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The map label for this gene is mutS [H]

Identifier: 222523659

GI number: 222523659

Start: 429715

End: 431241

Strand: Direct

Name: mutS [H]

Synonym: Chy400_0365

Alternate gene names: 222523659

Gene position: 429715-431241 (Clockwise)

Preceding gene: 222523654

Following gene: 222523660

Centisome position: 8.16

GC content: 51.87

Gene sequence:

>1527_bases
ATGGTTTCGCTCAGTATTCTTCACTACCACGACGGTCTCCAAACAGAAGCAACCAGCCAGCCTGATTTCTTTCCCGATCT
AAACCTGGATCAGGTGGTAGAAGCCATCACAAAACCCGGACAGGAGTACAACTTACAACCCTTTTTCTGGACTCCCTTAC
GCGATGCTCAAGCCGTCCGCTACCGGCAAGAGGTGTTTCAGGACCTGGAAAAAGCTCCTATCCTGGAAGCTATCAAGCAG
TTTGCGGAAGGTATGAGGGTGGTGCGACGTTATCTGGCGATGATGGAGCAACTTAACTTTGCCGATCACAGAAAGGGGTG
GCTCCTGGAAGCAGCCCTGGTCTATTGTGACACCGTAACAACTCTGGCTCGCCATCTCGTCGATCTTCCCTTGAGGTCGA
ATGGCCTTTCGACTTTCCGAGAACATCTGACAACCTGCATTCAGTCACCGGCATTCCGTTCCCTGGCTACCGATAGTCAA
CACGTCAAAAACGCCCTGGCTGCCATCAAGTATAGCGTGATTATCGAGAGTGGCAAGTTCAGCGTAAAGCGCTACGAGGG
CGAGGTAGATTACAGCTCGGAAGTGGAACATGTCTTCAGCAAGTTCAAACAACGTGATGCCCAGGATTATCTGGTACACC
TTCCAGAAAGAGCTGGAATGAGTCACATTGAGGCCAAGATCCTCGAGTTCGTCGCCAGGTTATATCCCGAACCCTTCGAG
GAGCTAGACCGCTTCTGTACGGAGCATAACCAGTTTCTCGACGAGACCATTCGCACGTTCGACCGCGAGATTCAGTTTTA
CGTGGCTTATCTGGAATATATCGCCGACCTCAAACGTCAGGGGCTACCCTTTTGTTATCCTCACGTCAGCGCAACGAGTA
AAGCAGTCTATGTACGCGATGGCTTCGATCTGGCCCTGGCTCATGCCTGGCGTTACGAACAGAAGACTATCACGCTGAAC
GATTTCTTCCTGACAGGCCCGGAACGCATTCTCGTCGTCACCGGACCCAATCAGGGAGGGAAGACGACATTTGCTCGGAT
GTTTGGGCAGTTACATTATCTCGCTAGCCTCGGCTGCCCTGTTCCGGGCCGGGAAGCAGGTCTGTTCCTGGCCGACCGCA
TCTTTACCCATTTCGAGCGCATAGAGGATAGTCAAAATCTACGGGGAAAACTGGAAGATGATCTGGTCCGTATGCACAGA
GCACTCATCCAGGCTACCCCTGACAGCATCTTCATCCTGAACGAAATTTTCTCCTCCACCACTGTTCAGGATGCACTTTT
TCTAAGTAAGGAAATTATGGCCCGGCTGACGGATCTGGATGTTTTGGGTGTTTGGGTGACGTTCCTCGACGAACTGGCTT
CGTTGAGCGAGAAAATGGTCAGCATGGTGGCATCGGTAGACCCCAATGATCCCGTCAGACGCACATTCCAGATCATTCGC
AAACCCGCCGATGGGTTGGCCTATGCTCTTTCATTGGCTCGTAAACATGGGCTGAGCCGTGAACAACTTCAGGAGCGAAT
ACGATGA

Upstream 100 bases:

>100_bases
GATGAGGCTCACCCTCAACTGCCATTACGGCTGATAGCCTCTACAGGGAAACGTTTTCTCTGTAGAGGCTTTTATTTTTG
AATCGATAAGAGGCATGATC

Downstream 100 bases:

>100_bases
TGAAGGTTTTTTTACTGCACCCCGATCAAGACTTTGACCCGTCGACGCCGTTGCTGCCTAATGTAGATGACCTGACGCAA
GACTTGTCATTGAACATCTT

Product: DNA mismatch repair protein MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MVSLSILHYHDGLQTEATSQPDFFPDLNLDQVVEAITKPGQEYNLQPFFWTPLRDAQAVRYRQEVFQDLEKAPILEAIKQ
FAEGMRVVRRYLAMMEQLNFADHRKGWLLEAALVYCDTVTTLARHLVDLPLRSNGLSTFREHLTTCIQSPAFRSLATDSQ
HVKNALAAIKYSVIIESGKFSVKRYEGEVDYSSEVEHVFSKFKQRDAQDYLVHLPERAGMSHIEAKILEFVARLYPEPFE
ELDRFCTEHNQFLDETIRTFDREIQFYVAYLEYIADLKRQGLPFCYPHVSATSKAVYVRDGFDLALAHAWRYEQKTITLN
DFFLTGPERILVVTGPNQGGKTTFARMFGQLHYLASLGCPVPGREAGLFLADRIFTHFERIEDSQNLRGKLEDDLVRMHR
ALIQATPDSIFILNEIFSSTTVQDALFLSKEIMARLTDLDVLGVWVTFLDELASLSEKMVSMVASVDPNDPVRRTFQIIR
KPADGLAYALSLARKHGLSREQLQERIR

Sequences:

>Translated_508_residues
MVSLSILHYHDGLQTEATSQPDFFPDLNLDQVVEAITKPGQEYNLQPFFWTPLRDAQAVRYRQEVFQDLEKAPILEAIKQ
FAEGMRVVRRYLAMMEQLNFADHRKGWLLEAALVYCDTVTTLARHLVDLPLRSNGLSTFREHLTTCIQSPAFRSLATDSQ
HVKNALAAIKYSVIIESGKFSVKRYEGEVDYSSEVEHVFSKFKQRDAQDYLVHLPERAGMSHIEAKILEFVARLYPEPFE
ELDRFCTEHNQFLDETIRTFDREIQFYVAYLEYIADLKRQGLPFCYPHVSATSKAVYVRDGFDLALAHAWRYEQKTITLN
DFFLTGPERILVVTGPNQGGKTTFARMFGQLHYLASLGCPVPGREAGLFLADRIFTHFERIEDSQNLRGKLEDDLVRMHR
ALIQATPDSIFILNEIFSSTTVQDALFLSKEIMARLTDLDVLGVWVTFLDELASLSEKMVSMVASVDPNDPVRRTFQIIR
KPADGLAYALSLARKHGLSREQLQERIR
>Mature_508_residues
MVSLSILHYHDGLQTEATSQPDFFPDLNLDQVVEAITKPGQEYNLQPFFWTPLRDAQAVRYRQEVFQDLEKAPILEAIKQ
FAEGMRVVRRYLAMMEQLNFADHRKGWLLEAALVYCDTVTTLARHLVDLPLRSNGLSTFREHLTTCIQSPAFRSLATDSQ
HVKNALAAIKYSVIIESGKFSVKRYEGEVDYSSEVEHVFSKFKQRDAQDYLVHLPERAGMSHIEAKILEFVARLYPEPFE
ELDRFCTEHNQFLDETIRTFDREIQFYVAYLEYIADLKRQGLPFCYPHVSATSKAVYVRDGFDLALAHAWRYEQKTITLN
DFFLTGPERILVVTGPNQGGKTTFARMFGQLHYLASLGCPVPGREAGLFLADRIFTHFERIEDSQNLRGKLEDDLVRMHR
ALIQATPDSIFILNEIFSSTTVQDALFLSKEIMARLTDLDVLGVWVTFLDELASLSEKMVSMVASVDPNDPVRRTFQIIR
KPADGLAYALSLARKHGLSREQLQERIR

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=179, Percent_Identity=25.1396648044693, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789089, Length=200, Percent_Identity=27.5, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17534743, Length=152, Percent_Identity=28.9473684210526, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 58333; Mature: 58333

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSLSILHYHDGLQTEATSQPDFFPDLNLDQVVEAITKPGQEYNLQPFFWTPLRDAQAVR
CCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHH
YRQEVFQDLEKAPILEAIKQFAEGMRVVRRYLAMMEQLNFADHRKGWLLEAALVYCDTVT
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHH
TLARHLVDLPLRSNGLSTFREHLTTCIQSPAFRSLATDSQHVKNALAAIKYSVIIESGKF
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHEEEECCCE
SVKRYEGEVDYSSEVEHVFSKFKQRDAQDYLVHLPERAGMSHIEAKILEFVARLYPEPFE
EEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHCCCHHCCHHHHHHHHHHHHHHHCCCCHH
ELDRFCTEHNQFLDETIRTFDREIQFYVAYLEYIADLKRQGLPFCYPHVSATSKAVYVRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEC
GFDLALAHAWRYEQKTITLNDFFLTGPERILVVTGPNQGGKTTFARMFGQLHYLASLGCP
CCHHHHHHHHHHCCCEEEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
VPGREAGLFLADRIFTHFERIEDSQNLRGKLEDDLVRMHRALIQATPDSIFILNEIFSST
CCCCCCCHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TVQDALFLSKEIMARLTDLDVLGVWVTFLDELASLSEKMVSMVASVDPNDPVRRTFQIIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
KPADGLAYALSLARKHGLSREQLQERIR
CCCHHHHHHHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure
MVSLSILHYHDGLQTEATSQPDFFPDLNLDQVVEAITKPGQEYNLQPFFWTPLRDAQAVR
CCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHH
YRQEVFQDLEKAPILEAIKQFAEGMRVVRRYLAMMEQLNFADHRKGWLLEAALVYCDTVT
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHH
TLARHLVDLPLRSNGLSTFREHLTTCIQSPAFRSLATDSQHVKNALAAIKYSVIIESGKF
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHEEEECCCE
SVKRYEGEVDYSSEVEHVFSKFKQRDAQDYLVHLPERAGMSHIEAKILEFVARLYPEPFE
EEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHCCCHHCCHHHHHHHHHHHHHHHCCCCHH
ELDRFCTEHNQFLDETIRTFDREIQFYVAYLEYIADLKRQGLPFCYPHVSATSKAVYVRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEC
GFDLALAHAWRYEQKTITLNDFFLTGPERILVVTGPNQGGKTTFARMFGQLHYLASLGCP
CCHHHHHHHHHHCCCEEEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
VPGREAGLFLADRIFTHFERIEDSQNLRGKLEDDLVRMHRALIQATPDSIFILNEIFSST
CCCCCCCHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TVQDALFLSKEIMARLTDLDVLGVWVTFLDELASLSEKMVSMVASVDPNDPVRRTFQIIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
KPADGLAYALSLARKHGLSREQLQERIR
CCCHHHHHHHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA