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The map label for this gene is pdhB [H]

Identifier: 222150961

GI number: 222150961

Start: 766914

End: 767891

Strand: Direct

Name: pdhB [H]

Synonym: MCCL_0711

Alternate gene names: 222150961

Gene position: 766914-767891 (Clockwise)

Preceding gene: 222150960

Following gene: 222150962

Centisome position: 36.48

GC content: 41.41

Gene sequence:

>978_bases
ATGGCACAAATGACAATGATTCAAGCGATTACAAATGCGCTTCAAACAGAACTAAAAAATGACGAAAACGTATTAGTTTT
CGGAGAAGACGTTGGTGTCAACGGTGGGGTATTCCGTGCGACTGAAGGACTTCAAAAAGAATTCGGTGAAGATCGTGTAT
TCGATACACCACTTGCTGAGTCTGGTATCGGTGGTTTAGCGGTAGGTTTATCATTAACTGGTTTCCGTCCGGTAATGGAA
ATTCAGTTCTTCGGATTCGTATTCGAAGTATTCGATTCAATTGCAGCACAATTATCTCGTCAATACTTCCGTTCAGGCGG
AACAAAGACTGCACCAGTTGTTATCCGTTCTCCATTTGGTGGTGGGGTACATACGCCAGAACTTCATGCAGATAACCTAG
AAGGTCTAATGGCACAAACACCTGGTGTTAAAGTTGTTATTCCATCAAACCCATATGATGCTAAAGGATTATTAATTTCA
GCAATTCGTGACAACGACCCTGTCGTTTACTTAGAGCATATGAAATTATACCGTTCATTCCGTGAAGAAGTACCTGAAGA
AGAGTATACGGTTGAAATCGGTAAAGCGGCAGTGAAACAAGAGGGTACTGATTTATCAATCATTACTTATGGTGCAATGG
TTCAAGAATCTATGAAAGCAGCAGAAACGTTAGCGAAAGATGGACATTCAGTAGAAGTCATCGACTTACGTACTGTTCAA
CCACTTGATATTGAAACAATCATTGCTTCTGTTGAGAAGACTGGTCGCGTTGTTGTCGTTCAGGAAGCACAAAAACAAGC
GGGTGTTGGTGCAAATGTCGTATCTGAAATTTCAGAGCGTGCGATTTTAAGCCTGGAAGCACCTATCGGACGTGTATCAG
CACCTGATACTGCTTACCCATTCACTCAAGCAGAAAACGTTTGGTTACCAAACAAAGAAGACATTATCGCAGTAGCGAAA
AAGACGTTAGAATTCTAA

Upstream 100 bases:

>100_bases
AACTGTGACGCAATTAATGGAGATTATGTACTCTGATAACGTTCCTCAAAATATTAAGGAACAGATGGAAATTTATAAAG
AGAAGGAGTCGAAATAAGTC

Downstream 100 bases:

>100_bases
TCTAGAAGATAAACGTGTAAAATGAAAAGTGACATCACGATGTTACTTTTCATTCATTTATTTTAATTCTTAATTCTTTA
GGAGGAATTTATTGTGGCAT

Product: pyruvate dehydrogenase E1 component beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAQMTMIQAITNALQTELKNDENVLVFGEDVGVNGGVFRATEGLQKEFGEDRVFDTPLAESGIGGLAVGLSLTGFRPVME
IQFFGFVFEVFDSIAAQLSRQYFRSGGTKTAPVVIRSPFGGGVHTPELHADNLEGLMAQTPGVKVVIPSNPYDAKGLLIS
AIRDNDPVVYLEHMKLYRSFREEVPEEEYTVEIGKAAVKQEGTDLSIITYGAMVQESMKAAETLAKDGHSVEVIDLRTVQ
PLDIETIIASVEKTGRVVVVQEAQKQAGVGANVVSEISERAILSLEAPIGRVSAPDTAYPFTQAENVWLPNKEDIIAVAK
KTLEF

Sequences:

>Translated_325_residues
MAQMTMIQAITNALQTELKNDENVLVFGEDVGVNGGVFRATEGLQKEFGEDRVFDTPLAESGIGGLAVGLSLTGFRPVME
IQFFGFVFEVFDSIAAQLSRQYFRSGGTKTAPVVIRSPFGGGVHTPELHADNLEGLMAQTPGVKVVIPSNPYDAKGLLIS
AIRDNDPVVYLEHMKLYRSFREEVPEEEYTVEIGKAAVKQEGTDLSIITYGAMVQESMKAAETLAKDGHSVEVIDLRTVQ
PLDIETIIASVEKTGRVVVVQEAQKQAGVGANVVSEISERAILSLEAPIGRVSAPDTAYPFTQAENVWLPNKEDIIAVAK
KTLEF
>Mature_324_residues
AQMTMIQAITNALQTELKNDENVLVFGEDVGVNGGVFRATEGLQKEFGEDRVFDTPLAESGIGGLAVGLSLTGFRPVMEI
QFFGFVFEVFDSIAAQLSRQYFRSGGTKTAPVVIRSPFGGGVHTPELHADNLEGLMAQTPGVKVVIPSNPYDAKGLLISA
IRDNDPVVYLEHMKLYRSFREEVPEEEYTVEIGKAAVKQEGTDLSIITYGAMVQESMKAAETLAKDGHSVEVIDLRTVQP
LDIETIIASVEKTGRVVVVQEAQKQAGVGANVVSEISERAILSLEAPIGRVSAPDTAYPFTQAENVWLPNKEDIIAVAKK
TLEF

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=326, Percent_Identity=40.1840490797546, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI34101272, Length=326, Percent_Identity=40.1840490797546, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=37.4233128834356, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=35.5828220858896, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI133778974, Length=98, Percent_Identity=37.7551020408163, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786622, Length=226, Percent_Identity=25.6637168141593, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17506935, Length=326, Percent_Identity=37.7300613496933, Blast_Score=230, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17538422, Length=325, Percent_Identity=37.5384615384615, Blast_Score=228, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=39.2638036809816, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI160714828, Length=326, Percent_Identity=39.2638036809816, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI160714832, Length=326, Percent_Identity=39.2638036809816, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=37.1165644171779, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=37.1165644171779, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=40, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=40, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35248; Mature: 35116

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQMTMIQAITNALQTELKNDENVLVFGEDVGVNGGVFRATEGLQKEFGEDRVFDTPLAE
CCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEHHHHHHHHHCCCCCCCCCCCHH
SGIGGLAVGLSLTGFRPVMEIQFFGFVFEVFDSIAAQLSRQYFRSGGTKTAPVVIRSPFG
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEECCCC
GGVHTPELHADNLEGLMAQTPGVKVVIPSNPYDAKGLLISAIRDNDPVVYLEHMKLYRSF
CCCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHH
REEVPEEEYTVEIGKAAVKQEGTDLSIITYGAMVQESMKAAETLAKDGHSVEVIDLRTVQ
HHHCCCCCEEEEHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
PLDIETIIASVEKTGRVVVVQEAQKQAGVGANVVSEISERAILSLEAPIGRVSAPDTAYP
CCCHHHHHHHHHHCCCEEEEECCHHHCCCCHHHHHHHHHHHEEEEECCCCCCCCCCCCCC
FTQAENVWLPNKEDIIAVAKKTLEF
CCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AQMTMIQAITNALQTELKNDENVLVFGEDVGVNGGVFRATEGLQKEFGEDRVFDTPLAE
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEHHHHHHHHHCCCCCCCCCCCHH
SGIGGLAVGLSLTGFRPVMEIQFFGFVFEVFDSIAAQLSRQYFRSGGTKTAPVVIRSPFG
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEECCCC
GGVHTPELHADNLEGLMAQTPGVKVVIPSNPYDAKGLLISAIRDNDPVVYLEHMKLYRSF
CCCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHH
REEVPEEEYTVEIGKAAVKQEGTDLSIITYGAMVQESMKAAETLAKDGHSVEVIDLRTVQ
HHHCCCCCEEEEHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
PLDIETIIASVEKTGRVVVVQEAQKQAGVGANVVSEISERAILSLEAPIGRVSAPDTAYP
CCCHHHHHHHHHHCCCEEEEECCHHHCCCCHHHHHHHHHHHEEEEECCCCCCCCCCCCCC
FTQAENVWLPNKEDIIAVAKKTLEF
CCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA