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The map label for this gene is cysM [H]

Identifier: 222152032

GI number: 222152032

Start: 1925025

End: 1926545

Strand: Direct

Name: cysM [H]

Synonym: MCCL_1789

Alternate gene names: 222152032

Gene position: 1925025-1926545 (Clockwise)

Preceding gene: 222152028

Following gene: 222152033

Centisome position: 91.57

GC content: 40.24

Gene sequence:

>1521_bases
ATGAGTTTACCTTTTATGGATATTTTTAAAGAATGGGCATCAGATTATGATGATGCTGTAACAGGACGTAACCCCGAATA
CAAAGATGTATTCTCAAACTATGATTTCATGATAGAAGAAGCGACAAAACACGTCGGAAAGCGCGTAACAGAATTTGGTC
CTGGAACAGGGAATTTAACAAATATGCTATTACAGCGCGGATTGGACGTACAAGCCGTAGAACCAAGTATTGATATGGCA
AAGTTAGGTGAAGCTAAGACAGGTATTACGTTCGAACGTGGCGATTTCCTAAACTTCAATGCTAGAGAAACAGATACATT
TATTTCTTCTTTTGCTTTTCACCACCTTACGGACAAAGAAAAGAAAGAAGCGATTGCACTTTATAAGCCGCTTCTCTCTG
AAGATGGAAACATCATTATATTGGACACAATGTTCAATTCCTTAGATGAAAAAGAACAGATTAAATCACATTATGACGCA
CGAGGTTATCATAATCTTGTTGAAGATCTGGAAAGAGAATATTATCCATTAAAGGAGACAATGAAAGAGATTGCCAACGA
CTTGGGATTTGATTATCAGTCCACTCAGATGAATCGTTTCGCCCATCTTCAAATATTAACTAAAAAAAAAATAAAAACTC
CTGCTGATTTAATCGGTAATACACCGCTAGTGGAACTTAAGCATTTTCCACTGAATAAAGGAAACCGTCTATTTGCAAAA
CTTGAGTTCTATAATCTGGGCGGCTCTGTAAAAGACAGACTGGGTGTCAACATTTTAGAACAGGCTTTACTTCGTGGCGA
TATTCAAAACGGTACAGTTGTTGAAGCTACAGCTGGTAATACAGGTATTGGTCTTGCACTCATCTGTCAGCAACATGAGC
TAAATCTACGCGTCTATGTGCCCGAGAAATTTAGTACCGAAAAGCAAAGTATCATGCGTGCATTAGGGGCTGAAATCGTA
AACACCCCTACAGAGAAAGGAATGCTCTTTGCACGTGAAGCAGCGCTGAAATTCGCTCAAGAAACCGGCGCATTCTATAC
AAATCAATTTGAATCAGCAGATAACCCTTCAAGCTATGATAAGCTAGCAGAGGAGATAAAAAGAGATGCTGGCAAGGTTG
ATGTAATCGTTGCTGGTGCAGGTAGTGGCGGTACGTTCACCGGTCTTGCAAAACATTTCAAAGAAAGTCATCGCGTTATC
GTAGAGCCTGAAGGTTCGATATTAAATGGTGGAGAATCTGGTAGTCACCGCACAGAAGGCATCGGCGTTGAAAAATGGCC
CGTATTCCTAGAAAAAGATTTAATCGATGCCGTTGAAACAATTTCTGATATCGATGCCTTTACACGTGTCTCAGAACTGG
CACAAAAAGAAGGCCTGCTTGTGGGGTCTTCAAGCGGGGCCGCGCTACATGCCGCACTTAAAACCCAAGAAAATATGACT
GATAGCAATATCGTCGTAATATTCCCTGATGCAGCAGAGCGATACTTATCACAACAAATATTTGATATTAAAGGAGAATA
G

Upstream 100 bases:

>100_bases
GCGCACAAATTCACAAACTATTATATTGAGCAAATAATAAATTCATGCTATTATTAATCCCGAGTTATCTGATAAGAATA
ATAATATTAGGAGTGTACCG

Downstream 100 bases:

>100_bases
ATTATGCAAAAGAAAACAATGATGATCCATGGAGGAAATACAATTGATGAATACACTGGAGCTGTGAACCCTCCAATTTA
CCAAACAAGCACGTACAAAC

Product: hypothetical protein

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MSLPFMDIFKEWASDYDDAVTGRNPEYKDVFSNYDFMIEEATKHVGKRVTEFGPGTGNLTNMLLQRGLDVQAVEPSIDMA
KLGEAKTGITFERGDFLNFNARETDTFISSFAFHHLTDKEKKEAIALYKPLLSEDGNIIILDTMFNSLDEKEQIKSHYDA
RGYHNLVEDLEREYYPLKETMKEIANDLGFDYQSTQMNRFAHLQILTKKKIKTPADLIGNTPLVELKHFPLNKGNRLFAK
LEFYNLGGSVKDRLGVNILEQALLRGDIQNGTVVEATAGNTGIGLALICQQHELNLRVYVPEKFSTEKQSIMRALGAEIV
NTPTEKGMLFAREAALKFAQETGAFYTNQFESADNPSSYDKLAEEIKRDAGKVDVIVAGAGSGGTFTGLAKHFKESHRVI
VEPEGSILNGGESGSHRTEGIGVEKWPVFLEKDLIDAVETISDIDAFTRVSELAQKEGLLVGSSSGAALHAALKTQENMT
DSNIVVIFPDAAERYLSQQIFDIKGE

Sequences:

>Translated_506_residues
MSLPFMDIFKEWASDYDDAVTGRNPEYKDVFSNYDFMIEEATKHVGKRVTEFGPGTGNLTNMLLQRGLDVQAVEPSIDMA
KLGEAKTGITFERGDFLNFNARETDTFISSFAFHHLTDKEKKEAIALYKPLLSEDGNIIILDTMFNSLDEKEQIKSHYDA
RGYHNLVEDLEREYYPLKETMKEIANDLGFDYQSTQMNRFAHLQILTKKKIKTPADLIGNTPLVELKHFPLNKGNRLFAK
LEFYNLGGSVKDRLGVNILEQALLRGDIQNGTVVEATAGNTGIGLALICQQHELNLRVYVPEKFSTEKQSIMRALGAEIV
NTPTEKGMLFAREAALKFAQETGAFYTNQFESADNPSSYDKLAEEIKRDAGKVDVIVAGAGSGGTFTGLAKHFKESHRVI
VEPEGSILNGGESGSHRTEGIGVEKWPVFLEKDLIDAVETISDIDAFTRVSELAQKEGLLVGSSSGAALHAALKTQENMT
DSNIVVIFPDAAERYLSQQIFDIKGE
>Mature_505_residues
SLPFMDIFKEWASDYDDAVTGRNPEYKDVFSNYDFMIEEATKHVGKRVTEFGPGTGNLTNMLLQRGLDVQAVEPSIDMAK
LGEAKTGITFERGDFLNFNARETDTFISSFAFHHLTDKEKKEAIALYKPLLSEDGNIIILDTMFNSLDEKEQIKSHYDAR
GYHNLVEDLEREYYPLKETMKEIANDLGFDYQSTQMNRFAHLQILTKKKIKTPADLIGNTPLVELKHFPLNKGNRLFAKL
EFYNLGGSVKDRLGVNILEQALLRGDIQNGTVVEATAGNTGIGLALICQQHELNLRVYVPEKFSTEKQSIMRALGAEIVN
TPTEKGMLFAREAALKFAQETGAFYTNQFESADNPSSYDKLAEEIKRDAGKVDVIVAGAGSGGTFTGLAKHFKESHRVIV
EPEGSILNGGESGSHRTEGIGVEKWPVFLEKDLIDAVETISDIDAFTRVSELAQKEGLLVGSSSGAALHAALKTQENMTD
SNIVVIFPDAAERYLSQQIFDIKGE

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=307, Percent_Identity=39.0879478827362, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI295821200, Length=307, Percent_Identity=39.0879478827362, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI4557415, Length=307, Percent_Identity=39.0879478827362, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI2367138, Length=297, Percent_Identity=34.6801346801347, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788754, Length=309, Percent_Identity=39.4822006472492, Blast_Score=150, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17534315, Length=358, Percent_Identity=35.4748603351955, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=336, Percent_Identity=34.2261904761905, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=32.5732899022801, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17562970, Length=303, Percent_Identity=32.6732673267327, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI115535073, Length=303, Percent_Identity=35.973597359736, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI32566674, Length=298, Percent_Identity=33.5570469798658, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17561720, Length=300, Percent_Identity=33, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=31.6037735849057, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71996324, Length=335, Percent_Identity=27.1641791044776, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=38.2911392405063, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=347, Percent_Identity=30.2593659942363, Blast_Score=109, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24643623, Length=339, Percent_Identity=36.8731563421829, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20129101, Length=339, Percent_Identity=36.8731563421829, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 56235; Mature: 56104

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPFMDIFKEWASDYDDAVTGRNPEYKDVFSNYDFMIEEATKHVGKRVTEFGPGTGNLT
CCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
NMLLQRGLDVQAVEPSIDMAKLGEAKTGITFERGDFLNFNARETDTFISSFAFHHLTDKE
HHHHHCCCCCEEECCCCCHHHCCCCCCCCEEECCCEECCCCCHHHHHHHHHHHHHCCCHH
KKEAIALYKPLLSEDGNIIILDTMFNSLDEKEQIKSHYDARGYHNLVEDLEREYYPLKET
HHHHHHHHHHHHCCCCCEEEEEHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHH
MKEIANDLGFDYQSTQMNRFAHLQILTKKKIKTPADLIGNTPLVELKHFPLNKGNRLFAK
HHHHHHHHCCCCCHHHHHHHHHEEEEHHHHCCCCHHHHCCCCEEEEEECCCCCCCEEEEE
LEFYNLGGSVKDRLGVNILEQALLRGDIQNGTVVEATAGNTGIGLALICQQHELNLRVYV
EEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEECCCEEEEEE
PEKFSTEKQSIMRALGAEIVNTPTEKGMLFAREAALKFAQETGAFYTNQFESADNPSSYD
CCCCCHHHHHHHHHHHHHHHCCCCHHCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
KLAEEIKRDAGKVDVIVAGAGSGGTFTGLAKHFKESHRVIVEPEGSILNGGESGSHRTEG
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCEECCCCCCCCCCCC
IGVEKWPVFLEKDLIDAVETISDIDAFTRVSELAQKEGLLVGSSSGAALHAALKTQENMT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCCC
DSNIVVIFPDAAERYLSQQIFDIKGE
CCCEEEEECCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLPFMDIFKEWASDYDDAVTGRNPEYKDVFSNYDFMIEEATKHVGKRVTEFGPGTGNLT
CCCHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
NMLLQRGLDVQAVEPSIDMAKLGEAKTGITFERGDFLNFNARETDTFISSFAFHHLTDKE
HHHHHCCCCCEEECCCCCHHHCCCCCCCCEEECCCEECCCCCHHHHHHHHHHHHHCCCHH
KKEAIALYKPLLSEDGNIIILDTMFNSLDEKEQIKSHYDARGYHNLVEDLEREYYPLKET
HHHHHHHHHHHHCCCCCEEEEEHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHH
MKEIANDLGFDYQSTQMNRFAHLQILTKKKIKTPADLIGNTPLVELKHFPLNKGNRLFAK
HHHHHHHHCCCCCHHHHHHHHHEEEEHHHHCCCCHHHHCCCCEEEEEECCCCCCCEEEEE
LEFYNLGGSVKDRLGVNILEQALLRGDIQNGTVVEATAGNTGIGLALICQQHELNLRVYV
EEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEECCCEEEEEE
PEKFSTEKQSIMRALGAEIVNTPTEKGMLFAREAALKFAQETGAFYTNQFESADNPSSYD
CCCCCHHHHHHHHHHHHHHHCCCCHHCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
KLAEEIKRDAGKVDVIVAGAGSGGTFTGLAKHFKESHRVIVEPEGSILNGGESGSHRTEG
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCEECCCCCCCCCCCC
IGVEKWPVFLEKDLIDAVETISDIDAFTRVSELAQKEGLLVGSSSGAALHAALKTQENMT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCCC
DSNIVVIFPDAAERYLSQQIFDIKGE
CCCEEEEECCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]