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The map label for this gene is purM

Identifier: 222150944

GI number: 222150944

Start: 746738

End: 747760

Strand: Direct

Name: purM

Synonym: MCCL_0694

Alternate gene names: 222150944

Gene position: 746738-747760 (Clockwise)

Preceding gene: 222150943

Following gene: 222150945

Centisome position: 35.52

GC content: 44.38

Gene sequence:

>1023_bases
ATGGCTGAAAGTTATAAACAATCAGGCGTTGATATCCATGCTGGGTATGAAGCGGTTGAGCGCATGAAAAAGCATGTGAA
CAAGACGATGCGTAAAGAAGTGCTTGGAGGGCTTGGCAGTTTCGGTGCGGCATTCGACCTATCACAGCTGAATATGAAAG
CACCTGTTCTCGTTTCAGGTACTGATGGAGTAGGTACGAAATTACGTCTTGCAATCGATAGTGATCGACATGACACAATC
GGAATCGATGCAGTGGCTATGTGCGTGAACGATATTTTAACGACAGGTGCGATGCCGTTATACTTCCTTGATTATCTCGC
ATTAAATAAAGTGGACCCTGTAATCGTCGAACAGATCGTTAAAGGTGTTGCTGATGGCTGTGCTGAAAGTGAATGTGCAC
TGATCGGCGGAGAAACAGCTGAAATGGGCGATATGTATCATACAGGTGATTATGATATCGCTGGCTTTGCTGTCGGGGCT
GTCGAGAAGGATGCATATATTACTGGTGAACGTATTGCTGAAGGTGACGTGATATTAGGACTTGCTTCAAGCGGTATTCA
CTCAAATGGTTACAGCTTGGTACGTAAGATCATTAAAGATAATAATCTCGATCTAGATGCTGAATTTGATAACGGTAAGA
CGCTGCTGGATGTCGTGTTAGAACCAACACGTCTATACGTTAAGAGCGCAAAAGCGATATTGGATGCAGCGGACGTACAC
GGTATGTGTCACGTGACCGGCGGCGGCTTTATTGAGAATGTTCCGCGTGTCTTTGTGACTGACGGATTATATCCGGAAAT
CGATGTTACAAACATTCCGCGTCAGAAGATCTTTGACTTATTACAGGAAAAAGGCAGCATCGACAAGATGGAGATGTACA
ATATCTTCAATATGGGTATCGGATTTATCTTTATCGTACCGAGAGAAGCGGTAGAGAAGGTACGCTCAGCAGTGAACGAA
GAAGTATTTGAAATCGGTCGTGTCGTACGCGGTGACAAAGCAATCGACATTAAAGGTGTGTAA

Upstream 100 bases:

>100_bases
AAGGCGAATGTAATGCCTGCTTTACTGGGAACTATCCGATTGAAATCGTGGATCATGTATTACCAGAAGAAAAAGACAAG
AAGAAGAAGGGAGTATAATT

Downstream 100 bases:

>100_bases
TATGATTAAAGTCGCGATATTTGCTTCAGGTAATGGGTCGAATTACGAGAAGATTATGGAGCATATTCAGGCAGGATTCC
TGGATCATATTGAAGTGACA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MAESYKQSGVDIHAGYEAVERMKKHVNKTMRKEVLGGLGSFGAAFDLSQLNMKAPVLVSGTDGVGTKLRLAIDSDRHDTI
GIDAVAMCVNDILTTGAMPLYFLDYLALNKVDPVIVEQIVKGVADGCAESECALIGGETAEMGDMYHTGDYDIAGFAVGA
VEKDAYITGERIAEGDVILGLASSGIHSNGYSLVRKIIKDNNLDLDAEFDNGKTLLDVVLEPTRLYVKSAKAILDAADVH
GMCHVTGGGFIENVPRVFVTDGLYPEIDVTNIPRQKIFDLLQEKGSIDKMEMYNIFNMGIGFIFIVPREAVEKVRSAVNE
EVFEIGRVVRGDKAIDIKGV

Sequences:

>Translated_340_residues
MAESYKQSGVDIHAGYEAVERMKKHVNKTMRKEVLGGLGSFGAAFDLSQLNMKAPVLVSGTDGVGTKLRLAIDSDRHDTI
GIDAVAMCVNDILTTGAMPLYFLDYLALNKVDPVIVEQIVKGVADGCAESECALIGGETAEMGDMYHTGDYDIAGFAVGA
VEKDAYITGERIAEGDVILGLASSGIHSNGYSLVRKIIKDNNLDLDAEFDNGKTLLDVVLEPTRLYVKSAKAILDAADVH
GMCHVTGGGFIENVPRVFVTDGLYPEIDVTNIPRQKIFDLLQEKGSIDKMEMYNIFNMGIGFIFIVPREAVEKVRSAVNE
EVFEIGRVVRGDKAIDIKGV
>Mature_339_residues
AESYKQSGVDIHAGYEAVERMKKHVNKTMRKEVLGGLGSFGAAFDLSQLNMKAPVLVSGTDGVGTKLRLAIDSDRHDTIG
IDAVAMCVNDILTTGAMPLYFLDYLALNKVDPVIVEQIVKGVADGCAESECALIGGETAEMGDMYHTGDYDIAGFAVGAV
EKDAYITGERIAEGDVILGLASSGIHSNGYSLVRKIIKDNNLDLDAEFDNGKTLLDVVLEPTRLYVKSAKAILDAADVHG
MCHVTGGGFIENVPRVFVTDGLYPEIDVTNIPRQKIFDLLQEKGSIDKMEMYNIFNMGIGFIFIVPREAVEKVRSAVNEE
VFEIGRVVRGDKAIDIKGV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=334, Percent_Identity=46.4071856287425, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI209869995, Length=334, Percent_Identity=46.4071856287425, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI209869993, Length=334, Percent_Identity=46.4071856287425, Blast_Score=298, Evalue=7e-81,
Organism=Escherichia coli, GI1788845, Length=333, Percent_Identity=50.7507507507508, Blast_Score=326, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17567511, Length=336, Percent_Identity=40.1785714285714, Blast_Score=224, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6321203, Length=337, Percent_Identity=42.7299703264095, Blast_Score=259, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24582400, Length=314, Percent_Identity=37.8980891719745, Blast_Score=192, Evalue=3e-49,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_MACCJ (B9EAZ0)

Other databases:

- EMBL:   AP009484
- RefSeq:   YP_002560097.1
- GeneID:   7389851
- GenomeReviews:   AP009484_GR
- KEGG:   mcl:MCCL_0694
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36787; Mature: 36655

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESYKQSGVDIHAGYEAVERMKKHVNKTMRKEVLGGLGSFGAAFDLSQLNMKAPVLVSG
CCCCHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHCCCCCCEEEEC
TDGVGTKLRLAIDSDRHDTIGIDAVAMCVNDILTTGAMPLYFLDYLALNKVDPVIVEQIV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHH
KGVADGCAESECALIGGETAEMGDMYHTGDYDIAGFAVGAVEKDAYITGERIAEGDVILG
HHHHCCCCCCCEEEECCCCHHHCCCEECCCCCCCEEEEECCCCCCEECCCEECCCCEEEE
LASSGIHSNGYSLVRKIIKDNNLDLDAEFDNGKTLLDVVLEPTRLYVKSAKAILDAADVH
EECCCCCCCHHHHHHHHHHCCCCCEEEECCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHC
GMCHVTGGGFIENVPRVFVTDGLYPEIDVTNIPRQKIFDLLQEKGSIDKMEMYNIFNMGI
CEEEECCCHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCC
GFIFIVPREAVEKVRSAVNEEVFEIGRVVRGDKAIDIKGV
EEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
>Mature Secondary Structure 
AESYKQSGVDIHAGYEAVERMKKHVNKTMRKEVLGGLGSFGAAFDLSQLNMKAPVLVSG
CCCHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHCCCCCCEEEEC
TDGVGTKLRLAIDSDRHDTIGIDAVAMCVNDILTTGAMPLYFLDYLALNKVDPVIVEQIV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHH
KGVADGCAESECALIGGETAEMGDMYHTGDYDIAGFAVGAVEKDAYITGERIAEGDVILG
HHHHCCCCCCCEEEECCCCHHHCCCEECCCCCCCEEEEECCCCCCEECCCEECCCCEEEE
LASSGIHSNGYSLVRKIIKDNNLDLDAEFDNGKTLLDVVLEPTRLYVKSAKAILDAADVH
EECCCCCCCHHHHHHHHHHCCCCCEEEECCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHC
GMCHVTGGGFIENVPRVFVTDGLYPEIDVTNIPRQKIFDLLQEKGSIDKMEMYNIFNMGI
CEEEECCCHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCC
GFIFIVPREAVEKVRSAVNEEVFEIGRVVRGDKAIDIKGV
EEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA