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The map label for this gene is dxr

Identifier: 222151095

GI number: 222151095

Start: 921939

End: 923069

Strand: Direct

Name: dxr

Synonym: MCCL_0846

Alternate gene names: 222151095

Gene position: 921939-923069 (Clockwise)

Preceding gene: 222151094

Following gene: 222151096

Centisome position: 43.85

GC content: 38.02

Gene sequence:

>1131_bases
ATGAAAAACATAGGAATATTAGGTGCCAGTGGTTCAGTTGGTACACAAGGATTAGACATTATAAGACAATATCCGGATAC
TTATAAGCTTGTAAGTTTCTCAGTCGGTAAGAATTTAGAGCTGGCAAATAAAATTATAGAAGAATTTAGGCCGGATATCT
GCTGTGTACAAGATAAAGAAGATATAGATAAGATTCAATCATCATCTATTAAAGTCGTATATGGTAATGACGGATTGATG
GAAATAGCTGCATATGTCAAAAATGACATGCTCTTAAATTCAATTATGGGGAGTATCGGCTTAAAACCTACTGTGCATGC
GATTAAACACGGCATCGATATTGCGCTTGCCAATAAAGAGACGCTTGTTGTTGCAGGAGAAATTATTATGCAGCTCGCAC
GTGAATACAATGTGAATATTATACCTGTAGATTCAGAACATTCTGCTATCTTTCAGTGCTTGAATGGTGAAGATCATAAA
CATATTGAGAAACTGATTATTACGGCGAGTGGAGGTTCATTTAGAGAGTTATCTCGCGAGGCACTGAAAGATGTCACTGT
ACAGGATGCACTGAAACATCCGAACTGGTCGATGGGCAAGAAGATTACAATTGATTCTGCGACAATGATGAATAAAGGAC
TTGAGGTCATTGAAGCAAGATGGCTGTTTGATATGCCGATCGATAAAATTGAAACTTTGTTACATAAGCAAAGTATCATA
CACTCAATGGTAGAGTTCAATGATACAAGTGTGATTGCTCAGCTTGGGACACCGGATATGCGTATGCCTATTCTTTATGC
ATTTAGTTATCCAGATCGTCTCGCGCGTAAAGCAGAACGACTAAATCTTGCTGAAGTTGGTCAGCTGGACTTTAAAGCGA
TGGATTTTGATAGATATCGATGTCTGAAACTCGCCTATGATGCGATCAGTATTGGTGGCACGATGCCAGTTGTAATGAAT
GCAGTCAACGAAGTTGTCGTACAGCAGTTTTTAGATGGAGAGATTGGTTTTTTAGATATTGAGACAATTATTGAACGTGA
AATGAATGCACATGATGTGATACAAAGTCCGGATCTTGAAACTATTCTTGAAATTGATGCACAGTATAAGTCAAGAAAGT
ATGAGGTGTAG

Upstream 100 bases:

>100_bases
AATAGGGTTATTTTTTGTGGTAGATTAGTATTTGAATTTCTTATGATGATTGCAAGATTTATGATAGAATAAAGCTATTA
AACGTAAAAAAGGTGAAGCA

Downstream 100 bases:

>100_bases
CGATGTTAGGATTATTAGCCTTTATATTAGTTTTTGGATTAATTGTTACGGTGCATGAACTCGGGCATTTAATCTTAGCT
AAACGTGCGGGTATCATGTG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKNIGILGASGSVGTQGLDIIRQYPDTYKLVSFSVGKNLELANKIIEEFRPDICCVQDKEDIDKIQSSSIKVVYGNDGLM
EIAAYVKNDMLLNSIMGSIGLKPTVHAIKHGIDIALANKETLVVAGEIIMQLAREYNVNIIPVDSEHSAIFQCLNGEDHK
HIEKLIITASGGSFRELSREALKDVTVQDALKHPNWSMGKKITIDSATMMNKGLEVIEARWLFDMPIDKIETLLHKQSII
HSMVEFNDTSVIAQLGTPDMRMPILYAFSYPDRLARKAERLNLAEVGQLDFKAMDFDRYRCLKLAYDAISIGGTMPVVMN
AVNEVVVQQFLDGEIGFLDIETIIEREMNAHDVIQSPDLETILEIDAQYKSRKYEV

Sequences:

>Translated_376_residues
MKNIGILGASGSVGTQGLDIIRQYPDTYKLVSFSVGKNLELANKIIEEFRPDICCVQDKEDIDKIQSSSIKVVYGNDGLM
EIAAYVKNDMLLNSIMGSIGLKPTVHAIKHGIDIALANKETLVVAGEIIMQLAREYNVNIIPVDSEHSAIFQCLNGEDHK
HIEKLIITASGGSFRELSREALKDVTVQDALKHPNWSMGKKITIDSATMMNKGLEVIEARWLFDMPIDKIETLLHKQSII
HSMVEFNDTSVIAQLGTPDMRMPILYAFSYPDRLARKAERLNLAEVGQLDFKAMDFDRYRCLKLAYDAISIGGTMPVVMN
AVNEVVVQQFLDGEIGFLDIETIIEREMNAHDVIQSPDLETILEIDAQYKSRKYEV
>Mature_376_residues
MKNIGILGASGSVGTQGLDIIRQYPDTYKLVSFSVGKNLELANKIIEEFRPDICCVQDKEDIDKIQSSSIKVVYGNDGLM
EIAAYVKNDMLLNSIMGSIGLKPTVHAIKHGIDIALANKETLVVAGEIIMQLAREYNVNIIPVDSEHSAIFQCLNGEDHK
HIEKLIITASGGSFRELSREALKDVTVQDALKHPNWSMGKKITIDSATMMNKGLEVIEARWLFDMPIDKIETLLHKQSII
HSMVEFNDTSVIAQLGTPDMRMPILYAFSYPDRLARKAERLNLAEVGQLDFKAMDFDRYRCLKLAYDAISIGGTMPVVMN
AVNEVVVQQFLDGEIGFLDIETIIEREMNAHDVIQSPDLETILEIDAQYKSRKYEV

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=387, Percent_Identity=39.2764857881137, Blast_Score=284, Evalue=7e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_MACCJ (B9EBE2)

Other databases:

- EMBL:   AP009484
- RefSeq:   YP_002560249.1
- GeneID:   7390512
- GenomeReviews:   AP009484_GR
- KEGG:   mcl:MCCL_0846
- OMA:   IHSMVEY
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42095; Mature: 42095

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: BINDING 119-119 BINDING 146-146 BINDING 170-170 BINDING 193-193 BINDING 215-215

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIGILGASGSVGTQGLDIIRQYPDTYKLVSFSVGKNLELANKIIEEFRPDICCVQDKE
CCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECCHH
DIDKIQSSSIKVVYGNDGLMEIAAYVKNDMLLNSIMGSIGLKPTVHAIKHGIDIALANKE
HHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCC
TLVVAGEIIMQLAREYNVNIIPVDSEHSAIFQCLNGEDHKHIEKLIITASGGSFRELSRE
EEEEHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHHHHEEEEEEECCCCHHHHHHH
ALKDVTVQDALKHPNWSMGKKITIDSATMMNKGLEVIEARWLFDMPIDKIETLLHKQSII
HHHCCHHHHHHCCCCCCCCCEEEECHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
HSMVEFNDTSVIAQLGTPDMRMPILYAFSYPDRLARKAERLNLAEVGQLDFKAMDFDRYR
HHHHHCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHCCHHHHCCCCCEEECHHHHH
CLKLAYDAISIGGTMPVVMNAVNEVVVQQFLDGEIGFLDIETIIEREMNAHDVIQSPDLE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCHHHCCCCCCHH
TILEIDAQYKSRKYEV
HHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNIGILGASGSVGTQGLDIIRQYPDTYKLVSFSVGKNLELANKIIEEFRPDICCVQDKE
CCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECCHH
DIDKIQSSSIKVVYGNDGLMEIAAYVKNDMLLNSIMGSIGLKPTVHAIKHGIDIALANKE
HHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCC
TLVVAGEIIMQLAREYNVNIIPVDSEHSAIFQCLNGEDHKHIEKLIITASGGSFRELSRE
EEEEHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHHHHEEEEEEECCCCHHHHHHH
ALKDVTVQDALKHPNWSMGKKITIDSATMMNKGLEVIEARWLFDMPIDKIETLLHKQSII
HHHCCHHHHHHCCCCCCCCCEEEECHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
HSMVEFNDTSVIAQLGTPDMRMPILYAFSYPDRLARKAERLNLAEVGQLDFKAMDFDRYR
HHHHHCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHCCHHHHCCCCCEEECHHHHH
CLKLAYDAISIGGTMPVVMNAVNEVVVQQFLDGEIGFLDIETIIEREMNAHDVIQSPDLE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCHHHCCCCCCHH
TILEIDAQYKSRKYEV
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA