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The map label for this gene is mutS [H]

Identifier: 222523660

GI number: 222523660

Start: 431238

End: 432755

Strand: Direct

Name: mutS [H]

Synonym: Chy400_0366

Alternate gene names: 222523660

Gene position: 431238-432755 (Clockwise)

Preceding gene: 222523659

Following gene: 222523661

Centisome position: 8.18

GC content: 51.38

Gene sequence:

>1518_bases
ATGATGAAGGTTTTTTTACTGCACCCCGATCAAGACTTTGACCCGTCGACGCCGTTGCTGCCTAATGTAGATGACCTGAC
GCAAGACTTGTCATTGAACATCTTGTTTAAGGCTATGGCTCGCGGCGACACGTTCTTGTTTCAGGTCGTTCGACAGGTTG
TGCTATCACCCCTGGATGAAAGCGCTTCAATCCTCTACCGACAGGAGATTCTGAAAGATTGCCTGAAATACCCCGACGTG
GTCAGACAAATGTACCTCATTCCGTTGACATTCCTCGAACGTAAACACAAACGGTGGTTGTGGATTTCGTTGCGTCATTC
CACCCCTACCTCAATCCTGAGCAGCGCTCGCGAGTTGCTGGCAGCCTCACTGGACTTGCTGCGTCAGTTGCGACTGATCG
CCGATCAGCATGTGAACACCTTCGAGTCGCAGGGTTTCCGCCGCTTTTTCACCATGATTCAGCGGGAACTGGACGACGAC
TATCTAAACCTTGTGGAAAAACACGTTCAGCAACTTCGTTTTTCCAGAGGTACTCTCCTTAGTGCGCAACCAGGCAAAGG
CAATGAAGGCAGCAACTACGTTCTCTGTTACCCGAACGACGCAGACCAACATTGGCTTCAACGCATGCTTACCTCGCACT
CACCAACCTATTCCTATACCCTGCACCCTCGTGATGAGGCAGGAGCGCGCATACTAGAGGAACTACGTGATCGGGGACTT
GCCCGTGCAGCAAACGCCGTTGGTCAGGCCGCCGAGCATATAGAAAGTTTCTTCAGAGTGCTGCAATGGGAATTGGCTTT
CTATATCGGCTGCCTGAACCTTTACGAACAACTAACCGCTCTGGGCAAGCCTGTGACCTTTCCGCAGCCTGTGCCGGCTC
ACGAGCGCCGACTCTCGTGTGCAGAATTGTATGATGTCACCCTGGCGTTAACGCTTGGATCATCTGTGGTGGGAAATGAT
ATCTCTGCTGATGGAAAATCGCTGATTATCGTTACCGGTCCAAACCGCGGCGGCAAAACTGTCTTCCTGCGCAGTGTTGG
CGTGGCTCAGTTGATGATGCAGTGTGGAATGTTTGTCCCAGCCGAATCGTTCCTGGCTAATCTGACGACCGGCCTGTTCA
CGCACTTCAAGCGCGAAGAGGACAAGACGATGGAAAGGGGCAAGTTTGAAGAAGAGCTTGCGCGCATGAGTGTGATCGTT
GACTACCTCACTCCAAACGCATTACTTTTGCTGAACGAGTCCTTTTCCGCCACCAACGAACGTGAAGGCTCGGAGATTGC
CAGACAAATTGTCAGCACTCTGATCGAGAAGGGTATCAAGGTATACTTCGTTACCCATTTGTATGAGTTTACCCGTTCTT
TCAACGGAGATAACATTCTTTTCCTGCGCGCCGAGCGATTGCCGGACGGAGAGCGTACCTTTAGGCTCAAGGAAGCCGAT
CCACTGAAGACCAGTTATGGCGTGGACTTGTATTACAGAATATTCGGTACGGAACAACAACAGGAGATGACGGACTGA

Upstream 100 bases:

>100_bases
CATTCCAGATCATTCGCAAACCCGCCGATGGGTTGGCCTATGCTCTTTCATTGGCTCGTAAACATGGGCTGAGCCGTGAA
CAACTTCAGGAGCGAATACG

Downstream 100 bases:

>100_bases
ACCAGACCACTAACCCACACTAAATAAATGACGCTTTTCTTTGCACGGCGACTGAACGTTGCCGTGAGCATCTGATAGAT
GTTTCATCTTGCCCGCGGAG

Product: DNA mismatch repair protein MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MMKVFLLHPDQDFDPSTPLLPNVDDLTQDLSLNILFKAMARGDTFLFQVVRQVVLSPLDESASILYRQEILKDCLKYPDV
VRQMYLIPLTFLERKHKRWLWISLRHSTPTSILSSARELLAASLDLLRQLRLIADQHVNTFESQGFRRFFTMIQRELDDD
YLNLVEKHVQQLRFSRGTLLSAQPGKGNEGSNYVLCYPNDADQHWLQRMLTSHSPTYSYTLHPRDEAGARILEELRDRGL
ARAANAVGQAAEHIESFFRVLQWELAFYIGCLNLYEQLTALGKPVTFPQPVPAHERRLSCAELYDVTLALTLGSSVVGND
ISADGKSLIIVTGPNRGGKTVFLRSVGVAQLMMQCGMFVPAESFLANLTTGLFTHFKREEDKTMERGKFEEELARMSVIV
DYLTPNALLLLNESFSATNEREGSEIARQIVSTLIEKGIKVYFVTHLYEFTRSFNGDNILFLRAERLPDGERTFRLKEAD
PLKTSYGVDLYYRIFGTEQQQEMTD

Sequences:

>Translated_505_residues
MMKVFLLHPDQDFDPSTPLLPNVDDLTQDLSLNILFKAMARGDTFLFQVVRQVVLSPLDESASILYRQEILKDCLKYPDV
VRQMYLIPLTFLERKHKRWLWISLRHSTPTSILSSARELLAASLDLLRQLRLIADQHVNTFESQGFRRFFTMIQRELDDD
YLNLVEKHVQQLRFSRGTLLSAQPGKGNEGSNYVLCYPNDADQHWLQRMLTSHSPTYSYTLHPRDEAGARILEELRDRGL
ARAANAVGQAAEHIESFFRVLQWELAFYIGCLNLYEQLTALGKPVTFPQPVPAHERRLSCAELYDVTLALTLGSSVVGND
ISADGKSLIIVTGPNRGGKTVFLRSVGVAQLMMQCGMFVPAESFLANLTTGLFTHFKREEDKTMERGKFEEELARMSVIV
DYLTPNALLLLNESFSATNEREGSEIARQIVSTLIEKGIKVYFVTHLYEFTRSFNGDNILFLRAERLPDGERTFRLKEAD
PLKTSYGVDLYYRIFGTEQQQEMTD
>Mature_505_residues
MMKVFLLHPDQDFDPSTPLLPNVDDLTQDLSLNILFKAMARGDTFLFQVVRQVVLSPLDESASILYRQEILKDCLKYPDV
VRQMYLIPLTFLERKHKRWLWISLRHSTPTSILSSARELLAASLDLLRQLRLIADQHVNTFESQGFRRFFTMIQRELDDD
YLNLVEKHVQQLRFSRGTLLSAQPGKGNEGSNYVLCYPNDADQHWLQRMLTSHSPTYSYTLHPRDEAGARILEELRDRGL
ARAANAVGQAAEHIESFFRVLQWELAFYIGCLNLYEQLTALGKPVTFPQPVPAHERRLSCAELYDVTLALTLGSSVVGND
ISADGKSLIIVTGPNRGGKTVFLRSVGVAQLMMQCGMFVPAESFLANLTTGLFTHFKREEDKTMERGKFEEELARMSVIV
DYLTPNALLLLNESFSATNEREGSEIARQIVSTLIEKGIKVYFVTHLYEFTRSFNGDNILFLRAERLPDGERTFRLKEAD
PLKTSYGVDLYYRIFGTEQQQEMTD

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=202, Percent_Identity=26.2376237623762, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI36949366, Length=135, Percent_Identity=27.4074074074074, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789089, Length=129, Percent_Identity=29.4573643410853, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17508445, Length=168, Percent_Identity=27.3809523809524, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=141, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321912, Length=134, Percent_Identity=29.1044776119403, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24664545, Length=141, Percent_Identity=31.2056737588652, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584320, Length=212, Percent_Identity=28.3018867924528, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 57727; Mature: 57727

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKVFLLHPDQDFDPSTPLLPNVDDLTQDLSLNILFKAMARGDTFLFQVVRQVVLSPLDE
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCH
SASILYRQEILKDCLKYPDVVRQMYLIPLTFLERKHKRWLWISLRHSTPTSILSSARELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHH
AASLDLLRQLRLIADQHVNTFESQGFRRFFTMIQRELDDDYLNLVEKHVQQLRFSRGTLL
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEE
SAQPGKGNEGSNYVLCYPNDADQHWLQRMLTSHSPTYSYTLHPRDEAGARILEELRDRGL
ECCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCHH
ARAANAVGQAAEHIESFFRVLQWELAFYIGCLNLYEQLTALGKPVTFPQPVPAHERRLSC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
AELYDVTLALTLGSSVVGNDISADGKSLIIVTGPNRGGKTVFLRSVGVAQLMMQCGMFVP
HHHHHHHHHEEECCHHHCCCCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHHHHCCCCCC
AESFLANLTTGLFTHFKREEDKTMERGKFEEELARMSVIVDYLTPNALLLLNESFSATNE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
REGSEIARQIVSTLIEKGIKVYFVTHLYEFTRSFNGDNILFLRAERLPDGERTFRLKEAD
CCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEECCCC
PLKTSYGVDLYYRIFGTEQQQEMTD
CCCCCCCCEEEEEEECCCHHHHCCC
>Mature Secondary Structure
MMKVFLLHPDQDFDPSTPLLPNVDDLTQDLSLNILFKAMARGDTFLFQVVRQVVLSPLDE
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCH
SASILYRQEILKDCLKYPDVVRQMYLIPLTFLERKHKRWLWISLRHSTPTSILSSARELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHH
AASLDLLRQLRLIADQHVNTFESQGFRRFFTMIQRELDDDYLNLVEKHVQQLRFSRGTLL
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEE
SAQPGKGNEGSNYVLCYPNDADQHWLQRMLTSHSPTYSYTLHPRDEAGARILEELRDRGL
ECCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCHH
ARAANAVGQAAEHIESFFRVLQWELAFYIGCLNLYEQLTALGKPVTFPQPVPAHERRLSC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
AELYDVTLALTLGSSVVGNDISADGKSLIIVTGPNRGGKTVFLRSVGVAQLMMQCGMFVP
HHHHHHHHHEEECCHHHCCCCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHHHHCCCCCC
AESFLANLTTGLFTHFKREEDKTMERGKFEEELARMSVIVDYLTPNALLLLNESFSATNE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
REGSEIARQIVSTLIEKGIKVYFVTHLYEFTRSFNGDNILFLRAERLPDGERTFRLKEAD
CCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEECCCC
PLKTSYGVDLYYRIFGTEQQQEMTD
CCCCCCCCEEEEEEECCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA