene position: 916698-919007 (Clockwise)

Preceding gene: 222524017

Following gene: 222524019

Centisome position: 17.4

GC content: 62.6

Gene sequence:

>2310_bases
ATGAACTATAGCGCACAACCAGATATGACCACCACGTCCACAGGTTTCACCATCAATGCCGGTGCACTGCTGGCAAGCGC
ACCGGCAACCGCAACCGCAACCGCCCTTAATGAAGCTCTGGCCGCATACGGTCTCTGTCTGCCGGTTGCCCCGTTACACA
CCGACGCAACGCTCGCCGAACTGGTAGCCTGTAACAGTGGTGGTCGGTATCGGTTGTACAGCGGGCCAATCGGTCGCTAT
GTGCGGGCAGCAACCCTGGAAACCGCCAGTGGTCTGTTGCACGTCGGCGGCCCAACCCTCAAGCGGGCAACTGGCTACAA
CCTGCACCGCGCACTGGCCGGGCAGGGCGTGCGCCTCGGTGATCTGCGTGAATTGACGTTCAATTTGCGCCCTTTGCCGG
CAATGACCACCCTGTACCTGGTAGCGGGGCCGCTTGACCGGTTGTTGATGCTGGCAGCCGATCTAATGACCGCCAATCTG
GAGCTGCGGGCATTAGCGTTCGATGCCGGTGGATTGCTCCTCATCGCCCTGGCCGGCCTGCCAGAAGTGGTGACTCGCCA
GTCGCAGCAGGTACTGGCAATGGCAGATCTCCATCAGCTCGCCGTTACCCGTGACCCCGCCAACGGCTGGCGGCATTGGG
AAGAGCTTGCGCGCCGGCATTGTGCTCTGCCCGCCGACCAACGCCTCGATATGACACTACCGCGCAGCAAACTGGCCGAG
GGGATCGCCGCCTGTCGGCAGATCGGTGATGCCGCTACCACCATCTGGGGCGATCTGGGTGTAGGGAGCATCCACGTCAC
GCCATTACCTGACGCCCGGCGCTATGCAACGTTGAAAGCGCAGCTAGCCACACTCGGCGCTCAACCGTGTTACGAGTTTG
GCCCACCGCCACAACCGCCCTATCCAACCCTGACCCCTCGCAAGCACCAGACGCCTGGCGATTGTATCGCTGCCCTCAAA
CAGGTGGTTGGTGACCGTTACCTGATCCACCATCCCGACCAACTGGCGGTCTACGGGCAGGACGCCTCGATTGCCGAGGC
CGAAGCATTGCCGTATGCGGTCGCCTTACCGGCCAGCACGGCTGAAGTCGCCGCCCTGATGCAGATTGCGGCTGCACATG
ATCTGCCGGTAGTTACCCGTGGGGCCGGCAGTGGCCTGGCAGGCGGCGCCGTACCAACACCGGGGTGCCTGGTGATTGGC
CTGAACCGCATGGAACAGATAACTATTGATCGCGGGCAACAGGTTGCCCACGTGGGCGCCGGTGTCATCACTGCCGAACT
ACAACGGGCCGCCGAGCGCGTTGGCCTCTTCTACCCCCCCGATCCGAGCAGTCAGGCGGCCTCGACCATCGGCGGCAATA
TCGCCTGCAACGCCGGTGGGCCGCGGTGTCTGAAATATGGAGTAACTGCCGATTACGTATTGGGATTAACGACGGTACTG
GCCGACGGCTCCATCGCCCGCTACGGCGATGGCCTGGCCGGTCAGGGTGAGAGCGATGGATTAGTGCAACTCCTTGTCGG
CTCCGAAGGAACCCTGGCCGTGATTACCGAGGCAACCCTGCGGCTGATCCCACTGCCCCGCGCCCGCCGCACGACCATGG
CGATCTTCGCCGATCTGGCCGCAGCCTGTGCCACAGTCGAACGGATCATGGCATCGGGGATTATTCCAGCCAGTCTGGAG
CTGATGGATGACACCACTATCGCCGCCGTGGAAGCGTATCTGCGCATCGGCCTGCCGGCTGATGCCGGAGCGATGTTATT
AATGCTGGCCGATGGTGAACCGGAAGCGGTTGAACGCGACGCAGCAGCCCTGGCCGAACTGGCAAAGGCCGGCGGCGCAC
AACGGGTAGCAGTGGCGCGCAACGCCACCGACGAAGCAAACCTCTGGCAGGCACGACGAGTGATCGCACCGGCCCTGGCT
CGCATTCGCCCTAACCGATTGGGTGAAGACATCAGCGTACCGGTGACCCGCATCGCCGAATGTGTCGGCCAGATCAAGCA
GGTAAGCGCCACCTACGGCCTGCCTATCGTAGTCTTTGGTCATGCCGGCGACGGCAACCTGCATCCAAACATCCTCTTCG
ATGCCCGCAATCCGACCGAAGTGGCGCGATTATGGCCGTGCGCAGAAGCCGTCTTCAAAGTGGCGCTGGCCGTGGGTGGT
ACGCTGTCGGGAGAGCACGGTATCGGCACCCTCAAACGACCATTCATGACCCAGGCGCTCGGTGAGGCCCAGCTTGCTGT
GCAACGTCAGATCAAAGCCCATTTCGACCCCACCGGTCGGCTGAATCCTGGCAAAGTACTCCCGGTATGA

Upstream 100 bases:

>100_bases
CGGCCATCAGAATGGATGAGATTGCTGCGGCAATTGCGCTGGTAGTAGATTATAATCCTGCCGGGTAAGTCAACGACCGC
AACCCAACCAACGTATACGC

Downstream 100 bases:

>100_bases
TGATCACCAGCCTCGCCAATCCAACCATCAAAGCCCTGCGTGCGCTCAGGCAACGCAAAGCTCGCGACGAGCAGGGGCGC
TACCTGATTGAAGGGATTCG

Product: D-lactate dehydrogenase

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 769; Mature: 769

Protein sequence:

>769_residues
MNYSAQPDMTTTSTGFTINAGALLASAPATATATALNEALAAYGLCLPVAPLHTDATLAELVACNSGGRYRLYSGPIGRY
VRAATLETASGLLHVGGPTLKRATGYNLHRALAGQGVRLGDLRELTFNLRPLPAMTTLYLVAGPLDRLLMLAADLMTANL
ELRALAFDAGGLLLIALAGLPEVVTRQSQQVLAMADLHQLAVTRDPANGWRHWEELARRHCALPADQRLDMTLPRSKLAE
GIAACRQIGDAATTIWGDLGVGSIHVTPLPDARRYATLKAQLATLGAQPCYEFGPPPQPPYPTLTPRKHQTPGDCIAALK
QVVGDRYLIHHPDQLAVYGQDASIAEAEALPYAVALPASTAEVAALMQIAAAHDLPVVTRGAGSGLAGGAVPTPGCLVIG
LNRMEQITIDRGQQVAHVGAGVITAELQRAAERVGLFYPPDPSSQAASTIGGNIACNAGGPRCLKYGVTADYVLGLTTVL
ADGSIARYGDGLAGQGESDGLVQLLVGSEGTLAVITEATLRLIPLPRARRTTMAIFADLAAACATVERIMASGIIPASLE
LMDDTTIAAVEAYLRIGLPADAGAMLLMLADGEPEAVERDAAALAELAKAGGAQRVAVARNATDEANLWQARRVIAPALA
RIRPNRLGEDISVPVTRIAECVGQIKQVSATYGLPIVVFGHAGDGNLHPNILFDARNPTEVARLWPCAEAVFKVALAVGG
TLSGEHGIGTLKRPFMTQALGEAQLAVQRQIKAHFDPTGRLNPGKVLPV

Sequences:

>Translated_769_residues
MNYSAQPDMTTTSTGFTINAGALLASAPATATATALNEALAAYGLCLPVAPLHTDATLAELVACNSGGRYRLYSGPIGRY
VRAATLETASGLLHVGGPTLKRATGYNLHRALAGQGVRLGDLRELTFNLRPLPAMTTLYLVAGPLDRLLMLAADLMTANL
ELRALAFDAGGLLLIALAGLPEVVTRQSQQVLAMADLHQLAVTRDPANGWRHWEELARRHCALPADQRLDMTLPRSKLAE
GIAACRQIGDAATTIWGDLGVGSIHVTPLPDARRYATLKAQLATLGAQPCYEFGPPPQPPYPTLTPRKHQTPGDCIAALK
QVVGDRYLIHHPDQLAVYGQDASIAEAEALPYAVALPASTAEVAALMQIAAAHDLPVVTRGAGSGLAGGAVPTPGCLVIG
LNRMEQITIDRGQQVAHVGAGVITAELQRAAERVGLFYPPDPSSQAASTIGGNIACNAGGPRCLKYGVTADYVLGLTTVL
ADGSIARYGDGLAGQGESDGLVQLLVGSEGTLAVITEATLRLIPLPRARRTTMAIFADLAAACATVERIMASGIIPASLE
LMDDTTIAAVEAYLRIGLPADAGAMLLMLADGEPEAVERDAAALAELAKAGGAQRVAVARNATDEANLWQARRVIAPALA
RIRPNRLGEDISVPVTRIAECVGQIKQVSATYGLPIVVFGHAGDGNLHPNILFDARNPTEVARLWPCAEAVFKVALAVGG
TLSGEHGIGTLKRPFMTQALGEAQLAVQRQIKAHFDPTGRLNPGKVLPV
>Mature_769_residues
MNYSAQPDMTTTSTGFTINAGALLASAPATATATALNEALAAYGLCLPVAPLHTDATLAELVACNSGGRYRLYSGPIGRY
VRAATLETASGLLHVGGPTLKRATGYNLHRALAGQGVRLGDLRELTFNLRPLPAMTTLYLVAGPLDRLLMLAADLMTANL
ELRALAFDAGGLLLIALAGLPEVVTRQSQQVLAMADLHQLAVTRDPANGWRHWEELARRHCALPADQRLDMTLPRSKLAE
GIAACRQIGDAATTIWGDLGVGSIHVTPLPDARRYATLKAQLATLGAQPCYEFGPPPQPPYPTLTPRKHQTPGDCIAALK
QVVGDRYLIHHPDQLAVYGQDASIAEAEALPYAVALPASTAEVAALMQIAAAHDLPVVTRGAGSGLAGGAVPTPGCLVIG
LNRMEQITIDRGQQVAHVGAGVITAELQRAAERVGLFYPPDPSSQAASTIGGNIACNAGGPRCLKYGVTADYVLGLTTVL
ADGSIARYGDGLAGQGESDGLVQLLVGSEGTLAVITEATLRLIPLPRARRTTMAIFADLAAACATVERIMASGIIPASLE
LMDDTTIAAVEAYLRIGLPADAGAMLLMLADGEPEAVERDAAALAELAKAGGAQRVAVARNATDEANLWQARRVIAPALA
RIRPNRLGEDISVPVTRIAECVGQIKQVSATYGLPIVVFGHAGDGNLHPNILFDARNPTEVARLWPCAEAVFKVALAVGG
TLSGEHGIGTLKRPFMTQALGEAQLAVQRQIKAHFDPTGRLNPGKVLPV

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=460, Percent_Identity=32.1739130434783, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI37595754, Length=483, Percent_Identity=30.8488612836439, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI119964728, Length=420, Percent_Identity=31.1904761904762, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI4501993, Length=458, Percent_Identity=23.3624454148472, Blast_Score=105, Evalue=2e-22,
Organism=Escherichia coli, GI1789351, Length=455, Percent_Identity=36.4835164835165, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI48994907, Length=444, Percent_Identity=24.7747747747748, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI1787977, Length=287, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71992373, Length=457, Percent_Identity=29.9781181619256, Blast_Score=191, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17534361, Length=424, Percent_Identity=29.7169811320755, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71992381, Length=460, Percent_Identity=29.1304347826087, Blast_Score=169, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71992392, Length=347, Percent_Identity=31.4121037463977, Blast_Score=168, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17556096, Length=467, Percent_Identity=23.1263383297645, Blast_Score=104, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320027, Length=483, Percent_Identity=26.5010351966874, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320023, Length=494, Percent_Identity=24.8987854251012, Blast_Score=157, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6320764, Length=456, Percent_Identity=25.4385964912281, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI18921117, Length=477, Percent_Identity=27.2536687631027, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24639277, Length=477, Percent_Identity=27.2536687631027, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24639275, Length=477, Percent_Identity=27.2536687631027, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24653753, Length=485, Percent_Identity=23.7113402061856, Blast_Score=95, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 80377; Mature: 80377

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYSAQPDMTTTSTGFTINAGALLASAPATATATALNEALAAYGLCLPVAPLHTDATLAE
CCCCCCCCCCCCCCCEEEECCHHEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LVACNSGGRYRLYSGPIGRYVRAATLETASGLLHVGGPTLKRATGYNLHRALAGQGVRLG
HHHCCCCCCEEEECCCHHHHHHHHHHHHHCCEEECCCCHHHHCCCCCHHHHHHCCCCEEC
DLRELTFNLRPLPAMTTLYLVAGPLDRLLMLAADLMTANLELRALAFDAGGLLLIALAGL
CHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEHHCC
PEVVTRQSQQVLAMADLHQLAVTRDPANGWRHWEELARRHCALPADQRLDMTLPRSKLAE
HHHHHCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
GIAACRQIGDAATTIWGDLGVGSIHVTPLPDARRYATLKAQLATLGAQPCYEFGPPPQPP
HHHHHHHHCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHCCCCCCCC
YPTLTPRKHQTPGDCIAALKQVVGDRYLIHHPDQLAVYGQDASIAEAEALPYAVALPAST
CCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCHHHHCCCEEEECCCCH
AEVAALMQIAAAHDLPVVTRGAGSGLAGGAVPTPGCLVIGLNRMEQITIDRGQQVAHVGA
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEECCCHHEEECCCCCEEHHHCC
GVITAELQRAAERVGLFYPPDPSSQAASTIGGNIACNAGGPRCLKYGVTADYVLGLTTVL
HHHHHHHHHHHHHCCEECCCCCCHHHHHHCCCCEEECCCCCCEEEECCCHHHHHHHHHHH
ADGSIARYGDGLAGQGESDGLVQLLVGSEGTLAVITEATLRLIPLPRARRTTMAIFADLA
CCCCHHHCCCCCCCCCCCCCEEEEEECCCCCEEEEEECEEEEECCCCCHHHHHHHHHHHH
AACATVERIMASGIIPASLELMDDTTIAAVEAYLRIGLPADAGAMLLMLADGEPEAVERD
HHHHHHHHHHHCCCCCCEEEHHCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHH
AAALAELAKAGGAQRVAVARNATDEANLWQARRVIAPALARIRPNRLGEDISVPVTRIAE
HHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHH
CVGQIKQVSATYGLPIVVFGHAGDGNLHPNILFDARNPTEVARLWPCAEAVFKVALAVGG
HHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
TLSGEHGIGTLKRPFMTQALGEAQLAVQRQIKAHFDPTGRLNPGKVLPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNYSAQPDMTTTSTGFTINAGALLASAPATATATALNEALAAYGLCLPVAPLHTDATLAE
CCCCCCCCCCCCCCCEEEECCHHEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LVACNSGGRYRLYSGPIGRYVRAATLETASGLLHVGGPTLKRATGYNLHRALAGQGVRLG
HHHCCCCCCEEEECCCHHHHHHHHHHHHHCCEEECCCCHHHHCCCCCHHHHHHCCCCEEC
DLRELTFNLRPLPAMTTLYLVAGPLDRLLMLAADLMTANLELRALAFDAGGLLLIALAGL
CHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEHHCC
PEVVTRQSQQVLAMADLHQLAVTRDPANGWRHWEELARRHCALPADQRLDMTLPRSKLAE
HHHHHCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
GIAACRQIGDAATTIWGDLGVGSIHVTPLPDARRYATLKAQLATLGAQPCYEFGPPPQPP
HHHHHHHHCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHCCCCCCCC
YPTLTPRKHQTPGDCIAALKQVVGDRYLIHHPDQLAVYGQDASIAEAEALPYAVALPAST
CCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCHHHHCCCEEEECCCCH
AEVAALMQIAAAHDLPVVTRGAGSGLAGGAVPTPGCLVIGLNRMEQITIDRGQQVAHVGA
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEECCCHHEEECCCCCEEHHHCC
GVITAELQRAAERVGLFYPPDPSSQAASTIGGNIACNAGGPRCLKYGVTADYVLGLTTVL
HHHHHHHHHHHHHCCEECCCCCCHHHHHHCCCCEEECCCCCCEEEECCCHHHHHHHHHHH
ADGSIARYGDGLAGQGESDGLVQLLVGSEGTLAVITEATLRLIPLPRARRTTMAIFADLA
CCCCHHHCCCCCCCCCCCCCEEEEEECCCCCEEEEEECEEEEECCCCCHHHHHHHHHHHH
AACATVERIMASGIIPASLELMDDTTIAAVEAYLRIGLPADAGAMLLMLADGEPEAVERD
HHHHHHHHHHHCCCCCCEEEHHCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHH
AAALAELAKAGGAQRVAVARNATDEANLWQARRVIAPALARIRPNRLGEDISVPVTRIAE
HHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHH
CVGQIKQVSATYGLPIVVFGHAGDGNLHPNILFDARNPTEVARLWPCAEAVFKVALAVGG
HHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
TLSGEHGIGTLKRPFMTQALGEAQLAVQRQIKAHFDPTGRLNPGKVLPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]