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The map label for this gene is acuC [H]

Identifier: 222151659

GI number: 222151659

Start: 1531292

End: 1532428

Strand: Direct

Name: acuC [H]

Synonym: MCCL_1412

Alternate gene names: 222151659

Gene position: 1531292-1532428 (Clockwise)

Preceding gene: 222151658

Following gene: 222151681

Centisome position: 72.84

GC content: 39.75

Gene sequence:

>1137_bases
ATGACAAAATTTGTCTACTCAAAAAAACTGCTGAAATATCGCTTTGGTGATGATCATCCTTTTAATCAGATGCGCCTGTT
ACTTACGAAATCATTACTTGAAAGCTTATCACTGCTGCATGAAGAAGATATCGTTGCACCCCGCACTGCAACAGATGAAG
AACTGATGCTTGTTCACCAGAAAGAATATATTGAAGCGGTAAAAAAAGCAGGTCAAGGAGAACTGAGTACCAGTGATTGC
AACAAGTTCGGACTTAATTCAAACGATACACCAAACTTTGAAAATATGCATGAAATGAGTGCATTGCTTGTTGGCGCAAC
GCTTACTGCATGCGACATTGTTATGAATGATATCGACCATACTGCATGCAACTTTGGTGGCGGACTACATCACGGCTTCA
CTGGACGTGCTTCAGGATTTTGTATCTATAATGATTCTGCAGTCGCAATAGAATATATGAAACGTAAATATAAACAACGC
GTACTGTATATTGATACCGACGCACATCATGGTGATGGTGTACAGTTTGCTTTCTATAATGATAATCAGATAATGACCTA
TTCTATTCATGAGACTGGCCGATACCTGTTCCCTGGAACCGGCGCCATTACTGAAAAGGGTGAAGGTGAAGGTTATTTAT
ATAGTATGAATATACCTGTTGATGCTTATACTGAAGATGATTCATTTCTGGAATGCTTTGAAGAAAGTTTACGCGCAGCA
TGTGAATTCTTTAAACCAGATATTATATTAAGTCAAAATGGTGCTGATGCCCATTATCTTGATCCATTGACACATCTCTC
TTGTACACATAGGACATACCAACACATCCCACAAATCGTCCTTCGATTAGCAAATGAATATACAAATGGTAGGTGGATTG
CTGTCGGAGGTGGTGGTTATAATATCTTTCAAGTCGCGCCACTCGCCTGGGCACAAGTATATAATGCGATGCTCGGACAC
AGCTATTTAGAAGGTTCAATACCAACTGACTGGATTACGATGTGGCAAAGTAAAGCACAAGTAAAGATTCCAAAAACATG
GAATGAAGATCTACAAGGGTACTCAGTCATACCTAGAAGACGCGATATCGAAGAAAAAAATAAAATGATGCTGGCGCGTG
TCGTGCAGCATTACTAG

Upstream 100 bases:

>100_bases
AAATCGTAACTTTGCGCATGATTGCGATGAACCCAAATATTGCTATATTTGATCTGGAGAAGAAAGGATTCACAGTACTT
GACCCTTTCGAAAGTGGCCT

Downstream 100 bases:

>100_bases
GTGGCTCGTGTTTTTATTTTACGAGCCACCTTACCAACCCATAAAAAGGACCTCGCATACGCAAGGCCCTTAATTTCTAT
TTCGTCGTTCCACGATATTC

Product: acetoin utilization protein AcuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MTKFVYSKKLLKYRFGDDHPFNQMRLLLTKSLLESLSLLHEEDIVAPRTATDEELMLVHQKEYIEAVKKAGQGELSTSDC
NKFGLNSNDTPNFENMHEMSALLVGATLTACDIVMNDIDHTACNFGGGLHHGFTGRASGFCIYNDSAVAIEYMKRKYKQR
VLYIDTDAHHGDGVQFAFYNDNQIMTYSIHETGRYLFPGTGAITEKGEGEGYLYSMNIPVDAYTEDDSFLECFEESLRAA
CEFFKPDIILSQNGADAHYLDPLTHLSCTHRTYQHIPQIVLRLANEYTNGRWIAVGGGGYNIFQVAPLAWAQVYNAMLGH
SYLEGSIPTDWITMWQSKAQVKIPKTWNEDLQGYSVIPRRRDIEEKNKMMLARVVQHY

Sequences:

>Translated_378_residues
MTKFVYSKKLLKYRFGDDHPFNQMRLLLTKSLLESLSLLHEEDIVAPRTATDEELMLVHQKEYIEAVKKAGQGELSTSDC
NKFGLNSNDTPNFENMHEMSALLVGATLTACDIVMNDIDHTACNFGGGLHHGFTGRASGFCIYNDSAVAIEYMKRKYKQR
VLYIDTDAHHGDGVQFAFYNDNQIMTYSIHETGRYLFPGTGAITEKGEGEGYLYSMNIPVDAYTEDDSFLECFEESLRAA
CEFFKPDIILSQNGADAHYLDPLTHLSCTHRTYQHIPQIVLRLANEYTNGRWIAVGGGGYNIFQVAPLAWAQVYNAMLGH
SYLEGSIPTDWITMWQSKAQVKIPKTWNEDLQGYSVIPRRRDIEEKNKMMLARVVQHY
>Mature_377_residues
TKFVYSKKLLKYRFGDDHPFNQMRLLLTKSLLESLSLLHEEDIVAPRTATDEELMLVHQKEYIEAVKKAGQGELSTSDCN
KFGLNSNDTPNFENMHEMSALLVGATLTACDIVMNDIDHTACNFGGGLHHGFTGRASGFCIYNDSAVAIEYMKRKYKQRV
LYIDTDAHHGDGVQFAFYNDNQIMTYSIHETGRYLFPGTGAITEKGEGEGYLYSMNIPVDAYTEDDSFLECFEESLRAAC
EFFKPDIILSQNGADAHYLDPLTHLSCTHRTYQHIPQIVLRLANEYTNGRWIAVGGGGYNIFQVAPLAWAQVYNAMLGHS
YLEGSIPTDWITMWQSKAQVKIPKTWNEDLQGYSVIPRRRDIEEKNKMMLARVVQHY

Specific function: Role in growth and sporulation on acetoin or butanediol. Involved in the breakdown of these compounds used as a carbon source [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI8923769, Length=307, Percent_Identity=32.8990228013029, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI13128862, Length=305, Percent_Identity=33.1147540983607, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI13128860, Length=305, Percent_Identity=32.7868852459016, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI293336691, Length=279, Percent_Identity=33.3333333333333, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI262073092, Length=223, Percent_Identity=34.5291479820628, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI262073088, Length=203, Percent_Identity=33.9901477832512, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI30795204, Length=351, Percent_Identity=26.7806267806268, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI17158039, Length=351, Percent_Identity=26.7806267806268, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI30795202, Length=351, Percent_Identity=26.7806267806268, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI13128864, Length=318, Percent_Identity=29.2452830188679, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI20070354, Length=323, Percent_Identity=28.4829721362229, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI62750349, Length=336, Percent_Identity=28.2738095238095, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI62750347, Length=336, Percent_Identity=28.2738095238095, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI153085395, Length=349, Percent_Identity=25.5014326647564, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI217272877, Length=295, Percent_Identity=26.4406779661017, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI209862883, Length=292, Percent_Identity=25, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI148539870, Length=351, Percent_Identity=25.0712250712251, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI169234807, Length=351, Percent_Identity=25.0712250712251, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI226529806, Length=325, Percent_Identity=27.3846153846154, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17508561, Length=310, Percent_Identity=32.9032258064516, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17561978, Length=304, Percent_Identity=33.2236842105263, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17534739, Length=319, Percent_Identity=30.4075235109718, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17540334, Length=311, Percent_Identity=30.8681672025724, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193206283, Length=311, Percent_Identity=30.8681672025724, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17540332, Length=311, Percent_Identity=30.8681672025724, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI193209491, Length=299, Percent_Identity=26.4214046822742, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25154020, Length=310, Percent_Identity=22.258064516129, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25154022, Length=313, Percent_Identity=22.6837060702875, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321244, Length=328, Percent_Identity=32.9268292682927, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6323999, Length=305, Percent_Identity=30.4918032786885, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6324307, Length=333, Percent_Identity=28.5285285285285, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325325, Length=214, Percent_Identity=30.8411214953271, Blast_Score=109, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24644244, Length=313, Percent_Identity=32.5878594249201, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24657891, Length=305, Percent_Identity=33.4426229508197, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24641720, Length=345, Percent_Identity=26.9565217391304, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI281360801, Length=345, Percent_Identity=26.9565217391304, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281360799, Length=345, Percent_Identity=26.9565217391304, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24642142, Length=312, Percent_Identity=26.6025641025641, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24642144, Length=312, Percent_Identity=26.6025641025641, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24642146, Length=312, Percent_Identity=26.6025641025641, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281360899, Length=312, Percent_Identity=26.6025641025641, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003085
- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 42966; Mature: 42835

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKFVYSKKLLKYRFGDDHPFNQMRLLLTKSLLESLSLLHEEDIVAPRTATDEELMLVHQ
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
KEYIEAVKKAGQGELSTSDCNKFGLNSNDTPNFENMHEMSALLVGATLTACDIVMNDIDH
HHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
TACNFGGGLHHGFTGRASGFCIYNDSAVAIEYMKRKYKQRVLYIDTDAHHGDGVQFAFYN
HHHCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCEEEEEECCCCCCCCEEEEEEC
DNQIMTYSIHETGRYLFPGTGAITEKGEGEGYLYSMNIPVDAYTEDDSFLECFEESLRAA
CCEEEEEEEECCCCEEECCCCCCCCCCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHH
CEFFKPDIILSQNGADAHYLDPLTHLSCTHRTYQHIPQIVLRLANEYTNGRWIAVGGGGY
HHHCCCCEEEECCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
NIFQVAPLAWAQVYNAMLGHSYLEGSIPTDWITMWQSKAQVKIPKTWNEDLQGYSVIPRR
EEEEEHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCEECCCC
RDIEEKNKMMLARVVQHY
CCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKFVYSKKLLKYRFGDDHPFNQMRLLLTKSLLESLSLLHEEDIVAPRTATDEELMLVHQ
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
KEYIEAVKKAGQGELSTSDCNKFGLNSNDTPNFENMHEMSALLVGATLTACDIVMNDIDH
HHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
TACNFGGGLHHGFTGRASGFCIYNDSAVAIEYMKRKYKQRVLYIDTDAHHGDGVQFAFYN
HHHCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCEEEEEECCCCCCCCEEEEEEC
DNQIMTYSIHETGRYLFPGTGAITEKGEGEGYLYSMNIPVDAYTEDDSFLECFEESLRAA
CCEEEEEEEECCCCEEECCCCCCCCCCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHH
CEFFKPDIILSQNGADAHYLDPLTHLSCTHRTYQHIPQIVLRLANEYTNGRWIAVGGGGY
HHHCCCCEEEECCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
NIFQVAPLAWAQVYNAMLGHSYLEGSIPTDWITMWQSKAQVKIPKTWNEDLQGYSVIPRR
EEEEEHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCEECCCC
RDIEEKNKMMLARVVQHY
CCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]