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The map label for this gene is bceR [H]

Identifier: 222150530

GI number: 222150530

Start: 283579

End: 284241

Strand: Direct

Name: bceR [H]

Synonym: MCCL_0280

Alternate gene names: 222150530

Gene position: 283579-284241 (Clockwise)

Preceding gene: 222150529

Following gene: 222150531

Centisome position: 13.49

GC content: 35.6

Gene sequence:

>663_bases
ATGATTGTTGAAGATGATCCGGTTATTCGTGAACATCTTGCTGAAGCACTGAAAAAATGGGGATATGAAGTATACATTGC
AAATAACTTTAATGATATCATTGAAGAATTTAATGATTACAAGCCGCATATAGTACTACTAGATATTAATTTACCTGCTT
ATAATGGTTATCACTGGTGTCAGGAAATAAGAAAGATTTCTCAAATTCCGATTATATTTATCAGTAGTAGAAATGATAGT
ATGGATCAGGTGATGGCGATGCAGATGGGTGCTGACGACTATATCGAGAAACCATTTAATATGACGGTCACAGTATCAAA
AGTTCAGGCGATGCTAAGAAGAAGTTATGACTTCTCCATTTTAGAAAAAGGGATAGAGATTAATGGTGCAGAGCTCATTC
CAGAACAGGCGAAGTTGAGTTTTCGGGATAAACACATTGACTTAACATTGACAGAACTTCAGATTATGCAAAGTCTATTT
AAAGCAAATGGAGGTTTTGTCAGTCGCAATGCACTCATCGAATCATGCTGGGAATCAGAGCATTTTATTGATGATAATAC
GCTTGCTGTCAACATGACACGATTACGTAAAAAGCTTCAGAACATTGGGCTTGATAATTTTATTGAAACAAAGAAAAATG
TCGGATATCGAGTGGTGAAGTAA

Upstream 100 bases:

>100_bases
AGAAGCGGAAATAGAACTTTAAAAATACCAGCCATGTGCTGGTATTTTTTGTTTGGAAATTATTATGGCATAATAAAACT
GAGGTGAGCATATGAAGATT

Downstream 100 bases:

>100_bases
TGGGTTTTATTAAATATAAATTGAATGAAATCATTATTATTATCGTGCTTTCATTATTATTTGGACTAATTATGATGCTT
TATAATACTCCTTTAGAAGG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MIVEDDPVIREHLAEALKKWGYEVYIANNFNDIIEEFNDYKPHIVLLDINLPAYNGYHWCQEIRKISQIPIIFISSRNDS
MDQVMAMQMGADDYIEKPFNMTVTVSKVQAMLRRSYDFSILEKGIEINGAELIPEQAKLSFRDKHIDLTLTELQIMQSLF
KANGGFVSRNALIESCWESEHFIDDNTLAVNMTRLRKKLQNIGLDNFIETKKNVGYRVVK

Sequences:

>Translated_220_residues
MIVEDDPVIREHLAEALKKWGYEVYIANNFNDIIEEFNDYKPHIVLLDINLPAYNGYHWCQEIRKISQIPIIFISSRNDS
MDQVMAMQMGADDYIEKPFNMTVTVSKVQAMLRRSYDFSILEKGIEINGAELIPEQAKLSFRDKHIDLTLTELQIMQSLF
KANGGFVSRNALIESCWESEHFIDDNTLAVNMTRLRKKLQNIGLDNFIETKKNVGYRVVK
>Mature_220_residues
MIVEDDPVIREHLAEALKKWGYEVYIANNFNDIIEEFNDYKPHIVLLDINLPAYNGYHWCQEIRKISQIPIIFISSRNDS
MDQVMAMQMGADDYIEKPFNMTVTVSKVQAMLRRSYDFSILEKGIEINGAELIPEQAKLSFRDKHIDLTLTELQIMQSLF
KANGGFVSRNALIESCWESEHFIDDNTLAVNMTRLRKKLQNIGLDNFIETKKNVGYRVVK

Specific function: Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. When activated by BceS, binds to the upstream region of the bceAB promoter and up-regulates the expression of these two genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=28.1818181818182, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1790860, Length=217, Percent_Identity=29.4930875576037, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=29.2792792792793, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=30.1801801801802, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=26.1467889908257, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=27.6018099547511, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=27.1111111111111, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=25.4310344827586, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1786784, Length=219, Percent_Identity=27.3972602739726, Blast_Score=88, Evalue=3e-19,
Organism=Escherichia coli, GI2367329, Length=208, Percent_Identity=28.3653846153846, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787229, Length=223, Percent_Identity=28.2511210762332, Blast_Score=84, Evalue=5e-18,
Organism=Escherichia coli, GI1789402, Length=217, Percent_Identity=24.4239631336406, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI145693140, Length=227, Percent_Identity=25.9911894273128, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=25.4545454545455, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788550, Length=102, Percent_Identity=32.3529411764706, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25555; Mature: 25555

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVEDDPVIREHLAEALKKWGYEVYIANNFNDIIEEFNDYKPHIVLLDINLPAYNGYHWC
CCCCCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCEEEEEEECCCCCCCHHHH
QEIRKISQIPIIFISSRNDSMDQVMAMQMGADDYIEKPFNMTVTVSKVQAMLRRSYDFSI
HHHHHHHCCCEEEEECCCCCHHHHHHHHCCCHHHHCCCCCEEEEHHHHHHHHHHCCCHHH
LEKGIEINGAELIPEQAKLSFRDKHIDLTLTELQIMQSLFKANGGFVSRNALIESCWESE
HHCCCCCCCHHHCCHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCC
HFIDDNTLAVNMTRLRKKLQNIGLDNFIETKKNVGYRVVK
CEECCCEEEEEHHHHHHHHHHCCCHHHHHHHHCCCEEECC
>Mature Secondary Structure
MIVEDDPVIREHLAEALKKWGYEVYIANNFNDIIEEFNDYKPHIVLLDINLPAYNGYHWC
CCCCCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCEEEEEEECCCCCCCHHHH
QEIRKISQIPIIFISSRNDSMDQVMAMQMGADDYIEKPFNMTVTVSKVQAMLRRSYDFSI
HHHHHHHCCCEEEEECCCCCHHHHHHHHCCCHHHHCCCCCEEEEHHHHHHHHHHCCCHHH
LEKGIEINGAELIPEQAKLSFRDKHIDLTLTELQIMQSLFKANGGFVSRNALIESCWESE
HHCCCCCCCHHHCCHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCC
HFIDDNTLAVNMTRLRKKLQNIGLDNFIETKKNVGYRVVK
CEECCCEEEEEHHHHHHHHHHCCCHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]