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The map label for this gene is gntK [H]

Identifier: 222150656

GI number: 222150656

Start: 433220

End: 434761

Strand: Direct

Name: gntK [H]

Synonym: MCCL_0406

Alternate gene names: 222150656

Gene position: 433220-434761 (Clockwise)

Preceding gene: 222150655

Following gene: 222150657

Centisome position: 20.61

GC content: 39.88

Gene sequence:

>1542_bases
GTGTTCAAAATAGGCGTAGATATAGGTACAACAAGTACAAAAGCGGTAATCTATAAAAATCAAGAGATAGTAGGGATACA
TCATGTTGAGTATCCGTTATTAACACCGACTACAGATACAGCTGAGCAATATCCGAATGAAATCTTTGAAGCGGTGTTAG
AAACCATCCGAGTGGTTGTGAAAAAAGCAGAAGCCGCAAAAAACGAAATTGATTTTATCAGCTTTTCTAGTGCAATGCAT
AGTTTGATCTTGATGGATGAACATAATAAACCACTTACCAATAGTATTACATGGGCAGATAATCGGAGTTATCAGTATGC
AGAAAAGCTTAACCGGGAACATGATGGTCTTGCTATCTATCATCGAACAGGGACACCGATTCATCCAATGAGCCCGTTGA
CCAAGATGTTATGGTTGAAAGAAACAGAAACCAAGCTTTATCAGTCGACTAAAAAATTCATTGGTATAAAAGGTTATGTG
TTCTACCAGCTCTTTAAAAGATATATCGAAGATTATTCTATATTAAGTGCCACGGGTATATTTAATATTCATCAGCTTGA
TTATGATGATGAAGTGCTCAAGCTTTTAGAAATCGATAAAAGTCAGCTATCGGAAGCTGTAGATACGACGACACTATTAA
CAGGCATTGATAAGCATTATGCAGAAATGATGAATATTGATGTCAACACACCGTTTGTTATCGGTGCGAGTGACGGTGTC
CTTAGTAATCTCGGTGTAGATGCATTTAAGCCTGGAGAAGTTGCAGTAACCATTGGTACAAGTGGTGCGATTCGCACAGT
AATTGATCAACCGAAAACAGACAGTCAAGGGAGATTGTTCTGCTATGCTCTGACGAAGGACAAATGGGTCATTGGTGGCC
CGGTGAATAATGGTGGTGTCGTCTTGCGCTGGATACGTGATGAGTTTGCTTCAAGTGAGATTGAGACAGCAAAGCGCCTC
GGTGTCGATAGCTATGAAGTATTGACTAAAATTGCTGAACGTGTGCCACCAGCGAGTAATGGCTTGATCTTTCATCCTTT
CCTCGCAGGAGAACGTGCGCCACATTGGAATGCCAATGTGCGTGGCTCATTCTTTGGATTAACCCTCTCGCATAAAAAAG
AGCATATGATTCGTGCGGCACTTGAAGGTGTCATCTTTAATCTCTATACGGTTTATATTGCGCTTTCTGTGCTGATGGAT
GAAGAAGTGAAGACATTAAAGGCAACAGGAGGATTTGCAAAAAGTGCACTATGGCGACAGATGATGTCCGATATTTTTGA
ACATGAAGTGATTGTACCAGAGAGTATCGAAAGTTCTTGTCTCGGTGCTTTTATTCTCGGTCAAATTGCCATCGGAGAAA
AAGATAACTTTGACCATGTCAGTGCTATGGTTGGTGCAACAAAGCCACATCAGCCGATTCAGGAAAATGTATACATATAT
CGTGAGATATTACCGATTTATATTAAAATGACACAGCAGTTGATGGAAACGTATGATGATATTGCTGCATTTCAAAGAAA
ATATGAAAAGAGGGGAATATAA

Upstream 100 bases:

>100_bases
GAGATAGAAAAGGTTATAAAGAAGTACTTCATATGAATTTCGATGATGTACATGAAGAAATAGATGATTTATTCTATTCG
CAGACGAAGGAGGAAATATA

Downstream 100 bases:

>100_bases
TGGATTTTATCGTACAACAATGGCCATTATTTACAGTCGCTATCGCGATTATTATTTTACTGGTCTTAATTATGGGACTC
AAACTTAACACGTTTATATC

Product: gluconokinase

Products: NA

Alternate protein names: Gluconate kinase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MFKIGVDIGTTSTKAVIYKNQEIVGIHHVEYPLLTPTTDTAEQYPNEIFEAVLETIRVVVKKAEAAKNEIDFISFSSAMH
SLILMDEHNKPLTNSITWADNRSYQYAEKLNREHDGLAIYHRTGTPIHPMSPLTKMLWLKETETKLYQSTKKFIGIKGYV
FYQLFKRYIEDYSILSATGIFNIHQLDYDDEVLKLLEIDKSQLSEAVDTTTLLTGIDKHYAEMMNIDVNTPFVIGASDGV
LSNLGVDAFKPGEVAVTIGTSGAIRTVIDQPKTDSQGRLFCYALTKDKWVIGGPVNNGGVVLRWIRDEFASSEIETAKRL
GVDSYEVLTKIAERVPPASNGLIFHPFLAGERAPHWNANVRGSFFGLTLSHKKEHMIRAALEGVIFNLYTVYIALSVLMD
EEVKTLKATGGFAKSALWRQMMSDIFEHEVIVPESIESSCLGAFILGQIAIGEKDNFDHVSAMVGATKPHQPIQENVYIY
REILPIYIKMTQQLMETYDDIAAFQRKYEKRGI

Sequences:

>Translated_513_residues
MFKIGVDIGTTSTKAVIYKNQEIVGIHHVEYPLLTPTTDTAEQYPNEIFEAVLETIRVVVKKAEAAKNEIDFISFSSAMH
SLILMDEHNKPLTNSITWADNRSYQYAEKLNREHDGLAIYHRTGTPIHPMSPLTKMLWLKETETKLYQSTKKFIGIKGYV
FYQLFKRYIEDYSILSATGIFNIHQLDYDDEVLKLLEIDKSQLSEAVDTTTLLTGIDKHYAEMMNIDVNTPFVIGASDGV
LSNLGVDAFKPGEVAVTIGTSGAIRTVIDQPKTDSQGRLFCYALTKDKWVIGGPVNNGGVVLRWIRDEFASSEIETAKRL
GVDSYEVLTKIAERVPPASNGLIFHPFLAGERAPHWNANVRGSFFGLTLSHKKEHMIRAALEGVIFNLYTVYIALSVLMD
EEVKTLKATGGFAKSALWRQMMSDIFEHEVIVPESIESSCLGAFILGQIAIGEKDNFDHVSAMVGATKPHQPIQENVYIY
REILPIYIKMTQQLMETYDDIAAFQRKYEKRGI
>Mature_513_residues
MFKIGVDIGTTSTKAVIYKNQEIVGIHHVEYPLLTPTTDTAEQYPNEIFEAVLETIRVVVKKAEAAKNEIDFISFSSAMH
SLILMDEHNKPLTNSITWADNRSYQYAEKLNREHDGLAIYHRTGTPIHPMSPLTKMLWLKETETKLYQSTKKFIGIKGYV
FYQLFKRYIEDYSILSATGIFNIHQLDYDDEVLKLLEIDKSQLSEAVDTTTLLTGIDKHYAEMMNIDVNTPFVIGASDGV
LSNLGVDAFKPGEVAVTIGTSGAIRTVIDQPKTDSQGRLFCYALTKDKWVIGGPVNNGGVVLRWIRDEFASSEIETAKRL
GVDSYEVLTKIAERVPPASNGLIFHPFLAGERAPHWNANVRGSFFGLTLSHKKEHMIRAALEGVIFNLYTVYIALSVLMD
EEVKTLKATGGFAKSALWRQMMSDIFEHEVIVPESIESSCLGAFILGQIAIGEKDNFDHVSAMVGATKPHQPIQENVYIY
REILPIYIKMTQQLMETYDDIAAFQRKYEKRGI

Specific function: Key Enzyme In The Regulation Of Glycerol Uptake And Metabolism. [C]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393575, Length=448, Percent_Identity=25, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI42794763, Length=459, Percent_Identity=25.2723311546841, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI189409120, Length=457, Percent_Identity=25.382932166302, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4504007, Length=457, Percent_Identity=25.382932166302, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI88196792, Length=526, Percent_Identity=23.384030418251, Blast_Score=114, Evalue=3e-25,
Organism=Escherichia coli, GI1790361, Length=501, Percent_Identity=26.3473053892216, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1789987, Length=499, Percent_Identity=23.8476953907816, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1787789, Length=502, Percent_Identity=24.7011952191235, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1790005, Length=462, Percent_Identity=23.5930735930736, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1789168, Length=478, Percent_Identity=19.2468619246862, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1789138, Length=510, Percent_Identity=23.5294117647059, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17535599, Length=455, Percent_Identity=25.0549450549451, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321755, Length=428, Percent_Identity=26.4018691588785, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17864214, Length=507, Percent_Identity=24.8520710059172, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24655555, Length=467, Percent_Identity=23.982869379015, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24655560, Length=467, Percent_Identity=23.982869379015, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24655570, Length=467, Percent_Identity=23.982869379015, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24655574, Length=467, Percent_Identity=23.982869379015, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24655565, Length=467, Percent_Identity=23.982869379015, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24654573, Length=458, Percent_Identity=23.7991266375546, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24656367, Length=496, Percent_Identity=21.9758064516129, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357867, Length=502, Percent_Identity=22.1115537848606, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24656372, Length=306, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR006002 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.12 [H]

Molecular weight: Translated: 57753; Mature: 57753

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKIGVDIGTTSTKAVIYKNQEIVGIHHVEYPLLTPTTDTAEQYPNEIFEAVLETIRVVV
CEEEEEEECCCCCEEEEEECCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KKAEAAKNEIDFISFSSAMHSLILMDEHNKPLTNSITWADNRSYQYAEKLNREHDGLAIY
HHHHHHCCCCCEEEHHHHHHEEEEEECCCCCCCCCEEECCCCCHHHHHHCCCCCCCEEEE
HRTGTPIHPMSPLTKMLWLKETETKLYQSTKKFIGIKGYVFYQLFKRYIEDYSILSATGI
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHEECCCE
FNIHQLDYDDEVLKLLEIDKSQLSEAVDTTTLLTGIDKHYAEMMNIDVNTPFVIGASDGV
EEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCH
LSNLGVDAFKPGEVAVTIGTSGAIRTVIDQPKTDSQGRLFCYALTKDKWVIGGPVNNGGV
HHHCCCCCCCCCCEEEEECCCCCHHHHHCCCCCCCCCCEEEEEECCCCEEECCCCCCCCE
VLRWIRDEFASSEIETAKRLGVDSYEVLTKIAERVPPASNGLIFHPFLAGERAPHWNANV
EEEEEHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCC
RGSFFGLTLSHKKEHMIRAALEGVIFNLYTVYIALSVLMDEEVKTLKATGGFAKSALWRQ
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MMSDIFEHEVIVPESIESSCLGAFILGQIAIGEKDNFDHVSAMVGATKPHQPIQENVYIY
HHHHHHHCCEECCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHH
REILPIYIKMTQQLMETYDDIAAFQRKYEKRGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFKIGVDIGTTSTKAVIYKNQEIVGIHHVEYPLLTPTTDTAEQYPNEIFEAVLETIRVVV
CEEEEEEECCCCCEEEEEECCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KKAEAAKNEIDFISFSSAMHSLILMDEHNKPLTNSITWADNRSYQYAEKLNREHDGLAIY
HHHHHHCCCCCEEEHHHHHHEEEEEECCCCCCCCCEEECCCCCHHHHHHCCCCCCCEEEE
HRTGTPIHPMSPLTKMLWLKETETKLYQSTKKFIGIKGYVFYQLFKRYIEDYSILSATGI
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHEECCCE
FNIHQLDYDDEVLKLLEIDKSQLSEAVDTTTLLTGIDKHYAEMMNIDVNTPFVIGASDGV
EEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCH
LSNLGVDAFKPGEVAVTIGTSGAIRTVIDQPKTDSQGRLFCYALTKDKWVIGGPVNNGGV
HHHCCCCCCCCCCEEEEECCCCCHHHHHCCCCCCCCCCEEEEEECCCCEEECCCCCCCCE
VLRWIRDEFASSEIETAKRLGVDSYEVLTKIAERVPPASNGLIFHPFLAGERAPHWNANV
EEEEEHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCC
RGSFFGLTLSHKKEHMIRAALEGVIFNLYTVYIALSVLMDEEVKTLKATGGFAKSALWRQ
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MMSDIFEHEVIVPESIESSCLGAFILGQIAIGEKDNFDHVSAMVGATKPHQPIQENVYIY
HHHHHHHCCEECCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHH
REILPIYIKMTQQLMETYDDIAAFQRKYEKRGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3020045; 7584049; 9384377 [H]