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The map label for this gene is femA [H]

Identifier: 222151288

GI number: 222151288

Start: 1148103

End: 1149344

Strand: Direct

Name: femA [H]

Synonym: MCCL_1041

Alternate gene names: 222151288

Gene position: 1148103-1149344 (Clockwise)

Preceding gene: 222151285

Following gene: 222151289

Centisome position: 54.61

GC content: 36.15

Gene sequence:

>1242_bases
ATGAAATTTACAACACTTACACGTGAAGCATTCAGTGCTTTCACAGACCAGCATCCAAGTCATTTTACACAGATGGCTGT
AAACTATGATCTGAAGATTTCAGAAGGTATAGAGACACATCTGCTCGGTGTGAAAGATGAGAATAATGAAATCATAGCTG
CAGGTCTATTTACATCAGTTCCTATAATGAAAATCTTCAAATATTTCTATTCAAACCGCGGTCCTGTCATGGATTATCAC
AATAGGGAGCTTGTAACGTTCTTCTTTAATGAACTTAAGAAGTATATGAAACAGCATAAAGCGTTAAATTTAAGAATAGA
CCCTTACGTACCATACCAGTTACGTAATCACGATGGGGACATCATCAAAACATATAAGACAGATGATATTTTTGAAACAT
TGAAATCCCTTGGTTTCAAGCATGACGGCTTTACAACTGGATTTCACCCGATACACCAAATCAGATGGCATTCAGTCCTG
GACCTAAAAGGTAAAACGAAGGAACAGCTCATAAAGGATATGGATAGTCTTAGGAAGCGTAATACTAAGAAGGTCATTAA
AAATGGTATTAAAGTAAGGTATCTGGAAAAAGACGAGCTCCATATTTTTCGTTCATTTATGCAGGATACAAGTGATAAGA
AGGATTTCGAAGATCGTGGAGATGAATATTATATCTCAAGATTAGAAAAATTTGGAGATCATGTGAAGATGCCGCTTGCC
TATATTGACTTTAATACTTATATTCCCGAGCTGGAAGCAGAGCTTACAGAAATAGAACGTGCAATAGACAAAGCCAAAGC
TGATATCGAAAGCAAACCAGAAAATAAAAAGGCACAAAATAAGTTAGCGGATAATGAAAGACAAAAACAAGCACTTTTAG
AGAAGCTGAAAGAAGCACAGCAACTGAAAGAAAAACATGGTGACACACTACCGATTGCTGCTGCGTTTTACTTTATAAAT
CCGCATGAAGTGGTCTATTATGCCGGAGGGTCTTCGAATGAATTCAGACATTTCTCTGGAAGTTATGCAATACAGTGGCA
CATGATCAACTATGCTATAGATCATGGCATCGACAAATATAATTTCTATGGTATTAGTGGTATCTTCAATGAGGATGCAC
CTGACGCTGGTGTTATTAAATTTAAAAAAGGTTATAATGCCGATGTCATTGAGTATATCGGTGATTTTGAACTCCCTGTC
AATAAAAGTGTCTATAATATATACAAACGAATCAAGAAATAA

Upstream 100 bases:

>100_bases
ATTAATAGTCTTAAAAGGAGCCGAACTATAATTATAAATGATTTTTACGGTATGAATATGTTAATATGATGCTTGAGATG
ATAAAAGAAGGAGAAAACAA

Downstream 100 bases:

>100_bases
GTATTACTGGAGGCAGTATCTATGAAGTTTACAGAATTAACCGTTGAGGAATATGACCAGTATATGTGGAAAACTGAGGC
GATGAGTCATTATTTTCAAA

Product: methicillin resistance protein FemA

Products: NA

Alternate protein names: Factor essential for expression of methicillin resistance A [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MKFTTLTREAFSAFTDQHPSHFTQMAVNYDLKISEGIETHLLGVKDENNEIIAAGLFTSVPIMKIFKYFYSNRGPVMDYH
NRELVTFFFNELKKYMKQHKALNLRIDPYVPYQLRNHDGDIIKTYKTDDIFETLKSLGFKHDGFTTGFHPIHQIRWHSVL
DLKGKTKEQLIKDMDSLRKRNTKKVIKNGIKVRYLEKDELHIFRSFMQDTSDKKDFEDRGDEYYISRLEKFGDHVKMPLA
YIDFNTYIPELEAELTEIERAIDKAKADIESKPENKKAQNKLADNERQKQALLEKLKEAQQLKEKHGDTLPIAAAFYFIN
PHEVVYYAGGSSNEFRHFSGSYAIQWHMINYAIDHGIDKYNFYGISGIFNEDAPDAGVIKFKKGYNADVIEYIGDFELPV
NKSVYNIYKRIKK

Sequences:

>Translated_413_residues
MKFTTLTREAFSAFTDQHPSHFTQMAVNYDLKISEGIETHLLGVKDENNEIIAAGLFTSVPIMKIFKYFYSNRGPVMDYH
NRELVTFFFNELKKYMKQHKALNLRIDPYVPYQLRNHDGDIIKTYKTDDIFETLKSLGFKHDGFTTGFHPIHQIRWHSVL
DLKGKTKEQLIKDMDSLRKRNTKKVIKNGIKVRYLEKDELHIFRSFMQDTSDKKDFEDRGDEYYISRLEKFGDHVKMPLA
YIDFNTYIPELEAELTEIERAIDKAKADIESKPENKKAQNKLADNERQKQALLEKLKEAQQLKEKHGDTLPIAAAFYFIN
PHEVVYYAGGSSNEFRHFSGSYAIQWHMINYAIDHGIDKYNFYGISGIFNEDAPDAGVIKFKKGYNADVIEYIGDFELPV
NKSVYNIYKRIKK
>Mature_413_residues
MKFTTLTREAFSAFTDQHPSHFTQMAVNYDLKISEGIETHLLGVKDENNEIIAAGLFTSVPIMKIFKYFYSNRGPVMDYH
NRELVTFFFNELKKYMKQHKALNLRIDPYVPYQLRNHDGDIIKTYKTDDIFETLKSLGFKHDGFTTGFHPIHQIRWHSVL
DLKGKTKEQLIKDMDSLRKRNTKKVIKNGIKVRYLEKDELHIFRSFMQDTSDKKDFEDRGDEYYISRLEKFGDHVKMPLA
YIDFNTYIPELEAELTEIERAIDKAKADIESKPENKKAQNKLADNERQKQALLEKLKEAQQLKEKHGDTLPIAAAFYFIN
PHEVVYYAGGSSNEFRHFSGSYAIQWHMINYAIDHGIDKYNFYGISGIFNEDAPDAGVIKFKKGYNADVIEYIGDFELPV
NKSVYNIYKRIKK

Specific function: Catalyzes the formation of the pentaglycine interpeptide bridge, which is characteristic of the S.aureus peptidoglycan. Adds glycines 2 and 3 of the pentaglycine bridge, using glycyl- tRNA(Gly) as donor. Involved in resistance to methicillin [H]

COG id: COG2348

COG function: function code V; Uncharacterized protein involved in methicillin resistance

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the femABX family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016181
- InterPro:   IPR003447
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02388 FemAB [H]

EC number: NA

Molecular weight: Translated: 48346; Mature: 48346

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFTTLTREAFSAFTDQHPSHFTQMAVNYDLKISEGIETHLLGVKDENNEIIAAGLFTSV
CCCCHHHHHHHHHHHCCCCHHHHHHHEEECEEECCCCCEEEEEEECCCCCEEEEHHHHHH
PIMKIFKYFYSNRGPVMDYHNRELVTFFFNELKKYMKQHKALNLRIDPYVPYQLRNHDGD
HHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCC
IIKTYKTDDIFETLKSLGFKHDGFTTGFHPIHQIRWHSVLDLKGKTKEQLIKDMDSLRKR
EEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHC
NTKKVIKNGIKVRYLEKDELHIFRSFMQDTSDKKDFEDRGDEYYISRLEKFGDHVKMPLA
CHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHCCHHCCCEE
YIDFNTYIPELEAELTEIERAIDKAKADIESKPENKKAQNKLADNERQKQALLEKLKEAQ
EEEHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
QLKEKHGDTLPIAAAFYFINPHEVVYYAGGSSNEFRHFSGSYAIQWHMINYAIDHGIDKY
HHHHHCCCCCEEEEEEEEECCCEEEEEECCCCCCCEECCCCEEEEEEEEEHHHHCCCCCC
NFYGISGIFNEDAPDAGVIKFKKGYNADVIEYIGDFELPVNKSVYNIYKRIKK
EEEEECCCCCCCCCCCCEEEECCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKFTTLTREAFSAFTDQHPSHFTQMAVNYDLKISEGIETHLLGVKDENNEIIAAGLFTSV
CCCCHHHHHHHHHHHCCCCHHHHHHHEEECEEECCCCCEEEEEEECCCCCEEEEHHHHHH
PIMKIFKYFYSNRGPVMDYHNRELVTFFFNELKKYMKQHKALNLRIDPYVPYQLRNHDGD
HHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCC
IIKTYKTDDIFETLKSLGFKHDGFTTGFHPIHQIRWHSVLDLKGKTKEQLIKDMDSLRKR
EEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHC
NTKKVIKNGIKVRYLEKDELHIFRSFMQDTSDKKDFEDRGDEYYISRLEKFGDHVKMPLA
CHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHCCHHCCCEE
YIDFNTYIPELEAELTEIERAIDKAKADIESKPENKKAQNKLADNERQKQALLEKLKEAQ
EEEHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
QLKEKHGDTLPIAAAFYFINPHEVVYYAGGSSNEFRHFSGSYAIQWHMINYAIDHGIDKY
HHHHHCCCCCEEEEEEEEECCCEEEEEECCCCCCCEECCCCEEEEEEEEEHHHHCCCCCC
NFYGISGIFNEDAPDAGVIKFKKGYNADVIEYIGDFELPVNKSVYNIYKRIKK
EEEEECCCCCCCCCCCCEEEECCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA