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The map label for this gene is graS [H]

Identifier: 222150531

GI number: 222150531

Start: 284241

End: 285137

Strand: Direct

Name: graS [H]

Synonym: MCCL_0281

Alternate gene names: 222150531

Gene position: 284241-285137 (Clockwise)

Preceding gene: 222150530

Following gene: 222150532

Centisome position: 13.52

GC content: 31.44

Gene sequence:

>897_bases
ATGGGTTTTATTAAATATAAATTGAATGAAATCATTATTATTATCGTGCTTTCATTATTATTTGGACTAATTATGATGCT
TTATAATACTCCTTTAGAAGGCATTGTATTAACTGCAGGTATTATTATATTTTTAGGAATTATTTATTTCAGTTACAGTA
TGATGATATATAAAAAAGTGTGTACGGTACAAGAAGAAAATTTACAATTGAAAGAAGAAATTCAGGACATAAGAAATGAA
AAGATCGAGTATCAAAGTGAAATAGAGTCATACTTCCTATTGTGGGTTCATCAAATGAAGACACCAATCACTGCTTCAAA
ATTGTTGCTGGAAGCTGAAGATATTCAAACAATTTCACAGATGCGTCACGAGATTCTGCAGATTGATAATTATACGAATC
TCGCACTCAGTTATCTAAAGCTAATGAATGAAAAGACAGACATGGTTTTTATGGAGGTGCGAATGGATGATTTAATCACC
CCTCTCATTAAACGTTACTCAATTCAATTTATTCATAACGATACAAAGCTGCATTACGAAAAAATATACGACAGTGTATT
AACTGATGCGAAATGGACTAGTGTGATGATAGAACAAATTTTAAATAATGCACTGAAGTATGCACGCGGTAAAAATATAT
GGATCAAATATAGCGAAGCAGAAAATATCTTGTCGGTAAAAGATGATGGCATAGGGATTAATACTTCTGATTTGCCCAAG
ATATTTGAAAAAGGCTTCTCCGGATATAATGGTAGATTGAATGATAAATCTAGCGGTATAGGTTTATATATTGTTAAAAC
GATTGCGCGAAGAATGAATGTCTCTGTTTCAGTAGAATCTGAATTAGGCAAAGGGACAATTTTTCATATGAAATTCCCGA
ACCTTACAAATTTGTAA

Upstream 100 bases:

>100_bases
TTGCTGTCAACATGACACGATTACGTAAAAAGCTTCAGAACATTGGGCTTGATAATTTTATTGAAACAAAGAAAAATGTC
GGATATCGAGTGGTGAAGTA

Downstream 100 bases:

>100_bases
GGTTCATTTTTATCTTTGTAAGAATAGATGAAGGTCAGGAAGTTCACGACCGAGTACAATTTACATATAGATTAAAATTA
AAGGAGTGACTTTCATGTTA

Product: sensor histidine kinase

Products: NA

Alternate protein names: Glycopeptide resistance-associated protein S [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MGFIKYKLNEIIIIIVLSLLFGLIMMLYNTPLEGIVLTAGIIIFLGIIYFSYSMMIYKKVCTVQEENLQLKEEIQDIRNE
KIEYQSEIESYFLLWVHQMKTPITASKLLLEAEDIQTISQMRHEILQIDNYTNLALSYLKLMNEKTDMVFMEVRMDDLIT
PLIKRYSIQFIHNDTKLHYEKIYDSVLTDAKWTSVMIEQILNNALKYARGKNIWIKYSEAENILSVKDDGIGINTSDLPK
IFEKGFSGYNGRLNDKSSGIGLYIVKTIARRMNVSVSVESELGKGTIFHMKFPNLTNL

Sequences:

>Translated_298_residues
MGFIKYKLNEIIIIIVLSLLFGLIMMLYNTPLEGIVLTAGIIIFLGIIYFSYSMMIYKKVCTVQEENLQLKEEIQDIRNE
KIEYQSEIESYFLLWVHQMKTPITASKLLLEAEDIQTISQMRHEILQIDNYTNLALSYLKLMNEKTDMVFMEVRMDDLIT
PLIKRYSIQFIHNDTKLHYEKIYDSVLTDAKWTSVMIEQILNNALKYARGKNIWIKYSEAENILSVKDDGIGINTSDLPK
IFEKGFSGYNGRLNDKSSGIGLYIVKTIARRMNVSVSVESELGKGTIFHMKFPNLTNL
>Mature_297_residues
GFIKYKLNEIIIIIVLSLLFGLIMMLYNTPLEGIVLTAGIIIFLGIIYFSYSMMIYKKVCTVQEENLQLKEEIQDIRNEK
IEYQSEIESYFLLWVHQMKTPITASKLLLEAEDIQTISQMRHEILQIDNYTNLALSYLKLMNEKTDMVFMEVRMDDLITP
LIKRYSIQFIHNDTKLHYEKIYDSVLTDAKWTSVMIEQILNNALKYARGKNIWIKYSEAENILSVKDDGIGINTSDLPKI
FEKGFSGYNGRLNDKSSGIGLYIVKTIARRMNVSVSVESELGKGTIFHMKFPNLTNL

Specific function: Member of the two-component regulatory system graR/graS involved in resistance against cationic antimicrobial peptides (CAMPs). GraS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phospha

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 34532; Mature: 34401

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFIKYKLNEIIIIIVLSLLFGLIMMLYNTPLEGIVLTAGIIIFLGIIYFSYSMMIYKKV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CTVQEENLQLKEEIQDIRNEKIEYQSEIESYFLLWVHQMKTPITASKLLLEAEDIQTISQ
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
MRHEILQIDNYTNLALSYLKLMNEKTDMVFMEVRMDDLITPLIKRYSIQFIHNDTKLHYE
HHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHEEHEEECCCHHHHH
KIYDSVLTDAKWTSVMIEQILNNALKYARGKNIWIKYSEAENILSVKDDGIGINTSDLPK
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCCCHHHHH
IFEKGFSGYNGRLNDKSSGIGLYIVKTIARRMNVSVSVESELGKGTIFHMKFPNLTNL
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
GFIKYKLNEIIIIIVLSLLFGLIMMLYNTPLEGIVLTAGIIIFLGIIYFSYSMMIYKKV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CTVQEENLQLKEEIQDIRNEKIEYQSEIESYFLLWVHQMKTPITASKLLLEAEDIQTISQ
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
MRHEILQIDNYTNLALSYLKLMNEKTDMVFMEVRMDDLITPLIKRYSIQFIHNDTKLHYE
HHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHEEHEEECCCHHHHH
KIYDSVLTDAKWTSVMIEQILNNALKYARGKNIWIKYSEAENILSVKDDGIGINTSDLPK
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCCCHHHHH
IFEKGFSGYNGRLNDKSSGIGLYIVKTIARRMNVSVSVESELGKGTIFHMKFPNLTNL
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA