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The map label for this gene is czcD [H]

Identifier: 222150569

GI number: 222150569

Start: 333106

End: 334062

Strand: Direct

Name: czcD [H]

Synonym: MCCL_0319

Alternate gene names: 222150569

Gene position: 333106-334062 (Clockwise)

Preceding gene: 222150568

Following gene: 222150571

Centisome position: 15.84

GC content: 37.2

Gene sequence:

>957_bases
ATGAGAAGCATTAATTCCCCAGAATATTTCCATCACGTAGAGCATTTAAAGAAACAGAATCAATCGAGAAGAACCTTATG
GGCGTCATTGCTGATTACGTTATTCTTCACGGTTGTAGAGGTCGTAGGGGGAATCCTGTCAAATTCACTTGCATTGCTTT
CTGATTCAATGCATATGTTAAGTGATGTTCTTGCTCTTGGGTTATCGATGATTGCGATATATTTTGCGAGTAAGAAACCA
ACTTCAAATCACACATTCGGCTTTTTAAGGCTGGAAATATTAGCTGCATTTCTAAATGGTCTTGCTTTAGTGGTCATTTC
AATCGGCATCTGTTATGAAGGTATTATGCGTATGATTCATCCGCAAGCGGTAGATGTCAAGCTTATGCTTATCATCTCTA
CTATCGGTTTAATTGTCAATATCATCCTTACATTTATCTTGATGCGCTCACTTAAAGGTGAAGATAATATTAATGTGCAA
AGCGCATTGTGGCATTTTATTGGCGATCTACTGAATTCGGTAGGTGTAATTGTAGCTGTTGCAGTTATTTACTTTACAGG
CTGGGTTTTGATAGACCCAATTTTAAGTATACTGATTTCGATCATCATCTTCCGTGGTGGATATAAGATTGTACGTAATG
CCTGGGTCATCTTAATGGAGCGTGTCCCAGAAGGGTATGATTCAGATGTGATTATTGCAGATATTAAAGCTTTTGACGGT
GTACTGGATGTGCACGAATTCCATCTATGGGCTATTACGACAGAACATTACTCGATTACAGCACACATTGTTGTAGATAA
TTTAGACGGTGTACGAAACTATGAACTGATCAATGCAATTAGTAACATGCTTAAAGAGAAATACAAGCTTGGGCATAGTA
CATTACAAGTTGAACATTTACAGAAGAATCATCTCGATGATCCTTACTTTGATAATATTAAGAAGGAGATAGAATAA

Upstream 100 bases:

>100_bases
TCTGGTATTTTCTTTTTTTAATATAATTCATATTTTAAATTATATACTGATTTATAGTGTACAATACTTATATGAAAATA
ATTGATAGGAGAGATATTAT

Downstream 100 bases:

>100_bases
GTATTGCTTATTCTATCTCCTTTTTGATTGTCACCCTATAAGTTGTATTGCCATTTTTATCTGATGCTTTCTTAATATAT
TTCTTAAGTTCTTTTTTAAA

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MRSINSPEYFHHVEHLKKQNQSRRTLWASLLITLFFTVVEVVGGILSNSLALLSDSMHMLSDVLALGLSMIAIYFASKKP
TSNHTFGFLRLEILAAFLNGLALVVISIGICYEGIMRMIHPQAVDVKLMLIISTIGLIVNIILTFILMRSLKGEDNINVQ
SALWHFIGDLLNSVGVIVAVAVIYFTGWVLIDPILSILISIIIFRGGYKIVRNAWVILMERVPEGYDSDVIIADIKAFDG
VLDVHEFHLWAITTEHYSITAHIVVDNLDGVRNYELINAISNMLKEKYKLGHSTLQVEHLQKNHLDDPYFDNIKKEIE

Sequences:

>Translated_318_residues
MRSINSPEYFHHVEHLKKQNQSRRTLWASLLITLFFTVVEVVGGILSNSLALLSDSMHMLSDVLALGLSMIAIYFASKKP
TSNHTFGFLRLEILAAFLNGLALVVISIGICYEGIMRMIHPQAVDVKLMLIISTIGLIVNIILTFILMRSLKGEDNINVQ
SALWHFIGDLLNSVGVIVAVAVIYFTGWVLIDPILSILISIIIFRGGYKIVRNAWVILMERVPEGYDSDVIIADIKAFDG
VLDVHEFHLWAITTEHYSITAHIVVDNLDGVRNYELINAISNMLKEKYKLGHSTLQVEHLQKNHLDDPYFDNIKKEIE
>Mature_318_residues
MRSINSPEYFHHVEHLKKQNQSRRTLWASLLITLFFTVVEVVGGILSNSLALLSDSMHMLSDVLALGLSMIAIYFASKKP
TSNHTFGFLRLEILAAFLNGLALVVISIGICYEGIMRMIHPQAVDVKLMLIISTIGLIVNIILTFILMRSLKGEDNINVQ
SALWHFIGDLLNSVGVIVAVAVIYFTGWVLIDPILSILISIIIFRGGYKIVRNAWVILMERVPEGYDSDVIIADIKAFDG
VLDVHEFHLWAITTEHYSITAHIVVDNLDGVRNYELINAISNMLKEKYKLGHSTLQVEHLQKNHLDDPYFDNIKKEIE

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=302, Percent_Identity=30.4635761589404, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI21359890, Length=324, Percent_Identity=27.1604938271605, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI21361112, Length=326, Percent_Identity=27.3006134969325, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI64762489, Length=286, Percent_Identity=29.7202797202797, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI289803013, Length=286, Percent_Identity=29.7202797202797, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI289803009, Length=286, Percent_Identity=29.7202797202797, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI289803007, Length=286, Percent_Identity=29.7202797202797, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI289803003, Length=286, Percent_Identity=29.7202797202797, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI20070323, Length=326, Percent_Identity=29.4478527607362, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI14210520, Length=228, Percent_Identity=29.3859649122807, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI52351208, Length=116, Percent_Identity=38.7931034482759, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI222080086, Length=128, Percent_Identity=34.375, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI40255009, Length=128, Percent_Identity=34.375, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI52352803, Length=124, Percent_Identity=38.7096774193548, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1786966, Length=302, Percent_Identity=39.7350993377483, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193210990, Length=308, Percent_Identity=29.5454545454545, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17555794, Length=309, Percent_Identity=30.7443365695793, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17555796, Length=307, Percent_Identity=30.6188925081433, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI32564488, Length=304, Percent_Identity=31.9078947368421, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17550440, Length=125, Percent_Identity=31.2, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17550442, Length=125, Percent_Identity=31.2, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=188, Percent_Identity=34.5744680851064, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=120, Percent_Identity=37.5, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=133, Percent_Identity=34.5864661654135, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325032, Length=240, Percent_Identity=26.25, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583858, Length=316, Percent_Identity=25.3164556962025, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24656728, Length=311, Percent_Identity=27.6527331189711, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24656724, Length=311, Percent_Identity=27.6527331189711, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24656720, Length=311, Percent_Identity=27.6527331189711, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24656715, Length=311, Percent_Identity=27.6527331189711, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21357035, Length=311, Percent_Identity=27.6527331189711, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI28574430, Length=145, Percent_Identity=31.7241379310345, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24584409, Length=145, Percent_Identity=31.7241379310345, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24645863, Length=107, Percent_Identity=37.3831775700935, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24585900, Length=147, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585898, Length=147, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585896, Length=147, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921672, Length=147, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35866; Mature: 35866

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSINSPEYFHHVEHLKKQNQSRRTLWASLLITLFFTVVEVVGGILSNSLALLSDSMHML
CCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDVLALGLSMIAIYFASKKPTSNHTFGFLRLEILAAFLNGLALVVISIGICYEGIMRMIH
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PQAVDVKLMLIISTIGLIVNIILTFILMRSLKGEDNINVQSALWHFIGDLLNSVGVIVAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AVIYFTGWVLIDPILSILISIIIFRGGYKIVRNAWVILMERVPEGYDSDVIIADIKAFDG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHCC
VLDVHEFHLWAITTEHYSITAHIVVDNLDGVRNYELINAISNMLKEKYKLGHSTLQVEHL
HHHHHHEEEEEEEECCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QKNHLDDPYFDNIKKEIE
HHCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MRSINSPEYFHHVEHLKKQNQSRRTLWASLLITLFFTVVEVVGGILSNSLALLSDSMHML
CCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDVLALGLSMIAIYFASKKPTSNHTFGFLRLEILAAFLNGLALVVISIGICYEGIMRMIH
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PQAVDVKLMLIISTIGLIVNIILTFILMRSLKGEDNINVQSALWHFIGDLLNSVGVIVAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AVIYFTGWVLIDPILSILISIIIFRGGYKIVRNAWVILMERVPEGYDSDVIIADIKAFDG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHCC
VLDVHEFHLWAITTEHYSITAHIVVDNLDGVRNYELINAISNMLKEKYKLGHSTLQVEHL
HHHHHHEEEEEEEECCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QKNHLDDPYFDNIKKEIE
HHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]