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The map label for this gene is arsC

Identifier: 222151733

GI number: 222151733

Start: 1608651

End: 1609046

Strand: Direct

Name: arsC

Synonym: MCCL_1486

Alternate gene names: 222151733

Gene position: 1608651-1609046 (Clockwise)

Preceding gene: 222151732

Following gene: 222151742

Centisome position: 76.52

GC content: 41.41

Gene sequence:

>396_bases
ATGGAGAAGAAGACACTTTATTTTATTTGTACAGGAAACTCCTGTCGCAGTCAGATGGCTGAAGGATGGGGAAAGCACAT
TCTAGGAGATACATGGAACGTTTATTCAGCAGGGATTGAAACACATGGTGTAAATCCTAAAGCCATTGAAGCGATGAGAG
AGGTGGGAATTGATATCTCTCATCATACATCAGACTTGATCGATCAGGATATTCTGAACAACTCAGACCTCGTCGTTACT
TTATGCAGTGATGCGGATAATAATTGTCCAATTCTGCCACCGAATGTAAAGAAAGAACACTGGGGATTTGATGACCCTGC
TGGTAAAGCATGGTCAGAATTCCAGCGTGTCAGAGATGAGATTGGTCACGCAATCGAACAATTTAAATTAAGATAG

Upstream 100 bases:

>100_bases
ATTTTAAAACAGGGATTGTCATCACAATTCCAGTTTTATTTATTACATTGTTCGGACTTTATTTAACATTAATATTATTT
TAAAGATTTGAGGGATTTTT

Downstream 100 bases:

>100_bases
CAAAATGACTGTGCTTTTTATAAGCACAGTCATTTTTTAGCTATATAATCCTAAATATTCAGCTATTCCATAGATCAATC
AGTGCCTGGATTGAGAAGAA

Product: arsenate reductase

Products: NA

Alternate protein names: Arsenate reductase; Arsenical pump modifier; Low molecular weight protein-tyrosine-phosphatase

Number of amino acids: Translated: 131; Mature: 131

Protein sequence:

>131_residues
MEKKTLYFICTGNSCRSQMAEGWGKHILGDTWNVYSAGIETHGVNPKAIEAMREVGIDISHHTSDLIDQDILNNSDLVVT
LCSDADNNCPILPPNVKKEHWGFDDPAGKAWSEFQRVRDEIGHAIEQFKLR

Sequences:

>Translated_131_residues
MEKKTLYFICTGNSCRSQMAEGWGKHILGDTWNVYSAGIETHGVNPKAIEAMREVGIDISHHTSDLIDQDILNNSDLVVT
LCSDADNNCPILPPNVKKEHWGFDDPAGKAWSEFQRVRDEIGHAIEQFKLR
>Mature_131_residues
MEKKTLYFICTGNSCRSQMAEGWGKHILGDTWNVYSAGIETHGVNPKAIEAMREVGIDISHHTSDLIDQDILNNSDLVVT
LCSDADNNCPILPPNVKKEHWGFDDPAGKAWSEFQRVRDEIGHAIEQFKLR

Specific function: Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARSC_MACCJ (B9E7M5)

Other databases:

- EMBL:   AP009484
- RefSeq:   YP_002560889.1
- GeneID:   7390194
- GenomeReviews:   AP009484_GR
- KEGG:   mcl:MCCL_1486
- OMA:   NILNRAD
- ProtClustDB:   PRK13530
- HAMAP:   MF_01624
- InterPro:   IPR014064
- InterPro:   IPR017867
- PANTHER:   PTHR11717
- SMART:   SM00226
- TIGRFAMs:   TIGR02691

Pfam domain/function: PF01451 LMWPc; SSF52788 Tyr_Pase_low_mol_wt

EC number: =3.1.3.48

Molecular weight: Translated: 14739; Mature: 14739

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: ACT_SITE 10-10 ACT_SITE 82-82 ACT_SITE 89-89

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKTLYFICTGNSCRSQMAEGWGKHILGDTWNVYSAGIETHGVNPKAIEAMREVGIDIS
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCHHHHHHHHHHCCCCC
HHTSDLIDQDILNNSDLVVTLCSDADNNCPILPPNVKKEHWGFDDPAGKAWSEFQRVRDE
CCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IGHAIEQFKLR
HHHHHHHHCCC
>Mature Secondary Structure
MEKKTLYFICTGNSCRSQMAEGWGKHILGDTWNVYSAGIETHGVNPKAIEAMREVGIDIS
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCHHHHHHHHHHCCCCC
HHTSDLIDQDILNNSDLVVTLCSDADNNCPILPPNVKKEHWGFDDPAGKAWSEFQRVRDE
CCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IGHAIEQFKLR
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA