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The map label for this gene is uvrA [H]

Identifier: 222150760

GI number: 222150760

Start: 540447

End: 543266

Strand: Direct

Name: uvrA [H]

Synonym: MCCL_0510

Alternate gene names: 222150760

Gene position: 540447-543266 (Clockwise)

Preceding gene: 222150759

Following gene: 222150761

Centisome position: 25.71

GC content: 40.04

Gene sequence:

>2820_bases
ATGAAGAATAAATCTATAATCGTCAAAGGCGCAAGAGCGCATAATTTAAAGAATGTTGATATTGAAATTCCGAGAGATAA
ACTCATTGTTATGACCGGTTTATCAGGTTCTGGTAAATCTAGTCTTGCATTCGATACAATCTATGCTGAAGGTCAGCGTA
GATATGTTGAGTCATTGAGTGCATATGCCAGACAATTCTTAGGGCAGATGGACAAACCGGATGTAGACACTATAGAAGGT
TTATCGCCTGCAATTTCGATTGACCAGAAGACAACAAGTAAGAACCCGAGAAGTACTGTTGCAACTGTTACTGAAATTTA
TGATTATTTAAGACTGCTATATGCTAGAATCGGTACACCTTATTGTCCAAATCATGGTATCCCTATCGAGTCGCAGACGG
TACAGCAGATGGTGGATCAAGTTATGGCATTAGAAGAAAGAACTAAGATACAGGTTATGGCTCCAATAGTGCAAGGCCGT
AAAGGAACGCATAAGAAACTGATTGAAGATATCTCTAAAAAAGGGTATGCGCGTATTATGGTAGATGGTGAAGTTTATGA
TGCTTCTGAAACAATCGACATCAATAAAAATACGAATCATGATATTCATGTTATTGTAGACCGACTTGTTGTGAAACCGG
GCATAGAAGCACGACTTGCGGATTCTCTTGAAAATGCTTTGAAACTTGCAGAAGGTAATGTTGTCATTGATTTAATCGAT
GGAGATGAACTGAAGTTTTCAGAACATCATGCCTGTCCGATTTGTGGATTCTCTATTGATAAGTTAGAACCTCGAATGTT
TTCTTTTAATAGCCCGTTTGGTGCATGTCCGGATTGTGATGGACTAGGTACAAAATTAGCAGTCGATTTAAACCTTGTCA
TTCCTGATGATAGCAAATCATTAACAAATGGTGTATTAGTGCCATGGGAGCCCATCAGTTCGAACTATTATCCGACATTA
CTCAAGCAGGCATGTAAACATTTCGGGATTTCTATGAAAGCGCCTTTTAGAGATTTATCTAAGGAAGATCAGGACATCAT
CCTGTATGGACACTCGGATGATATTTCCTTTACCTTCAGACAAGATAATGGTGTATCGCGTAAACGTGTAATGAAATTTG
AAGGTATTGTGAATAATATCGAACGTAGATATAAGGAGAGTCCTTCAGAATATACACGTGAGCAGATGAAGAAGTATATG
GTGGATGAGGTCTGTCACACATGTCATGGCTATCGTCTTTCTGAAGAAGCGATGAGTGTTAAGATTAATGATCAGCATAT
AGGAGAAGTTGTAACGTTATCTATCAGAGAAGCATTACAATATTTCAGTAACCTTGAACTTTCAAAGAAAGAACAGCAAA
TTGCTGAACTCGTCCTGAAAGAAATCACTGAAAGGTTGACATTCTTATATAATGTAGGACTGGAATACCTCACTTTAAAT
AGAACAGCAGGAACACTTTCTGGTGGAGAAGCACAGCGTATCCGACTTGCAACGCAGATTGGTTCAAGATTAACAGGTGT
AATGTATGTTCTGGATGAACCGTCCATAGGTCTGCACCAGAGAGATAACGACCGTCTCATCGATACACTGAAATCCATGA
GAGATATTGGAAACACCCTTATTGTCGTTGAACATGATGAAGATACGATGCTTGCTGCTGATTATTTGATTGACATTGGT
CCAGGAGCGGGTGTACATGGAGGACAGGTTGTCGCACAAGGTACACCAAAGCAAGTGATGAAGAATAAGAAGTCGTTAAC
AGGTCAGTATTTAAGCGGTGTAAAAAGAATTGAGCTTCCTGAAGAAAGACGTAAACCAGATGGCAGATTCTTAACGGTAG
AAGGTGCAACAAGTAATAATTTAAAGGGTGTGGATGTTCAGATTCCACTGGGCATGATGACAGTGGTAACTGGAGTCTCA
GGTTCCGGAAAAAGTACGCTTGTTAACGATGTGCTGTATAAGGCGCTTGCTCAGAAGCTATATAAATCGAAAGAAAAACC
GGGACCTCATAAAGCAGTAAAGGGGATAGAACATATTGATAAGATAATCGATATTGATCAATCTCCTATAGGTAGGACAC
CACGTTCCAATCCTGCGACTTATACGAGTCTGTTTGATGATATACGTGATGTCTTTGCGCAGACGAATGAAGCGAAGTTA
AGAGGTTATCAAAAAGGACGCTTCAGCTTTAATGTTAAAGGAGGCCGCTGTGAGGCTTGTCACGGAGACGGTATCATCAA
GATAGAGATGCACTTTCTTCCTGATGTCTACGTGCCGTGCGAAGTCTGTCACGGTAAGCGATATAATCGCGAAACGCTCG
AAGTGAAATATAAGGATAAAAACATTGCAGATATTCTTGATATGACGATTGAAGATGCTTACCATTTCTTTGAGAACATT
CCTAAGATTAAGCGTAAACTTAAGACTATCATGGACGTCGGACTAGGTTATATTCAGCTTGGACAACCTGCCACAACTCT
TTCAGGGGGTGAGGCACAACGTGTTAAGCTAGCTTCAGAACTGCATAAACGCAGTACGGGTAAAACGTTATATATTCTGG
ATGAACCGACGACTGGATTACACGTCGATGATATTGCAAGATTACTGAAAGTTTTACAGCAACTTGTCGAAAACGGGGAT
ACGGTTCTGATTATTGAACATAATCTTGACGTGATCAAGATGGCAGACTTCATTGTTGACCTTGGTCCAGAAGGTGGGGA
TAACGGTGGACAGATTATCGCAAGTGGTACTCCAGAACAGATTATGCAAGTGCGTGAATCTTACACAGGTCAATATTTAA
AGCATCATATAGAGAGATAA

Upstream 100 bases:

>100_bases
CTTGAACATGAAATGAAAGAAGCGGCAAAAGCTTTAGATTTTGAACGTGCTACAGAACTCAGAGATGCACTGTTTGAGTT
AAAAGCAGAAGGGTGAGCGC

Downstream 100 bases:

>100_bases
GTGTTGAGCTCATTGTCAAATCATCTCTAGCATAACCCGAGCGTTGCAGAAAATTGTCAACAATTTTTTGCAGCGCTCGG
GTTTTGTTGGTGATTATGAA

Product: excinuclease ABC subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 939; Mature: 939

Protein sequence:

>939_residues
MKNKSIIVKGARAHNLKNVDIEIPRDKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEG
LSPAISIDQKTTSKNPRSTVATVTEIYDYLRLLYARIGTPYCPNHGIPIESQTVQQMVDQVMALEERTKIQVMAPIVQGR
KGTHKKLIEDISKKGYARIMVDGEVYDASETIDINKNTNHDIHVIVDRLVVKPGIEARLADSLENALKLAEGNVVIDLID
GDELKFSEHHACPICGFSIDKLEPRMFSFNSPFGACPDCDGLGTKLAVDLNLVIPDDSKSLTNGVLVPWEPISSNYYPTL
LKQACKHFGISMKAPFRDLSKEDQDIILYGHSDDISFTFRQDNGVSRKRVMKFEGIVNNIERRYKESPSEYTREQMKKYM
VDEVCHTCHGYRLSEEAMSVKINDQHIGEVVTLSIREALQYFSNLELSKKEQQIAELVLKEITERLTFLYNVGLEYLTLN
RTAGTLSGGEAQRIRLATQIGSRLTGVMYVLDEPSIGLHQRDNDRLIDTLKSMRDIGNTLIVVEHDEDTMLAADYLIDIG
PGAGVHGGQVVAQGTPKQVMKNKKSLTGQYLSGVKRIELPEERRKPDGRFLTVEGATSNNLKGVDVQIPLGMMTVVTGVS
GSGKSTLVNDVLYKALAQKLYKSKEKPGPHKAVKGIEHIDKIIDIDQSPIGRTPRSNPATYTSLFDDIRDVFAQTNEAKL
RGYQKGRFSFNVKGGRCEACHGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVKYKDKNIADILDMTIEDAYHFFENI
PKIKRKLKTIMDVGLGYIQLGQPATTLSGGEAQRVKLASELHKRSTGKTLYILDEPTTGLHVDDIARLLKVLQQLVENGD
TVLIIEHNLDVIKMADFIVDLGPEGGDNGGQIIASGTPEQIMQVRESYTGQYLKHHIER

Sequences:

>Translated_939_residues
MKNKSIIVKGARAHNLKNVDIEIPRDKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEG
LSPAISIDQKTTSKNPRSTVATVTEIYDYLRLLYARIGTPYCPNHGIPIESQTVQQMVDQVMALEERTKIQVMAPIVQGR
KGTHKKLIEDISKKGYARIMVDGEVYDASETIDINKNTNHDIHVIVDRLVVKPGIEARLADSLENALKLAEGNVVIDLID
GDELKFSEHHACPICGFSIDKLEPRMFSFNSPFGACPDCDGLGTKLAVDLNLVIPDDSKSLTNGVLVPWEPISSNYYPTL
LKQACKHFGISMKAPFRDLSKEDQDIILYGHSDDISFTFRQDNGVSRKRVMKFEGIVNNIERRYKESPSEYTREQMKKYM
VDEVCHTCHGYRLSEEAMSVKINDQHIGEVVTLSIREALQYFSNLELSKKEQQIAELVLKEITERLTFLYNVGLEYLTLN
RTAGTLSGGEAQRIRLATQIGSRLTGVMYVLDEPSIGLHQRDNDRLIDTLKSMRDIGNTLIVVEHDEDTMLAADYLIDIG
PGAGVHGGQVVAQGTPKQVMKNKKSLTGQYLSGVKRIELPEERRKPDGRFLTVEGATSNNLKGVDVQIPLGMMTVVTGVS
GSGKSTLVNDVLYKALAQKLYKSKEKPGPHKAVKGIEHIDKIIDIDQSPIGRTPRSNPATYTSLFDDIRDVFAQTNEAKL
RGYQKGRFSFNVKGGRCEACHGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVKYKDKNIADILDMTIEDAYHFFENI
PKIKRKLKTIMDVGLGYIQLGQPATTLSGGEAQRVKLASELHKRSTGKTLYILDEPTTGLHVDDIARLLKVLQQLVENGD
TVLIIEHNLDVIKMADFIVDLGPEGGDNGGQIIASGTPEQIMQVRESYTGQYLKHHIER
>Mature_939_residues
MKNKSIIVKGARAHNLKNVDIEIPRDKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEG
LSPAISIDQKTTSKNPRSTVATVTEIYDYLRLLYARIGTPYCPNHGIPIESQTVQQMVDQVMALEERTKIQVMAPIVQGR
KGTHKKLIEDISKKGYARIMVDGEVYDASETIDINKNTNHDIHVIVDRLVVKPGIEARLADSLENALKLAEGNVVIDLID
GDELKFSEHHACPICGFSIDKLEPRMFSFNSPFGACPDCDGLGTKLAVDLNLVIPDDSKSLTNGVLVPWEPISSNYYPTL
LKQACKHFGISMKAPFRDLSKEDQDIILYGHSDDISFTFRQDNGVSRKRVMKFEGIVNNIERRYKESPSEYTREQMKKYM
VDEVCHTCHGYRLSEEAMSVKINDQHIGEVVTLSIREALQYFSNLELSKKEQQIAELVLKEITERLTFLYNVGLEYLTLN
RTAGTLSGGEAQRIRLATQIGSRLTGVMYVLDEPSIGLHQRDNDRLIDTLKSMRDIGNTLIVVEHDEDTMLAADYLIDIG
PGAGVHGGQVVAQGTPKQVMKNKKSLTGQYLSGVKRIELPEERRKPDGRFLTVEGATSNNLKGVDVQIPLGMMTVVTGVS
GSGKSTLVNDVLYKALAQKLYKSKEKPGPHKAVKGIEHIDKIIDIDQSPIGRTPRSNPATYTSLFDDIRDVFAQTNEAKL
RGYQKGRFSFNVKGGRCEACHGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVKYKDKNIADILDMTIEDAYHFFENI
PKIKRKLKTIMDVGLGYIQLGQPATTLSGGEAQRVKLASELHKRSTGKTLYILDEPTTGLHVDDIARLLKVLQQLVENGD
TVLIIEHNLDVIKMADFIVDLGPEGGDNGGQIIASGTPEQIMQVRESYTGQYLKHHIER

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=936, Percent_Identity=57.2649572649573, Blast_Score=1092, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 104815; Mature: 104815

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKSIIVKGARAHNLKNVDIEIPRDKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLS
CCCCCEEEECCCCCCCCCCEEECCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHH
AYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYLRLLYARIGTP
HHHHHHHCCCCCCCCCHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
YCPNHGIPIESQTVQQMVDQVMALEERTKIQVMAPIVQGRKGTHKKLIEDISKKGYARIM
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEHHHCCCCCCHHHHHHHHHCCCCEEEE
VDGEVYDASETIDINKNTNHDIHVIVDRLVVKPGIEARLADSLENALKLAEGNVVIDLID
ECCEEECCCCEEEECCCCCCCHHHEEHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
GDELKFSEHHACPICGFSIDKLEPRMFSFNSPFGACPDCDGLGTKLAVDLNLVIPDDSKS
CCCEEECCCCCCCEECCCHHCCCCCCEECCCCCCCCCCCCCCCCEEEEEEEEEECCCCCH
LTNGVLVPWEPISSNYYPTLLKQACKHFGISMKAPFRDLSKEDQDIILYGHSDDISFTFR
HHCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCCEEEEEE
QDNGVSRKRVMKFEGIVNNIERRYKESPSEYTREQMKKYMVDEVCHTCHGYRLSEEAMSV
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEE
KINDQHIGEVVTLSIREALQYFSNLELSKKEQQIAELVLKEITERLTFLYNVGLEYLTLN
EECCHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
RTAGTLSGGEAQRIRLATQIGSRLTGVMYVLDEPSIGLHQRDNDRLIDTLKSMRDIGNTL
CCCCCCCCCCHHHHHHHHHHCCHHCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEE
IVVEHDEDTMLAADYLIDIGPGAGVHGGQVVAQGTPKQVMKNKKSLTGQYLSGVKRIELP
EEEECCCCCEEEEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHCCHHHHCCCCCCCCC
EERRKPDGRFLTVEGATSNNLKGVDVQIPLGMMTVVTGVSGSGKSTLVNDVLYKALAQKL
HHHCCCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YKSKEKPGPHKAVKGIEHIDKIIDIDQSPIGRTPRSNPATYTSLFDDIRDVFAQTNEAKL
HHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
RGYQKGRFSFNVKGGRCEACHGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVKYKDK
CCCCCCCEEEEECCCEEEEECCCCEEEEEEEECCCCCCCHHHHCCCCCCCCEEEEEECCC
NIADILDMTIEDAYHFFENIPKIKRKLKTIMDVGLGYIQLGQPATTLSGGEAQRVKLASE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHH
LHKRSTGKTLYILDEPTTGLHVDDIARLLKVLQQLVENGDTVLIIEHNLDVIKMADFIVD
HHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHC
LGPEGGDNGGQIIASGTPEQIMQVRESYTGQYLKHHIER
CCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNKSIIVKGARAHNLKNVDIEIPRDKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLS
CCCCCEEEECCCCCCCCCCEEECCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHH
AYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYLRLLYARIGTP
HHHHHHHCCCCCCCCCHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
YCPNHGIPIESQTVQQMVDQVMALEERTKIQVMAPIVQGRKGTHKKLIEDISKKGYARIM
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEHHHCCCCCCHHHHHHHHHCCCCEEEE
VDGEVYDASETIDINKNTNHDIHVIVDRLVVKPGIEARLADSLENALKLAEGNVVIDLID
ECCEEECCCCEEEECCCCCCCHHHEEHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
GDELKFSEHHACPICGFSIDKLEPRMFSFNSPFGACPDCDGLGTKLAVDLNLVIPDDSKS
CCCEEECCCCCCCEECCCHHCCCCCCEECCCCCCCCCCCCCCCCEEEEEEEEEECCCCCH
LTNGVLVPWEPISSNYYPTLLKQACKHFGISMKAPFRDLSKEDQDIILYGHSDDISFTFR
HHCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCCEEEEEE
QDNGVSRKRVMKFEGIVNNIERRYKESPSEYTREQMKKYMVDEVCHTCHGYRLSEEAMSV
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEE
KINDQHIGEVVTLSIREALQYFSNLELSKKEQQIAELVLKEITERLTFLYNVGLEYLTLN
EECCHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
RTAGTLSGGEAQRIRLATQIGSRLTGVMYVLDEPSIGLHQRDNDRLIDTLKSMRDIGNTL
CCCCCCCCCCHHHHHHHHHHCCHHCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEE
IVVEHDEDTMLAADYLIDIGPGAGVHGGQVVAQGTPKQVMKNKKSLTGQYLSGVKRIELP
EEEECCCCCEEEEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHCCHHHHCCCCCCCCC
EERRKPDGRFLTVEGATSNNLKGVDVQIPLGMMTVVTGVSGSGKSTLVNDVLYKALAQKL
HHHCCCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YKSKEKPGPHKAVKGIEHIDKIIDIDQSPIGRTPRSNPATYTSLFDDIRDVFAQTNEAKL
HHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
RGYQKGRFSFNVKGGRCEACHGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVKYKDK
CCCCCCCEEEEECCCEEEEECCCCEEEEEEEECCCCCCCHHHHCCCCCCCCEEEEEECCC
NIADILDMTIEDAYHFFENIPKIKRKLKTIMDVGLGYIQLGQPATTLSGGEAQRVKLASE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHH
LHKRSTGKTLYILDEPTTGLHVDDIARLLKVLQQLVENGDTVLIIEHNLDVIKMADFIVD
HHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHC
LGPEGGDNGGQIIASGTPEQIMQVRESYTGQYLKHHIER
CCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA