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The map label for this gene is guaB [H]

Identifier: 222523951

GI number: 222523951

Start: 824191

End: 825672

Strand: Direct

Name: guaB [H]

Synonym: Chy400_0666

Alternate gene names: 222523951

Gene position: 824191-825672 (Clockwise)

Preceding gene: 222523949

Following gene: 222523952

Centisome position: 15.64

GC content: 57.96

Gene sequence:

>1482_bases
ATGGGCATTGCCTGGGAAGAAAAATTTACCCGCGAAGGATTGACGTTCGACGATGTGTTGCTCATTCCGGCAGAATCTGA
TGTCTTACCAGCCACAGTCGATGTCTCAACCTGGCTCACCCGCAACATTCGCCTCAATATCCCCATCGTCAGCGCAGCGA
TGGACACCGTTACCGAGCACCGGCTGGCAATTGCTTTGGCCCGTGAGGGAGGGATCGGGATCATTCACAAAAATATGCCC
ATTGCCAGTCAGGCCGAAATGGTACGCAAGGTGAAACGCTCAGAGAGCGGTATGATCACCGATCCAATCACCCTTCCGCC
CGACCGCACAGTGGGCGATGCACTCGATCTGATGGCCGAATACAAGATTTCCGGCGTTCCGGTCACAACTGCCGATGGCG
ATCTGGTCGGGATCATCACCAATCGCGATTTGCGGTTCGAGACCGATCGTAACCGCCCGATTCGCGATCTGATGACATCG
CGGAATCTGGTGACGGTGCCCGAAGGCACAACGCTCGAAGAGGCGAAGGAGGTCTTACACCGCCACCGGATCGAGAAGGT
ACTGGTTGTGGACGAACGCGGTAAGCTGAGTGGCATGATTACCGTCAAAGACATCATGAAGCGGATCGAGTATCCGCACG
CCTGCAAAGATGACATGGGACGGCTGCGCGTTGGCGCAGCCGTCGGCGTTAGTGGCGATTACATCGAGCGGGCGACCGAA
CTGGTGCGCGCCGGGGTTGATGTGCTGGTCATCGATACCGCTCACGGCCATTCGCGTGGCGTATTGAATGCCGTGGTCAA
ATTACGCGAATTGTTCCCACGGGTTCAGATCATTGGCGGCAATGTCTCAACTGCTGCCGCAACCATTGCCCTGATCGAGC
GTGGGGTCGATGGGGTCAAAGTCGGACAGGGACCAGGCTCCATCTGCACGACCCGAGTCGTCACCGGTGCCGGCATGCCG
CAGATCACGGCAATTTTCGATTGCGCACGCGCCGCCGAACCCTACGGCATCCCAATCATTGCCGATGGCGGTATCAAATA
TTCTGGTGATATTCCAAAGGCAATTGCTGCCGGTGCCCACAGCGTGATGATCGGCTCGATCTTCGCCGGCACCGAAGAGA
GTCCCGGCGAACTCATCCTGTACGAGGGGCGCAGTTACAAGAGCTACCGTGGAATGGGGAGCATCGGCGCTATGCAGCGC
GGTGGTGGTGATCGCTACTTCCAGACCAATGTGACCGAGGCGCGCAAACTGGTTGCCGAGGGCATCGAAGGCATGGTGCC
GTTCAAAGGGCCACTGAGCGATACCGTCTACCAACTGGTAGGTGGTTTGCGCGCCGGGATGGGCTATGTCGGAGCAGCCA
ACATCGAAGCCCTGCGCCGCGATGCCCGCTTCATTCGGATCACCACTGCCGGACAGATCGAAAGCCATCCGCACGATGTA
GTGATTACCAAGCAGGCCCCGAATTATGGCGGTCGTCAGTAA

Upstream 100 bases:

>100_bases
ATCCACCAATGCGCACGGTACCGTCTCAATGCGGTAGTCTTCGATCCCCCTGCGCCGACCGCGGGGGATTTTTGTACATC
ATTATGATGTGGAGGTCACT

Downstream 100 bases:

>100_bases
GCGGTGTCTACGCAACCAGGTGCGCTGTTTGACCACAGCGCACCCGTTCTGGCGAGGCTGACCAGAAAACCGTTCCGCGT
CGTGATGCACGTATCGCGTG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MGIAWEEKFTREGLTFDDVLLIPAESDVLPATVDVSTWLTRNIRLNIPIVSAAMDTVTEHRLAIALAREGGIGIIHKNMP
IASQAEMVRKVKRSESGMITDPITLPPDRTVGDALDLMAEYKISGVPVTTADGDLVGIITNRDLRFETDRNRPIRDLMTS
RNLVTVPEGTTLEEAKEVLHRHRIEKVLVVDERGKLSGMITVKDIMKRIEYPHACKDDMGRLRVGAAVGVSGDYIERATE
LVRAGVDVLVIDTAHGHSRGVLNAVVKLRELFPRVQIIGGNVSTAAATIALIERGVDGVKVGQGPGSICTTRVVTGAGMP
QITAIFDCARAAEPYGIPIIADGGIKYSGDIPKAIAAGAHSVMIGSIFAGTEESPGELILYEGRSYKSYRGMGSIGAMQR
GGGDRYFQTNVTEARKLVAEGIEGMVPFKGPLSDTVYQLVGGLRAGMGYVGAANIEALRRDARFIRITTAGQIESHPHDV
VITKQAPNYGGRQ

Sequences:

>Translated_493_residues
MGIAWEEKFTREGLTFDDVLLIPAESDVLPATVDVSTWLTRNIRLNIPIVSAAMDTVTEHRLAIALAREGGIGIIHKNMP
IASQAEMVRKVKRSESGMITDPITLPPDRTVGDALDLMAEYKISGVPVTTADGDLVGIITNRDLRFETDRNRPIRDLMTS
RNLVTVPEGTTLEEAKEVLHRHRIEKVLVVDERGKLSGMITVKDIMKRIEYPHACKDDMGRLRVGAAVGVSGDYIERATE
LVRAGVDVLVIDTAHGHSRGVLNAVVKLRELFPRVQIIGGNVSTAAATIALIERGVDGVKVGQGPGSICTTRVVTGAGMP
QITAIFDCARAAEPYGIPIIADGGIKYSGDIPKAIAAGAHSVMIGSIFAGTEESPGELILYEGRSYKSYRGMGSIGAMQR
GGGDRYFQTNVTEARKLVAEGIEGMVPFKGPLSDTVYQLVGGLRAGMGYVGAANIEALRRDARFIRITTAGQIESHPHDV
VITKQAPNYGGRQ
>Mature_492_residues
GIAWEEKFTREGLTFDDVLLIPAESDVLPATVDVSTWLTRNIRLNIPIVSAAMDTVTEHRLAIALAREGGIGIIHKNMPI
ASQAEMVRKVKRSESGMITDPITLPPDRTVGDALDLMAEYKISGVPVTTADGDLVGIITNRDLRFETDRNRPIRDLMTSR
NLVTVPEGTTLEEAKEVLHRHRIEKVLVVDERGKLSGMITVKDIMKRIEYPHACKDDMGRLRVGAAVGVSGDYIERATEL
VRAGVDVLVIDTAHGHSRGVLNAVVKLRELFPRVQIIGGNVSTAAATIALIERGVDGVKVGQGPGSICTTRVVTGAGMPQ
ITAIFDCARAAEPYGIPIIADGGIKYSGDIPKAIAAGAHSVMIGSIFAGTEESPGELILYEGRSYKSYRGMGSIGAMQRG
GGDRYFQTNVTEARKLVAEGIEGMVPFKGPLSDTVYQLVGGLRAGMGYVGAANIEALRRDARFIRITTAGQIESHPHDVV
ITKQAPNYGGRQ

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=492, Percent_Identity=41.6666666666667, Blast_Score=355, Evalue=8e-98,
Organism=Homo sapiens, GI34328928, Length=492, Percent_Identity=41.6666666666667, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI156616279, Length=492, Percent_Identity=41.6666666666667, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI34328930, Length=492, Percent_Identity=41.6666666666667, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI217035152, Length=475, Percent_Identity=42.1052631578947, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI66933016, Length=494, Percent_Identity=40.080971659919, Blast_Score=342, Evalue=4e-94,
Organism=Homo sapiens, GI217035148, Length=492, Percent_Identity=40.650406504065, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI217035150, Length=492, Percent_Identity=38.8211382113821, Blast_Score=318, Evalue=8e-87,
Organism=Homo sapiens, GI50541956, Length=371, Percent_Identity=33.1536388140162, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI50541954, Length=248, Percent_Identity=40.3225806451613, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541952, Length=248, Percent_Identity=40.3225806451613, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541948, Length=248, Percent_Identity=40.3225806451613, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI156104880, Length=248, Percent_Identity=39.5161290322581, Blast_Score=165, Evalue=9e-41,
Organism=Escherichia coli, GI1788855, Length=483, Percent_Identity=59.6273291925466, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1786293, Length=243, Percent_Identity=39.0946502057613, Blast_Score=161, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=501, Percent_Identity=35.9281437125749, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=38.6416861826698, Blast_Score=265, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI17560440, Length=230, Percent_Identity=39.1304347826087, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322012, Length=485, Percent_Identity=40.6185567010309, Blast_Score=351, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6323464, Length=486, Percent_Identity=40.9465020576132, Blast_Score=339, Evalue=6e-94,
Organism=Saccharomyces cerevisiae, GI6323585, Length=486, Percent_Identity=39.7119341563786, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6319352, Length=341, Percent_Identity=42.8152492668622, Blast_Score=270, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6319353, Length=135, Percent_Identity=37.037037037037, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641071, Length=494, Percent_Identity=40.080971659919, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24641073, Length=494, Percent_Identity=40.080971659919, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=40.3628117913832, Blast_Score=300, Evalue=2e-81,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53042; Mature: 52911

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIAWEEKFTREGLTFDDVLLIPAESDVLPATVDVSTWLTRNIRLNIPIVSAAMDTVTEH
CCCCCCHHHHHCCCCCCCEEEEECCCCCCCEEEEHHHHEECCEEEECEEHHHHHHHHHHC
RLAIALAREGGIGIIHKNMPIASQAEMVRKVKRSESGMITDPITLPPDRTVGDALDLMAE
EEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEECCEECCCCCCHHHHHHHHHH
YKISGVPVTTADGDLVGIITNRDLRFETDRNRPIRDLMTSRNLVTVPEGTTLEEAKEVLH
HEECCEEEEECCCCEEEEEECCCEEEECCCCCCHHHHHHCCCEEECCCCCCHHHHHHHHH
RHRIEKVLVVDERGKLSGMITVKDIMKRIEYPHACKDDMGRLRVGAAVGVSGDYIERATE
HHCCCEEEEEECCCCCEEEEEHHHHHHHCCCCCCCHHCCCCEEEEEEECCCCHHHHHHHH
LVRAGVDVLVIDTAHGHSRGVLNAVVKLRELFPRVQIIGGNVSTAAATIALIERGVDGVK
HHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCEE
VGQGPGSICTTRVVTGAGMPQITAIFDCARAAEPYGIPIIADGGIKYSGDIPKAIAAGAH
ECCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEECCCEEECCCCCHHHHCCCC
SVMIGSIFAGTEESPGELILYEGRSYKSYRGMGSIGAMQRGGGDRYFQTNVTEARKLVAE
CEEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHH
GIEGMVPFKGPLSDTVYQLVGGLRAGMGYVGAANIEALRRDARFIRITTAGQIESHPHDV
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCCE
VITKQAPNYGGRQ
EEEECCCCCCCCC
>Mature Secondary Structure 
GIAWEEKFTREGLTFDDVLLIPAESDVLPATVDVSTWLTRNIRLNIPIVSAAMDTVTEH
CCCCCHHHHHCCCCCCCEEEEECCCCCCCEEEEHHHHEECCEEEECEEHHHHHHHHHHC
RLAIALAREGGIGIIHKNMPIASQAEMVRKVKRSESGMITDPITLPPDRTVGDALDLMAE
EEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEECCEECCCCCCHHHHHHHHHH
YKISGVPVTTADGDLVGIITNRDLRFETDRNRPIRDLMTSRNLVTVPEGTTLEEAKEVLH
HEECCEEEEECCCCEEEEEECCCEEEECCCCCCHHHHHHCCCEEECCCCCCHHHHHHHHH
RHRIEKVLVVDERGKLSGMITVKDIMKRIEYPHACKDDMGRLRVGAAVGVSGDYIERATE
HHCCCEEEEEECCCCCEEEEEHHHHHHHCCCCCCCHHCCCCEEEEEEECCCCHHHHHHHH
LVRAGVDVLVIDTAHGHSRGVLNAVVKLRELFPRVQIIGGNVSTAAATIALIERGVDGVK
HHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCEE
VGQGPGSICTTRVVTGAGMPQITAIFDCARAAEPYGIPIIADGGIKYSGDIPKAIAAGAH
ECCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEECCCEEECCCCCHHHHCCCC
SVMIGSIFAGTEESPGELILYEGRSYKSYRGMGSIGAMQRGGGDRYFQTNVTEARKLVAE
CEEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHH
GIEGMVPFKGPLSDTVYQLVGGLRAGMGYVGAANIEALRRDARFIRITTAGQIESHPHDV
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCCE
VITKQAPNYGGRQ
EEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]