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The map label for this gene is putP2 [H]

Identifier: 222151882

GI number: 222151882

Start: 1773172

End: 1774704

Strand: Direct

Name: putP2 [H]

Synonym: MCCL_1639

Alternate gene names: 222151882

Gene position: 1773172-1774704 (Clockwise)

Preceding gene: 222151877

Following gene: 222151893

Centisome position: 84.34

GC content: 39.07

Gene sequence:

>1533_bases
ATGGGTTTGATATTAGGTCATACTTTTCAAAACGTAAAGATTGAAACAACCTGGATGACATATGTCATGATTGCTGTATA
TTTCTTAATTCTGTTAGGTATCGGTTATTATGCATATAAACAATCAACAAGCACATTAGATGAATACATGCTTGGTGGTC
GTAACCTCGGACCATTAGTAACAGCACTTTCTGCTGGAGCAGCTGATATGAGCGGATGGATGCTGATGGGATTACCAGGT
TCAGTATACTCTACAGGACTCTCTGCAACCTGGATTGCAATCGGATTAACGATAGGGGCTTGGTTAAACTATATCCTAGT
TGCACCGAGATTACGTGTATATACGGAGCTTGCAGATAATGCAATTACAATTCCGGACTTCTTCGAAAAACGTGTAAGTG
ATCATACGCGTATATTAAAGATTATTTCAGGACTTGTTATCGTTGTTTTCTTCACATTATATACGCATGCCGGAATGGTA
TCAGGTGGAGTATTATTCGAAAGTGCCTTCGGATTAAACTACCATTACGGTCTAGTACTGACTGCCAGTATCGTAATTAT
CTATACATTGTTCGGTGGATATCTTGCAGTGTCACTGACAGACTTCTTCCAAGGGGTTATCATGTTAATTGCATTAGTGT
TAGTACCAATCGTCGCATTGATGAAATTAAATGGTATGGAAGCGTTTGATACAGTTGTAGAGCTTAAACCAACAAACTTA
GATTTCTTTAAAGGTACGACAACGATCGGTATTATTTCATTGCTTGCATGGGGATTAGGATACTTTGGACAACCTCATAT
TATCGTGCGTTTTATGTCAATTAAGTCTCATAAACAATTACCGGCAGCACGTCGTATCGGTATTTCATGGATGGCTATAT
CGTTAATTGGTGCATGTGTTACAGGACTTGTTGGTATTGCATTTGTCAATAAATCAGGTGCTAAGTTAGACAACGCTGAA
ACAATCTTCGTAATGATGAGTCAAGTGCTCTTCCATCCATTAATTGCTGGATTCTTCCTGGCAGCGATTTTAGCGGCTAT
TATGAGTACGATTTCTTCACAGCTACTCGTTACAAGTAGTGCATTAACACAAGATTTCTATATGTTGTTACGTAAAACAA
GCATTCAGGATACGAGTCGTGAGAAAGAGTTCGTTATGATTGGACGCCTATCAGTATTACTCGTTGCGATTGTTTCAATG
GCAATCGCATGGAGCCCAAATGATACAATCTTAAACTTAGTTGGTAACGCATGGGCAGGATTTGGTGCGGCATTCGGACC
GCTCGTATTGTTATCACTTTACTGGAAAGGTTTAACGAAGCATGGTGCAATTACAGGTATGGTACTCGGATCAATCACAG
TAATCTTCTGGATTGTGATGAAATCACACGGTGGCATCTTTGAGTTATATGAAATCGTTCCAGGGTTCTTTATCAGTTTG
GTGTCAACTGTACTTGTGAGTATGATTACCCCAAAACCTGAACAACGTATTATTGACGAGTTCGATGAAATGAAACGAAT
TGTGAATTCATAA

Upstream 100 bases:

>100_bases
AATTCTATGAAAACGCTTAAATCACCATTATAATAGATATATTGTTACTCTAGTACAATATAATTCAGTGCTAATTGTAA
AAATAAAGGAGGATAAACAA

Downstream 100 bases:

>100_bases
TGAAAAGGTCGAGACAACGTGTCTCGACCTTTTACTCTTCCTGCAAAGTTACGTGTTTATATGTGCAGATTAAACACTTT
GCTATTCATATACATGAATA

Product: high affinity proline permease

Products: NA

Alternate protein names: Proline permease 2 [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MGLILGHTFQNVKIETTWMTYVMIAVYFLILLGIGYYAYKQSTSTLDEYMLGGRNLGPLVTALSAGAADMSGWMLMGLPG
SVYSTGLSATWIAIGLTIGAWLNYILVAPRLRVYTELADNAITIPDFFEKRVSDHTRILKIISGLVIVVFFTLYTHAGMV
SGGVLFESAFGLNYHYGLVLTASIVIIYTLFGGYLAVSLTDFFQGVIMLIALVLVPIVALMKLNGMEAFDTVVELKPTNL
DFFKGTTTIGIISLLAWGLGYFGQPHIIVRFMSIKSHKQLPAARRIGISWMAISLIGACVTGLVGIAFVNKSGAKLDNAE
TIFVMMSQVLFHPLIAGFFLAAILAAIMSTISSQLLVTSSALTQDFYMLLRKTSIQDTSREKEFVMIGRLSVLLVAIVSM
AIAWSPNDTILNLVGNAWAGFGAAFGPLVLLSLYWKGLTKHGAITGMVLGSITVIFWIVMKSHGGIFELYEIVPGFFISL
VSTVLVSMITPKPEQRIIDEFDEMKRIVNS

Sequences:

>Translated_510_residues
MGLILGHTFQNVKIETTWMTYVMIAVYFLILLGIGYYAYKQSTSTLDEYMLGGRNLGPLVTALSAGAADMSGWMLMGLPG
SVYSTGLSATWIAIGLTIGAWLNYILVAPRLRVYTELADNAITIPDFFEKRVSDHTRILKIISGLVIVVFFTLYTHAGMV
SGGVLFESAFGLNYHYGLVLTASIVIIYTLFGGYLAVSLTDFFQGVIMLIALVLVPIVALMKLNGMEAFDTVVELKPTNL
DFFKGTTTIGIISLLAWGLGYFGQPHIIVRFMSIKSHKQLPAARRIGISWMAISLIGACVTGLVGIAFVNKSGAKLDNAE
TIFVMMSQVLFHPLIAGFFLAAILAAIMSTISSQLLVTSSALTQDFYMLLRKTSIQDTSREKEFVMIGRLSVLLVAIVSM
AIAWSPNDTILNLVGNAWAGFGAAFGPLVLLSLYWKGLTKHGAITGMVLGSITVIFWIVMKSHGGIFELYEIVPGFFISL
VSTVLVSMITPKPEQRIIDEFDEMKRIVNS
>Mature_509_residues
GLILGHTFQNVKIETTWMTYVMIAVYFLILLGIGYYAYKQSTSTLDEYMLGGRNLGPLVTALSAGAADMSGWMLMGLPGS
VYSTGLSATWIAIGLTIGAWLNYILVAPRLRVYTELADNAITIPDFFEKRVSDHTRILKIISGLVIVVFFTLYTHAGMVS
GGVLFESAFGLNYHYGLVLTASIVIIYTLFGGYLAVSLTDFFQGVIMLIALVLVPIVALMKLNGMEAFDTVVELKPTNLD
FFKGTTTIGIISLLAWGLGYFGQPHIIVRFMSIKSHKQLPAARRIGISWMAISLIGACVTGLVGIAFVNKSGAKLDNAET
IFVMMSQVLFHPLIAGFFLAAILAAIMSTISSQLLVTSSALTQDFYMLLRKTSIQDTSREKEFVMIGRLSVLLVAIVSMA
IAWSPNDTILNLVGNAWAGFGAAFGPLVLLSLYWKGLTKHGAITGMVLGSITVIFWIVMKSHGGIFELYEIVPGFFISLV
STVLVSMITPKPEQRIIDEFDEMKRIVNS

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=501, Percent_Identity=67.4650698602794, Blast_Score=680, Evalue=0.0,
Organism=Homo sapiens, GI14140236, Length=543, Percent_Identity=22.8360957642726, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4507031, Length=472, Percent_Identity=23.9406779661017, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI109659836, Length=549, Percent_Identity=22.040072859745, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI110835708, Length=218, Percent_Identity=26.1467889908257, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI4507035, Length=362, Percent_Identity=23.7569060773481, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1787251, Length=487, Percent_Identity=48.4599589322382, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI87082237, Length=437, Percent_Identity=30.2059496567506, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1790503, Length=468, Percent_Identity=27.3504273504274, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1790113, Length=396, Percent_Identity=26.5151515151515, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17539284, Length=411, Percent_Identity=24.5742092457421, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24645928, Length=371, Percent_Identity=25.3369272237197, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24651739, Length=488, Percent_Identity=26.0245901639344, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640370, Length=358, Percent_Identity=25.9776536312849, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281362918, Length=196, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI221459588, Length=448, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221459584, Length=387, Percent_Identity=23.7726098191214, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24651741, Length=384, Percent_Identity=25.5208333333333, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573698, Length=455, Percent_Identity=23.0769230769231, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 55671; Mature: 55540

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLILGHTFQNVKIETTWMTYVMIAVYFLILLGIGYYAYKQSTSTLDEYMLGGRNLGPLV
CCEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHH
TALSAGAADMSGWMLMGLPGSVYSTGLSATWIAIGLTIGAWLNYILVAPRLRVYTELADN
HHHHCCCCCCCCEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
AITIPDFFEKRVSDHTRILKIISGLVIVVFFTLYTHAGMVSGGVLFESAFGLNYHYGLVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHCCCCCHHHHHH
TASIVIIYTLFGGYLAVSLTDFFQGVIMLIALVLVPIVALMKLNGMEAFDTVVELKPTNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEECCCCC
DFFKGTTTIGIISLLAWGLGYFGQPHIIVRFMSIKSHKQLPAARRIGISWMAISLIGACV
CCCCCCHHHHHHHHHHHHHCCCCCCHHEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TGLVGIAFVNKSGAKLDNAETIFVMMSQVLFHPLIAGFFLAAILAAIMSTISSQLLVTSS
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALTQDFYMLLRKTSIQDTSREKEFVMIGRLSVLLVAIVSMAIAWSPNDTILNLVGNAWAG
HHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FGAAFGPLVLLSLYWKGLTKHGAITGMVLGSITVIFWIVMKSHGGIFELYEIVPGFFISL
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VSTVLVSMITPKPEQRIIDEFDEMKRIVNS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GLILGHTFQNVKIETTWMTYVMIAVYFLILLGIGYYAYKQSTSTLDEYMLGGRNLGPLV
CEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHH
TALSAGAADMSGWMLMGLPGSVYSTGLSATWIAIGLTIGAWLNYILVAPRLRVYTELADN
HHHHCCCCCCCCEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
AITIPDFFEKRVSDHTRILKIISGLVIVVFFTLYTHAGMVSGGVLFESAFGLNYHYGLVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHCCCCCHHHHHH
TASIVIIYTLFGGYLAVSLTDFFQGVIMLIALVLVPIVALMKLNGMEAFDTVVELKPTNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEECCCCC
DFFKGTTTIGIISLLAWGLGYFGQPHIIVRFMSIKSHKQLPAARRIGISWMAISLIGACV
CCCCCCHHHHHHHHHHHHHCCCCCCHHEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TGLVGIAFVNKSGAKLDNAETIFVMMSQVLFHPLIAGFFLAAILAAIMSTISSQLLVTSS
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALTQDFYMLLRKTSIQDTSREKEFVMIGRLSVLLVAIVSMAIAWSPNDTILNLVGNAWAG
HHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FGAAFGPLVLLSLYWKGLTKHGAITGMVLGSITVIFWIVMKSHGGIFELYEIVPGFFISL
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VSTVLVSMITPKPEQRIIDEFDEMKRIVNS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA