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The map label for this gene is hprK

Identifier: 222150761

GI number: 222150761

Start: 543423

End: 544352

Strand: Direct

Name: hprK

Synonym: MCCL_0511

Alternate gene names: 222150761

Gene position: 543423-544352 (Clockwise)

Preceding gene: 222150760

Following gene: 222150762

Centisome position: 25.85

GC content: 40.54

Gene sequence:

>930_bases
ATGATAACAAGTATAGAACTAATTGATAAATTTGACCTTAAGTTTATAGCGGGCAATGTCGCAATAGAAATCCCGGTAGC
TAATGCAGACATTTCGCGACCGGGCCTTGAAATGGCAGGTTTCTTCTCTCATTATTCTTCCGACCGCATACAAATACTTG
GCACGACTGAGATGTCTTTCTTTGAAACGTTGTCAAAAGAAGAACGTGCAGAACGAATGGTAAAGCTTTGTCGTAAGGAA
ACCCCTTGCATTATCTTAACAAGAAACATTCCGGCACCACAGGAACTTATTGATGCATGTAATCGTAAAGGGACACCACT
TCTTCAGAGCAAAGAGGCAACAACAAGTTTAATCAGCAAGATTACATCTTATCTTGAGAGTGAGCTTGCACCTGAAACGA
CGATGCACGGCGTGCTGGTCGATGTATACGGGGTAGGTGTGTTGATTACCGGTGATTCTGGAGTAGGTAAGAGTGAGACA
GCACTAGAACTTGTTAAACGTGGACATCGTCTTGTTGCAGATGACAACGTGGAAATAAAGGAAGTTTCACGTAATGTACT
GATGGGCAAAGCACCAAAGTTGATAGAACATCTTCTTGAAATTAGAGGACTAGGCATCATCAATGTAATGACTTTATTTG
GTGCAGGGAGTGTCCTTCCAGAGAAACGTCTAATGCTCAATATTAATCTGGAAACATGGAACAAAGATAAAGTTTACGAC
CGCATAGGATTAATCGAAGAAAAATTATCAATTCTTGATTCTCAAATTACGAAGAAGACGATTCCTGTCAGACCAGGGCG
TAACTTAGCGGTAATTATAGAAGTTGCTGCGATGAACTATCGTCTCAATAAGATGGGAACGAACACCGCAAAAGATTTTA
ATGAACGCCAGAATGAACAAATTAGAAGGCAGTCGATAAAGGAGATTTAA

Upstream 100 bases:

>100_bases
TCAACAATTTTTTGCAGCGCTCGGGTTTTGTTGGTGATTATGAATTGTAAATTGATATAAAGTTATTTAATATAAATGTT
AAGAGAAAGTGAGGAAAACT

Downstream 100 bases:

>100_bases
CATGACACCATTTGATCCAGTTGCATTTGAACTCTTTGGCTATCCAGTGAGATGGTACGGTATTATTATTGCATTTGGTA
TTTTAGTCGGATATCTTATC

Product: HPr kinase/phosphorylase

Products: NA

Alternate protein names: HPrK/P; HPr(Ser) kinase/phosphorylase

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MITSIELIDKFDLKFIAGNVAIEIPVANADISRPGLEMAGFFSHYSSDRIQILGTTEMSFFETLSKEERAERMVKLCRKE
TPCIILTRNIPAPQELIDACNRKGTPLLQSKEATTSLISKITSYLESELAPETTMHGVLVDVYGVGVLITGDSGVGKSET
ALELVKRGHRLVADDNVEIKEVSRNVLMGKAPKLIEHLLEIRGLGIINVMTLFGAGSVLPEKRLMLNINLETWNKDKVYD
RIGLIEEKLSILDSQITKKTIPVRPGRNLAVIIEVAAMNYRLNKMGTNTAKDFNERQNEQIRRQSIKEI

Sequences:

>Translated_309_residues
MITSIELIDKFDLKFIAGNVAIEIPVANADISRPGLEMAGFFSHYSSDRIQILGTTEMSFFETLSKEERAERMVKLCRKE
TPCIILTRNIPAPQELIDACNRKGTPLLQSKEATTSLISKITSYLESELAPETTMHGVLVDVYGVGVLITGDSGVGKSET
ALELVKRGHRLVADDNVEIKEVSRNVLMGKAPKLIEHLLEIRGLGIINVMTLFGAGSVLPEKRLMLNINLETWNKDKVYD
RIGLIEEKLSILDSQITKKTIPVRPGRNLAVIIEVAAMNYRLNKMGTNTAKDFNERQNEQIRRQSIKEI
>Mature_309_residues
MITSIELIDKFDLKFIAGNVAIEIPVANADISRPGLEMAGFFSHYSSDRIQILGTTEMSFFETLSKEERAERMVKLCRKE
TPCIILTRNIPAPQELIDACNRKGTPLLQSKEATTSLISKITSYLESELAPETTMHGVLVDVYGVGVLITGDSGVGKSET
ALELVKRGHRLVADDNVEIKEVSRNVLMGKAPKLIEHLLEIRGLGIINVMTLFGAGSVLPEKRLMLNINLETWNKDKVYD
RIGLIEEKLSILDSQITKKTIPVRPGRNLAVIIEVAAMNYRLNKMGTNTAKDFNERQNEQIRRQSIKEI

Specific function: Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-pr

COG id: COG1493

COG function: function code T; Serine kinase of the HPr protein, regulates carbohydrate metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPrK/P family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRK_MACCJ (B9EAF7)

Other databases:

- EMBL:   AP009484
- RefSeq:   YP_002559914.1
- GeneID:   7390495
- GenomeReviews:   AP009484_GR
- KEGG:   mcl:MCCL_0511
- OMA:   IHGVLVD
- ProtClustDB:   PRK05428
- HAMAP:   MF_01249
- InterPro:   IPR003755
- InterPro:   IPR011104
- InterPro:   IPR011126
- TIGRFAMs:   TIGR00679

Pfam domain/function: PF07475 Hpr_kinase_C; PF02603 Hpr_kinase_N

EC number: NA

Molecular weight: Translated: 34493; Mature: 34493

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: ACT_SITE 136-136 ACT_SITE 157-157 ACT_SITE 175-175 ACT_SITE 241-241

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITSIELIDKFDLKFIAGNVAIEIPVANADISRPGLEMAGFFSHYSSDRIQILGTTEMSF
CCCCHHHHHHCCEEEEECCEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHH
FETLSKEERAERMVKLCRKETPCIILTRNIPAPQELIDACNRKGTPLLQSKEATTSLISK
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
ITSYLESELAPETTMHGVLVDVYGVGVLITGDSGVGKSETALELVKRGHRLVADDNVEIK
HHHHHHHHCCCCHHHHHHEEEEECCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCHHH
EVSRNVLMGKAPKLIEHLLEIRGLGIINVMTLFGAGSVLPEKRLMLNINLETWNKDKVYD
HHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHH
RIGLIEEKLSILDSQITKKTIPVRPGRNLAVIIEVAAMNYRLNKMGTNTAKDFNERQNEQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCEEHHHCCCCHHHHHHHHHHHH
IRRQSIKEI
HHHHHHHCC
>Mature Secondary Structure
MITSIELIDKFDLKFIAGNVAIEIPVANADISRPGLEMAGFFSHYSSDRIQILGTTEMSF
CCCCHHHHHHCCEEEEECCEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHH
FETLSKEERAERMVKLCRKETPCIILTRNIPAPQELIDACNRKGTPLLQSKEATTSLISK
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
ITSYLESELAPETTMHGVLVDVYGVGVLITGDSGVGKSETALELVKRGHRLVADDNVEIK
HHHHHHHHCCCCHHHHHHEEEEECCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCHHH
EVSRNVLMGKAPKLIEHLLEIRGLGIINVMTLFGAGSVLPEKRLMLNINLETWNKDKVYD
HHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHH
RIGLIEEKLSILDSQITKKTIPVRPGRNLAVIIEVAAMNYRLNKMGTNTAKDFNERQNEQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCEEHHHCCCCHHHHHHHHHHHH
IRRQSIKEI
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA