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The map label for this gene is coaW [H]

Identifier: 222152028

GI number: 222152028

Start: 1920840

End: 1921652

Strand: Direct

Name: coaW [H]

Synonym: MCCL_1785

Alternate gene names: 222152028

Gene position: 1920840-1921652 (Clockwise)

Preceding gene: 222152024

Following gene: 222152032

Centisome position: 91.37

GC content: 37.88

Gene sequence:

>813_bases
ATGAAAATAGGAATCGATGCAGGTGGTACCTTAATCAAAATTGCCATCCTTGAAAACGATACATTTACATATAAAAAAGA
AAAATCTACAGATATCGAACGCGTTGCAGCATGGCTGAACACTGTGCCAGATGCACAAGTAGCTCTAACAGGCGGAAAAG
CTACCTATTTAAATAGTCTTATTTCACAAGATGCGTTTCAATCAATCGAGTTTGATGCGACATTTAAAGGAATTCAATCC
TTTTTAGATGAAAATAATATGCATCTCGATAAATTTGTATTCAGCAATGTAGGTACAGGAACTTCCATCCACTTTGTTGA
TGAGAATAAACAAATTCGTGCAGGCGGAACAGGTGCAGGTGGCGGTATGATGATGGGACTTTCATACTTACTGACCGGGA
AAGAAGATTTTGCAGATATCGTTGCAATAGCTAAAGCAGGTAACCGCGACATTATCGATCTTAAAGTAAAACATATTTAT
AAAGGTGATAAAACACCGATTCCAGGTGAACTTACAGCCGCTAACTTCGGGAACGTACTTCACAATAAAGATACCGAAAG
CTTTACAGATGCAGATAAGATTGCTTCTGTCCTCGGAATCGTCGGAGAAACAGTGACGACAGTGTCTATCCATGCAGCTA
GAGAGTTTGGAGCAGAATACGTAGTTTATATCGGTTCTAGCTTTCTAGACAACAAATTATTACAGGATATCGTCGTAAAT
TATACTAAATTACGTAACTTCAAACCTTACTTTATCGAAAACGGAGAATATTCAGGTGCTGTGGGCACACTTAGATTAAT
GGATGAAAAATAA

Upstream 100 bases:

>100_bases
TATTTTACCCATTTTTTAAATATTAGAACATGAAAGTTTATTTTTGACTGCTAAACATCACCTTATATGATAAGATAAAA
TAAAAAATGTGAGGTTTATG

Downstream 100 bases:

>100_bases
CGTAAAGGCTCAGCCTTTACGTTATTTTTTAAGCATCTTTATTAAACTTACAAGCATCGGCAACAATGTCGCACTCATTA
CCGATGCTGCAAATATACTA

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-II; Pantothenic acid kinase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKIGIDAGGTLIKIAILENDTFTYKKEKSTDIERVAAWLNTVPDAQVALTGGKATYLNSLISQDAFQSIEFDATFKGIQS
FLDENNMHLDKFVFSNVGTGTSIHFVDENKQIRAGGTGAGGGMMMGLSYLLTGKEDFADIVAIAKAGNRDIIDLKVKHIY
KGDKTPIPGELTAANFGNVLHNKDTESFTDADKIASVLGIVGETVTTVSIHAAREFGAEYVVYIGSSFLDNKLLQDIVVN
YTKLRNFKPYFIENGEYSGAVGTLRLMDEK

Sequences:

>Translated_270_residues
MKIGIDAGGTLIKIAILENDTFTYKKEKSTDIERVAAWLNTVPDAQVALTGGKATYLNSLISQDAFQSIEFDATFKGIQS
FLDENNMHLDKFVFSNVGTGTSIHFVDENKQIRAGGTGAGGGMMMGLSYLLTGKEDFADIVAIAKAGNRDIIDLKVKHIY
KGDKTPIPGELTAANFGNVLHNKDTESFTDADKIASVLGIVGETVTTVSIHAAREFGAEYVVYIGSSFLDNKLLQDIVVN
YTKLRNFKPYFIENGEYSGAVGTLRLMDEK
>Mature_270_residues
MKIGIDAGGTLIKIAILENDTFTYKKEKSTDIERVAAWLNTVPDAQVALTGGKATYLNSLISQDAFQSIEFDATFKGIQS
FLDENNMHLDKFVFSNVGTGTSIHFVDENKQIRAGGTGAGGGMMMGLSYLLTGKEDFADIVAIAKAGNRDIIDLKVKHIY
KGDKTPIPGELTAANFGNVLHNKDTESFTDADKIASVLGIVGETVTTVSIHAAREFGAEYVVYIGSSFLDNKLLQDIVVN
YTKLRNFKPYFIENGEYSGAVGTLRLMDEK

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis [H]

COG id: COG5146

COG function: function code H; Pantothenate kinase, acetyl-CoA regulated

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II pantothenate kinase family [H]

Homologues:

Organism=Homo sapiens, GI13375789, Length=177, Percent_Identity=32.2033898305085, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI24430175, Length=175, Percent_Identity=29.1428571428571, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI24430167, Length=175, Percent_Identity=29.1428571428571, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI23510402, Length=175, Percent_Identity=29.1428571428571, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI85838513, Length=180, Percent_Identity=28.3333333333333, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI23510400, Length=191, Percent_Identity=28.7958115183246, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI20544156, Length=181, Percent_Identity=30.3867403314917, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24667450, Length=181, Percent_Identity=30.3867403314917, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24667454, Length=181, Percent_Identity=30.3867403314917, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20544160, Length=181, Percent_Identity=30.3867403314917, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17864532, Length=181, Percent_Identity=30.3867403314917, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011602
- InterPro:   IPR014642
- InterPro:   IPR004567 [H]

Pfam domain/function: PF03630 Fumble [H]

EC number: =2.7.1.33 [H]

Molecular weight: Translated: 29371; Mature: 29371

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00227 TUBULIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGIDAGGTLIKIAILENDTFTYKKEKSTDIERVAAWLNTVPDAQVALTGGKATYLNSL
CEEECCCCCCEEEEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHH
ISQDAFQSIEFDATFKGIQSFLDENNMHLDKFVFSNVGTGTSIHFVDENKQIRAGGTGAG
HHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEECCCCEEECCCCCCC
GGMMMGLSYLLTGKEDFADIVAIAKAGNRDIIDLKVKHIYKGDKTPIPGELTAANFGNVL
CHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCEEHHHHCHHH
HNKDTESFTDADKIASVLGIVGETVTTVSIHAAREFGAEYVVYIGSSFLDNKLLQDIVVN
CCCCCCCCCCHHHHHHHHHHHCCHHEEEEEEEHHHHCCEEEEEECCHHHHHHHHHHHHHH
YTKLRNFKPYFIENGEYSGAVGTLRLMDEK
HHHHCCCCCEEEECCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKIGIDAGGTLIKIAILENDTFTYKKEKSTDIERVAAWLNTVPDAQVALTGGKATYLNSL
CEEECCCCCCEEEEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHH
ISQDAFQSIEFDATFKGIQSFLDENNMHLDKFVFSNVGTGTSIHFVDENKQIRAGGTGAG
HHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEECCCCEEECCCCCCC
GGMMMGLSYLLTGKEDFADIVAIAKAGNRDIIDLKVKHIYKGDKTPIPGELTAANFGNVL
CHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCEEHHHHCHHH
HNKDTESFTDADKIASVLGIVGETVTTVSIHAAREFGAEYVVYIGSSFLDNKLLQDIVVN
CCCCCCCCCCHHHHHHHHHHHCCHHEEEEEEEHHHHCCEEEEEECCHHHHHHHHHHHHHH
YTKLRNFKPYFIENGEYSGAVGTLRLMDEK
HHHHCCCCCEEEECCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA